BRPI0806538A2 - Derivados de glicinamida de espiropiperidina - Google Patents

Derivados de glicinamida de espiropiperidina

Info

Publication number: BRPI0806538A2
Authority: BR; Brazil
Prior art keywords: spyropiperidine; glycinamide derivatives; glycinamide; derivatives; spyropiperidine glycinamide
Prior art date: 2007-01-12

Application number

BRPI0806538-1A2A

Other languages

English (en)

Inventor

Caterina Bissantz

Erwin Goetschi

Christophe Grundschober

Raffaello Masciadri

Hasane Ratni

Mark Rogers-Evans

Patrick Schnider

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-12

Filing date

2008-01-03

Publication date

2014-04-22

2008-01-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-04-22 Publication of BRPI0806538A2 publication Critical patent/BRPI0806538A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0806538-1A2A 2007-01-12 2008-01-03 Derivados de glicinamida de espiropiperidina BRPI0806538A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07100486		2007-01-12
PCT/EP2008/050028 WO2008084005A1 (en)	2007-01-12	2008-01-03	Spiropiperidine glycinamide derivatives

Publications (1)

Publication Number	Publication Date
BRPI0806538A2 true BRPI0806538A2 (pt)	2014-04-22

Family

ID=39201768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0806538-1A2A BRPI0806538A2 (pt)	2007-01-12	2008-01-03	Derivados de glicinamida de espiropiperidina

Country Status (17)

Country	Link
US (3)	US20080171760A1 (pt)
EP (1)	EP2104677B1 (pt)
JP (1)	JP2010515700A (pt)
KR (1)	KR101129791B1 (pt)
CN (1)	CN101583615B (pt)
AR (1)	AR064831A1 (pt)
AT (1)	ATE536356T1 (pt)
AU (1)	AU2008204491B2 (pt)
BR (1)	BRPI0806538A2 (pt)
CA (1)	CA2674958A1 (pt)
CL (1)	CL2008000059A1 (pt)
ES (1)	ES2376378T3 (pt)
IL (1)	IL199583A0 (pt)
MX (1)	MX2009007411A (pt)
PE (1)	PE20081851A1 (pt)
TW (1)	TW200836728A (pt)
WO (1)	WO2008084005A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2009119394A (ru) *	2006-12-07	2011-01-20	Ф. Хоффманн-Ля Рош Аг (Ch)	Производные спиро-пиперидина в качестве антагонистов рецептора v1a
CA2673307A1 (en) *	2006-12-22	2008-07-03	F. Hoffman-La Roche Ag	Spiro-piperidine derivatives
EP2104677B1 (en) *	2007-01-12	2011-12-07	F. Hoffmann-La Roche AG	Spiropiperidine glycinamide derivatives
WO2010054961A1 (en)	2008-11-13	2010-05-20	F. Hoffmann-La Roche Ag	Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes
EP2358714B1 (en)	2008-11-18	2012-08-01	F. Hoffmann-La Roche AG	Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
MY150837A (en)	2008-11-28	2014-02-28	Hoffmann La Roche	Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
US8420633B2 (en)	2010-03-31	2013-04-16	Hoffmann-La Roche Inc.	Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en)	2010-04-13	2013-06-11	Hoffmann-La Roche Inc.	Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en)	2010-04-21	2013-07-23	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en)	2010-04-26	2013-07-09	Hoffmann-La Roche Inc.	Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en)	2010-05-10	2013-08-20	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
PL3083633T3 (pl)	2013-12-19	2018-04-30	F.Hoffmann-La Roche Ag	Spirooksazolony
TW201600522A (zh)	2014-02-20	2016-01-01	赫孚孟拉羅股份公司	螺－唑酮
AU2015345102A1 (en) *	2014-11-14	2017-03-30	F. Hoffmann-La Roche Ag	Spiro-thiazolones

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3370091A (en)	1964-06-15	1968-02-20	Hoffmann La Roche	2 aminobenzhydrylhalides
US3531467A (en)	1966-12-23	1970-09-29	Hoffmann La Roche	Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives
DK78692D0 (da)	1992-06-12	1992-06-12	Lundbeck & Co As H	Dimere piperidin- og piperazinderivater
IT1271026B (it)	1994-10-21	1997-05-26	Isagro Ricerca Srl	Derivati dell'acido b-amminopropionico ad attivita' fungicida
GB9601724D0 (en) *	1996-01-29	1996-03-27	Merck Sharp & Dohme	Therapeutic agents
US20040152741A1 (en)	2002-09-09	2004-08-05	Nps Allelix Corporation	Arylglycine derivatives and their use as glycine transport inhibitors
AU2003263155A1 (en)	2002-09-20	2004-04-08	H. Lundbeck A/S	Method for manufacture of dihydroisobenzofuran derivatives
AU2003215549A1 (en)	2003-02-03	2004-08-30	Janssen Pharmaceutica N.V.	Mercaptoimidazoles as ccr2 receptor antagonists
US7244852B2 (en) *	2003-02-27	2007-07-17	Abbott Laboratories	Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
JP2007510662A (ja) *	2003-11-04	2007-04-26	エリクシアーファーマシューティカルズ，インコーポレイテッド	治療化合物およびその使用
PT1904477E (pt) *	2005-07-14	2009-03-12	Hoffmann La Roche	Derivados de indol-3-carbonil-espiro-piperidina como antagonistas do receptor de v1a
US8193208B2 (en) *	2005-09-09	2012-06-05	Purdue Pharma L.P.	Fused and spirocycle compounds and the use thereof
EP2104677B1 (en) *	2007-01-12	2011-12-07	F. Hoffmann-La Roche AG	Spiropiperidine glycinamide derivatives

