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BRPI0418820A - reator de exposição de fase de gás lìquido para cultivo de célula - Google Patents

reator de exposição de fase de gás lìquido para cultivo de célula

Info

Publication number
BRPI0418820A
BRPI0418820A BRPI0418820-9A BRPI0418820A BRPI0418820A BR PI0418820 A BRPI0418820 A BR PI0418820A BR PI0418820 A BRPI0418820 A BR PI0418820A BR PI0418820 A BRPI0418820 A BR PI0418820A
Authority
BR
Brazil
Prior art keywords
cells
gas phase
gas
cell cultivation
liquid gas
Prior art date
Application number
BRPI0418820-9A
Other languages
English (en)
Inventor
Uwe Marx
Marco Riedel
Hikmat Bushnaq-Josting
Original Assignee
Probiogen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiogen Ag filed Critical Probiogen Ag
Publication of BRPI0418820A publication Critical patent/BRPI0418820A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10Hollow fibers or tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

REATOR DE EXPOSIçãO DE FASE DE GáS LìQUIDO PARA CULTIVO DE CéLULA. A presente invenção refere-se a um método e de um dispositivo para iniciar o crescimento de células e para o cultivo de células em densidades altas, nos quais as células a serem cultivadas estão situadas em membranas de filamento oco e são levadas alternadamente para um agente intermediário nutriente liquido e para uma fase de gás presente acima dos mesmos. O dispositivo é um biorreator de exposição de fase de gás líquido contendo uma câmara de abastecimento na qual estão dispostas membranas de filamento oco dotadas de um diâmetro interno de até 5 mm e cujo volume interno forma compartimentos. Após as células terem sido introduzidas nos compartimentos de cultura, aproximadamente uma metade da câmara de abastecimento é preenchida com agente intermediário nutriente e a outra metade com uma mistura de gás. Após a perfusão do agente intermediário e o gás ter sido ligado, tem início a exposição cíclica das membranas de filamento oco e das células contidas nas mesmas na fase líquida ou na fase de gás.
BRPI0418820-9A 2004-06-14 2004-06-14 reator de exposição de fase de gás lìquido para cultivo de célula BRPI0418820A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DE2004/001248 WO2005121311A1 (de) 2004-06-14 2004-06-14 Flüssig-gas-phasenexpositionsreaktor für die zellkultivierung

Publications (1)

Publication Number Publication Date
BRPI0418820A true BRPI0418820A (pt) 2007-11-13

Family

ID=34958103

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418820-9A BRPI0418820A (pt) 2004-06-14 2004-06-14 reator de exposição de fase de gás lìquido para cultivo de célula

Country Status (16)

