[go: up one dir, main page]

BRPI0406702A - Modificação cristalina de 2-(3,5-bis-trifluormetil-fenil)-n-[6-(1,1-dioxo-1 lâmboa^6^-tiomorfolin-4-il)-4-(4-flúor-2-metil-fenil)-pi ridin-3-il]-n-metil-isobutiramida - Google Patents

Modificação cristalina de 2-(3,5-bis-trifluormetil-fenil)-n-[6-(1,1-dioxo-1 lâmboa^6^-tiomorfolin-4-il)-4-(4-flúor-2-metil-fenil)-pi ridin-3-il]-n-metil-isobutiramida

Info

Publication number
BRPI0406702A
BRPI0406702A BR0406702-9A BRPI0406702A BRPI0406702A BR PI0406702 A BRPI0406702 A BR PI0406702A BR PI0406702 A BRPI0406702 A BR PI0406702A BR PI0406702 A BRPI0406702 A BR PI0406702A
Authority
BR
Brazil
Prior art keywords
methyl
phenyl
pyridin
bis
thiomorpholin
Prior art date
Application number
BR0406702-9A
Other languages
English (en)
Inventor
Torsten Hoffmann
Fabienne Hoffmann-Emery
Sonia Nick
Urs Schwitter
Pius Waldmeier
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0406702A publication Critical patent/BRPI0406702A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"MODIFICAçãO CRISTALINA DE 2-(3,5-BIS-TRI-FLUORMETIL-FENIL)-N-¢6-(1,1-DIOXO-1 LâMBOA~ 6¬ -TIOMORFOLIN-4-IL)-4-(4-FLúOR-2-METIL-FENIL)-PIRIDIN-3-IL!- N-METIL-ISOBUTIRAMIDA". A presente invenção refere-se a uma nova modificação cristalina de 2-(3,5-bis-trifluormetil-fenil)-N-¢6-(1,1,-dioXo1<sym>¬ 6¬tiomorfolin-4-il)-4-(4-flúor-2-metil-fenil)-piridin-3-il!-N-metil-isobutirami da caracterizada pelo seguinte padrão de difração de raios X obtido com uma radiação CU~ K<244>~ a 20 (2 teta) = 4,5, 6,4, 7,5, 7,7, 8,0, 8,2, 10,0, 10,2, 10,9, 11,1, 12,9, 13,4, 14,0, 14,5, 15,1, 15,6, 16,2, 16,5, 17,3, 17,5, 18,0, 18,9, 19,3, 19,5, 19,9, 20,1, 20,6, 21,0, 21,4, 22,7, 23,1 e 23,6 e um espectro de infravermelho com faixas agudas a 2925, 2854, 1637, 1604, 1484, 1395, 1375, 1285, 1230, 1172, 1125, 1082, 999, 943, 893, 863, 860, 782, 705, 684 cm¬ -1¬ e em que o ponto de fusão extrapolado (DSC) é 137,2,198>C.
BR0406702-9A 2003-01-31 2004-01-23 Modificação cristalina de 2-(3,5-bis-trifluormetil-fenil)-n-[6-(1,1-dioxo-1 lâmboa^6^-tiomorfolin-4-il)-4-(4-flúor-2-metil-fenil)-pi ridin-3-il]-n-metil-isobutiramida BRPI0406702A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002134 2003-01-31
PCT/EP2004/000547 WO2004067007A1 (en) 2003-01-31 2004-01-23 NEW CRYSTALLINE MODIFICATION OF 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)-4(4-FLUORO-2-METHYL-PHENYL)-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE

Publications (1)

Publication Number Publication Date
BRPI0406702A true BRPI0406702A (pt) 2005-12-20

Family

ID=32798734

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0406702-9A BRPI0406702A (pt) 2003-01-31 2004-01-23 Modificação cristalina de 2-(3,5-bis-trifluormetil-fenil)-n-[6-(1,1-dioxo-1 lâmboa^6^-tiomorfolin-4-il)-4-(4-flúor-2-metil-fenil)-pi ridin-3-il]-n-metil-isobutiramida

Country Status (28)

Country Link
US (1) US7160881B2 (pt)
EP (1) EP1592428B1 (pt)
JP (1) JP5026702B2 (pt)
KR (1) KR100700421B1 (pt)
CN (1) CN100562320C (pt)
AR (1) AR042980A1 (pt)
AT (1) ATE366576T1 (pt)
AU (1) AU2004208483B8 (pt)
BR (1) BRPI0406702A (pt)
CA (1) CA2514037C (pt)
CL (1) CL2004000150A1 (pt)
CO (1) CO5580750A2 (pt)
DE (1) DE602004007486T2 (pt)
ES (1) ES2290666T3 (pt)
GT (1) GT200400009A (pt)
HR (1) HRP20050664A2 (pt)
IL (1) IL169600A (pt)
MX (1) MXPA05008171A (pt)
MY (1) MY135785A (pt)
NO (1) NO20053431L (pt)
NZ (1) NZ541243A (pt)
PA (1) PA8594601A1 (pt)
PE (1) PE20040944A1 (pt)
PL (1) PL378404A1 (pt)
RU (1) RU2330022C2 (pt)
TW (1) TWI293294B (pt)
WO (1) WO2004067007A1 (pt)
ZA (1) ZA200505567B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007000198A (es) 2004-07-06 2007-03-15 Hoffmann La Roche Proceso para la preparacion de derivados de carboxamida-piridina utilizados como intermediarios en la sintesis de antagonistas del receptor nk-1.
BRPI0606187A2 (pt) 2005-02-25 2009-06-09 Hoffmann La Roche comprimidos com capacidade de dispersão da substáncia do fármaco melhorada
CA2772168C (en) * 2009-08-27 2019-01-08 Glaxosmithkline Llc Anhydrate forms of a pyridine derivative
CN103755592A (zh) * 2013-12-30 2014-04-30 镇江圣安医药有限公司 (2z)-氰基-3-羟基-n-[4-(三氟甲基)苯基]-2-丁烯酰胺的衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2024507C1 (ru) * 1991-11-18 1994-12-15 Евгений Яковлевич Левитин 5-хлор-2-пиридиламид-4-нитро-n-(карбоксиметил)антраниловой кислоты, проявляющий противовоспалительную активность
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
ATE364606T1 (de) * 1993-12-29 2007-07-15 Merck Sharp & Dohme Substituierte morpholinderivate und ihre verwendung als arzneimittel
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
ES2226622T3 (es) * 1999-02-24 2005-04-01 F. Hoffmann-La Roche Ag Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1.
MXPA03009720A (es) * 2001-04-23 2004-01-29 Hoffmann La Roche USO DE ANTAGONISTAS DEL RECEPTOR DE NK-1 PARA TRATAMIENTO O PREVENCIoN DE HIPERPLASIA PROSTATICA BENIGNA.
US6849624B2 (en) * 2001-07-31 2005-02-01 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted amides

Also Published As

Publication number Publication date
DE602004007486T2 (de) 2008-04-30
KR20050096964A (ko) 2005-10-06
JP2006514999A (ja) 2006-05-18
IL169600A (en) 2010-11-30
KR100700421B1 (ko) 2007-03-28
EP1592428A1 (en) 2005-11-09
NO20053431D0 (no) 2005-07-14
AR042980A1 (es) 2005-07-13
AU2004208483B2 (en) 2008-03-06
CA2514037A1 (en) 2004-08-12
NZ541243A (en) 2008-04-30
PE20040944A1 (es) 2004-12-14
DE602004007486D1 (de) 2007-08-23
EP1592428B1 (en) 2007-07-11
US20040186100A1 (en) 2004-09-23
WO2004067007A1 (en) 2004-08-12
AU2004208483A1 (en) 2004-08-12
AU2004208483B8 (en) 2008-04-03
CN100562320C (zh) 2009-11-25
CA2514037C (en) 2012-03-13
PL378404A1 (pl) 2006-04-03
ATE366576T1 (de) 2007-08-15
HRP20050664A2 (en) 2006-12-31
GT200400009A (es) 2004-12-01
MY135785A (en) 2008-06-30
ZA200505567B (en) 2007-05-30
NO20053431L (no) 2005-10-05
MXPA05008171A (es) 2005-10-05
TW200510358A (en) 2005-03-16
RU2005127216A (ru) 2006-04-10
RU2330022C2 (ru) 2008-07-27
TWI293294B (en) 2008-02-11
JP5026702B2 (ja) 2012-09-19
ES2290666T3 (es) 2008-02-16
CO5580750A2 (es) 2005-11-30
PA8594601A1 (es) 2004-09-16
US7160881B2 (en) 2007-01-09
CN1744900A (zh) 2006-03-08
CL2004000150A1 (es) 2005-01-07

Similar Documents

Publication Publication Date Title
ATE151758T1 (de) 4-benzoyl-isoxazol derivate, deren herstellung und deren verwendung als herbizide
PE20030735A1 (es) Derivados de benzotiazol
AU2003248978A1 (en) Fused heteroaryl derivatives for use as p38 kinase inhibitors in the treatment of i.a. rheumatoid arthristis
ECSP045359A (es) Isoxazolinas 5 metiloximetil sustituidas por 3-heteroarilo utilizadas con herbicidas
BRPI0601393A (pt) toners de fusão ultrabaixa contendo resinas cristalinas
WO2008117175A3 (en) Novel benzamide derivatives as modulators of the follicle stimulating hormone
EA200870585A1 (ru) Замещённые пиридиламидные соединения в качестве модуляторов гистаминового н-рецептора
MX2010008361A (es) Derivados de arilamida oxazepinopirimidona sustituidos.
BRPI0406702A (pt) Modificação cristalina de 2-(3,5-bis-trifluormetil-fenil)-n-[6-(1,1-dioxo-1 lâmboa^6^-tiomorfolin-4-il)-4-(4-flúor-2-metil-fenil)-pi ridin-3-il]-n-metil-isobutiramida
WO2008022060A3 (en) Imidazo-pyridine derivatives for modulating protein kinase activity
ATE427310T1 (de) Kondensierte bicyclische pyrimidinderivate
Zhao et al. A new facile synthesis of 2-aminothiazole-5-carboxylates
WO2008037681A8 (en) 5-{2-[4-(2-methyl-5-quinolinyl)-l-piperidinyl] ethyl} quinolinone derivatives as 5ht1a receptor modulators for treating sexual dysfunction, cognition impairement, psychotic disorders, anxiety, depression, etc.
WO2002060874A8 (en) Potassium channel inhibitors
ATE486071T1 (de) Azabicycloä3.1.0ühexan-derivate als modulatoren des dopamin-d3-rezeptors
IL158277A0 (en) Halogen-substituted quinoline derivatives and ectoparasite control agent
FR2803846B1 (fr) 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation
AU2003303098A8 (en) Process for the preparation of 2-aminomethylpyridine derivative
NO20045123L (no) Nitroserte imidazopyridiner
CR10037A (es) Procedimientos novedosos para la preparación de derivados de piperacinil y diazapanil benzamida
DOP2004000808A (es) Nueva modificacion cristalina de la 2-(3,5-bis-trifluormetilfenil)-n-[6-(1,1-dioxo-1 6-tiomorfolin-4-il)-4-(4-fluor-2-metil-fenil)-piridin-3-il]-n-metil-isobutiramida
EP1496059A4 (en) CONDENSED BICYCLIC PYRIMIDINE DERIVATIVES
ATE42549T1 (de) Bis(arylpiperazinyl)-schwefelverbindungen.
EP1574509A4 (en) PROCESS FOR PREPARING 1-ACETOXY-3 (SUBSTITUTED PHENYL) PROPENENE
BR0308390A (pt) Controle de desgaste de refratário

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements