BRPI0515089A - derivados halogenados de benzamida - Google Patents
derivados halogenados de benzamidaInfo
- Publication number
- BRPI0515089A BRPI0515089A BRPI0515089-2A BRPI0515089A BRPI0515089A BR PI0515089 A BRPI0515089 A BR PI0515089A BR PI0515089 A BRPI0515089 A BR PI0515089A BR PI0515089 A BRPI0515089 A BR PI0515089A
- Authority
- BR
- Brazil
- Prior art keywords
- benzamide derivatives
- alkyl
- halogenated
- halogenated benzamide
- halogen
- Prior art date
Links
- 150000003936 benzamides Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 244000005709 gut microbiome Species 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 244000052613 viral pathogen Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
DERIVADOS HALOGENADOS DE BENZAMIDA A presente invenção se refere a um derivado halogenado de benzamida, de acordo com a fórmula (III): caracterizado por apresentar uma maior especificidade para patógenos virais e um menor poder de ruptura, de modo a beneficiar a microflora do intestino, em que R~ 1~ representa um átomo de halogênio e R~ 2~-R~ 6~ representam, independentemente, hidrogênio, hidroxila, C~ 1~-C~ 4~ alquila, C~ 1~-C~ 4~ alcóxi, acilóxi, nitro, halogênio, -C(O)R~ 7~, onde R~ 7~ representa C~ 1~- C~ 4~ alquila ou um composto aromático, incluindo os sais e hidratos desses compostos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60835404P | 2004-09-09 | 2004-09-09 | |
| US60/608,354 | 2004-09-09 | ||
| PCT/US2005/031868 WO2006031566A2 (en) | 2004-09-09 | 2005-09-06 | Halogenated benzamide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0515089A true BRPI0515089A (pt) | 2008-07-08 |
| BRPI0515089B1 BRPI0515089B1 (pt) | 2019-07-16 |
| BRPI0515089B8 BRPI0515089B8 (pt) | 2021-05-25 |
Family
ID=36060542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0515089A BRPI0515089B8 (pt) | 2004-09-09 | 2005-09-06 | derivados halogenados de benzamida |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7285567B2 (pt) |
| EP (1) | EP1789040B1 (pt) |
| JP (1) | JP4998852B2 (pt) |
| KR (1) | KR101344984B1 (pt) |
| CN (1) | CN101035531B (pt) |
| AP (1) | AP2451A (pt) |
| AU (1) | AU2005285157B2 (pt) |
| BR (1) | BRPI0515089B8 (pt) |
| CA (1) | CA2580347C (pt) |
| CY (1) | CY1118689T1 (pt) |
| DK (1) | DK1789040T3 (pt) |
| EA (1) | EA012606B1 (pt) |
| ES (1) | ES2559672T3 (pt) |
| HR (1) | HRP20151439T1 (pt) |
| HU (1) | HUE026613T2 (pt) |
| IL (2) | IL181849A (pt) |
| ME (1) | ME02370B (pt) |
| MX (1) | MX2007002969A (pt) |
| PL (1) | PL1789040T3 (pt) |
| PT (1) | PT1789040E (pt) |
| RS (1) | RS54453B1 (pt) |
| SI (1) | SI1789040T1 (pt) |
| UA (1) | UA90864C2 (pt) |
| WO (1) | WO2006031566A2 (pt) |
| ZA (1) | ZA200702066B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1474395T1 (sl) * | 2002-02-12 | 2008-02-29 | Smithkline Beecham Corp | Nikotinamidni derivati, uporabni kot inhibitorji p38 |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| EP1871365A2 (en) * | 2005-04-12 | 2008-01-02 | Romark Laboratories, L.C. | Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases , pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
| WO2007081974A2 (en) | 2006-01-09 | 2007-07-19 | Romark Laboratories, L.C. | Viral hepatitis treatment |
| US8124632B2 (en) * | 2007-08-03 | 2012-02-28 | Romark Laboratories, L.C. | Alkylsulfonyl-substituted thiazolide compounds |
| KR101697800B1 (ko) | 2009-02-13 | 2017-01-18 | 로마크 레버러토리즈, 엘.씨. | 니타족사니드의 서방성 제약 제형 |
| BRPI1010547A2 (pt) * | 2009-05-12 | 2019-04-09 | Romark Laboratories L.C. | composto, composição, e, métodos para tratar uma infecção viral, e rhabdovírus |
| PT2445349T (pt) | 2009-06-26 | 2022-05-16 | Romark Laboratories Lc | Compostos e métodos para tratamento da gripe |
| CN102335171B (zh) * | 2010-07-27 | 2013-09-11 | 中国农业科学院上海兽医研究所 | 一类n-(2-噻唑)苯甲酰胺衍生物的应用 |
| CN103648282B (zh) | 2011-05-16 | 2017-02-15 | 罗马克实验室有限公司 | 噻唑化物类化合物用于预防和治疗病毒性疾病、癌症和由细胞内感染引起的疾病的用途 |
| WO2014052831A1 (en) * | 2012-09-28 | 2014-04-03 | Xavier University Of Louisiana | Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease |
| WO2016077420A1 (en) | 2014-11-11 | 2016-05-19 | Romark Laboratories, L.C. | Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof |
| US11135202B2 (en) | 2016-03-31 | 2021-10-05 | Romark Laboratories L.C. | Thiazolide compounds for treating viral infections |
| EP3442580B1 (en) | 2016-04-11 | 2020-09-23 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
| WO2018195035A1 (en) | 2017-04-18 | 2018-10-25 | Romark Laboratories L.C. | Inhibition of protein disulfide-isomerase a3 |
| JP2023537237A (ja) | 2020-07-20 | 2023-08-31 | ロマーク ラボラトリーズ，リミティド カンパニー | チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩 |
| CA3189487A1 (en) | 2020-08-24 | 2023-03-03 | Jean-Francois Rossignol | Use of thiazolides against coronaviruses |
