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BR9914213A - Derivados de imidazol[4,5-c]piridin-4-ona com ação inibidora do fator xa - Google Patents

Derivados de imidazol[4,5-c]piridin-4-ona com ação inibidora do fator xa

Info

Publication number
BR9914213A
BR9914213A BR9914213-9A BR9914213A BR9914213A BR 9914213 A BR9914213 A BR 9914213A BR 9914213 A BR9914213 A BR 9914213A BR 9914213 A BR9914213 A BR 9914213A
Authority
BR
Brazil
Prior art keywords
factor
inhibitory action
pyridin
imidazole derivatives
compounds
Prior art date
Application number
BR9914213-9A
Other languages
English (en)
Inventor
Gante Joachim
Werner Mederski
Horst Juraszyk
Hanns Wurziger
Dieter Dorsch
Hans-Peter Buchstaller
Sabine Bernotat-Danielowski
Melzer Guido
Soheila Anzali
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9914213A publication Critical patent/BR9914213A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE IMIDAZOL[4,5-C]PIRIDIN-4-ONA COM AçãO INIBIDORA DO FATOR XA"<D>. A invenção refere-se a novos compostos de fórmula (I), onde R, R1, R2, R3, n e p têm o significado definido na reivindicação 1. Os referidos compostos são inibidores de fator Xa da coagulação e podem ser usados para profilaxia e/ou terapia de distúrbios tromboembólicos.
BR9914213-9A 1998-10-01 1999-09-09 Derivados de imidazol[4,5-c]piridin-4-ona com ação inibidora do fator xa BR9914213A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845153A DE19845153A1 (de) 1998-10-01 1998-10-01 Imidazo[4,5]-pyridin-4-on-derivate
PCT/EP1999/006655 WO2000020416A1 (de) 1998-10-01 1999-09-09 Imidazo[4,5-c-]-pyridin-4-on-derivate mit faktor xa hemmender wirkung

Publications (1)

Publication Number Publication Date
BR9914213A true BR9914213A (pt) 2001-06-26

Family

ID=7883005

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914213-9A BR9914213A (pt) 1998-10-01 1999-09-09 Derivados de imidazol[4,5-c]piridin-4-ona com ação inibidora do fator xa

Country Status (18)

Country Link
US (1) US6492384B1 (pt)
EP (1) EP1117664A1 (pt)
JP (1) JP2002526542A (pt)
KR (1) KR20010074980A (pt)
CN (1) CN1324358A (pt)
AR (1) AR020688A1 (pt)
AU (1) AU752574B2 (pt)
BR (1) BR9914213A (pt)
CA (1) CA2346033A1 (pt)
DE (1) DE19845153A1 (pt)
HU (1) HUP0104164A3 (pt)
ID (1) ID29466A (pt)
MY (1) MY130736A (pt)
NO (1) NO20011638L (pt)
PL (1) PL346542A1 (pt)
SK (1) SK4282001A3 (pt)
WO (1) WO2000020416A1 (pt)
ZA (1) ZA200103498B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533465A (ja) 1998-12-23 2002-10-08 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害剤としての窒素を含む複素二環類
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
CN1439008A (zh) * 2000-06-23 2003-08-27 布里斯托尔-迈尔斯斯奎布药品公司 作为因子xa抑制剂的1－(杂芳环基－苯基)－稠合吡唑衍生物
AU2002310070A1 (en) 2001-05-22 2002-12-03 Bristol-Myers Squibb Company Bicyclic inhibitors of factor xa
EP1472254A4 (en) * 2002-02-08 2006-02-15 Glsynthesis Inc PURINE AND ISOSTERIC ANTIBACTERIAL COMPOUNDS
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
US20040242566A1 (en) 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
EP1625122A1 (en) 2003-05-14 2006-02-15 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
CA2535619A1 (en) 2003-08-13 2005-02-24 Takeda Pharmaceutical Company Limited 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
EP2161273B1 (en) * 2003-12-22 2015-04-15 K.U.Leuven Research & Development Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
US7381732B2 (en) * 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
ATE426601T1 (de) * 2004-12-21 2009-04-15 Gilead Sciences Inc Imidazoa4,5-cupyridinverbindung und verfahren zur antiviralen behandlung
ME02005B (me) 2005-09-14 2012-08-31 Takeda Pharmaceuticals Co Inhibitori dipeptidil peptidaze za lečenje dijabetesa
CN101360723A (zh) 2005-09-16 2009-02-04 武田药品工业株式会社 制备嘧啶二酮衍生物的方法
TW200734338A (en) * 2006-01-16 2007-09-16 Organon Nv 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TWI360549B (en) * 2006-07-07 2012-03-21 Gilead Sciences Inc Novel pyridazine compound and use thereof
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
EP2475252B1 (en) 2009-09-11 2016-11-16 GLSynthesis Inc. Selective antibacterials for clostridium difficile infections
CN107922396B (zh) 2015-07-20 2022-08-05 建新公司 集落刺激因子-1受体(csf-1r)抑制剂

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE574846C (de) * 1933-04-21 Wilhelm Germann Schienenbefestigung unter Verwendung von Schienenfuehrungsleisten
DE595151C (de) * 1934-04-04 Buderus Eisenwerk Verfahren und Vorrichtung zum Regeln des Gewichts von in Schleudergussmaschinen herzustellenden Rohren
DE546449C (de) * 1932-03-12 Mueller Paul Verbindung von Belagblechen
DE602521C (de) * 1934-09-10 Wilhelm Stoeckicht Dipl Ing Umlaufraederwechselgetriebe, insbesondere fuer Kraftfahrzeuge
DE505893C (de) * 1926-08-07 1930-08-26 Medizinische Produkte Ag F Verfahren zur Herstellung von Eiweiss-Halogen-Schwefelverbindungen
DE564960C (de) * 1931-05-13 1932-11-24 Siemens Schuckertwerke Akt Ges Einrichtung zur Anpassung der Drehzahlregelung, insbesondere von Dampfturbinen, an veraenderte Betriebsverhaeltnisse
DE628556C (de) * 1932-12-07 1936-04-08 Wolf Johannes Mueller Dr Verfahren zur Herstellung von insbesondere hochkonzentrierten Wasserglasloesungen
DE702013C (de) * 1933-07-17 1941-01-29 Union Oil Co Verfahren zur Abscheidung von Paraffin aus paraffinhaltigen OElen
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US5798364A (en) * 1992-03-26 1998-08-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Imidazopyridines
DE4140519A1 (de) * 1991-12-09 1993-06-17 Merck Patent Gmbh Benzofurane
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DE4236026A1 (de) 1992-10-24 1994-04-28 Merck Patent Gmbh Imidazopyridine
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AU3645697A (en) * 1996-07-08 1998-02-02 Du Pont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin

Also Published As

Publication number Publication date
ZA200103498B (en) 2002-08-13
CA2346033A1 (en) 2000-04-13
WO2000020416A1 (de) 2000-04-13
MY130736A (en) 2007-07-31
NO20011638D0 (no) 2001-03-30
ID29466A (id) 2001-08-30
KR20010074980A (ko) 2001-08-09
AR020688A1 (es) 2002-05-22
AU5861899A (en) 2000-04-26
HUP0104164A3 (en) 2002-08-28
EP1117664A1 (de) 2001-07-25
HUP0104164A2 (hu) 2002-04-29
JP2002526542A (ja) 2002-08-20
AU752574B2 (en) 2002-09-26
US6492384B1 (en) 2002-12-10
DE19845153A1 (de) 2000-04-06
SK4282001A3 (en) 2002-10-08
NO20011638L (no) 2001-03-30
PL346542A1 (en) 2002-02-11
CN1324358A (zh) 2001-11-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.