BRPI0801811F1 - composition, procurement and use of pharmaceutical composition of gels, foams, mouthwashes or varnishes with reduced concentration of phosphate and / or calcium supplemented fluoride for professional topical application or home use - Google Patents
composition, procurement and use of pharmaceutical composition of gels, foams, mouthwashes or varnishes with reduced concentration of phosphate and / or calcium supplemented fluoride for professional topical application or home useInfo
- Publication number
- BRPI0801811F1 BRPI0801811F1 BRC10801811A BRPI0801811A BRPI0801811F1 BR PI0801811 F1 BRPI0801811 F1 BR PI0801811F1 BR C10801811 A BRC10801811 A BR C10801811A BR PI0801811 A BRPI0801811 A BR PI0801811A BR PI0801811 F1 BRPI0801811 F1 BR PI0801811F1
- Authority
- BR
- Brazil
- Prior art keywords
- fluoride
- product
- phosphate
- calcium
- concentration
- Prior art date
Links
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title abstract 9
- 229910019142 PO4 Inorganic materials 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 4
- 239000010452 phosphate Substances 0.000 title abstract 4
- 230000000699 topical effect Effects 0.000 title abstract 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 3
- 239000011575 calcium Substances 0.000 title abstract 3
- 229910052791 calcium Inorganic materials 0.000 title abstract 3
- 239000006260 foam Substances 0.000 title abstract 3
- 239000000499 gel Substances 0.000 title abstract 3
- 239000002324 mouth wash Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000002966 varnish Substances 0.000 title abstract 3
- 208000002925 dental caries Diseases 0.000 abstract 3
- 238000005299 abrasion Methods 0.000 abstract 2
- 230000007059 acute toxicity Effects 0.000 abstract 2
- 231100000403 acute toxicity Toxicity 0.000 abstract 2
- 238000005516 engineering process Methods 0.000 abstract 2
- 230000003628 erosive effect Effects 0.000 abstract 2
- 239000001736 Calcium glycerylphosphate Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000007844 bleaching agent Substances 0.000 abstract 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 abstract 1
- 229910001634 calcium fluoride Inorganic materials 0.000 abstract 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 abstract 1
- 229940095618 calcium glycerophosphate Drugs 0.000 abstract 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 210000003298 dental enamel Anatomy 0.000 abstract 1
- 239000003975 dentin desensitizing agent Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940051866 mouthwash Drugs 0.000 abstract 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 abstract 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 abstract 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 abstract 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 abstract 1
- 239000000606 toothpaste Substances 0.000 abstract 1
- 229940025703 topical product Drugs 0.000 abstract 1
- 230000003442 weekly effect Effects 0.000 abstract 1
- 230000002087 whitening effect Effects 0.000 abstract 1
Landscapes
- Cosmetics (AREA)
Abstract
composição, obtenção e uso de composição farmacêutica de géis, espumas, enxaguatórios bucais ou vernizes com reduzida concentração de fluoreto suplementado com fosfato e/ou cálcio para aplicação tópica profissional ou uso caseiro". os produtos de aplicação tópica de fluoreto são efetivos no controle da cárie, erosão e abrasão dentária, principalmente em pacientes de risco determinado de cárie ou cárie-ativo, erosão e/ou abrasão clinicamente diagnosticada. sua eficiência se baseia na alta concentração de fluoreto que induz a formação de fluoreto de cálcio na superficie do esmalte dentário protegendo-a contra o ataque ácido. entretanto, como apresentam uma grande quantidade de fluoreto, em crianças pode causar toxicidade aguda, como já relatada na literatura. a presente invenção provê uma formulação farmacêutica na forma de gel, espuma, enxaguatório bucal, de uso diário ou semanal, ou verniz, com reduzida concentração de fluoreto (1%; 1,32%; 0,02 ou 0,1%; 2,5%) de forma a aumentar a eficácia do produto quando comparado aos produtos de uso tópico comerciais e diminiuir o risco de ocorrência da toxicidade aguda. para atingir este objetivo suplementa-se o produto tópico com uma fonte de fosfato (trimetafosfato de sódio - tmp ou hexametafosfato de sódio - hmp) na concentração de 0,1 a 10%, ou uma fonte de cálcio e fosfato (glicerofosfato de cálcio - cagp) na concentração de 0,1 a 5%, durante o preparo do produto. o acréscimo destes ativos no produto não insolubiliza o fluoreto, pois os compostos são insolúveis na mistura. como não há interação entre os ativos (fontes de fluoreto com tmp, hmp, ou com cagp) a formulação é de fácil manufatura sem acréscimos de outras tecnologias ou fórmulas ou designer dos recipientes para manter a efetividade do produto. ao produto, poderão ser acrescidos agentes antiplaca, branqueadores e desensibilizantes. o produto pode ser manufaturado e comercializado diretamente para o consumo por indústrias farmacêuticas ou de cosméticos, não sendo só restrito seu uso a crianças, mas também aos adultos, já que apresenta efetividade superior aos produtos comerciais. esta tecnologia pode ser utilizada em outros produtos da área odontológica como: dentifrícios fluoretados ou produtos de uso caseiro.composition, obtaining and use of pharmaceutical composition of gels, foams, mouthwashes or varnishes with low concentration of phosphate and / or calcium supplemented fluoride for professional topical application or home use. "Topical fluoride application products are effective in controlling the dental caries, erosion and abrasion, especially in patients at clinically diagnosed risk of caries or active caries, erosion and / or abrasion, its efficiency is based on the high concentration of fluoride that induces the formation of calcium fluoride on the surface of the dental enamel. however, as they present a large amount of fluoride, in children it can cause acute toxicity, as already reported in the literature .The present invention provides a pharmaceutical formulation in the form of a gel, foam, mouthwash for daily or weekly, or varnish, with reduced fluoride concentration (1%; 1.32%; 0.02 or 0.1%; 2.5%) to increase the efficacy of the product compared to commercial topical products and to decrease the risk of acute toxicity occurring. To achieve this, the topical product is supplemented with a source of phosphate (sodium trimetaphosphate - tmp or sodium hexametaphosphate - hmp) at a concentration of 0.1 to 10%, or a source of calcium and phosphate (calcium glycerophosphate - cagp) at a concentration of 0.1 to 5% during the preparation of the product. The addition of these actives in the product does not insolubilize fluoride because the compounds are insoluble in the mixture. As there is no interaction between the assets (fluoride sources with tmp, hmp, or cagp) the formulation is easy to manufacture without adding other technologies or formulas or container designers to maintain product effectiveness. Antiplate, whitening and desensitizing agents may be added to the product. The product can be manufactured and marketed directly for consumption by pharmaceutical or cosmetic industries, not only being restricted to children, but also to adults, since it has superior effectiveness to commercial products. This technology can be used in other dental products such as fluoride toothpastes or home care products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRC10801811A BRPI0801811F1 (en) | 2008-04-29 | 2008-04-29 | composition, procurement and use of pharmaceutical composition of gels, foams, mouthwashes or varnishes with reduced concentration of phosphate and / or calcium supplemented fluoride for professional topical application or home use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRC10801811A BRPI0801811F1 (en) | 2008-04-29 | 2008-04-29 | composition, procurement and use of pharmaceutical composition of gels, foams, mouthwashes or varnishes with reduced concentration of phosphate and / or calcium supplemented fluoride for professional topical application or home use |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0801811A2 BRPI0801811A2 (en) | 2011-01-11 |
| BRPI0801811E2 BRPI0801811E2 (en) | 2011-04-12 |
| BRPI0801811B1 BRPI0801811B1 (en) | 2016-06-07 |
| BRPI0801811F1 true BRPI0801811F1 (en) | 2017-04-11 |
Family
ID=43417147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRC10801811A BRPI0801811F1 (en) | 2008-04-29 | 2008-04-29 | composition, procurement and use of pharmaceutical composition of gels, foams, mouthwashes or varnishes with reduced concentration of phosphate and / or calcium supplemented fluoride for professional topical application or home use |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BRPI0801811F1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160175350A1 (en) * | 2013-07-31 | 2016-06-23 | Colgate-Palmolive Company | Aluminum chlorohydrate salts exhibiting high sec peak 3 |
-
2008
- 2008-04-29 BR BRC10801811A patent/BRPI0801811F1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0801811E2 (en) | 2011-04-12 |
| BRPI0801811B1 (en) | 2016-06-07 |
| BRPI0801811A2 (en) | 2011-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
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