BRPI0610134A2 - derivados de 2-amino-4-fenilquinazolina e o uso do mesmo como moduladores de hsp90 - Google Patents

derivados de 2-amino-4-fenilquinazolina e o uso do mesmo como moduladores de hsp90 Download PDF

Info

Publication number: BRPI0610134A2
Authority: BR; Brazil
Prior art keywords: amino; quinazoline; chloro; phenyl; denotes
Prior art date: 2005-05-19

Application number

BRPI0610134-8A

Other languages

English (en)

Portuguese (pt)

Inventor

Hans-Michael Eggenweiler

Michael Wolf

Hans-Peter Buchstaller

Original Assignee

Mereck Patent Ges Mit Beschr N

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-19

Filing date

2006-04-24

Publication date

2010-06-01

2006-04-24 Application filed by Mereck Patent Ges Mit Beschr N filed Critical Mereck Patent Ges Mit Beschr N

2010-06-01 Publication of BRPI0610134A2 publication Critical patent/BRPI0610134A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
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- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Neurology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Biotechnology (AREA)
Obesity (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Gastroenterology & Hepatology (AREA)
Psychiatry (AREA)
Toxicology (AREA)

BRPI0610134-8A 2005-05-19 2006-04-24 derivados de 2-amino-4-fenilquinazolina e o uso do mesmo como moduladores de hsp90 BRPI0610134A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102005022977A DE102005022977A1 (de)	2005-05-19	2005-05-19	Phenylchinazolinderivate
DE102005022977.8		2005-05-19
PCT/EP2006/003734 WO2006122631A1 (de)	2005-05-19	2006-04-24	2-amin0-4-phenylchinazolinderivate und ihre verwendung als hsp90 modulatoren

Publications (1)

Publication Number	Publication Date
BRPI0610134A2 true BRPI0610134A2 (pt)	2010-06-01

Family

ID=36763987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0610134-8A BRPI0610134A2 (pt)	2005-05-19	2006-04-24	derivados de 2-amino-4-fenilquinazolina e o uso do mesmo como moduladores de hsp90

Country Status (14)

Country	Link
US (1)	US7947696B2 (es)
EP (1)	EP1881965A1 (es)
JP (1)	JP5075117B2 (es)
KR (1)	KR20080016651A (es)
CN (1)	CN101180278B (es)
AR (1)	AR054047A1 (es)
AU (1)	AU2006246744B2 (es)
BR (1)	BRPI0610134A2 (es)
CA (1)	CA2608766A1 (es)
DE (1)	DE102005022977A1 (es)
MX (1)	MX2007014264A (es)
RU (1)	RU2421449C2 (es)
WO (1)	WO2006122631A1 (es)
ZA (1)	ZA200710966B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7910595B2 (en) *	2005-12-21	2011-03-22	Abbott Laboratories	Anti-viral compounds
AR061185A1 (es)	2006-05-26	2008-08-13	Chugai Pharmaceutical Co Ltd	Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
DE602008003404D1 (de)	2007-02-01	2010-12-23	Astrazeneca Ab	5,6,7,8-tetrahydropteridin-derivate als hsp90-hemmer
CN101675059A (zh)	2007-03-01	2010-03-17	中外制药株式会社	大环状化合物
ATE540028T1 (de) *	2007-03-27	2012-01-15	Synta Pharmaceuticals Corp	Als hsp90-inhibitoren geeignete triazinon- und diazinonderivate
EP3243814B1 (en)	2007-04-16	2018-10-17	AbbVie Inc.	7-substituted indole as mcl-1 inhibitors
GB2449293A (en) *	2007-05-17	2008-11-19	Evotec	Compounds having Hsp90 inhibitory activity
DE102007032739A1 (de)	2007-07-13	2009-01-15	Merck Patent Gmbh	Chinazolinamidderivate
GB0722680D0 (en) *	2007-11-19	2007-12-27	Topotarget As	Therapeutic compounds and their use
US20110281908A1 (en) *	2008-10-06	2011-11-17	Emory University	Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
DE102008061214A1 (de) *	2008-12-09	2010-06-10	Merck Patent Gmbh	Chinazolinamidderivate
RU2571662C2 (ru)	2009-03-25	2015-12-20	Эббви Инк.	Противовирусные соединения и их применения
AR077405A1 (es)	2009-07-10	2011-08-24	Sanofi Aventis	Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
DE102010046837A1 (de) *	2010-09-29	2012-03-29	Merck Patent Gmbh	Phenylchinazolinderivate
US8912181B2 (en)	2011-01-07	2014-12-16	Taiho Pharmaceutical Co., Ltd.	Bicyclic compound or salt thereof
AR091858A1 (es) *	2012-07-25	2015-03-04	Sova Pharmaceuticals Inc	INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
EP3154547B1 (en) *	2014-06-13	2023-06-07	Yuma Therapeutics, Inc.	Pyrimidine compounds and methods using the same
WO2017147701A1 (en)	2016-03-01	2017-09-08	Ontario Institute For Cancer Research (Oicr)	Inhibitors of wdr5 protein-protein binding
MX2018010374A (es)	2016-03-01	2019-03-28	Propellon Therapeutics Inc	Inhibidores del enlace proteína-proteína de wdr5.
KR101990669B1 (ko) *	2016-05-31	2019-06-19	전남대학교산학협력단	퀴나졸린 유도체, 이의 제조방법 및 이를 함유하는 인플루엔자 바이러스 치료용 약학적 조성물
JP7507162B2 (ja) *	2019-01-04	2024-06-27	ベルブルックラボズ，エルエルシー	治療薬としてのｃＧＡＳ活性の阻害剤
WO2024076677A2 (en) *	2022-10-07	2024-04-11	Bellbrook Labs, Llc	Imidazolyl-alkoxyquinolin-2-amines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06192099A (ja) *	1992-10-07	1994-07-12	Sumitomo Pharmaceut Co Ltd	腫瘍壊死因子産生阻害剤
US5646154A (en)	1992-10-07	1997-07-08	Sumitomo Pharmaceuticals Co., Ltd.	Pharmaceutical compositions for inhibiting the formation of tumor necrosis factor
JPH11209350A (ja) *	1998-01-26	1999-08-03	Eisai Co Ltd	含窒素複素環誘導体およびその医薬
US7053105B2 (en) *	2000-09-25	2006-05-30	Janssen Pharmaceutica, N.V.	Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
AR038658A1 (es) *	2001-06-15	2005-01-26	Novartis Ag	Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento
DE10163991A1 (de) *	2001-12-24	2003-07-03	Merck Patent Gmbh	Pyrrolo-pyrimidine
NZ546044A (en) *	2003-08-29	2009-09-25	Vernalis Cambridge Ltd	Pyrimidothiophene compounds
JP2007510642A (ja) *	2003-11-03	2007-04-26	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	中枢神経系障害の治療のための新規ノルエピネフリン再取込み阻害薬

