BRPI0616091B8 - produto processado pelo calor e respectivos métodos de produção de produto de planta comestível e de planta transgênica, de redução do conteúdo de acrilamida em produto de planta e de sobreexpressão de gene em tubérculo de batata, seqüência de polinucleotídeo isolado e planta - Google Patents
produto processado pelo calor e respectivos métodos de produção de produto de planta comestível e de planta transgênica, de redução do conteúdo de acrilamida em produto de planta e de sobreexpressão de gene em tubérculo de batata, seqüência de polinucleotídeo isolado e planta Download PDFInfo
- Publication number
- BRPI0616091B8 BRPI0616091B8 BRPI0616091A BRPI0616091A BRPI0616091B8 BR PI0616091 B8 BRPI0616091 B8 BR PI0616091B8 BR PI0616091 A BRPI0616091 A BR PI0616091A BR PI0616091 A BRPI0616091 A BR PI0616091A BR PI0616091 B8 BRPI0616091 B8 BR PI0616091B8
- Authority
- BR
- Brazil
- Prior art keywords
- plant
- product
- reduction
- heat
- isolated polynucleotide
- Prior art date
Links
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 241000196324 Embryophyta Species 0.000 title 3
- 235000002595 Solanum tuberosum Nutrition 0.000 title 1
- 244000061456 Solanum tuberosum Species 0.000 title 1
- 235000018927 edible plant Nutrition 0.000 title 1
- 238000003208 gene overexpression Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
- 235000013305 food Nutrition 0.000 abstract 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
- A23L19/12—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops of potatoes
- A23L19/18—Roasted or fried products, e.g. snacks or chips
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/82—Asparaginase (3.5.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- General Preparation And Processing Of Foods (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Confectionery (AREA)
Abstract
produto processado pelo calor e respectivos métodos de produção de produto de planta comestível e de planta transgênica, de redução de conteúdo de acrilamida em produto de planta e de sobreexpressão de gene em tubérculo de batata, seqüência de polinucleotídeo isolado e planta. a presente invenção proporciona seqüências de polinucleotídeos e polipeptídeos a partir de plantas, métodos de redução dos níveis de asparagina livre em plantas, métodos de produção de alimentos processados pelo calor contendo níveis reduzidos de acrilamida e plantas e alimentos obtidos por estes métodos.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71833505P | 2005-09-20 | 2005-09-20 | |
| US60/718,335 | 2005-09-20 | ||
| US83378806P | 2006-07-28 | 2006-07-28 | |
| US60/833,788 | 2006-07-28 | ||
| PCT/US2006/036515 WO2007035752A2 (en) | 2005-09-20 | 2006-09-19 | Low acrylamide foods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0616091A2 BRPI0616091A2 (pt) | 2013-02-13 |
| BRPI0616091B8 true BRPI0616091B8 (pt) | 2020-01-28 |
Family
ID=37889473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0616091A BRPI0616091B8 (pt) | 2005-09-20 | 2006-09-19 | produto processado pelo calor e respectivos métodos de produção de produto de planta comestível e de planta transgênica, de redução do conteúdo de acrilamida em produto de planta e de sobreexpressão de gene em tubérculo de batata, seqüência de polinucleotídeo isolado e planta |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20070074304A1 (pt) |
| EP (2) | EP1974039B1 (pt) |
| JP (1) | JP5368097B2 (pt) |
| CN (2) | CN101313070B (pt) |
| AT (1) | ATE478957T1 (pt) |
| AU (1) | AU2006292286B2 (pt) |
| BR (1) | BRPI0616091B8 (pt) |
| CA (1) | CA2623266C (pt) |
| DE (1) | DE602006016489D1 (pt) |
| ES (1) | ES2538213T3 (pt) |
| NZ (1) | NZ567293A (pt) |
| PL (2) | PL1974039T3 (pt) |
| RU (1) | RU2458133C2 (pt) |
| WO (1) | WO2007035752A2 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ535395A (en) | 2002-02-20 | 2009-01-31 | Simplot Co J R | Precise plant breeding using plant DNA border like sequences instead of Agrobacterium borders |
| US7534934B2 (en) | 2002-02-20 | 2009-05-19 | J.R. Simplot Company | Precise breeding |
| PL1799028T3 (pl) * | 2004-09-24 | 2015-06-30 | Simplot Co J R | Wyciszanie genów |
| US8252742B2 (en) * | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| US20090123626A1 (en) * | 2007-09-28 | 2009-05-14 | J.R. Simplot Company | Reduced acrylamide plants and foods |
| US20100255167A1 (en) * | 2009-04-07 | 2010-10-07 | Frito-Lay North America, Inc. | Method for Reducing Acrylamide in Food Products |
| WO2011162250A1 (ja) * | 2010-06-25 | 2011-12-29 | 吉岡 禎三 | 加熱処理加工食品中のアクリルアミド低減方法 |
| US20130059045A1 (en) * | 2011-09-07 | 2013-03-07 | Franklin S. Tiegs | Oven baked french fry with reduced acrylamide level |
| GB201115893D0 (en) | 2011-09-14 | 2011-10-26 | Plant Bioscience Ltd | Over-expression of GCN2-Type protein kinase in plants |
| CN104884626A (zh) * | 2012-11-20 | 2015-09-02 | 杰.尔.辛普洛公司 | Tal介导的转移dna插入 |
| CA2993801C (en) * | 2013-05-02 | 2021-01-05 | J.R. Simplot Company | Potato transformation vector for silencing endogenous asparagine synthetase-1 and polyphenol oxidase-5, phosphorylase-l and dikinase r1 |
| EP3157324A1 (en) * | 2014-06-17 | 2017-04-26 | J.R. Simplot Company | Potato cultivar w8 |
| CN107002135A (zh) * | 2014-10-10 | 2017-08-01 | 杰.尔.辛普洛公司 | 事件特异性检测方法 |
| CA2985369A1 (en) | 2015-05-14 | 2016-11-17 | J.R. Simplot Company | Potato cultivar v11 |
| WO2017042162A1 (en) * | 2015-09-09 | 2017-03-16 | Philip Morris Products S.A. | Plants with reduced asparagine content |
| CN108347894B (zh) | 2015-10-08 | 2019-10-29 | 杰.尔.辛普洛公司 | 马铃薯栽培品种y9 |
| CA3000750A1 (en) | 2015-10-08 | 2017-04-13 | J.R. Simplot Company | Potato cultivar x17 |
| SG11201809406PA (en) * | 2016-04-27 | 2018-11-29 | Nexgen Plants Pty Ltd | Construct and vector for intragenic plant transformation |
| CN110938555A (zh) * | 2019-06-14 | 2020-03-31 | 南京农业大学 | 一种地衣芽孢杆菌z-1及其l-天冬酰胺酶基因与应用 |
| CN112391397B (zh) * | 2020-11-25 | 2023-01-31 | 云南中烟工业有限责任公司 | 一种烟草黄酮单加氧酶基因NtCYP75B2及其应用 |
| US12053009B2 (en) | 2021-01-08 | 2024-08-06 | Intercontinental Great Brands Llc | Method of reducing asparagine in whole grain flours |
| US20250031650A1 (en) * | 2021-11-05 | 2025-01-30 | Colorado State University Research Foundation | Wheat plants with reduced free asparagine concentration in grain |
| CN117683109B (zh) * | 2024-02-04 | 2024-04-19 | 云南师范大学 | ScF3'H基因在提高马铃薯抗寒性中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3587718T2 (de) | 1984-03-06 | 1994-08-04 | Mgi Pharma Inc | Herbizide Resistenz in Pflanzen. |
| US6617496B1 (en) | 1985-10-16 | 2003-09-09 | Monsanto Company | Effecting virus resistance in plants through the use of negative strand RNAs |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| US5256558A (en) * | 1989-05-03 | 1993-10-26 | The Trustees Of Rockefeller University | Gene encoding plant asparagine synthetase |
| DE4220758A1 (de) * | 1992-06-24 | 1994-01-05 | Inst Genbiologische Forschung | DNA-Sequenz und Plasmide zur Herstellung von Pflanzen mit veränderter Saccharose-Konzentration |
| US6969782B2 (en) * | 1993-10-06 | 2005-11-29 | Ajinomoto Co., Inc. | Method of producing transgenic plants having improved amino acid composition |
| ES2093578T1 (es) * | 1993-10-06 | 1997-01-01 | Univ New York | Plantas transgenicas que presentan asimilacion mejorada del nitrogeno. |
| US6620987B1 (en) * | 1998-04-09 | 2003-09-16 | E. I. Dupont De Nemours & Company | Nucleic acid encoding a starch R1 phosphorylation protein homolog from maize |
| BR9915152A (pt) * | 1998-11-09 | 2001-08-07 | Planttec Biotechnologie Gmbh | Moléculas de ácido nucléico de arroz e o seu uso para a produção de amido modificado |
| WO2003014357A1 (en) * | 2001-08-09 | 2003-02-20 | University Of Saskatchewan | Wheat plants having increased resistance to imidazolinone herbicides |
| US7534934B2 (en) | 2002-02-20 | 2009-05-19 | J.R. Simplot Company | Precise breeding |
| NZ535395A (en) | 2002-02-20 | 2009-01-31 | Simplot Co J R | Precise plant breeding using plant DNA border like sequences instead of Agrobacterium borders |
| US20050034188A1 (en) | 2002-03-20 | 2005-02-10 | J. R. Simplot Company | Refined plant transformation |
