BRPI0411594A - derivados de n-pirrolidin-3-il-amida como inibidores de re-absorção de serotonina e noradrenalina - Google Patents
derivados de n-pirrolidin-3-il-amida como inibidores de re-absorção de serotonina e noradrenalinaInfo
- Publication number
- BRPI0411594A BRPI0411594A BRPI0411594-5A BRPI0411594A BRPI0411594A BR PI0411594 A BRPI0411594 A BR PI0411594A BR PI0411594 A BRPI0411594 A BR PI0411594A BR PI0411594 A BRPI0411594 A BR PI0411594A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- het
- aryl
- alkoxy
- serotonin
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 6
- 229940076279 serotonin Drugs 0.000 title abstract 3
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 title abstract 2
- 239000003772 serotonin uptake inhibitor Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 21
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- -1 -C (X) Y Chemical group 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"DERIVADOS DE N-PIRROLIDIN-3-IL-AMIDA COMO INIBIDORES DE RE-ABSORçãO DE SEROTONINA E NORADRENALINA". Um composto da fórmula (I) e derivados farmacêutica e/ou veterinariamente aceitáveis deste, em que R¬ 1¬ é H, C~ 1~-6alquila, -C(X)Y, C~ 3-~ 8CiCloalquila, arila, het, aril-C~ 1~-4alquila, ou het-C~ 1~-4alquila, em que os grupos cicloalquila, arila ou het são opcionalmente substituídos por pelo menos um substituinte independentemente selecionado de C~ 1~-8alquila, C~ 1~-8alcoxi, OH, halo, CF~ 3~, OCF~ 3~, SCF~ 3~, hidroxi-C~ 1~-6alquila, C~ 1-~4alcoxi-C~ 1~-6alquila e C~ 1~-4alquilS-C~ 1~-4alquila; R¬ 2¬ é arila ou heteroarila, cada uma opcionalmente substituída por pelo menos um substituinte independentemente selecionado de C~ 1~8alquila, C~ 1~-8alcoxi, OH, halo, CF~ 3~, OCF~ 3~, SCF~ 3~, hidroxi-C~ 1~-6alquila, C~ 1~4alCoxi-C~ 1~-6alquila e C~ 1~-4alquil-S-C~ 1~-4alquila; R¬ 3¬ é C~ 1~-6alquila, C~ 3~-8cicloalquila, C~ 3-~8Cicloalquil-C~ 1~-6alquila, arila, het, aril-C~ 1~-4alquila ou het-C~ 1~-4alquila, em que os grupos cicloalquila, arila ou het são opcionalmente substituídos por pelo menos um substituinte independentemente selecionado de C~ 1~-6alquila, C~ 1~6alcoxi, OH, halo, CF~ 3~, OCF~ 3~, SCF~ 3~, hidroxi-C~ 1~-6alquila, C~ 1~-4alcoxi-C~ 1~-6alquila e C~ 1~-4alqUil-S-C~ 1~-4alquila; X é S ou O; Y é H, C~ 1~-6alquila, arila, het, aril-C~ 1~4alquila ou het-C~ 1~-4alquila; n é 1 ou 2, contanto que quando n for 1, m seja O ou 1 e quando n for 2, m seja 0, em que se m for 0, então * representa um centro de quiral. Os compostos da invenção exibem atividade como inibidores de re-absorção tanto de serotonina quanto de noradrenalina e portanto têm utilidade em uma variedade de áreas terapêuticas, por exemplo incontinência urinária.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0314048.0A GB0314048D0 (en) | 2003-06-17 | 2003-06-17 | Novel compounds |
| US49312603P | 2003-08-06 | 2003-08-06 | |
| PCT/IB2004/001943 WO2004110995A1 (en) | 2003-06-17 | 2004-06-07 | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0411594A true BRPI0411594A (pt) | 2006-08-29 |
Family
ID=33554153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0411594-5A BRPI0411594A (pt) | 2003-06-17 | 2004-06-07 | derivados de n-pirrolidin-3-il-amida como inibidores de re-absorção de serotonina e noradrenalina |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7378436B2 (pt) |
| EP (1) | EP1638933B1 (pt) |
| JP (1) | JP4137159B2 (pt) |
| KR (1) | KR100803796B1 (pt) |
