BRPI0009956A - composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e betametasona, e, uso da mesma - Google Patents
composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e betametasona, e, uso da mesmaInfo
- Publication number
- BRPI0009956A BRPI0009956A BRPI0009956A BRPI0009956A BRPI0009956A BR PI0009956 A BRPI0009956 A BR PI0009956A BR PI0009956 A BRPI0009956 A BR PI0009956A BR PI0009956 A BRPI0009956 A BR PI0009956A BR PI0009956 A BRPI0009956 A BR PI0009956A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- calcipotriol
- betamethasone
- dermatological
- aqueous pharmaceutical
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 title 1
- 229960002537 betamethasone Drugs 0.000 title 1
- LWQQLNNNIPYSNX-UROSTWAQSA-N calcipotriol Chemical compound C1([C@H](O)/C=C/[C@@H](C)[C@@H]2[C@]3(CCCC(/[C@@H]3CC2)=C\C=C\2C([C@@H](O)C[C@H](O)C/2)=C)C)CC1 LWQQLNNNIPYSNX-UROSTWAQSA-N 0.000 title 1
- 229960002882 calcipotriol Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"composição farmacêutica para uso dermatológico, uso de uma composição, e, método de tratamento de psoríase e doenças de pele relacionadas". a presente invenção refere-se a uma composição farmacêutica para uso dermatológico, referida composição compreendendo um primeiro componente a farmacologicamente ativo consistindo de pelo menos uma vitamina d ou análogo de vitamina d, e um segundo componente b farmacologicamente ativo consistindo de pelo menos um corticosteróide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122012030847-1A BR122012030847B1 (pt) | 1999-04-23 | 2000-01-27 | Composição farmacêutica não aquosa para uso dermatológico, e, uso da mesma |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199900561 | 1999-04-23 | ||
| PCT/DK2000/000033 WO2000064450A1 (en) | 1999-04-23 | 2000-01-27 | Pharmaceutical composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0009956A true BRPI0009956A (pt) | 2002-01-08 |
| BRPI0009956B1 BRPI0009956B1 (pt) | 2014-11-11 |
| BRPI0009956B8 BRPI0009956B8 (pt) | 2021-07-06 |
Family
ID=8094933
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122012030847-1A BR122012030847B1 (pt) | 1999-04-23 | 2000-01-27 | Composição farmacêutica não aquosa para uso dermatológico, e, uso da mesma |
| BR122012030846A BR122012030846B8 (pt) | 1999-04-23 | 2000-01-27 | composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e pelo menos um corticoesteróide, e, uso da mesma |
| BRPI0009956 BRPI0009956B8 (pt) | 1999-04-23 | 2000-01-27 | Composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e betametasona, e, uso da mesma |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122012030847-1A BR122012030847B1 (pt) | 1999-04-23 | 2000-01-27 | Composição farmacêutica não aquosa para uso dermatológico, e, uso da mesma |
| BR122012030846A BR122012030846B8 (pt) | 1999-04-23 | 2000-01-27 | composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e pelo menos um corticoesteróide, e, uso da mesma |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6753013B1 (pt) |
| EP (5) | EP2450043B1 (pt) |
| JP (4) | JP4426729B2 (pt) |
| KR (1) | KR100694526B1 (pt) |
| CN (1) | CN1173703C (pt) |
| AU (1) | AU774600B2 (pt) |
| BG (1) | BG65115B1 (pt) |
| BR (3) | BR122012030847B1 (pt) |
| CA (1) | CA2370565C (pt) |
| CY (5) | CY1113967T1 (pt) |
| CZ (1) | CZ303142B6 (pt) |
| DK (5) | DK2455083T3 (pt) |
| ES (5) | ES2432691T3 (pt) |
| HK (1) | HK1045650B (pt) |
| HR (1) | HRP20010779B1 (pt) |
| HU (1) | HU230045B1 (pt) |
| IL (2) | IL145983A0 (pt) |
| IS (1) | IS6120A (pt) |
| LT (2) | LT3146969T (pt) |
| ME (1) | ME00298B (pt) |
| MX (1) | MXPA01010676A (pt) |
| NO (1) | NO329486B1 (pt) |
| NZ (1) | NZ515142A (pt) |
| PL (1) | PL199123B1 (pt) |
| PT (5) | PT1178808E (pt) |
| RS (1) | RS52182B (pt) |
| RU (1) | RU2238734C2 (pt) |
| SI (3) | SI2915534T1 (pt) |
| SK (1) | SK287653B6 (pt) |
| WO (1) | WO2000064450A1 (pt) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263580B2 (en) * | 1998-09-11 | 2012-09-11 | Stiefel Research Australia Pty Ltd | Vitamin formulation |
| DK2455083T3 (da) | 1999-04-23 | 2013-09-30 | Leo Pharma As | Farmaceutisk sammensætning til dermal anvendelse omfattende calcipotriol og betamethason til behandling af psoriasis |
| WO2006120681A2 (en) * | 2005-05-10 | 2006-11-16 | Dermipsor Ltd. | Compositions and methods for skin care |
| US20090098065A1 (en) * | 2000-01-11 | 2009-04-16 | Avikam Harel | Composition and methods for the treatment of skin disorders |
| EP1330468B1 (en) * | 2000-09-18 | 2007-08-01 | Applied Research Systems ARS Holding N.V. | Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op) for treating excess of glucocorticoids |
| AU9163701A (en) | 2000-10-27 | 2002-05-06 | Leo Pharma As | Topical composition containing at least one vitamin D or one vitamin D analogue and at least one corticosteroid |
| US20090143328A1 (en) * | 2001-08-13 | 2009-06-04 | Mcdonald George | Method of Treating Cancer by Administration of Topical Active Corticosteroids |
| US20030175314A1 (en) * | 2001-11-19 | 2003-09-18 | Didriksen Erik Johannes | Pharmaceutical composition for dermal application |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US20080138296A1 (en) * | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| JP2006505583A (ja) | 2002-10-25 | 2006-02-16 | フォーミックス エルティーディー. | 化粧剤および医薬用フォーム |
| US20080031907A1 (en) * | 2002-10-25 | 2008-02-07 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US10117812B2 (en) * | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| EP1458678A1 (en) * | 2002-11-18 | 2004-09-22 | Teva Pharmaceutical Industries Limited | A crystallization method for purification of calcipotriene |
| EP1854466A1 (en) * | 2002-12-17 | 2007-11-14 | Galderma Research & Development, S.N.C. | Pharmaceutical composition comprising a combination of calcitriol and clobetasol propionate |
| DE60316724T2 (de) * | 2002-12-17 | 2008-07-17 | Galderma S.A. | Pharmazeutische zusammensetzung enthaltend calcitriol und clobetasolpropionat |
| FR2848454B1 (fr) * | 2002-12-17 | 2007-03-30 | Galderma Res & Dev | Composition pharmaceutique comprenant une association de calcitriol et d'un corticosteroide |
| JP2004359585A (ja) * | 2003-06-03 | 2004-12-24 | Medorekkusu:Kk | 被膜形成型の副腎皮質ステロイド薬含有外用製剤 |
| FR2856301B1 (fr) | 2003-06-23 | 2007-08-03 | Galderma Res & Dev | Composition sous forme de spray comprenant un actif pharmaceutique, au moins un silicone volatile et une phase non polaire non volatile |
| US8795693B2 (en) * | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| AR045241A1 (es) * | 2003-08-12 | 2005-10-19 | Novartis Consumer Health Sa | Composicion topica que comprende terbinafina e hidrocortisona |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8404667B2 (en) * | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| US20070299041A1 (en) * | 2004-05-26 | 2007-12-27 | Cedars-Sinai Medical Center | Induction of innate immunity by vitamin d3 and its analogs |
