BRPI0409734A - processo para a preparação de análogo de closporina a - Google Patents
processo para a preparação de análogo de closporina aInfo
- Publication number
- BRPI0409734A BRPI0409734A BRPI0409734-3A BRPI0409734A BRPI0409734A BR PI0409734 A BRPI0409734 A BR PI0409734A BR PI0409734 A BRPI0409734 A BR PI0409734A BR PI0409734 A BRPI0409734 A BR PI0409734A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- analog
- closporin
- cyclosporin
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 3
- 229930105110 Cyclosporin A Natural products 0.000 abstract 2
- 108010036949 Cyclosporine Proteins 0.000 abstract 2
- 229960001265 ciclosporin Drugs 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- -1 cyclosporin A aldehyde Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE ANáLOGO DE CICLOSPORINA A". A invenção refere-se a um novo processo para a preparação de um análogo de ciclosporina A da fórmula I, o qual compreende: a) a alilação de um aldeído da ciclosporina A protegido com um reagente de alila-metal e b) a conversão do composto obtido na etapa a) no análogo de ciclosporina A da fórmula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03007921 | 2003-04-08 | ||
| PCT/EP2004/003504 WO2004089960A2 (en) | 2003-04-08 | 2004-04-02 | Process for preparation of cyclosporin “a” analogues having a terminal diene group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0409734A true BRPI0409734A (pt) | 2006-05-09 |
Family
ID=33155122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409734-3A BRPI0409734A (pt) | 2003-04-08 | 2004-04-02 | processo para a preparação de análogo de closporina a |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040220091A1 (pt) |
| EP (1) | EP1613646A2 (pt) |
| JP (1) | JP2006525961A (pt) |
| KR (1) | KR20050119200A (pt) |
| CN (1) | CN1798759A (pt) |
| AU (1) | AU2004228159A1 (pt) |
| BR (1) | BRPI0409734A (pt) |
| CA (1) | CA2521116A1 (pt) |
| CO (1) | CO5680450A2 (pt) |
| EC (1) | ECSP056091A (pt) |
| MA (1) | MA27831A1 (pt) |
| MX (1) | MXPA05010794A (pt) |
| NO (1) | NO20054478L (pt) |
| RU (1) | RU2005130508A (pt) |
| TN (1) | TNSN05255A1 (pt) |
| TW (1) | TW200505946A (pt) |
| WO (1) | WO2004089960A2 (pt) |
| ZA (1) | ZA200507980B (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6859799B1 (en) | 1998-11-30 | 2005-02-22 | Gemstar Development Corporation | Search engine for video and graphics |
| US7103906B1 (en) | 2000-09-29 | 2006-09-05 | International Business Machines Corporation | User controlled multi-device media-on-demand system |
| KR20090031796A (ko) | 2000-10-11 | 2009-03-27 | 유나이티드 비디오 프로퍼티즈, 인크. | 데이터의 기억 장치를 주문형 매체 배달 시스템의 서버에 제공하기 위한 시스템 및 방법 |
| US7493646B2 (en) | 2003-01-30 | 2009-02-17 | United Video Properties, Inc. | Interactive television systems with digital video recording and adjustable reminders |
| WO2004082629A2 (en) | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| CA2575280C (en) * | 2004-07-29 | 2012-08-14 | Amr Technology, Inc. | Novel processes for stereoselective synthesis of trans isatx 247 |
| US8086575B2 (en) | 2004-09-23 | 2011-12-27 | Rovi Solutions Corporation | Methods and apparatus for integrating disparate media formats in a networked media system |
| JP2008514701A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキン類似体およびそれらの薬学的使用 |
| EP1804823A4 (en) | 2004-09-29 | 2010-06-09 | Amr Technology Inc | NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS |
| US7361636B2 (en) | 2004-10-06 | 2008-04-22 | Amr Technology, Inc. | Cyclosporin alkynes and their utility as pharmaceutical agents |
| KR100780718B1 (ko) | 2004-12-28 | 2007-12-26 | 엘지.필립스 엘시디 주식회사 | 도포액 공급장치를 구비한 슬릿코터 |
| US8607287B2 (en) | 2005-12-29 | 2013-12-10 | United Video Properties, Inc. | Interactive media guidance system having multiple devices |
| US9681105B2 (en) | 2005-12-29 | 2017-06-13 | Rovi Guides, Inc. | Interactive media guidance system having multiple devices |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US20090019492A1 (en) | 2007-07-11 | 2009-01-15 | United Video Properties, Inc. | Systems and methods for mirroring and transcoding media content |
| CA3014633C (en) | 2007-10-08 | 2022-05-17 | Aurinia Pharmaceuticals Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors |
| US8601526B2 (en) | 2008-06-13 | 2013-12-03 | United Video Properties, Inc. | Systems and methods for displaying media content and media guidance information |
| FR2934997B1 (fr) * | 2008-08-14 | 2010-09-24 | Minakem | Derives cyclopropyl-et cyclobutyl-dioxazaborocanes ou dioxazaborecanes |
| CA2764635C (en) | 2009-06-09 | 2018-05-22 | Lux Biosciences, Inc. | Topical drug delivery systems for ophthalmic use |
| US9014546B2 (en) | 2009-09-23 | 2015-04-21 | Rovi Guides, Inc. | Systems and methods for automatically detecting users within detection regions of media devices |
| PL2651965T3 (pl) | 2010-12-15 | 2019-04-30 | Contravir Pharmaceuticals Inc | Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3 |
| US8805418B2 (en) | 2011-12-23 | 2014-08-12 | United Video Properties, Inc. | Methods and systems for performing actions based on location-based rules |
| AR090964A1 (es) | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
| US9674563B2 (en) | 2013-11-04 | 2017-06-06 | Rovi Guides, Inc. | Systems and methods for recommending content |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| EP4201952A1 (en) | 2021-12-21 | 2023-06-28 | Curia Spain, S.A.U. | Process for the controlled synthesis of voclosporin |
| WO2025119925A1 (en) | 2023-12-05 | 2025-06-12 | Medichem, S.A. | Process for preparing voclosporin |
| WO2025141456A1 (en) * | 2023-12-27 | 2025-07-03 | Indena S.P.A. | Process for the preparation of voclosporin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE95193T1 (de) * | 1987-06-17 | 1993-10-15 | Sandoz Ag | Cyclosporine und deren benutzung als arzneimittel. |
| WO1998048791A1 (en) * | 1997-04-30 | 1998-11-05 | The Regents Of The University Of California | Synthesis of discodermolide and analogs |
| JP4261049B2 (ja) * | 1997-10-08 | 2009-04-30 | アイソテクニカ インコーポレイテッド | 重水素化シクロスポリンアナログおよび免疫調節剤としてのそれらの使用 |
| DE10143979A1 (de) * | 2001-09-07 | 2003-03-27 | Clariant Gmbh | Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren |
| ES2266564T3 (es) * | 2001-10-19 | 2007-03-01 | Isotechnika Inc. | Sintesis de analogos de cicloporinas. |
| RU2337106C2 (ru) * | 2001-10-19 | 2008-10-27 | Изотехника Инк. | Смесь аналогов циклоспорина и ее применение в качестве иммуномодулирующего агента |
-
2004
- 2004-03-31 TW TW093108938A patent/TW200505946A/zh unknown
- 2004-04-02 EP EP04725333A patent/EP1613646A2/en not_active Withdrawn
- 2004-04-02 MX MXPA05010794A patent/MXPA05010794A/es unknown
- 2004-04-02 BR BRPI0409734-3A patent/BRPI0409734A/pt not_active Application Discontinuation
- 2004-04-02 JP JP2006504961A patent/JP2006525961A/ja not_active Withdrawn
- 2004-04-02 CA CA002521116A patent/CA2521116A1/en not_active Abandoned
- 2004-04-02 AU AU2004228159A patent/AU2004228159A1/en not_active Abandoned
- 2004-04-02 RU RU2005130508/04A patent/RU2005130508A/ru not_active Application Discontinuation
- 2004-04-02 KR KR1020057019162A patent/KR20050119200A/ko not_active Withdrawn
- 2004-04-02 WO PCT/EP2004/003504 patent/WO2004089960A2/en not_active Ceased
- 2004-04-02 CN CNA2004800154235A patent/CN1798759A/zh active Pending
- 2004-04-02 ZA ZA200507980A patent/ZA200507980B/en unknown
- 2004-04-05 US US10/817,991 patent/US20040220091A1/en not_active Abandoned
-
2005
- 2005-09-28 NO NO20054478A patent/NO20054478L/no not_active Application Discontinuation
- 2005-10-06 CO CO05101444A patent/CO5680450A2/es not_active Application Discontinuation
- 2005-10-07 MA MA28540A patent/MA27831A1/fr unknown
- 2005-10-07 EC EC2005006091A patent/ECSP056091A/es unknown
- 2005-10-07 TN TNP2005000255A patent/TNSN05255A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TNSN05255A1 (en) | 2007-07-10 |
| CN1798759A (zh) | 2006-07-05 |
| ZA200507980B (en) | 2006-11-29 |
| CO5680450A2 (es) | 2006-09-29 |
| ECSP056091A (es) | 2006-03-01 |
| EP1613646A2 (en) | 2006-01-11 |
| NO20054478L (no) | 2005-10-17 |
| US20040220091A1 (en) | 2004-11-04 |
| RU2005130508A (ru) | 2006-06-27 |
| MXPA05010794A (es) | 2005-12-14 |
| JP2006525961A (ja) | 2006-11-16 |
| MA27831A1 (fr) | 2006-04-03 |
| AU2004228159A1 (en) | 2004-10-21 |
| WO2004089960A2 (en) | 2004-10-21 |
| WO2004089960A3 (en) | 2005-01-06 |
| KR20050119200A (ko) | 2005-12-20 |
| TW200505946A (en) | 2005-02-16 |
| NO20054478D0 (no) | 2005-09-28 |
| CA2521116A1 (en) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |