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BRPI0518266A2 - medicamento oral de libertaÇço modificada de pelo menos um princÍpio ativo sob a forma multimicrocapsular - Google Patents

medicamento oral de libertaÇço modificada de pelo menos um princÍpio ativo sob a forma multimicrocapsular

Info

Publication number
BRPI0518266A2
BRPI0518266A2 BRPI0518266-2A BRPI0518266A BRPI0518266A2 BR PI0518266 A2 BRPI0518266 A2 BR PI0518266A2 BR PI0518266 A BRPI0518266 A BR PI0518266A BR PI0518266 A2 BRPI0518266 A2 BR PI0518266A2
Authority
BR
Brazil
Prior art keywords
active ingredient
release
modified
oral
medicinal product
Prior art date
Application number
BRPI0518266-2A
Other languages
English (en)
Inventor
Florence Guimberteau
Catherine Castan
Remi Meyrueix
Gerard G Soula
Original Assignee
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Publication of BRPI0518266A2 publication Critical patent/BRPI0518266A2/pt
Publication of BRPI0518266A8 publication Critical patent/BRPI0518266A8/pt
Publication of BRPI0518266B1 publication Critical patent/BRPI0518266B1/pt
Publication of BRPI0518266B8 publication Critical patent/BRPI0518266B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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Abstract

MEDICAMENTO ORAL DE LIBERAÇAO MODIFICADA DE PELO MENOS UM PRINCÍPIO ATIVO SOB A FORMA MULTIMICROCAPSULAR. O campo da invenção é aquele dos medicamentos ou composições farmacêuticas orais, mais particularmente do tipo daquelas que compreendem um ou vários princípios ativos. A finalidade da invenção é fornecer um medicamento oral aperfeiçoado administrável em uma ou várias ingestões diárias, de liberação modificada de princípio ativo (em particular um princípio ativo), permitindo melhorar a eficácia profilática e terapêutica desse medicamento. Essa finalidade é atingida pela forma galênica oral multímicrocapsular, de acordo com a invenção, na qual a liberação do PA é regida por um duplo mecanismo de acionamento da liberação: "tempo de acionamento" e "pH de acionamento". Esse medicamento compreende mícrocápsulas de liberação modificada de princípio ativo, comportando, cada uma, um núcleo que compreende o princípio ativo e um ou vários agentes intumescedores e pelo menos um revestimento que permite a liberação modificada do princípio ativo.
BRPI0518266A 2004-11-24 2005-11-02 medicamento oral de liberação modificada de pelo menos um princípio ativo sob a forma multimicrocapsular BRPI0518266B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0452748A FR2878159B1 (fr) 2004-11-24 2004-11-24 Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire
FR0452748 2004-11-24
PCT/FR2005/050922 WO2006056711A2 (fr) 2004-11-24 2005-11-02 Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire

Publications (4)

Publication Number Publication Date
BRPI0518266A2 true BRPI0518266A2 (pt) 2008-11-11
BRPI0518266A8 BRPI0518266A8 (pt) 2016-03-29
BRPI0518266B1 BRPI0518266B1 (pt) 2020-07-07
BRPI0518266B8 BRPI0518266B8 (pt) 2021-05-25

Family

ID=34953830

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518266A BRPI0518266B8 (pt) 2004-11-24 2005-11-02 medicamento oral de liberação modificada de pelo menos um princípio ativo sob a forma multimicrocapsular

Country Status (18)

Country Link
US (1) US20080305160A1 (pt)
EP (1) EP1827396B1 (pt)
JP (1) JP5619342B2 (pt)
KR (1) KR101391287B1 (pt)
CN (1) CN101094658B (pt)
AU (1) AU2005308639B2 (pt)
BR (1) BRPI0518266B8 (pt)
CA (1) CA2589137C (pt)
ES (1) ES2588160T3 (pt)
FR (1) FR2878159B1 (pt)
HU (1) HUE029440T2 (pt)
IL (1) IL183357A (pt)
MX (1) MX2007006212A (pt)
PT (1) PT1827396T (pt)
SG (1) SG157406A1 (pt)
TW (1) TW200630123A (pt)
WO (1) WO2006056711A2 (pt)
ZA (1) ZA200704163B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2359812C (en) 2000-11-20 2004-02-10 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
WO2008070072A2 (en) * 2006-12-01 2008-06-12 Mutual Pharmaceutical Company, Inc. Carvedilol forms, compositions, and methods of preparation thereof
US20090028935A1 (en) * 2006-12-01 2009-01-29 Kristin Arnold Carvedilol forms, compositions, and methods of preparation thereof
JP2010530408A (ja) * 2007-06-18 2010-09-09 ドルハイ クリニカ エゲースセーギュジ ケーエフティー． 殺生物性カプセル、それらを含む製剤、及び該製剤を含む衛生パッド
US20090111736A1 (en) * 2007-10-29 2009-04-30 Sri International Orally-Absorbed Solid Dose Formulation for Vancomycin
JP2011512406A (ja) * 2008-02-22 2011-04-21 ハナル バイオファーマ カンパニー リミテッド 複合製剤
WO2009104916A2 (ko) * 2008-02-22 2009-08-27 한올제약주식회사 심혈관계 질환 치료용 약제학적 제제
VN27088A1 (en) * 2008-07-31 2011-08-25 Feyecon Bv Microencapsulate and process for the manufacture thereof.
US9023369B2 (en) * 2009-04-22 2015-05-05 Ralf Malessa Freeze-dried composition of active substances
MX361138B (es) * 2010-06-16 2018-11-28 Takeda Pharmaceuticals Usa Inc Formas novedosas de dosificacion de liberacion modificada de inhibidor de xantina oxidorreductasa o inhibidores de xantina oxidasa.
CN101912403B (zh) * 2010-08-02 2012-01-11 陶灵刚 一种头孢哌酮钠他唑巴坦钠药物组合物微球注射剂
WO2013151518A1 (en) * 2012-04-04 2013-10-10 Mahmut Bilgic Capsule formulations comprising ceftibuten
RU2016147009A (ru) 2014-05-01 2018-06-04 Сан Фармасьютикал Индастриз Лимитед Композиции с пролонгированным высвобождением в виде суспензии
WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
CN105560212B (zh) * 2016-03-24 2018-11-02 长沙佰顺生物科技有限公司 一种卡托普利微囊的制备方法
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JP2019527214A (ja) 2016-07-14 2019-09-26 アカオジェン インコーポレイテッド 細菌感染症の処置における使用のためのセフチブテンとクラブラン酸の組み合わせ
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) * 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
CN111465396B (zh) 2017-12-20 2024-07-09 普渡制药公司 防滥用硫酸吗啡剂型
CN108558690B (zh) * 2018-03-28 2021-04-20 浙江海正药业股份有限公司 环丝氨酸酯化物盐酸盐的晶型及其制备方法
US11400065B2 (en) 2019-03-01 2022-08-02 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
KR102546722B1 (ko) * 2020-04-21 2023-06-23 주식회사 바이오스탠다드 바이오코폴리머 마이크로 캡슐 포함 안정화 조성물, 그의 제조방법 및 이를 이용한 피부상태 개선용 화장료 조성물
GB202116589D0 (en) 2021-11-17 2021-12-29 Rb Health Us Llc Novel composition
GB202116588D0 (en) 2021-11-17 2021-12-29 Rb Health Us Llc Novel composition
GB202116590D0 (en) 2021-11-17 2021-12-29 Rb Health Us Llc Novel composition
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434153A (en) * 1982-03-22 1984-02-28 Alza Corporation Drug delivery system comprising a reservoir containing a plurality of tiny pills
US4833905A (en) * 1983-06-03 1989-05-30 Micromatic Textron Inc. Method for splining clutch hubs with close tolerance spline bellmouth and oil seal surface roundness
JPS62195323A (ja) * 1986-02-24 1987-08-28 Eisai Co Ltd 胃内滞留型粒子
JPS63176157A (ja) * 1987-01-09 1988-07-20 レックスマーク・インターナショナル・インコーポレーテッド ドツト・マトリツクス・プリンタ用印刷ヘッド
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
JP2000103732A (ja) * 1998-07-28 2000-04-11 Tanabe Seiyaku Co Ltd 腸内適所放出型製剤
US6638534B1 (en) * 1998-07-28 2003-10-28 Tanabe Seiyaku Co., Ltd. Preparation capable of releasing drug at target site in intestine
US6632451B2 (en) * 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
US6814978B2 (en) * 2000-12-29 2004-11-09 Mcneil-Ppc, Inc. Process for preparing a soft tablet
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
JP4578124B2 (ja) * 2003-03-12 2010-11-10 武田薬品工業株式会社 高濃度に活性成分を球形核に付着させた医薬組成物
NZ544608A (en) * 2003-07-17 2008-07-31 Reddys Lab Ltd Dr Pharmaceutical compositions having a swellable coating comprising prolamin

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ZA200704163B (en) 2008-08-27
KR20070098823A (ko) 2007-10-05
BRPI0518266A8 (pt) 2016-03-29
MX2007006212A (es) 2007-07-09
FR2878159A1 (fr) 2006-05-26
WO2006056711A2 (fr) 2006-06-01
BRPI0518266B1 (pt) 2020-07-07
IL183357A0 (en) 2007-09-20
TW200630123A (en) 2006-09-01
ES2588160T3 (es) 2016-10-31
WO2006056711A3 (fr) 2006-08-31
JP2008520633A (ja) 2008-06-19
AU2005308639A1 (en) 2006-06-01
CA2589137C (fr) 2014-08-26
HUE029440T2 (en) 2017-02-28
CN101094658B (zh) 2016-10-05
AU2005308639B2 (en) 2011-05-26
US20080305160A1 (en) 2008-12-11
EP1827396A2 (fr) 2007-09-05
CN101094658A (zh) 2007-12-26
KR101391287B1 (ko) 2014-05-19
SG157406A1 (en) 2009-12-29
BRPI0518266B8 (pt) 2021-05-25
CA2589137A1 (fr) 2006-06-01
FR2878159B1 (fr) 2008-10-17
JP5619342B2 (ja) 2014-11-05
PT1827396T (pt) 2016-08-31
IL183357A (en) 2014-12-31

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