2005
- 2005-05-19 DE DE102005022977A patent/DE102005022977A1/de not_active Withdrawn
2006
- 2006-04-24 AU AU2006246744A patent/AU2006246744B2/en not_active Ceased
- 2006-04-24 CA CA002608766A patent/CA2608766A1/en not_active Abandoned
- 2006-04-24 CN CN2006800174191A patent/CN101180278B/zh not_active Expired - Fee Related
- 2006-04-24 RU RU2007146388/04A patent/RU2421449C2/ru not_active IP Right Cessation
- 2006-04-24 JP JP2008511580A patent/JP5075117B2/ja not_active Expired - Fee Related
- 2006-04-24 MX MX2007014264A patent/MX2007014264A/es active IP Right Grant
- 2006-04-24 KR KR1020077029415A patent/KR20080016651A/ko not_active Ceased
- 2006-04-24 WO PCT/EP2006/003734 patent/WO2006122631A1/de not_active Ceased
- 2006-04-24 EP EP06724519A patent/EP1881965A1/de not_active Withdrawn
- 2006-04-24 US US11/914,604 patent/US7947696B2/en not_active Expired - Fee Related
- 2006-04-24 BR BRPI0610134-8A patent/BRPI0610134A2/pt not_active IP Right Cessation
- 2006-05-19 AR ARP060102035A patent/AR054047A1/es not_active Application Discontinuation
2007
- 2007-12-18 ZA ZA200710966A patent/ZA200710966B/xx unknown

Also Published As

Publication number	Publication date
US7947696B2 (en)	2011-05-24
WO2006122631A1 (de)	2006-11-23
AU2006246744A1 (en)	2006-11-23
KR20080016651A (ko)	2008-02-21
JP2008540587A (ja)	2008-11-20
AR054047A1 (es)	2007-05-30
US20080214586A1 (en)	2008-09-04
CN101180278A (zh)	2008-05-14
RU2421449C2 (ru)	2011-06-20
JP5075117B2 (ja)	2012-11-14
HK1119690A1 (en)	2009-03-13
EP1881965A1 (de)	2008-01-30
RU2007146388A (ru)	2009-06-27
CN101180278B (zh)	2011-05-04
DE102005022977A1 (de)	2006-12-07
ZA200710966B (en)	2008-12-31
CA2608766A1 (en)	2006-11-23
AU2006246744B2 (en)	2011-11-03
MX2007014264A (es)	2008-01-22

Publication	Publication Date	Title
CA2652394C (en)	2015-04-07	Triazole derivatives ii
ES2394513T3 (es)	2013-02-01	Derivados triazol inhibidores de HSP90
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