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BRPI0611965A2 - modulação sinergìstica de cinase flt3 usando um inibidor de flt3 e um inibidor de farnesil transferase - Google Patents

modulação sinergìstica de cinase flt3 usando um inibidor de flt3 e um inibidor de farnesil transferase

Info

Publication number
BRPI0611965A2
BRPI0611965A2 BRPI0611965-4A BRPI0611965A BRPI0611965A2 BR PI0611965 A2 BRPI0611965 A2 BR PI0611965A2 BR PI0611965 A BRPI0611965 A BR PI0611965A BR PI0611965 A2 BRPI0611965 A2 BR PI0611965A2
Authority
BR
Brazil
Prior art keywords
flt3
inhibitor
modulation
kinase
farnesyl transferase
Prior art date
Application number
BRPI0611965-4A
Other languages
English (en)
Inventor
Christian Andrew Baumann
Michael David Gaul
Robert W Tuman
Dana L Johnson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0611965A2 publication Critical patent/BRPI0611965A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

MODULAçãO SINERGìSTICA DE CINASE FLT3 USANDO UM INIBIDOR DE FLT3 E UM INIBIDOR DE FARNESIL TRANSFERASE. A presente invenção é dirigida para um método de inibição da atividade de tirosina cinase FLT3, ou redução da atividade ou expressão de cinase FLT3 em uma célula ou um sujeito, compreendendo a administração de um inibidor de farnesil transferase e um inibidor de cinase FLT3, selecionado dos compostos de Fórmula I': Incluídos na pi esente invenção, se encontram os métodos profiláticos e terapêuticos para tratamento de um sujeito em risco de (ou suscetível ao risco) desenvolver um distúrbio de proliferação celular ou um distúrbio correlacionado à FLT3.
BRPI0611965-4A 2005-06-10 2006-06-07 modulação sinergìstica de cinase flt3 usando um inibidor de flt3 e um inibidor de farnesil transferase BRPI0611965A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69007005P 2005-06-10 2005-06-10
US79332006P 2006-04-19 2006-04-19
PCT/US2006/022412 WO2006138155A1 (en) 2005-06-10 2006-06-07 Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor

Publications (1)

Publication Number Publication Date
BRPI0611965A2 true BRPI0611965A2 (pt) 2009-11-10

Family

ID=37075591

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0611965-4A BRPI0611965A2 (pt) 2005-06-10 2006-06-07 modulação sinergìstica de cinase flt3 usando um inibidor de flt3 e um inibidor de farnesil transferase

Country Status (9)

Country Link
US (2) US20060281788A1 (pt)
EP (1) EP1898912A1 (pt)
JP (1) JP5078885B2 (pt)
KR (1) KR101433595B1 (pt)
AU (1) AU2006259638B2 (pt)
BR (1) BRPI0611965A2 (pt)
CA (1) CA2611474C (pt)
NZ (1) NZ563678A (pt)
WO (1) WO2006138155A1 (pt)

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Also Published As

Publication number Publication date
WO2006138155A1 (en) 2006-12-28
US20060281788A1 (en) 2006-12-14
KR20080018947A (ko) 2008-02-28
US8557847B2 (en) 2013-10-15
EP1898912A1 (en) 2008-03-19
JP2008543772A (ja) 2008-12-04
JP5078885B2 (ja) 2012-11-21
NZ563678A (en) 2011-04-29
AU2006259638A1 (en) 2006-12-28
KR101433595B1 (ko) 2014-08-26
AU2006259638B2 (en) 2010-12-09
CA2611474A1 (en) 2006-12-28
CA2611474C (en) 2013-11-12
US20090197913A1 (en) 2009-08-06

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