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BRPI0409002A - pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos - Google Patents

pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos

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Publication number
BRPI0409002A
BRPI0409002A BRPI0409002-0A BRPI0409002A BRPI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A
Authority
BR
Brazil
Prior art keywords
psychosis
treatment
receptor antagonists
neurological disorders
substituted pyrazoles
Prior art date
Application number
BRPI0409002-0A
Other languages
English (en)
Inventor
Kai Schiemann
Oliver Schadt
Christoph Van Amsterdam
Gerd Bartoszyk
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0409002A publication Critical patent/BRPI0409002A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
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  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
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Abstract

"PIRAZóIS 1,3,4-SUBSTITUìDOS PARA USO COMO ANTAGONISTAS RECEPTORES 5H-T NO TRATAMENTO DE PSICOSES E DISTúRBIOS NEUROLóGICOS". A presente invenção refere-se a compostos de fórmula (I) e sais e solvatos dos mesmos, em que X, R¬ 1¬, R¬ 2¬, R¬ 5¬ e Q possuem os significados indicados na reivindicação 1, que são adequados como ligantes de receptores de 5HT; bem como como compostos intermediários de fórmula (IA).
BRPI0409002-0A 2003-04-05 2004-03-08 pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos BRPI0409002A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003115573 DE10315573A1 (de) 2003-04-05 2003-04-05 Substituierte Pyrazole
PCT/EP2004/002354 WO2004089910A1 (de) 2003-04-05 2004-03-08 1,3,4-substituierte pyrazole als 5-ht rezeptor-antagonisten zur behandlung von psychosen und neurologischen störungen

Publications (1)

Publication Number Publication Date
BRPI0409002A true BRPI0409002A (pt) 2006-03-28

Family

ID=32981074

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409002-0A BRPI0409002A (pt) 2003-04-05 2004-03-08 pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos

Country Status (16)

Country Link
US (1) US7566709B2 (pt)
EP (1) EP1611107B1 (pt)
JP (1) JP4740116B2 (pt)
KR (1) KR20050119194A (pt)
CN (1) CN1768043A (pt)
AR (1) AR043838A1 (pt)
AT (1) ATE478052T1 (pt)
AU (1) AU2004228121B2 (pt)
BR (1) BRPI0409002A (pt)
CA (1) CA2521202A1 (pt)
DE (2) DE10315573A1 (pt)
ES (1) ES2349922T3 (pt)
MX (1) MXPA05010646A (pt)
RU (1) RU2005133990A (pt)
WO (1) WO2004089910A1 (pt)
ZA (1) ZA200508951B (pt)

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DE10315569A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazolverbindungen
CA2581454A1 (en) 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyrimidine compounds, process for their preparation and compositions containing them
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AU2006261841B8 (en) 2005-06-27 2012-12-06 Exelixis Patent Company Llc Pyrazole based LXR modulators
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WO2007016674A2 (en) 2005-08-02 2007-02-08 Lexicon Genetics Incorporated 2-aminoaryl pyridines as protein kinases inhibitors
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TW201601632A (zh) 2013-11-20 2016-01-16 杜邦股份有限公司 １－芳基－３－烷基吡唑殺蟲劑
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Also Published As

Publication number Publication date
KR20050119194A (ko) 2005-12-20
JP2006522036A (ja) 2006-09-28
CN1768043A (zh) 2006-05-03
ES2349922T3 (es) 2011-01-13
AR043838A1 (es) 2005-08-17
ATE478052T1 (de) 2010-09-15
US20070105871A1 (en) 2007-05-10
DE502004011551D1 (de) 2010-09-30
EP1611107B1 (de) 2010-08-18
MXPA05010646A (es) 2005-12-12
AU2004228121A1 (en) 2004-10-21
DE10315573A1 (de) 2004-10-14
JP4740116B2 (ja) 2011-08-03
EP1611107A1 (de) 2006-01-04
AU2004228121B2 (en) 2010-11-04
WO2004089910A1 (de) 2004-10-21
US7566709B2 (en) 2009-07-28
CA2521202A1 (en) 2004-10-21
RU2005133990A (ru) 2006-03-20
ZA200508951B (en) 2007-03-28

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