| AP (1) | AP2005003467A0 (pt) |
| AR (1) | AR044715A1 (pt) |
| AT (1) | ATE398107T1 (pt) |
| AU (1) | AU2004247487B2 (pt) |
| BR (1) | BRPI0411594A (pt) |
| CA (1) | CA2530159C (pt) |
| CY (1) | CY1110434T1 (pt) |
| DE (1) | DE602004014372D1 (pt) |
| DK (1) | DK1638933T3 (pt) |
| EA (1) | EA009881B1 (pt) |
| EC (1) | ECSP056232A (pt) |
| ES (1) | ES2305776T3 (pt) |
| HR (2) | HRP20080339T3 (pt) |
| IL (1) | IL172063A0 (pt) |
| IS (1) | IS8136A (pt) |
| MA (1) | MA27885A1 (pt) |
| MX (1) | MXPA05013960A (pt) |
| NL (1) | NL1026438C2 (pt) |
| NZ (1) | NZ544046A (pt) |
| PA (1) | PA8605301A1 (pt) |
| PE (1) | PE20050631A1 (pt) |
| PL (1) | PL1638933T3 (pt) |
| PT (1) | PT1638933E (pt) |
| SI (1) | SI1638933T1 (pt) |
| TW (1) | TW200505852A (pt) |
| UY (1) | UY28360A1 (pt) |
| WO (1) | WO2004110995A1 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100888275B1 (ko) * | 2000-07-31 | 2009-03-10 | 니코메드 댄마크 에이에스 | 코 투여용 펜타닐 조성물 |
| AU2004247487B2 (en) * | 2003-06-17 | 2010-05-20 | Pfizer Inc. | N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline re-uptake inhibitors |
| MX2007004661A (es) | 2004-10-18 | 2007-06-22 | Lilly Co Eli | Derivados de 1-(hetero)aril-3-amino-pirrolidina para usarse como antagonistas del receptor mglur3. |
| US7122683B2 (en) | 2004-11-23 | 2006-10-17 | Pfizer Inc. | Amides useful as monoamine re-uptake inhibitors |
| GB0425766D0 (en) * | 2004-11-23 | 2004-12-22 | Pfizer Ltd | Novel compounds |
| EP1828119A1 (en) * | 2004-12-14 | 2007-09-05 | Pfizer Limited | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenalin re-uptake inhibitors |
| WO2006064336A2 (en) * | 2004-12-14 | 2006-06-22 | Pfizer Limited | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenalin re-uptake inhibitors |
| TWI410406B (zh) | 2005-05-13 | 2013-10-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物 |
| JP4949387B2 (ja) * | 2005-06-02 | 2012-06-06 | エフ．ホフマン−ラ ロシュ アーゲー | ピペリジン−４−イルアミド誘導体、およびｓｓｔ受容体サブタイプ５アンタゴニストとしてのその使用 |
| WO2007135530A2 (en) * | 2006-05-22 | 2007-11-29 | Pfizer Limited | Pharmaceutically & veterinarily suitable salt |
| US20080014152A1 (en) * | 2006-07-13 | 2008-01-17 | Di Mauro Thomas M | Intranasal delivery of clenbuterol across the cribriform plate and into the brain |
| JP5219465B2 (ja) * | 2006-11-10 | 2013-06-26 | 大塚製薬株式会社 | 医薬 |
| US20100056497A1 (en) * | 2007-01-31 | 2010-03-04 | Dainippon Sumitomo Pharma Co., Ltd | Amide derivative |
| JP2010189275A (ja) * | 2007-06-14 | 2010-09-02 | Dainippon Sumitomo Pharma Co Ltd | ナフタレン誘導体 |
| US8263652B2 (en) * | 2007-10-31 | 2012-09-11 | Sk Biopharmaceuticals Co., Ltd. | Stabilized pediatric suspension of carisbamate |
| WO2009078481A1 (ja) * | 2007-12-19 | 2009-06-25 | Dainippon Sumitomo Pharma Co., Ltd. | 二環性へテロ環誘導体 |
| EP2318362B1 (en) | 2008-07-24 | 2013-09-25 | Theravance, Inc. | 3-(phenoxyphenylmethyl)pyrrolidine compounds |
| ES2397247T3 (es) | 2008-11-14 | 2013-03-05 | Theravance, Inc. | Forma cristalina de un compuesto 4-[2-(2-fluorofenoximetil)fenil]piperidina |
| WO2010120910A1 (en) * | 2009-04-15 | 2010-10-21 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| CN102482256B (zh) | 2009-06-24 | 2014-11-26 | 大日本住友制药株式会社 | N-取代的环状氨基衍生物 |
| US7994209B2 (en) | 2009-07-13 | 2011-08-09 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
| WO2011011231A1 (en) | 2009-07-21 | 2011-01-27 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
