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BRPI0507675A - derivados de 2'-c-metil nucleosìdeo - Google Patents

derivados de 2'-c-metil nucleosìdeo

Info

Publication number
BRPI0507675A
BRPI0507675A BRPI0507675-7A BRPI0507675A BRPI0507675A BR PI0507675 A BRPI0507675 A BR PI0507675A BR PI0507675 A BRPI0507675 A BR PI0507675A BR PI0507675 A BRPI0507675 A BR PI0507675A
Authority
BR
Brazil
Prior art keywords
nucleoside derivatives
methyl nucleoside
methyl
derivatives
nucleoside
Prior art date
Application number
BRPI0507675-7A
Other languages
English (en)
Inventor
K Raja Reddy
Mark D Erion
Original Assignee
Merck & Co Inc
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Metabasis Therapeutics Inc filed Critical Merck & Co Inc
Publication of BRPI0507675A publication Critical patent/BRPI0507675A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DE 2' -C-METIL NUCLEOSìDEO. Abaixo estão descritos compostos de fórmula I, estereoisómeros, e sais ou pró-drogas farmaceuticamente aceitáveis dos mesmos, sua preparação e seus usos para o tratamento da infecção viral hepatite C:
BRPI0507675-7A 2004-02-13 2005-02-14 derivados de 2'-c-metil nucleosìdeo BRPI0507675A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54474304P 2004-02-13 2004-02-13
US10/903,215 US20050182252A1 (en) 2004-02-13 2004-07-29 Novel 2'-C-methyl nucleoside derivatives
PCT/US2005/004447 WO2005084192A2 (en) 2004-02-13 2005-02-14 Novel 2’-c-methyl nucleoside derivatives

Publications (1)

Publication Number Publication Date
BRPI0507675A true BRPI0507675A (pt) 2007-07-17

Family

ID=34841195

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507675-7A BRPI0507675A (pt) 2004-02-13 2005-02-14 derivados de 2'-c-metil nucleosìdeo

Country Status (5)

Country Link
US (4) US20050182252A1 (pt)
EP (1) EP1720556A4 (pt)
JP (1) JP2007522237A (pt)
BR (1) BRPI0507675A (pt)
WO (1) WO2005084192A2 (pt)

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Also Published As

Publication number Publication date
US20050182252A1 (en) 2005-08-18
US20070179114A1 (en) 2007-08-02
US7666855B2 (en) 2010-02-23
US20070042989A1 (en) 2007-02-22
WO2005084192A3 (en) 2006-05-11
EP1720556A4 (en) 2012-05-09
EP1720556A2 (en) 2006-11-15
JP2007522237A (ja) 2007-08-09
US20090131370A1 (en) 2009-05-21
WO2005084192A2 (en) 2005-09-15

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