| EP1758589A1 (en) * | 2004-06-17 | 2007-03-07 | Galderma S.A. | Composition for the treatment of psoriasis comprising a silicone agent, a corticosteroid and vitamin d or a derivative thereof |
| CA2567684A1 (en) * | 2004-06-17 | 2005-12-29 | Galderma S.A. | Composition in the form of a spray comprising a combination of clobetasol propionate and calcitriol, an alcohol phase and an oily phase |
| FR2871695B1 (fr) | 2004-06-17 | 2008-07-04 | Galderma Sa | Composition pharmaceutique comprenant un agent silicone et deux principes actifs solubilises |
| FR2871697B1 (fr) * | 2004-06-17 | 2007-06-29 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, au moins un silicone volatile et une phase huileuse non volatile |
| FR2871698B1 (fr) * | 2004-06-17 | 2008-07-04 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques et une phase huileuse |
| FR2871693B1 (fr) * | 2004-06-17 | 2006-08-25 | Galderma Sa | Utilisation d'une composition pharmaceutique comprenant du calcitriol et du propionate de clobetasol pour le traitement du psoriasis |
| FR2871694B1 (fr) * | 2004-06-17 | 2008-07-04 | Galderma Sa | Composition pharmaceutique comprenant un onguent oleagineux et deux principes actifs solubilises |
| FR2871700B1 (fr) * | 2004-06-17 | 2006-11-17 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, et une phase huileuse |
| FR2871696B1 (fr) * | 2004-06-17 | 2006-11-10 | Galderma Sa | Composition topique pour le traitement du psoriasis |
| BRPI0511389A (pt) * | 2004-06-17 | 2007-12-04 | Galderma Sa | composição e seu uso |
| FR2871699A1 (fr) * | 2004-06-17 | 2005-12-23 | Galderma Sa | Composition de type emulsion inverse contenant du calcitrol et du 17-propionate de clobetasol, et ses utilisations en cosmetiques et en dermatologie |
| JP2006131544A (ja) * | 2004-11-05 | 2006-05-25 | Medorekkusu:Kk | 皮膚疾患治療用外用剤 |
| DE602005021245D1 (de) * | 2004-11-22 | 2010-06-24 | Wisconsin Alumni Res Found | 2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen |
| WO2006111426A1 (en) * | 2005-04-19 | 2006-10-26 | Galderma S.A. | Composition of film-forming solution type, comprising vitamin d or a derivative thereof and a corticosteroid, and use thereof in dermatology |
| FR2884419B1 (fr) * | 2005-04-19 | 2007-06-22 | Galderma Sa | Composition de type solution filmogene comprenant de la vitamine d ou un de ses derives et un corticosteroide, et son utilisation en dermatologie |
| US9173835B2 (en) * | 2005-05-10 | 2015-11-03 | Dermipsor Ltd. | Compositions and methods for treating hyperproliferative epidermal diseases |
| JP5612263B2 (ja) * | 2005-06-01 | 2014-10-22 | スティーフェル リサーチ オーストラリア ピーティーワイ リミテッド | ビタミン製剤 |
| US20080152596A1 (en) * | 2005-07-19 | 2008-06-26 | Foamix Ltd. | Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof |
| JP5204088B2 (ja) | 2006-03-17 | 2013-06-05 | レオ ファーマ アクティーゼルスカブ | 医薬中間体の異性化 |
| ATE444071T1 (de) * | 2006-08-17 | 2009-10-15 | Klever Mode S L | Pharmazeutische zusammensetzungen zur behandlung von hauterkrankungen |
| CN101505725A (zh) * | 2006-08-29 | 2009-08-12 | 特瓦制药工业有限公司 | 包含含维生素D的化合物和皮质类固醇化合物的具有低pH相容性的稳定的药理学活性组合物 |
| JP2010504994A (ja) * | 2006-09-28 | 2010-02-18 | ウイスコンシン アラムニ リサーチ ファンデーション | 2−メチレン−(20s,25s)−19,27−ジノル−(22e)−ビタミンd類縁体 |
| US7741314B2 (en) * | 2006-09-28 | 2010-06-22 | Wisconsin Alumni Research Foundation | 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| FR2909284B1 (fr) * | 2006-11-30 | 2012-09-21 | Galderma Sa | Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien |
| ES2272198B1 (es) * | 2006-12-28 | 2008-06-01 | Laboratorios Viñas S.A. | Procedimiento para la obtencion de hidrato de calcipotriol. |
| EP1970049A1 (en) * | 2007-03-15 | 2008-09-17 | Drug Delivery Solutions Limited | Polyaphron topical composition with vitamin D and corticosteroid |
| EP1970048A1 (en) * | 2007-03-15 | 2008-09-17 | Drug Delivery Solutions Limited | Polyaphron topical composition with vitamin D |
| US10265265B2 (en) | 2007-03-15 | 2019-04-23 | Drug Delivery Solutions Limited | Topical composition |
| EP2008651A1 (en) | 2007-06-26 | 2008-12-31 | Drug Delivery Solutions Limited | A bioerodible patch |
| HU227970B1 (en) | 2007-07-10 | 2012-07-30 | Egis Gyogyszergyar Nyrt | Pharmaceutical compositions containing silicones of high volatility |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) * | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| US20090192228A1 (en) * | 2008-01-28 | 2009-07-30 | Actavis Group Ptc Ehf | Controlled-Release Tolterodine Compositions and Methods |
| US9220701B2 (en) * | 2008-10-03 | 2015-12-29 | Nexmed Holdings, Inc. | Stabilized composition for treating psoriasis |
| RU2396081C1 (ru) * | 2008-12-29 | 2010-08-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения дерматозов, поддающихся глюкокортикостероидной терапии, и способ ее получения |
| WO2010125470A2 (en) | 2009-04-28 | 2010-11-04 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
| WO2010129062A1 (en) * | 2009-05-07 | 2010-11-11 | Jason Carbol | Pharmaceutical composition including a corticosteroid and a vitamin d analog having improved stability |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| US20110053898A1 (en) * | 2009-08-26 | 2011-03-03 | Glenmark Generics Ltd | Topical composition comprising vitamin d analogue and corticosteroids |
| LT2482822T (lt) | 2009-10-01 | 2018-09-10 | Adare Pharmaceuticals, Inc. | Geriamosios kortikosteroidų kompozicijos |
| MX359879B (es) | 2009-10-02 | 2018-10-12 | Foamix Pharmaceuticals Ltd | Composiciones tópicas de tetraciclina. |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| CN102770121B (zh) * | 2009-12-22 | 2014-10-15 | 利奥制药有限公司 | 包含溶剂混合物和维生素d衍生物或类似物的药物组合物 |
| ES2529506T3 (es) | 2010-06-11 | 2015-02-20 | Leo Pharma A/S | Una composición farmacéutica para aspersión que comprende un análogo de la vitamina D y un corticosteroide |
| US8685381B2 (en) | 2010-10-23 | 2014-04-01 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
| US8968755B2 (en) | 2010-10-23 | 2015-03-03 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
| HRP20191711T1 (hr) | 2011-03-14 | 2019-12-13 | Drug Delivery Solutions Ltd | Oftalmološki pripravak |
| US11154535B2 (en) | 2012-07-31 | 2021-10-26 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| US10045935B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| CN103110648A (zh) * | 2013-01-25 | 2013-05-22 | 江苏圣宝罗药业有限公司 | 钙泊三醇倍他米松软膏及其制备方法 |
| CN105102438B (zh) | 2013-01-29 | 2019-04-30 | 埃维克辛公司 | 抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物 |
| WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| CN104666312B (zh) * | 2015-02-12 | 2017-11-07 | 重庆华邦制药有限公司 | 含有卡泊三醇和二丙酸倍他米松的制剂 |
| MA41818A (fr) * | 2015-03-27 | 2018-01-30 | Leo Pharma As | Timbre à micro-aiguilles pour administration d'un principe actif à la peau |