| EP2523945A1 (en) * | 2010-01-11 | 2012-11-21 | Theravance, Inc. | 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors |
| EP2550252B1 (en) * | 2010-03-22 | 2015-05-06 | Theravance Biopharma R&D IP, LLC | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds |
| CN103153950B (zh) | 2010-10-11 | 2015-11-25 | 施万生物制药研发Ip有限责任公司 | 血清素再摄取抑制剂 |
| US8501964B2 (en) | 2010-12-03 | 2013-08-06 | Theravance, Inc. | Serotonin reuptake inhibitors |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE138773C (pt) | ||||
| US3963745A (en) | 1972-04-03 | 1976-06-15 | A. H. Robins Company, Incorporated | Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides |
| US4002757A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | N-(1-substituted-3-pyrrolidinyl)-4-quinolinecarboxamides |
| US4020072A (en) * | 1976-05-04 | 1977-04-26 | E. R. Squibb & Sons, Inc. | 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines |
| GB1574419A (en) * | 1977-11-11 | 1980-09-03 | Anphar Sa | Piperidine compounds |
| CH628885A5 (en) * | 1978-01-01 | 1982-03-31 | Anphar Sa | Piperidine derivative |
| US5130312A (en) * | 1987-07-17 | 1992-07-14 | Janssen Pharmaceutica N.V. | Substituted N-(3-hydroxy-4-piperidinyl)benzamides |
| FR2642069B1 (fr) | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
| AU704139B2 (en) | 1995-11-22 | 1999-04-15 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU4167099A (en) | 1998-06-19 | 2000-01-05 | Nissan Chemical Industries Ltd. | Heterocyclic compounds as hypoglycemic agents |
| US6670299B1 (en) * | 1999-07-03 | 2003-12-30 | Northwestern University | Cyclopentadienyl-containing low-valent early transition metal olefin polymerization catalysts |
| FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| DE60124730T2 (de) | 2000-03-03 | 2007-10-04 | Eisai R&D Management Co., Ltd. | Neue methoden unter verwendung von cholinesteraseinhibitoren |
| CA2397981C (en) * | 2000-03-06 | 2010-12-21 | Acadia Pharmaceuticals, Inc. | Azacyclic compounds for use in the treatment of serotonin related diseases |
| WO2002024694A1 (en) | 2000-09-22 | 2002-03-28 | Smithkline Beecham, P.L.C. | Pyrazolopyridines and pyrazolopyridazines as antidiabetics |
| CN1458923A (zh) | 2000-09-25 | 2003-11-26 | 埃科特莱茵药品有限公司 | 抗疟用取代氨基－氮杂－环烷类化合物 |
| JP4619655B2 (ja) | 2001-09-14 | 2011-01-26 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体 |
| WO2003037865A1 (en) | 2001-10-31 | 2003-05-08 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Novel anticancer compounds |
| GB0128287D0 (en) | 2001-11-26 | 2002-01-16 | Smithkline Beecham Plc | Novel method and compounds |
| IL165907A0 (en) * | 2002-06-24 | 2006-01-15 | Acadia Pharm Inc | N-substituted piperidine derivatives as serotonin receptor agents |
| WO2004009549A2 (en) | 2002-07-18 | 2004-01-29 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
| WO2004022536A1 (en) | 2002-09-04 | 2004-03-18 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| DE60327106D1 (de) | 2002-12-20 | 2009-05-20 | Chemocentryx Inc | Inhibitoren der bindungder chemokine i-tac bzw. sdf-1 an den ccxckr2-rezeptor |
| AU2004247487B2 (en) * | 2003-06-17 | 2010-05-20 | Pfizer Inc. | N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline re-uptake inhibitors |
-
2004
- 2004-06-07 AU AU2004247487A patent/AU2004247487B2/en not_active Expired - Fee Related
- 2004-06-07 AT AT04736241T patent/ATE398107T1/de not_active IP Right Cessation
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