2008
- 2008-01-03 EP EP08701212A patent/EP2104677B1/en not_active Not-in-force
- 2008-01-03 WO PCT/EP2008/050028 patent/WO2008084005A1/en not_active Ceased
- 2008-01-03 AU AU2008204491A patent/AU2008204491B2/en not_active Expired - Fee Related
- 2008-01-03 CA CA002674958A patent/CA2674958A1/en not_active Abandoned
- 2008-01-03 JP JP2009545158A patent/JP2010515700A/ja active Pending
- 2008-01-03 BR BRPI0806538-1A2A patent/BRPI0806538A2/pt not_active IP Right Cessation
- 2008-01-03 MX MX2009007411A patent/MX2009007411A/es not_active Application Discontinuation
- 2008-01-03 CN CN200880002180XA patent/CN101583615B/zh not_active Expired - Fee Related
- 2008-01-03 AT AT08701212T patent/ATE536356T1/de active
- 2008-01-03 KR KR1020097016714A patent/KR101129791B1/ko not_active Expired - Fee Related
- 2008-01-03 ES ES08701212T patent/ES2376378T3/es active Active
- 2008-01-07 US US11/969,993 patent/US20080171760A1/en not_active Abandoned
- 2008-01-07 US US11/969,983 patent/US20080194610A1/en not_active Abandoned
- 2008-01-07 US US11/969,975 patent/US7498339B2/en not_active Expired - Fee Related
- 2008-01-09 TW TW097100900A patent/TW200836728A/zh unknown
- 2008-01-09 PE PE2008000099A patent/PE20081851A1/es not_active Application Discontinuation
- 2008-01-10 CL CL200800059A patent/CL2008000059A1/es unknown
- 2008-01-10 AR ARP080100089A patent/AR064831A1/es unknown
2009
- 2009-06-25 IL IL199583A patent/IL199583A0/en unknown

Also Published As

Publication number	Publication date
AU2008204491A1 (en)	2008-07-17
ATE536356T1 (de)	2011-12-15
AR064831A1 (es)	2009-04-29
US20080194610A1 (en)	2008-08-14
EP2104677B1 (en)	2011-12-07
CN101583615A (zh)	2009-11-18
TW200836728A (en)	2008-09-16
CA2674958A1 (en)	2008-07-17
CN101583615B (zh)	2012-07-04
PE20081851A1 (es)	2009-01-09
EP2104677A1 (en)	2009-09-30
US20080171759A1 (en)	2008-07-17
JP2010515700A (ja)	2010-05-13
US20080171760A1 (en)	2008-07-17
ES2376378T3 (es)	2012-03-13
CL2008000059A1 (es)	2008-07-18
AU2008204491B2 (en)	2012-05-03
KR20090097217A (ko)	2009-09-15
WO2008084005A1 (en)	2008-07-17
US7498339B2 (en)	2009-03-03
KR101129791B1 (ko)	2012-03-23
IL199583A0 (en)	2010-03-28
MX2009007411A (es)	2009-07-17

Publication	Publication Date	Title
BRPI0813707A2 (pt)	2014-12-30	Derivados de pirimidinil-piridazinona
BRPI0820112A2 (pt)	2015-05-05	Derivados de isoxazol-piridina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0820113A2 (pt)	2015-05-05	Derivados de isoxazolo-piridazina
BRPI0812155A2 (pt)	2019-09-24	derivados de espiroindolinona
BRPI0817935A2 (pt)	2015-04-07	Derivados de biarila
DK2209786T3 (da)	2013-06-03	Pyrimidinsubstituerede purinderivater
BRPI0814236A2 (pt)	2015-01-06	Derivados de quinazolinamida
BRPI0812518A2 (pt)	2015-03-31	Derivados de indazolamida
EP2226315A4 (en)	2012-01-25	2-aminoquinazoline DERIVATIVE
BRPI0806538A2 (pt)	2014-04-22	Derivados de glicinamida de espiropiperidina
ATE475662T1 (de)	2010-08-15	Dihydropyrazolopyrimidinonderivate
CR10841A (es)	2009-06-30	Imidazotriazinas imidazopirimidinas inhibidores de cinasa
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
BRPI0813836A2 (pt)	2015-01-06	Derivados pirazólicos
BRPI0820649A2 (pt)	2015-06-16	Derivados de isoxazalo-pirazina
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
DK2035394T3 (da)	2009-10-05	2-pyrazincarboxamidderivater
EP2233838A4 (en)	2013-01-09	COOKER
BRPI0915064A2 (pt)	2015-10-27	derivados de qunoxalinadiona
BRPI0913832A2 (pt)	2015-10-20	derivados de pirrolopiridinilpirimidin-2-ilamina
DK2152370T3 (da)	2011-08-15	Aryletherpyridazinonderivater
BRPI0821258A2 (pt)	2015-06-16	Derivados de ciclopropilamina
ATE544764T1 (de)	2012-02-15	5-hydroxymethyloxazolidin-2-onderivate

Legal Events

Date	Code	Title	Description
2014-08-26	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A ANUIDADE.
2014-12-30	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2277 DE 26/08/2014.