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BRPI0515161A - substratos enzimáticos derivados de fenoxazinona e seu uso como revelador na detecção de microorganismos com atividade de peptidase - Google Patents

substratos enzimáticos derivados de fenoxazinona e seu uso como revelador na detecção de microorganismos com atividade de peptidase

Info

Publication number
BRPI0515161A
BRPI0515161A BRPI0515161-9A BRPI0515161A BRPI0515161A BR PI0515161 A BRPI0515161 A BR PI0515161A BR PI0515161 A BRPI0515161 A BR PI0515161A BR PI0515161 A BRPI0515161 A BR PI0515161A
Authority
BR
Brazil
Prior art keywords
developer
detection
peptidase activity
phenoxazinone
microorganisms
Prior art date
Application number
BRPI0515161-9A
Other languages
English (en)
Inventor
Rosaleen Joy Anderson
Paul William Groundwater
Arthur James
Daniel Monget
Andrey Victorovich Zaytsev
Original Assignee
Biomerieux Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux Sa filed Critical Biomerieux Sa
Publication of BRPI0515161A publication Critical patent/BRPI0515161A/pt
Publication of BRPI0515161B1 publication Critical patent/BRPI0515161B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/045—Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SUBSTRATOS ENZIMáTICOS DERIVADOS DE FENOXAZINONA E SEU USO COMO REVELADOR NA DETECçãO DE MICROORGANISMOS COM ATIVIDADE DE PEPTIDASE. A presente invenção refere-se a novas substratos enzimáticos da fórmula geral: em que: R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, A e X são como definidos na reivindicação 1, meios reacionais contendo os mesmos e seu uso para detectar e/ou identificar e/ou quantificar microorganismos que expressam peJo menos uma atividade de peptidase. Aplicação: diagnóstico.
BRPI0515161A 2004-09-10 2005-09-09 substratos enzimáticos derivados de fenoxazinona e seu uso como revelador na detecção de microorganismos com atividade de peptidase BRPI0515161B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0409593A FR2875242B1 (fr) 2004-09-10 2004-09-10 Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase
PCT/FR2005/002249 WO2006030119A1 (fr) 2004-09-10 2005-09-09 Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganisme a activite peptidase

Publications (2)

Publication Number Publication Date
BRPI0515161A true BRPI0515161A (pt) 2008-07-08
BRPI0515161B1 BRPI0515161B1 (pt) 2017-05-02

Family

ID=34948347

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515161A BRPI0515161B1 (pt) 2004-09-10 2005-09-09 substratos enzimáticos derivados de fenoxazinona e seu uso como revelador na detecção de microorganismos com atividade de peptidase

Country Status (9)

Country Link
US (2) US7626018B2 (pt)
EP (1) EP1786828B1 (pt)
JP (1) JP5043666B2 (pt)
CN (1) CN101044156A (pt)
AT (1) ATE540966T1 (pt)
BR (1) BRPI0515161B1 (pt)
ES (1) ES2380800T3 (pt)
FR (1) FR2875242B1 (pt)
WO (1) WO2006030119A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2916763B1 (fr) 2007-05-31 2013-11-15 Biomerieux Sa Nouveaux substrats de peptidase
FR2948685A1 (fr) 2009-07-30 2011-02-04 Biomerieux Sa Nouveaux substrats
FR2948686B1 (fr) * 2009-07-30 2011-08-19 Biomerieux Sa Nouveaux substrats de peptidase
FR2948684B1 (fr) 2009-07-30 2011-08-19 Biomerieux Sa Nouveaux substrats de peptidase
CN102382641B (zh) * 2011-09-22 2013-07-24 厦门大学 检测次氯酸的荧光探针及其制备方法
US9296712B2 (en) * 2013-03-15 2016-03-29 Edison Pharmaceuticals, Inc. Resorufin derivatives for treatment of oxidative stress disorders
CN111233781B (zh) * 2020-03-13 2021-08-27 郑州大学 水相中催化分子氧氧化生成2-羟基酚噁嗪-3-酮类化合物的方法
JP2024516380A (ja) * 2021-04-18 2024-04-15 ヴェンタナ メディカル システムズ， インク． 形態学的マーカー染色
JP2025524846A (ja) 2022-07-27 2025-08-01 江蘇恒瑞医薬股▲ふん▼有限公司 縮合環系化合物、その調製方法及びその医薬的使用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405301A1 (fr) * 1977-10-04 1979-05-04 Api Labor Substrats et procede permettant l'identification rapide de bacteries du genre streptococcus
DE3411574A1 (de) * 1984-03-29 1985-10-10 Boehringer Mannheim Gmbh, 6800 Mannheim Glycoside von resorufin-derivaten, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der aktivitaet von glycosidasen
CA1322733C (en) 1989-05-25 1993-10-05 Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of Agriculture Differential agars medium for separating streptococcus lactis and streptococcus on the basis of butyrate esterase activity
FR2653447B1 (fr) * 1989-10-20 1991-12-27 Bio Merieux Procede et reactifs pour la detection de micro-organismes.
FR2671561B1 (fr) * 1991-01-16 1993-03-26 Bio Merieux Procede et milieu d'identification de bacteries du genre listeria.
DE4119956A1 (de) * 1991-06-18 1992-12-24 Fanghaenel Silvia Dipl Biochem Verfahren zur identifizierung und differenzierung gramnegativer bakterien mittels l-prolinaminopeptidase
FR2713240B1 (fr) 1993-12-02 1996-03-01 Bio Merieux Milieu nutritif pour la culture de microorganismes.
US6387650B1 (en) 1995-06-07 2002-05-14 Biocontrol Systems, Inc. Method and composition for detecting bacterial contamination in food products
US20020164580A1 (en) * 1995-12-07 2002-11-07 Diversa Corporation Combinatorial screening of mixed populations of organisms
FR2751663B1 (fr) 1996-07-29 1998-10-02 Bio Merieux Procede de mise en evidence d'une activite enzymatique de microorganismes
US5888760A (en) 1997-04-10 1999-03-30 Dade Microscan Inc. Universal test systems and methods of use thereof for identifying multiple families of microorganisms
FR2763342B1 (fr) 1997-05-13 2000-11-03 Biochimie Appliquee Soc Milieu de culture pour la detection specifique des enterobacteries, procede pour son obtention et son utilisation
US6235493B1 (en) * 1997-08-06 2001-05-22 The Regents Of The University Of California Amino acid substituted-cresyl violet, synthetic fluorogenic substrates for the analysis of agents in individual in vivo cells or tissue
FR2767535B1 (fr) 1997-08-20 2000-02-04 Bio Merieux Milieux de culture et d'identification specifique de differentes especes de candida et procedes d'analyse
FR2774097B1 (fr) * 1998-01-28 2000-09-29 Bio Merieux Utilisation de derives d'indolamine dans la detection d'une activite de peptidase ou dans la detection de micro-organismes
JP4414515B2 (ja) * 1999-08-30 2010-02-10 三菱化学メディエンス株式会社 微生物の鑑別方法
FR2800377B1 (fr) * 1999-10-28 2003-05-09 Bio Merieux Substrat enzymatique, procede de synthese et utilisations
FR2801903B1 (fr) * 1999-12-06 2004-01-30 Biomerieux Sa Nouveaux substrats enzymatiques pour la detection de pseudomonas aeruginosa, compositions les contenant et procede de detection de cette espece
JP2002010799A (ja) * 2000-06-29 2002-01-15 Kikkoman Corp 細菌検査培地
US6933126B2 (en) * 2001-09-19 2005-08-23 Applera Corporation Membrane transportable fluorescent substrates
DE10251894A1 (de) * 2002-11-07 2004-05-19 C-Cit Ag Peptidgebundene Chromogene zur Bestimmung von Enzymaktivitäten
FR2850378B1 (fr) 2003-01-29 2005-03-04 Bio Merieux Substrats enzymatiques, milieux de culture les contenant, utilisation pour detecter une activite aminopeptidase et/ou differencier des bacteries a gram+ par rapport a des bacteries a gram-
FR2854893B1 (fr) * 2003-05-13 2006-07-07 Biomerieux Sa Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase

Also Published As

Publication number Publication date
FR2875242B1 (fr) 2006-11-17
WO2006030119A1 (fr) 2006-03-23
US20100028926A1 (en) 2010-02-04
BRPI0515161B1 (pt) 2017-05-02
ES2380800T3 (es) 2012-05-18
CN101044156A (zh) 2007-09-26
EP1786828A1 (fr) 2007-05-23
US20080293094A1 (en) 2008-11-27
US7626018B2 (en) 2009-12-01
JP2008512106A (ja) 2008-04-24
JP5043666B2 (ja) 2012-10-10
FR2875242A1 (fr) 2006-03-17
EP1786828B1 (fr) 2012-01-11
ATE540966T1 (de) 2012-01-15
US7932050B2 (en) 2011-04-26

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07K 1/13 , C12Q 1/37 , C12Q 1/04

Ipc: C07D 265/38 (2006.01), C07K 1/13 (2006.01), C12Q 1

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2846 DE 22-07-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.