| TW201636025A (zh) * | 2015-04-15 | 2016-10-16 | Maruho Kk | 皮膚用之醫藥組成物 |
| KR101641372B1 (ko) * | 2015-05-08 | 2016-07-20 | (주)동구바이오제약 | 안정성과 피부투과율이 향상된 약학 조성물 |
| CN107157917B (zh) * | 2016-03-08 | 2019-12-27 | 上海通用药业股份有限公司 | 一种用于治疗银屑病的软膏的制备方法 |
| CN107157920B (zh) * | 2016-03-08 | 2019-12-27 | 上海通用药业股份有限公司 | 一种包含维生素d或其衍生物的半固体制剂的制备方法 |
| CN107157918B (zh) * | 2016-03-08 | 2019-12-27 | 上海通用药业股份有限公司 | 一种用于银屑病治疗的半固体制剂的制备方法 |
| CN107157919B (zh) * | 2016-03-08 | 2019-12-27 | 上海通用药业股份有限公司 | 一种用于治疗银屑病的半固体制剂的制备方法 |
| GB201604318D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| CA2978573A1 (en) | 2016-09-08 | 2018-03-08 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
| WO2019072353A1 (en) * | 2017-10-11 | 2019-04-18 | Elmasry Mohamed Zakria Ahmed Ali | TOPICAL PHARMACEUTICAL PREPARATION OF BETAMETHASONE, CALCIPOTRIOL AND ROSE OIL FOR THE TREATMENT OF PSORIASIS |
| EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
| FR3083701B1 (fr) | 2018-07-13 | 2020-08-14 | Gifrer Barbezat | Liniment oleo-alcalin |
| JP7350985B2 (ja) * | 2020-03-19 | 2023-09-26 | シオノギヘルスケア株式会社 | ベタメタゾン吉草酸エステル含有組成物 |
| US12005067B2 (en) * | 2020-12-04 | 2024-06-11 | Incyte Corporation | JAK inhibitor with a vitamin D analog for treatment of skin diseases |
| CN115177586A (zh) * | 2022-08-31 | 2022-10-14 | 江苏知原药业股份有限公司 | 一种卡泊三醇组合物 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB892127A (en) * | 1958-03-03 | 1962-03-21 | Merck & Co Inc | Therapeutic preparations comprising steroids and vitamin d |
| DK116528A (pt) * | 1966-09-30 | |||
| US4083974A (en) | 1977-03-07 | 1978-04-11 | The Upjohn Company | Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether |
| JPS59139315A (ja) * | 1983-01-31 | 1984-08-10 | Taisho Pharmaceut Co Ltd | クリ−ム剤 |
| US4569935A (en) * | 1983-03-17 | 1986-02-11 | University Of Tennessee Research Corp. | Topical treatment of psoriasis with imidazole antibiotics |
| US4610978A (en) * | 1983-03-22 | 1986-09-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same |
| JP2522962B2 (ja) * | 1986-09-19 | 1996-08-07 | 中外製薬株式会社 | 乾癬治療剤 |
| US4847071A (en) | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
| GB8821129D0 (en) * | 1988-09-09 | 1988-10-12 | Unilever Plc | Cosmetic composition |
| GB8904154D0 (en) * | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9004544D0 (en) | 1990-03-01 | 1990-04-25 | Leo Pharm Prod Ltd | Novel treatment ii |
| US5087620A (en) * | 1990-05-17 | 1992-02-11 | Bristol-Myers Squibb Co. | Controlled dermal penetration enhancement using imidazoles |
| US5185150A (en) | 1990-08-24 | 1993-02-09 | Wisconsin Alumni Research Fdn. | Cosmetic compositions containing 19-nor-vitamin D compounds |
| IL99368A (en) | 1991-09-02 | 1996-01-19 | Teva Pharma | Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine |
| GB9226860D0 (en) * | 1992-12-23 | 1993-02-17 | Leo Pharm Prod Ltd | Novel treatment |
| USRE39706E1 (en) * | 1993-01-15 | 2007-06-26 | Leo Pharma A/S | Crystalline form of a vitamin D analogue |
| GB9314400D0 (en) * | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
| JPH07173053A (ja) * | 1993-12-20 | 1995-07-11 | Otsuka Pharmaceut Co Ltd | 抗微生物剤 |
| JP3506474B2 (ja) * | 1994-01-07 | 2004-03-15 | 帝人株式会社 | 安定性の向上した乾癬治療剤 |
| TW460296B (en) * | 1994-09-01 | 2001-10-21 | Janssen Pharmaceutica Nv | Topical ketoconazole emulsion compositions without sodium sulfite |
| US5840925A (en) * | 1995-06-29 | 1998-11-24 | Hauser, Inc. | Trioxane dimer compounds having antiproliferative and antitumor activities |
| WO1997013518A1 (en) * | 1995-10-10 | 1997-04-17 | Marilyn Strube | Treatment of pruritus with vitamin d and analogs thereof |
| FR2740042B1 (fr) * | 1995-10-23 | 1997-11-14 | Oreal | Support, et composition contenant ce support et un actif cosmetique ou dermatologique stabilise |
| SG70009A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Vitamin d3 analogs |
| JPH1067757A (ja) * | 1996-06-21 | 1998-03-10 | Ss Pharmaceut Co Ltd | トリアゾール誘導体またはその塩 |
| JPH10139669A (ja) * | 1996-11-05 | 1998-05-26 | Teijin Ltd | 脂漏性角化症治療剤 |
| ATE312087T1 (de) * | 1997-05-16 | 2005-12-15 | Woman & Infants Hospital | Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen |
| WO1998051664A1 (en) * | 1997-05-16 | 1998-11-19 | Women & Infants Hospital | 3-epi vitamin d2 compounds and uses thereof |
| US6372233B1 (en) * | 1997-12-09 | 2002-04-16 | Chugai Seiyaku Kabushiki Kaisha | Lotions containing vitamin D3 derivatives |
| KR20010032892A (ko) * | 1997-12-09 | 2001-04-25 | 나가야마 오사무 | 비타민 d3유도체를 함유하는 크림제 |
| JPH11188054A (ja) * | 1997-12-25 | 1999-07-13 | Lion Corp | 皮膚外用部材 |
| JPH11246329A (ja) * | 1998-02-27 | 1999-09-14 | Shiseido Co Ltd | 皮膚外用剤 |
| BR9904847B1 (pt) * | 1998-03-04 | 2010-07-13 | loção em emulsão de vitamina d3 ativa. | |
| US5886038A (en) * | 1998-03-24 | 1999-03-23 | Panda Pharmaceuticals, L.L.C. | Composition and method for treatment of psoriasis |
| US5990100A (en) | 1998-03-24 | 1999-11-23 | Panda Pharmaceuticals, L.L.C. | Composition and method for treatment of psoriasis |
| DK2455083T3 (da) | 1999-04-23 | 2013-09-30 | Leo Pharma As | Farmaceutisk sammensætning til dermal anvendelse omfattende calcipotriol og betamethason til behandling af psoriasis |
-
2000
- 2000-01-27 DK DK11196067.0T patent/DK2455083T3/da active
- 2000-01-27 PT PT00901483T patent/PT1178808E/pt unknown
- 2000-01-27 CZ CZ20013739A patent/CZ303142B6/cs not_active IP Right Cessation
- 2000-01-27 LT LTEP16185207.4T patent/LT3146969T/lt unknown
- 2000-01-27 PT PT111960696T patent/PT2450043T/pt unknown
- 2000-01-27 SI SI200031093T patent/SI2915534T1/sl unknown
- 2000-01-27 NZ NZ515142A patent/NZ515142A/xx not_active IP Right Cessation
- 2000-01-27 EP EP11196069.6A patent/EP2450043B1/en not_active Revoked
- 2000-01-27 PT PT111960670T patent/PT2455083E/pt unknown
- 2000-01-27 PT PT16185207T patent/PT3146969T/pt unknown
- 2000-01-27 DK DK11196069.6T patent/DK2450043T3/en active
- 2000-01-27 PT PT141873299T patent/PT2915534T/pt unknown
- 2000-01-27 RS YU75701A patent/RS52182B/sr unknown
- 2000-01-27 MX MXPA01010676A patent/MXPA01010676A/es active IP Right Grant
- 2000-01-27 DK DK00901483.8T patent/DK1178808T4/da active
- 2000-01-27 SI SI200031072T patent/SI1178808T1/sl unknown
- 2000-01-27 JP JP2000613441A patent/JP4426729B2/ja not_active Expired - Lifetime
- 2000-01-27 EP EP11196067.0A patent/EP2455083B1/en not_active Expired - Lifetime
- 2000-01-27 BR BR122012030847-1A patent/BR122012030847B1/pt not_active IP Right Cessation
- 2000-01-27 RU RU2001131558A patent/RU2238734C2/ru active
- 2000-01-27 ES ES11196067T patent/ES2432691T3/es not_active Expired - Lifetime
- 2000-01-27 KR KR1020017013576A patent/KR100694526B1/ko not_active Expired - Lifetime
- 2000-01-27 IL IL14598300A patent/IL145983A0/xx active IP Right Grant
- 2000-01-27 EP EP16185207.4A patent/EP3146969B1/en not_active Expired - Lifetime
- 2000-01-27 SI SI200031094T patent/SI3146969T1/en unknown