| US7037540B2 (en) * | 2002-09-19 | 2006-05-02 | Frito-Lay North America, Inc. | Method for reducing acrylamide formation in thermally processed foods |
| AU2003298095A1 (en) * | 2002-10-18 | 2004-05-04 | Cropdesign N.V. | Identification of e2f target genes and uses thereof |
| US7220440B2 (en) | 2002-10-25 | 2007-05-22 | The Procter & Gamble Company | Method for reduction of acrylamide in roasted coffee beans, roasted coffee beans having reduced levels of acrylamide, and article of commerce |
| US20060233930A1 (en) * | 2002-11-08 | 2006-10-19 | Bayer Cropscience Gmbh | Process for reducing the acrylamide content of heat-treated foods |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| AU2003294908B2 (en) | 2002-12-19 | 2009-11-05 | Dsm Ip Assets B.V. | Novel food production process |
| US7189422B2 (en) | 2003-06-25 | 2007-03-13 | The Procter And Gamble Company | Method for reduction of acrylamide in cocoa products, cocoa products having reduced levels of acrylamide, and article of commerce |
| US6989167B2 (en) | 2003-06-25 | 2006-01-24 | Procter + Gamble Co. | Method for reducing acrylamide in foods comprising reducing the level of reducing sugars, foods having reduced levels of acrylamide, and article of commerce |
| US7527815B2 (en) | 2003-06-25 | 2009-05-05 | The Procter & Gamble Company | Method for reducing acrylamide in corn-based foods, corn-based foods having reduced levels of acrylamide, and article of commerce |
| WO2005025330A1 (en) | 2003-09-12 | 2005-03-24 | Mccain Foods Limited | Method of reducing acrylamide in food products |
| EP1740059A2 (en) | 2004-02-09 | 2007-01-10 | Cargill, Incorporated | Coating food for reducing acrylamide formation |
| PL1799028T3 (pl) | 2004-09-24 | 2015-06-30 | Simplot Co J R | Wyciszanie genów |
| US20090123626A1 (en) * | 2007-09-28 | 2009-05-14 | J.R. Simplot Company | Reduced acrylamide plants and foods |
-
2006
- 2006-09-19 RU RU2008115111/10A patent/RU2458133C2/ru active
- 2006-09-19 ES ES10004151.6T patent/ES2538213T3/es active Active
- 2006-09-19 CN CN200680043287.XA patent/CN101313070B/zh active Active
- 2006-09-19 WO PCT/US2006/036515 patent/WO2007035752A2/en not_active Ceased
- 2006-09-19 BR BRPI0616091A patent/BRPI0616091B8/pt active IP Right Grant
- 2006-09-19 US US11/523,088 patent/US20070074304A1/en not_active Abandoned
- 2006-09-19 NZ NZ567293A patent/NZ567293A/en unknown
- 2006-09-19 PL PL06803867T patent/PL1974039T3/pl unknown
- 2006-09-19 CA CA2623266A patent/CA2623266C/en active Active
- 2006-09-19 EP EP06803867A patent/EP1974039B1/en active Active
- 2006-09-19 DE DE602006016489T patent/DE602006016489D1/de active Active
- 2006-09-19 EP EP20100004151 patent/EP2333076B1/en active Active
- 2006-09-19 AU AU2006292286A patent/AU2006292286B2/en active Active
- 2006-09-19 JP JP2008532322A patent/JP5368097B2/ja active Active
- 2006-09-19 PL PL10004151T patent/PL2333076T3/pl unknown
- 2006-09-19 CN CN201510301163.8A patent/CN104894159A/zh active Pending
- 2006-09-19 AT AT06803867T patent/ATE478957T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2458133C2 (ru) | 2012-08-10 |
| WO2007035752A3 (en) | 2007-11-01 |
| EP2333076A3 (en) | 2011-10-05 |
| EP2333076A2 (en) | 2011-06-15 |
| AU2006292286A1 (en) | 2007-03-29 |
| ATE478957T1 (de) | 2010-09-15 |
| NZ567293A (en) | 2011-12-22 |
| BRPI0616091A2 (pt) | 2013-02-13 |
| RU2008115111A (ru) | 2009-10-27 |
| CN104894159A (zh) | 2015-09-09 |
| EP1974039A2 (en) | 2008-10-01 |
| CN101313070A (zh) | 2008-11-26 |
| AU2006292286B2 (en) | 2013-02-14 |
| DE602006016489D1 (de) | 2010-10-07 |
| WO2007035752A2 (en) | 2007-03-29 |
| CA2623266A1 (en) | 2007-03-29 |
| JP5368097B2 (ja) | 2013-12-18 |
| ES2538213T3 (es) | 2015-06-18 |
| JP2009508526A (ja) | 2009-03-05 |
| PL1974039T3 (pl) | 2011-02-28 |
| CN101313070B (zh) | 2015-07-15 |
| PL2333076T3 (pl) | 2015-08-31 |
| EP2333076B1 (en) | 2015-04-29 |
| US20070074304A1 (en) | 2007-03-29 |
| EP1974039B1 (en) | 2010-08-25 |
| CA2623266C (en) | 2018-08-21 |
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