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BRPI0211258B8 - método para a preparação de um pó de gelatina substancialmente reticulada, composição, e, kit - Google Patents

método para a preparação de um pó de gelatina substancialmente reticulada, composição, e, kit

Info

Publication number
BRPI0211258B8
BRPI0211258B8 BRPI0211258A BRPI0211258A BRPI0211258B8 BR PI0211258 B8 BRPI0211258 B8 BR PI0211258B8 BR PI0211258 A BRPI0211258 A BR PI0211258A BR PI0211258 A BRPI0211258 A BR PI0211258A BR PI0211258 B8 BRPI0211258 B8 BR PI0211258B8
Authority
BR
Brazil
Prior art keywords
cross
linked gelatin
preparing
composition
gelatin powder
Prior art date
Application number
BRPI0211258A
Other languages
English (en)
Inventor
J Reich Cary
A Osawa Edward
Qian Zhen
Original Assignee
Baxter Healthcare Sa
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare Sa, Baxter Int filed Critical Baxter Healthcare Sa
Publication of BR0211258A publication Critical patent/BR0211258A/pt
Publication of BRPI0211258B1 publication Critical patent/BRPI0211258B1/pt
Publication of BRPI0211258B8 publication Critical patent/BRPI0211258B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"método para a preparação de um pó de gelatina substancialmente reticulada, composição, e, kit". composições de gelatina reticulada seca são preparadas as quais se reidratam rapidamente para produzirem hidrogéis de gelatina adequados como selantes hemostáticos. a gelatina é reticulada na presença de certos auxiliares de reidratação, tais como polietileno glicol, polivinilpirrolidona, e dextrano, com o propósito de produzir um pó seco de gelatina reticulada. tem sido verificado que o uso de auxiliares de reidratação aumenta substancialmente a taxa de reidratação na presença de um meio de reidratação aquoso, tipicamente meio salino contendo trombina.
BRPI0211258A 2001-07-17 2002-06-21 método para a preparação de um pó de gelatina substancialmente reticulada, composição, e, kit BRPI0211258B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/908,464 US7435425B2 (en) 2001-07-17 2001-07-17 Dry hemostatic compositions and methods for their preparation
PCT/US2002/020022 WO2003007845A1 (en) 2001-07-17 2002-06-21 Dry hemostatic compositions and methods for their preparation

Publications (3)

Publication Number Publication Date
BR0211258A BR0211258A (pt) 2004-07-27
BRPI0211258B1 BRPI0211258B1 (pt) 2015-06-02
BRPI0211258B8 true BRPI0211258B8 (pt) 2021-07-27

Family

ID=25425842

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0211258A BRPI0211258B8 (pt) 2001-07-17 2002-06-21 método para a preparação de um pó de gelatina substancialmente reticulada, composição, e, kit

Country Status (15)

Country Link
US (4) US7435425B2 (pt)
EP (2) EP1414370B1 (pt)
JP (1) JP4316374B2 (pt)
KR (1) KR100904582B1 (pt)
CN (2) CN100402096C (pt)
AT (2) ATE358455T1 (pt)
AU (1) AU2002345846B2 (pt)
BR (1) BRPI0211258B8 (pt)
CA (1) CA2453592C (pt)
DE (2) DE60219319T2 (pt)
DK (2) DK1803417T3 (pt)
ES (2) ES2317600T3 (pt)
MX (1) MXPA04000514A (pt)
PT (2) PT1803417E (pt)
WO (1) WO2003007845A1 (pt)

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JP4316374B2 (ja) 2009-08-19
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