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BRPI0411652A - processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos - Google Patents

processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos

Info

Publication number
BRPI0411652A
BRPI0411652A BRPI0411652-6A BRPI0411652A BRPI0411652A BR PI0411652 A BRPI0411652 A BR PI0411652A BR PI0411652 A BRPI0411652 A BR PI0411652A BR PI0411652 A BRPI0411652 A BR PI0411652A
Authority
BR
Brazil
Prior art keywords
preparation
derivatives
peptide substituted
spirobenzoazepine
novel
Prior art date
Application number
BRPI0411652-6A
Other languages
English (en)
Inventor
Xiaohu Deng
Birdella Kenney
Jimmy T Liang
Neelakandha Mani
Frank J Villani
Fan Zhang-Plasket
Hua Zhong
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0411652A publication Critical patent/BRPI0411652A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE ESPIROBENZOAZEPINA SUBSTITUìDOS NãO-PEPTìDICOS". A presente invenção refere-se a novos compostos de espirobenzoazepina, novos processos para a preparação de derivados de espirobenzoazepina substituídos não-peptídicos e novos processos para a preparação de intermediários na preparação de tais derivados. Novos intermediários na preparação de derivados de espirobenzoazepina substituídos não-peptídicos.
BRPI0411652-6A 2003-06-17 2004-06-16 processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos BRPI0411652A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47951503P 2003-06-17 2003-06-17
PCT/US2004/019951 WO2005000819A1 (en) 2003-06-17 2004-06-16 Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives

Publications (1)

Publication Number Publication Date
BRPI0411652A true BRPI0411652A (pt) 2006-08-08

Family

ID=33551892

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411652-6A BRPI0411652A (pt) 2003-06-17 2004-06-16 processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos

Country Status (20)

Country Link
US (2) US20040259857A1 (pt)
EP (1) EP1633721A1 (pt)
JP (1) JP2007516177A (pt)
KR (1) KR20060023164A (pt)
CN (1) CN1835926A (pt)
AR (1) AR044781A1 (pt)
AU (1) AU2004252135A1 (pt)
BR (1) BRPI0411652A (pt)
CA (1) CA2529513A1 (pt)
CL (1) CL2004001508A1 (pt)
CO (1) CO5650238A2 (pt)
CR (1) CR8167A (pt)
EA (1) EA200501829A1 (pt)
HR (1) HRP20051005A2 (pt)
IL (1) IL172629A0 (pt)
IS (1) IS8185A (pt)
NO (1) NO20060184L (pt)
RS (1) RS20050933A (pt)
TW (1) TW200510323A (pt)
WO (1) WO2005000819A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI354555B (en) * 2003-06-17 2011-12-21 Ortho Mcneil Pharm Inc Substituted spirobenzazepines
US20070173490A1 (en) * 2006-01-20 2007-07-26 Lian Huang Novel solid forms of (4R)-1-[2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl]-1,2,3,5- tetrahydro-spiro[4h-1-benzazepine-4,1'-[2]cyclopentene]-3'-carboxylic acid
DK2078022T3 (da) 2006-09-22 2012-02-13 Janssen Pharmaceutica Nv Spirobenzazepiner anvendt som vasopressinantagonister
CN101541807A (zh) 2006-09-22 2009-09-23 詹森药业有限公司 用作血管升压素拮抗剂的螺环苯并氮杂
AR066834A1 (es) * 2007-06-06 2009-09-16 Janssen Pharmaceutica Nv Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central.
JP2009035513A (ja) * 2007-08-02 2009-02-19 Ube Ind Ltd ４−ｎ−（メチルベンゾイル）アミノ−２−メチル安息香酸の製法
CN105609662B (zh) * 2015-12-22 2017-12-12 洪杰波 一种钙钛矿光伏材料专用的空穴传输材料的制备方法
US20230416262A1 (en) * 2020-08-07 2023-12-28 Casma Therapeutics, Inc. Trpml modulators
CN112939864B (zh) * 2021-01-29 2022-05-06 中国医科大学 螺[苯并[c]氮杂-1,1’-环己基]-3-酮类化合物
CN113735792B (zh) * 2021-09-22 2024-10-18 上海新礼泰药业有限公司 氯苯唑酸葡胺及其中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW462964B (en) * 1998-05-26 2001-11-11 Sumitomo Pharma Guanidine derivatives for the treatment and prevention of disorders caused by inhibiting hyperactivity of Na/H exchange transport system and process for producing the same
AU7178001A (en) * 2000-07-05 2002-01-14 Ortho Mcneil Pharm Inc Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
TWI354555B (en) * 2003-06-17 2011-12-21 Ortho Mcneil Pharm Inc Substituted spirobenzazepines

Also Published As

Publication number Publication date
CA2529513A1 (en) 2005-01-06
EA200501829A1 (ru) 2006-06-30
HRP20051005A2 (en) 2006-09-30
US20040259857A1 (en) 2004-12-23
TW200510323A (en) 2005-03-16
CR8167A (es) 2008-09-10
CL2004001508A1 (es) 2005-05-27
EP1633721A1 (en) 2006-03-15
CO5650238A2 (es) 2006-06-30
IL172629A0 (en) 2006-04-10
US20090105220A1 (en) 2009-04-23
JP2007516177A (ja) 2007-06-21
RS20050933A (sr) 2008-04-04
AR044781A1 (es) 2005-10-05
KR20060023164A (ko) 2006-03-13
WO2005000819A1 (en) 2005-01-06
NO20060184L (no) 2006-03-13
IS8185A (is) 2005-12-15
CN1835926A (zh) 2006-09-20
AU2004252135A1 (en) 2005-01-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2140 DE 10/01/2012.