- 2000-01-27 EP EP14187329.9A patent/EP2915534B1/en not_active Expired - Lifetime
- 2000-01-27 AU AU22783/00A patent/AU774600B2/en not_active Expired
- 2000-01-27 DK DK16185207.4T patent/DK3146969T3/en active
- 2000-01-27 US US09/959,367 patent/US6753013B1/en not_active Expired - Lifetime
- 2000-01-27 ME MEP-2008-391A patent/ME00298B/me unknown
- 2000-01-27 BR BR122012030846A patent/BR122012030846B8/pt not_active IP Right Cessation
- 2000-01-27 BR BRPI0009956 patent/BRPI0009956B8/pt not_active IP Right Cessation
- 2000-01-27 ES ES14187329.9T patent/ES2671785T3/es not_active Expired - Lifetime
- 2000-01-27 ES ES00901483T patent/ES2388425T5/es not_active Expired - Lifetime
- 2000-01-27 DK DK14187329.9T patent/DK2915534T3/en active
- 2000-01-27 CA CA002370565A patent/CA2370565C/en not_active Expired - Lifetime
- 2000-01-27 SK SK1518-2001A patent/SK287653B6/sk not_active IP Right Cessation
- 2000-01-27 LT LTEP14187329.9T patent/LT2915534T/lt unknown
- 2000-01-27 HU HU0200879A patent/HU230045B1/hu unknown
- 2000-01-27 HR HR20010779A patent/HRP20010779B1/xx not_active IP Right Cessation
- 2000-01-27 CN CNB008076677A patent/CN1173703C/zh not_active Expired - Lifetime
- 2000-01-27 EP EP00901483.8A patent/EP1178808B2/en not_active Expired - Lifetime
- 2000-01-27 PL PL351387A patent/PL199123B1/pl unknown
- 2000-01-27 WO PCT/DK2000/000033 patent/WO2000064450A1/en not_active Ceased
- 2000-01-27 ES ES11196069.6T patent/ES2602450T3/es not_active Expired - Lifetime
- 2000-01-27 HK HK02107078.8A patent/HK1045650B/zh unknown
- 2000-01-27 ES ES16185207.4T patent/ES2674563T3/es not_active Expired - Lifetime
-
2001
- 2001-10-16 IL IL145983A patent/IL145983A/en not_active IP Right Cessation
- 2001-10-19 BG BG106030A patent/BG65115B1/bg unknown
- 2001-10-22 IS IS6120A patent/IS6120A/is unknown
- 2001-10-23 NO NO20015175A patent/NO329486B1/no not_active IP Right Cessation
-
2008
- 2008-07-24 JP JP2008191182A patent/JP5721926B2/ja not_active Expired - Lifetime
-
2012
- 2012-07-31 CY CY20121100676T patent/CY1113967T1/el unknown
-
2013
- 2013-01-29 JP JP2013014098A patent/JP2013075923A/ja active Pending
- 2013-09-19 CY CY20131100822T patent/CY1114420T1/el unknown
-
2015
- 2015-04-27 JP JP2015090105A patent/JP5886999B2/ja not_active Expired - Lifetime
-
2016
- 2016-10-19 CY CY20161101042T patent/CY1118206T1/el unknown
-
2018
- 2018-06-08 CY CY20181100600T patent/CY1120313T1/el unknown
- 2018-09-04 CY CY181100924T patent/CY1120659T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0009956A (pt) | composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e betametasona, e, uso da mesma | |
| BRPI0412526A (pt) | composto, uso de um composto, composição farmacêutica, formulação em aerossol farmacêutica, e, método para o tratamento de um paciente humano ou animal com uma condição anti-inflamatória e/ou alérgica | |
| BR0209658A (pt) | Derivados de 4-amino-5-fenil-7-1ciclobutil-pirrolo [2,3-d] pirimidina | |
| PT1079806E (pt) | Preparacoes para a aplicacao de anti-inflamatorios, especialmente, agentes anti-septicos e/ou agentes de promocao da cura de feridas, no tracto respiratorio superior e/ou no ouvido | |
| BR0211673A (pt) | Terapia dermal utilizando derivados de fosfato de agentes de transferência de elétrons | |
| BR0311939A (pt) | composição farmacêutica, método para tratar inflamação em um mamìfero e uso de uma citocina protetora de tecido orgánico | |
