BRPI0409930A - cristais de solvato derivado do ácido quinolinacarboxìlico - Google Patents
cristais de solvato derivado do ácido quinolinacarboxìlicoInfo
- Publication number
- BRPI0409930A BRPI0409930A BRPI0409930-3A BRPI0409930A BRPI0409930A BR PI0409930 A BRPI0409930 A BR PI0409930A BR PI0409930 A BRPI0409930 A BR PI0409930A BR PI0409930 A BRPI0409930 A BR PI0409930A
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- crystal
- oxo
- compound
- acid
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 7
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
- 239000012453 solvate Substances 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 3
- -1 4- (5-methyl-2-oxo-1,3-dioxolen-4-yl) -methyl-1piperazinyl Chemical group 0.000 abstract 2
- JBMKAUGHUNFTOL-UHFFFAOYSA-N Aldoclor Chemical class C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC=NS2(=O)=O JBMKAUGHUNFTOL-UHFFFAOYSA-N 0.000 abstract 2
- 229940126062 Compound A Drugs 0.000 abstract 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- DJXNJVFEFSWHLY-UHFFFAOYSA-N quinoline-3-carboxylic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-N 0.000 abstract 2
- 239000003451 thiazide diuretic agent Substances 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"CRISTAIS DE SOLVATO DERIVADO DO áCIDO QUINOLINACARBOXìLICO". Um principal objetivo é fornecer um cristal de solvato em acetonitrila do ácido 6-flúor-1-metil-7-¢4-(5-metil-2-oxo-1,3-dioxolen-4-il)-metil-1piperazinil!- 4-oxo-4H-¢1,3! tiazeto ¢3,2-a! quinolina-3-carboxílico (Composto B), que é um intermediário para produzir preferencialmente o cristal do tipo III do ácido 6-flúor-1-metil-7-¢4-(5-metil-2-oxo-1,3-dioxolen-4-il)-metil-1-piperazinil!- 4-oxo-4H-¢1,3! tiazeto ¢3,2-a! quinolina-3-carboxílico (Composto A). Um cristal de Composto B pode ser precipitado preferencialmente por controle da concentração de supersaturação em cristalização usando-se acetonitrila como um solvente. Subseqüentemente, o cristal do tipo III de Composto A pode ser produzido por realização de dissolvatação do cristal.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003124643 | 2003-04-30 | ||
| JP2004006057 | 2004-01-13 | ||
| PCT/JP2004/006216 WO2004096815A1 (ja) | 2003-04-30 | 2004-04-28 | キノリンカルボン酸誘導体溶媒和物の結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0409930A true BRPI0409930A (pt) | 2006-04-25 |
Family
ID=33422075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409930-3A BRPI0409930A (pt) | 2003-04-30 | 2004-04-28 | cristais de solvato derivado do ácido quinolinacarboxìlico |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7612205B2 (pt) |
| EP (2) | EP2354144A1 (pt) |
| JP (1) | JP4655930B2 (pt) |
| KR (1) | KR101088988B1 (pt) |
| AU (2) | AU2004234287A1 (pt) |
| BR (1) | BRPI0409930A (pt) |
| CA (1) | CA2523854C (pt) |
| ES (1) | ES2388921T3 (pt) |
| MX (1) | MXPA05011525A (pt) |
| PL (1) | PL1626051T3 (pt) |
| PT (1) | PT1626051E (pt) |
| RU (1) | RU2335503C2 (pt) |
| WO (1) | WO2004096815A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012001357A1 (en) | 2010-06-30 | 2012-01-05 | Cipla Limited | Crystalline form of prulifloxacin and processes for its preparation |
| RU2484768C1 (ru) * | 2012-02-07 | 2013-06-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации | Способ прогнозирования течения глаукомной оптической нейропатии |
| JP2021519334A (ja) | 2018-03-26 | 2021-08-10 | クリア クリーク バイオ， インコーポレイテッド | ジヒドロオロト酸デヒドロゲナーゼを阻害するための組成物および方法 |
| US20210300873A1 (en) | 2020-03-20 | 2021-09-30 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
| JP2023518419A (ja) * | 2020-03-20 | 2023-05-01 | クリア クリーク バイオ， インコーポレイテッド | ブレキナルナトリウムの安定した多形性組成物ならびにその使用および製造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751579B2 (ja) * | 1987-11-07 | 1995-06-05 | 日本新薬株式会社 | キノリンカルボン酸誘導体 |
| SU1558915A1 (ru) * | 1988-07-29 | 1990-04-23 | Пермский фармацевтический институт | 2-(5 @ -Нитрофурил)-2,3-дигидро-5Н-1,3,4-тиадиазоло[2,3-в]-хиназолинон-5, про вл ющий противомикробную активность |
-
2004
- 2004-04-28 EP EP11161811A patent/EP2354144A1/en not_active Withdrawn
- 2004-04-28 BR BRPI0409930-3A patent/BRPI0409930A/pt not_active Application Discontinuation
- 2004-04-28 MX MXPA05011525A patent/MXPA05011525A/es active IP Right Grant
- 2004-04-28 WO PCT/JP2004/006216 patent/WO2004096815A1/ja not_active Ceased
- 2004-04-28 KR KR1020057020448A patent/KR101088988B1/ko not_active Expired - Lifetime
- 2004-04-28 US US10/555,039 patent/US7612205B2/en not_active Expired - Lifetime
- 2004-04-28 PL PL04730102T patent/PL1626051T3/pl unknown
- 2004-04-28 JP JP2005505937A patent/JP4655930B2/ja not_active Expired - Lifetime
- 2004-04-28 EP EP04730102A patent/EP1626051B1/en not_active Expired - Lifetime
- 2004-04-28 AU AU2004234287A patent/AU2004234287A1/en not_active Abandoned
- 2004-04-28 ES ES04730102T patent/ES2388921T3/es not_active Expired - Lifetime
- 2004-04-28 RU RU2005137156/04A patent/RU2335503C2/ru active
- 2004-04-28 PT PT04730102T patent/PT1626051E/pt unknown
- 2004-04-28 CA CA2523854A patent/CA2523854C/en not_active Expired - Lifetime
-
2010
- 2010-04-01 AU AU2010201309A patent/AU2010201309B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP2354144A1 (en) | 2011-08-10 |
| ES2388921T3 (es) | 2012-10-19 |
| MXPA05011525A (es) | 2005-12-12 |
| AU2010201309B2 (en) | 2011-10-13 |
| EP1626051A4 (en) | 2008-06-25 |
| RU2335503C2 (ru) | 2008-10-10 |
| AU2004234287A1 (en) | 2004-11-11 |
| PL1626051T3 (pl) | 2012-10-31 |
| JP4655930B2 (ja) | 2011-03-23 |
| KR101088988B1 (ko) | 2011-12-01 |
| US7612205B2 (en) | 2009-11-03 |
| EP1626051B1 (en) | 2012-06-13 |
| CA2523854A1 (en) | 2004-11-11 |
| WO2004096815A1 (ja) | 2004-11-11 |
| JPWO2004096815A1 (ja) | 2006-07-13 |
| KR20060008930A (ko) | 2006-01-27 |
| PT1626051E (pt) | 2012-08-01 |
| EP1626051A1 (en) | 2006-02-15 |
| CA2523854C (en) | 2012-10-16 |
| US20070149540A1 (en) | 2007-06-28 |
| RU2005137156A (ru) | 2006-06-10 |
| AU2010201309A1 (en) | 2010-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |