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BRPI0408148A - derivados de ácido benzoilureidopiridil-piperidina e -pirrolidina-carboxìlico, processos para a preparação e uso dos mesmos - Google Patents

derivados de ácido benzoilureidopiridil-piperidina e -pirrolidina-carboxìlico, processos para a preparação e uso dos mesmos

Info

Publication number
BRPI0408148A
BRPI0408148A BRPI0408148-0A BRPI0408148A BRPI0408148A BR PI0408148 A BRPI0408148 A BR PI0408148A BR PI0408148 A BRPI0408148 A BR PI0408148A BR PI0408148 A BRPI0408148 A BR PI0408148A
Authority
BR
Brazil
Prior art keywords
benzoylureidopyridyl
piperidine
carboxylic acid
acid derivatives
processes
Prior art date
Application number
BRPI0408148-0A
Other languages
English (en)
Inventor
Karl Schoenafinger
Dieter Kadereit
Elisabeth Defossa
Andreas Herling
Thomas Klabunde
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BRPI0408148A publication Critical patent/BRPI0408148A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADOS DE áCIDO BENZOILUREIDOPIRIDILPIPERIDINA E -PIRROLIDINA-CARBOXìLICO, PROCESSOS PARA A PREPARAçãO E USO DOS MESMOS". A presente invenção refere-se a derivados de ácido benzoilureidopiridil-piperidina e pirrolidina-carboxílico substituídos, processos para preparação e uso dos mesmos. A invenção refere-se a compostos da fórmula (I), nos quais os radicais têm os significados indicados, bem como a seus sais fisiologicamente compatíveis. Os compostos são apropriados, por exemplo, como medicamentos para prevenção e tratamento de diabetes do tipo 2.
BRPI0408148-0A 2003-03-07 2004-02-21 derivados de ácido benzoilureidopiridil-piperidina e -pirrolidina-carboxìlico, processos para a preparação e uso dos mesmos BRPI0408148A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10309929A DE10309929B4 (de) 2003-03-07 2003-03-07 Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
PCT/EP2004/001735 WO2004078743A1 (de) 2003-03-07 2004-02-21 Substituierte benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, verfahren zu deren herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
BRPI0408148A true BRPI0408148A (pt) 2006-03-01

Family

ID=32945839

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408148-0A BRPI0408148A (pt) 2003-03-07 2004-02-21 derivados de ácido benzoilureidopiridil-piperidina e -pirrolidina-carboxìlico, processos para a preparação e uso dos mesmos

Country Status (18)

Country Link
EP (1) EP1603895B1 (pt)
JP (1) JP2006519795A (pt)
KR (1) KR20050108487A (pt)
CN (1) CN1759109A (pt)
AT (1) ATE386735T1 (pt)
AU (1) AU2004218267A1 (pt)
BR (1) BRPI0408148A (pt)
CA (1) CA2518322A1 (pt)
CO (1) CO5690587A2 (pt)
DE (2) DE10309929B4 (pt)
HR (1) HRP20050779A2 (pt)
MA (1) MA27745A1 (pt)
MX (1) MXPA05009122A (pt)
NO (1) NO20054418L (pt)
PL (1) PL377293A1 (pt)
RU (1) RU2005131011A (pt)
WO (1) WO2004078743A1 (pt)
ZA (1) ZA200506119B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006053274A2 (en) 2004-11-15 2006-05-18 Bristol-Myers Squibb Company 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
WO2006055435A1 (en) 2004-11-15 2006-05-26 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
US7226942B2 (en) 2004-11-15 2007-06-05 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
KR20120104534A (ko) * 2009-10-06 2012-09-21 브리스톨-마이어스 스큅 컴퍼니 피롤리딘 ｇｐｒ40 조절제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034004A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
DE10116768A1 (de) * 2001-04-04 2002-10-10 Aventis Pharma Gmbh Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
YU91002A (sh) * 2000-06-09 2006-05-25 Aventis Pharma Deutschland Derivati acilfenil-karbamida, postupak za njihovu proizvodnju i njihova primena kao leka
PE20021091A1 (es) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
DE10125567B4 (de) * 2001-05-25 2004-08-26 Aventis Pharma Deutschland Gmbh Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10215907A1 (de) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
ATE443041T1 (de) * 2002-07-11 2009-10-15 Sanofi Aventis Deutschland Harnstoff- und urethan-substituierte acylharnstoffe, verfahren zu deren herstellung und deren verwendung als arzneimittel
HRP20050022A2 (en) * 2002-07-12 2006-03-31 Sanofi-Aventis Deutschland Gmbh Heterocyclically substituted benzoylureas, method for their production and their use as medicaments

Also Published As

Publication number Publication date
DE10309929A1 (de) 2004-12-02
KR20050108487A (ko) 2005-11-16
DE502004006253D1 (de) 2008-04-03
WO2004078743A1 (de) 2004-09-16
EP1603895B1 (de) 2008-02-20
CO5690587A2 (es) 2006-10-31
ZA200506119B (en) 2006-11-29
CA2518322A1 (en) 2004-09-16
JP2006519795A (ja) 2006-08-31
EP1603895A1 (de) 2005-12-14
PL377293A1 (pl) 2006-01-23
MXPA05009122A (es) 2005-10-20
ATE386735T1 (de) 2008-03-15
RU2005131011A (ru) 2006-05-10
DE10309929B4 (de) 2006-02-23
AU2004218267A1 (en) 2004-09-16
NO20054418L (no) 2005-09-23
HRP20050779A2 (en) 2006-10-31
MA27745A1 (fr) 2006-02-01
CN1759109A (zh) 2006-04-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.