| ES2063073T3 (es) | Derivados de arilmetilenilo conocidos y nuevos seleccionados de tiazolidinonas, imidazolidinonas y oxazolidinonas utiles como agentes antialergicos y agentes antiinflamatorios. | |
| BR0115109A (pt) | Agentes terapêuticos e métodos de uso dos mesmos para a modulação da angiogênese | |
| BR0116370A (pt) | Composto, composição farmacêutica, uso de um composto, e, método de tratamento de uma doença ou condição mediada por hppar em um paciente. | |
| BR9910066A (pt) | Composição farmacêutica fluida que permite a liberação controlada de pelo menos uma substância ativa, processo de fabricação de uma composição farmacêutica, e, utilização de uma composição | |
| BR0114927A (pt) | Composição de gel farmacêutica substancialmente não aquosa para aplicação na pele, e, uso da composição | |
| BRPI0113042B8 (pt) | composto da fórmula ou um seu solvato fisiologicamente aceitável, uso do mesmo, composição farmacêutica, formulação farmacêutica, método para o tratamento de um indivíduo humano ou animal com uma condição inflamatória e/ou alérgica, e, processo para preparar um composto ou um seu solvato | |
| KR950002785A (ko) | 골량을 증가시키기 위한 부갑상선 호르몬 및 랄옥시펜 | |
| BR9712610A (pt) | Composições farmacêutica e liquida, uso de aciclovir ou de um derivado do mesmo farmaceuticamente aceitável, processo para preparação de uma composição, e, disportivo de aplicação tópica. | |
| BR0314308A (pt) | Composto, composição farmacêutica, métodos para bloquear uma combinação de mu, kappa, delta ou receptor (heterodìmero) dos mesmos em mamìferos, para tratar ou prevenir obesidade e doenças relacionadas, para suprimir o apetite em um paciente em necessidade deste, e para realizar a perda de peso em um paciente obeso, e, uso de um composto | |
| ATE323473T1 (de) | Pharmazeutische zusammensetzungen enthaltend resveratrol und verwendungen davon | |
| BR0003897A (pt) | Aditivo para aumento da resistência à água de formulações cosméticas ou dermatológicas e seus usos | |
| BR0313388A (pt) | Método para tratar, remediar ou evitar a psorìase em um paciente, uso de um composto de antagonista de cgrp, composição farmacêutica para tratamento da psorìase, e, método para identificar um composto candidato para o uso em um medicamento para tratar a psorìase | |
| EP0382066A3 (de) | Verwendung von Dihydroliponsäure als Analgetikum, Antiphlogistikum und/oder Zytoprotektivum | |
| BR0314797A (pt) | Derivados da pirimidineamida e o uso dos mesmos | |
| WO2005007072A3 (en) | Methods and pharmaceutical compositions for healing wounds | |
| DE69932939D1 (de) | Fulvinsäure und dessen verwendung zur behandlung von diversen krankheitszuständen | |
| BR0316458A (pt) | Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto | |
| BR9908510A (pt) | Uso de um composto, composto, processo para a preparação de um composto, composição farmacêutica, e, processo de tratar um paciente que sofre de, ou em risco de, uma doença micobacteriana | |
| BRPI0416275A (pt) | métodos de tratar, controlar ou prevenir um cáncer especìfico e uma doença associada com angiogênese indesejada |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 11/11/2014, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/01/00, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 23A ANUIDADE. |
|
| B21H | Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2707 DE 22/11/2022 POR TER SIDO INDEVIDA. |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 11/11/2024 |