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BRPI0519000A2 - variantes de il-7 com imunogenicidade reduzida - Google Patents

variantes de il-7 com imunogenicidade reduzida

Info

Publication number
BRPI0519000A2
BRPI0519000A2 BRPI0519000-2A BRPI0519000A BRPI0519000A2 BR PI0519000 A2 BRPI0519000 A2 BR PI0519000A2 BR PI0519000 A BRPI0519000 A BR PI0519000A BR PI0519000 A2 BRPI0519000 A2 BR PI0519000A2
Authority
BR
Brazil
Prior art keywords
variants
reduced immunogenicity
polypeptides
modified
alterations
Prior art date
Application number
BRPI0519000-2A
Other languages
English (en)
Inventor
Stephen D Gillies
Jeffrey C Way
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0519000A2 publication Critical patent/BRPI0519000A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • AIDS & HIV (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

VARIANTES DE IL-7 COM IMUNOGENICIDADE REDUZIDA. A presente invenção refere-se em geral a moléculas de IL-7 modificadas para reduzir sua imunogenicidade. Essas moléculas incluem também proteínas de fusão compreendendo as ditas moléculas de IL-7 modificadas e moléculas de imunoglobulina ou porções das mesmas.
BRPI0519000-2A 2004-12-09 2005-12-08 variantes de il-7 com imunogenicidade reduzida BRPI0519000A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63447004P 2004-12-09 2004-12-09
PCT/EP2005/013145 WO2006061219A2 (en) 2004-12-09 2005-12-08 Il-7 variants with reduced immunogenicity

Publications (1)

Publication Number Publication Date
BRPI0519000A2 true BRPI0519000A2 (pt) 2008-12-23

Family

ID=36578271

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519000-2A BRPI0519000A2 (pt) 2004-12-09 2005-12-08 variantes de il-7 com imunogenicidade reduzida

Country Status (14)

Country Link
US (1) US7589179B2 (pt)
EP (1) EP1819728B1 (pt)
JP (1) JP4937132B2 (pt)
KR (1) KR20070085886A (pt)
CN (1) CN101072793B (pt)
AT (1) ATE465176T1 (pt)
AU (1) AU2005313492B2 (pt)
BR (1) BRPI0519000A2 (pt)
CA (1) CA2591297C (pt)
DE (1) DE602005020837D1 (pt)
ES (1) ES2342964T3 (pt)
RU (1) RU2437893C2 (pt)
WO (1) WO2006061219A2 (pt)
ZA (1) ZA200705559B (pt)

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US20060141581A1 (en) 2006-06-29
WO2006061219A3 (en) 2007-01-11
RU2437893C2 (ru) 2011-12-27
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CA2591297A1 (en) 2006-06-15
DE602005020837D1 (de) 2010-06-02
ES2342964T3 (es) 2010-07-20
EP1819728A2 (en) 2007-08-22
US7589179B2 (en) 2009-09-15
WO2006061219A2 (en) 2006-06-15
KR20070085886A (ko) 2007-08-27
CA2591297C (en) 2015-01-13
CN101072793A (zh) 2007-11-14
AU2005313492A1 (en) 2006-06-15
ZA200705559B (en) 2008-10-29
CN101072793B (zh) 2012-06-20
ATE465176T1 (de) 2010-05-15
EP1819728B1 (en) 2010-04-21

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