Country Link
EP (1) EP1756263B1 (pt)
JP (1) JP2008502331A (pt)
CN (1) CN1969037A (pt)
AT (1) ATE383416T1 (pt)
AU (1) AU2004320591A1 (pt)
BR (1) BRPI0418820A (pt)
CA (1) CA2568646A1 (pt)
CY (1) CY1107919T1 (pt)
DE (1) DE502004005931D1 (pt)
DK (1) DK1756263T3 (pt)
ES (1) ES2299837T3 (pt)
PL (1) PL1756263T3 (pt)
PT (1) PT1756263E (pt)
RU (1) RU2340662C2 (pt)
SI (1) SI1756263T1 (pt)
WO (1) WO2005121311A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050768A1 (en) * 2006-08-23 2008-02-28 Tautheta Instruments Llc Metabolic Monitoring Device
CN102166380B (zh) * 2011-03-17 2013-03-27 南方医科大学南方医院 基于双层硝酸纤维素膜灌流式的生物人工肝反应器
WO2015073918A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2016121775A1 (ja) 2015-01-26 2016-08-04 宇部興産株式会社 細胞の培養方法及びキット
EP3141499A1 (de) 2015-09-09 2017-03-15 Siemens Aktiengesellschaft Antrieb für eine bandförderanlage, verfahren zum montieren eines antriebs an eine bandförderanlage sowie bandförderanlage
CN105176815B (zh) * 2015-10-20 2017-03-22 哈尔滨工业大学 一种用于人工皮肤组织培养的气液界面灌注式生物反应器及其制备方法和使用方法
RU180071U1 (ru) * 2016-05-23 2018-05-31 Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр "Казанский научный центр Российской академии наук" Линия получения лекарственного средства Na-, Fe-, Ca-полигалактуронат
KR101976955B1 (ko) * 2017-11-17 2019-05-09 영남대학교 산학협력단 박테리오 파지 배양 시스템
RU2681678C1 (ru) * 2017-11-22 2019-03-12 Федеральное государственное бюджетное научное учреждение "Федеральный научный агроинженерный центр ВИМ" (ФГБНУ ФНАЦ ВИМ) Биореактор для культивирования мультипотентных мезенхимальных стволовых клеток
TWI846694B (zh) 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
RU2727359C2 (ru) * 2018-06-27 2020-07-21 Рубен Вагеевич Оганесян Камера многокамерного биореактора для выращивания тканеинженерных конструкций
CN108949558A (zh) * 2018-07-20 2018-12-07 中南大学 用于植物细胞高密度培养的滚筒中空纤维反应器及番石榴叶细胞高密度培养的方法
CA3115769A1 (en) 2018-10-10 2020-04-16 Stamm Vegh Corporation Continuous flow microbioreactor
RU2723955C1 (ru) * 2019-12-30 2020-06-18 Рубен Вагеевич Оганесян Многокамерный биореактор для выращивания тканеинженерных конструкций
DE102020102420A1 (de) * 2020-01-31 2021-08-05 Rwth Aachen Gas-Flüssig-Reaktor zur blasenfreien Begasung einer Prozessflüssigkeit
BR112022015287A2 (pt) 2020-02-03 2022-12-20 Stamm Vegh Corp Plataforma, sistemas e dispositivos para impressão 3d
CN114907978A (zh) * 2022-05-23 2022-08-16 江南大学 适用于哺乳动物细胞高密度培养的低剪切力灌流培养系统及方法
WO2026008773A1 (en) * 2024-07-04 2026-01-08 Cellular Agriculture Ltd Cell culture construct
EP4674943A1 (en) * 2024-07-04 2026-01-07 Cellular Agriculture Ltd A meat culture construct for a meat culturing system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10304236A1 (de) * 2002-01-28 2003-08-28 Probiogen Ag Verfahren und Vorrichtung zur Kultivierung von Zellen in hohen Dichten und zur Gewinnung von Produkten aus diesen Zellen
DE10211106B4 (de) * 2002-03-12 2004-12-09 Bio-Energie-Consult Innovations- Und Technologie Gmbh Verfahren zur Verbesserung der Sauerstoffzufuhr für Zellkulturen in Bioreaktoren
AU2003245850A1 (en) * 2002-05-31 2003-12-19 Probiogen Ag Culture systems for the sterile continuous cultivation of cells

Also Published As

Publication number Publication date
WO2005121311A1 (de) 2005-12-22
CY1107919T1 (el) 2013-09-04
RU2340662C2 (ru) 2008-12-10
DK1756263T3 (da) 2008-05-13
AU2004320591A1 (en) 2005-12-22
PL1756263T3 (pl) 2008-06-30
JP2008502331A (ja) 2008-01-31
ATE383416T1 (de) 2008-01-15
CA2568646A1 (en) 2005-12-22
PT1756263E (pt) 2008-04-07
EP1756263B1 (de) 2008-01-09
RU2007101315A (ru) 2008-07-20
ES2299837T3 (es) 2008-06-01
DE502004005931D1 (de) 2008-02-21
EP1756263A1 (de) 2007-02-28
SI1756263T1 (sl) 2008-06-30
CN1969037A (zh) 2007-05-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.