| WO2022218239A1 (zh) * | 2021-04-12 | 2022-10-20 | 杜心赟 | 新型噻唑类化合物及其制备方法和用途 |
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| GB1276663A (en) | 1968-12-24 | 1972-06-07 | Ici Ltd | Stimulation of plant growth |
| ZA712295B (en) * | 1970-04-15 | 1972-01-26 | Shell Int Research | Fungicidal compounds |
| GB1437800A (en) | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| US4315018A (en) | 1978-12-07 | 1982-02-09 | Rossignol Jean F | Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives |
| JPS60205454A (ja) * | 1984-03-29 | 1985-10-17 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| US5169846A (en) | 1989-10-12 | 1992-12-08 | Crooks Michael J | Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators |
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| DK0755386T3 (da) * | 1994-04-13 | 2002-08-26 | Romark Lab Lc | Benzamid-derivater, sammensætninger indeholdende nævnte derivat og anvendelse deraf |
| US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
| US5578621A (en) | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
| MX9604483A (es) * | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5859038A (en) | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
| US5856348A (en) | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5965590A (en) * | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5968961A (en) | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| DE19528046A1 (de) * | 1994-11-21 | 1996-05-23 | Bayer Ag | Triazolyl-Derivate |
| US5935591A (en) | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| CA2407587A1 (en) * | 2000-04-28 | 2001-11-08 | Sankyo Company, Limited | Ppar.gamma. modulators |
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| WO2002049632A1 (en) * | 2000-12-18 | 2002-06-27 | Institute Of Medicinal Molecular Design. Inc. | Inhibitors against the production and release of inflammatory cytokines |
| JP2003064056A (ja) * | 2001-08-27 | 2003-03-05 | Sankyo Co Ltd | アミド誘導体 |
| WO2003035602A1 (en) * | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Lipid modulators |
| CA2488367A1 (en) * | 2002-06-06 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Antiallergic agents |
| US6737382B1 (en) * | 2002-10-23 | 2004-05-18 | Nippon Soda Co. Ltd. | Insecticidal aminothiazole derivatives |
| CA2553423C (en) * | 2004-01-23 | 2012-03-20 | Amgen Inc. | Heterocyclic compounds for use in the treatment of cancer and the inhibition of angiogenesis |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
-
2005
- 2005-06-09 UA UAA200702713A patent/UA90864C2/ru unknown
- 2005-09-06 SI SI200532034T patent/SI1789040T1/sl unknown
- 2005-09-06 JP JP2007531304A patent/JP4998852B2/ja not_active Expired - Fee Related
- 2005-09-06 PT PT58001421T patent/PT1789040E/pt unknown
- 2005-09-06 AP AP2007003950A patent/AP2451A/xx active
- 2005-09-06 HU HUE05800142A patent/HUE026613T2/hu unknown
- 2005-09-06 ZA ZA200702066A patent/ZA200702066B/xx unknown
- 2005-09-06 US US11/221,256 patent/US7285567B2/en not_active Expired - Lifetime
- 2005-09-06 WO PCT/US2005/031868 patent/WO2006031566A2/en not_active Ceased
- 2005-09-06 HR HRP20151439TT patent/HRP20151439T1/hr unknown
- 2005-09-06 DK DK05800142.1T patent/DK1789040T3/en active
- 2005-09-06 EA EA200700432A patent/EA012606B1/ru not_active IP Right Cessation
- 2005-09-06 ES ES05800142.1T patent/ES2559672T3/es not_active Expired - Lifetime
- 2005-09-06 EP EP05800142.1A patent/EP1789040B1/en not_active Expired - Lifetime
- 2005-09-06 CA CA2580347A patent/CA2580347C/en not_active Expired - Fee Related
- 2005-09-06 BR BRPI0515089A patent/BRPI0515089B8/pt not_active IP Right Cessation
- 2005-09-06 PL PL05800142T patent/PL1789040T3/pl unknown
- 2005-09-06 CN CN2005800338784A patent/CN101035531B/zh not_active Expired - Fee Related
- 2005-09-06 RS RS20160058A patent/RS54453B1/sr unknown
- 2005-09-06 ME MEP-2016-7A patent/ME02370B/me unknown
- 2005-09-06 MX MX2007002969A patent/MX2007002969A/es active IP Right Grant
- 2005-09-06 AU AU2005285157A patent/AU2005285157B2/en not_active Ceased
-
2007
- 2007-03-11 IL IL181849A patent/IL181849A/en not_active IP Right Cessation
- 2007-03-29 KR KR1020077007159A patent/KR101344984B1/ko not_active Expired - Fee Related
- 2007-10-01 US US11/865,532 patent/US7645783B2/en active Active
- 2007-10-01 US US11/865,541 patent/US7550493B2/en not_active Expired - Lifetime
-
2009
- 2009-12-29 IL IL203061A patent/IL203061A/en active IP Right Grant
-
2016
- 2016-01-20 CY CY20161100061T patent/CY1118689T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/09/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2686 DE 28-06-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |