BR9912178A - Vacinas de peptìdeo sintéticas para febre aftosa - Google Patents
Vacinas de peptìdeo sintéticas para febre aftosaInfo
- Publication number
- BR9912178A BR9912178A BR9912178-6A BR9912178A BR9912178A BR 9912178 A BR9912178 A BR 9912178A BR 9912178 A BR9912178 A BR 9912178A BR 9912178 A BR9912178 A BR 9912178A
- Authority
- BR
- Brazil
- Prior art keywords
- fmdv
- peptide
- foot
- mouth disease
- relates
- Prior art date
Links
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 title abstract 3
- 241000710198 Foot-and-mouth disease virus Species 0.000 title abstract 3
- 229940023041 peptide vaccine Drugs 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 4
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 230000008029 eradication Effects 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000283707 Capra Species 0.000 abstract 1
- 108090000565 Capsid Proteins Proteins 0.000 abstract 1
- 102100023321 Ceruloplasmin Human genes 0.000 abstract 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241001494479 Pecora Species 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Patente de Invenção: <B>"VACINAS DE PEPTìDEO SINTéTICAS PARA FEBRE AFTOSA"<D>. A presente invenção refere-se ao uso de uma composição de peptídeo como um imunógeno, como cada peptídeo contido ali compreendendo um sítio antigênico alvo derivado da proteína de capsídeo de VP1 de Vírus de Febre Aftosa (FMDV). O sítio antigênico está covalentemente ligado ao epítopo de célula T auxiliar, de preferência, a outras seq³ências imunoestimuladoras, de preferência por ligação(ões) de peptídeo convencional(is) através de síntese direta, para a prevenção de infecção de FMDV e erradicação de Vírus de Febre Aftosa (FMDV). Mais particularmente, a presente invenção refere-se ao uso de tal composição de peptídeo como um imunógeno para eliciar a produção de animais incluindo, suíno, gado bovino, carneiro, cabras e espécies de tipo selvagem suscetíveis, de anticorpos policlonais de alto título que pode eficazmente neutralizar, in vitro, múltiplas cepas ou sorotipos de FMDV, e ao uso de tal composição como uma vacina para prevenir, e/ou reduzir a incidência de infecção por FMDV apesar do sorotipo, e assim efetuar erradicação de FMD. A presente invenção também refere-se aos peptídeos nas composições, e a imunoensaios e/ou a kits de diagnóstico contendo um ou mais destes peptídeos, e a métodos de diagnose de FMDV em mamíferos usando tais materiais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/100,600 US6107021A (en) | 1998-06-20 | 1998-06-20 | Synthetic peptide vaccines for foot-and-mouth disease |
| PCT/US1999/013921 WO1999066954A1 (en) | 1998-06-20 | 1999-06-21 | Synthetic peptide vaccines for foot-and-mouth disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9912178A true BR9912178A (pt) | 2001-04-10 |
| BRPI9912178B1 BRPI9912178B1 (pt) | 2017-03-28 |
Family
ID=22280576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9912178A BRPI9912178B1 (pt) | 1998-06-20 | 1999-06-21 | peptídeo e conjugados de peptídeo, biblioteca de antígenos sintéticos estruturados, composição farmacêutica e método de diagnose in vitro de infecção por fmdv |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6107021A (pt) |
| EP (1) | EP1089759B1 (pt) |
| JP (1) | JP2002518461A (pt) |
| KR (1) | KR100602553B1 (pt) |
| CN (4) | CN100435846C (pt) |
| AR (1) | AR019152A1 (pt) |
| AU (1) | AU754939B2 (pt) |
| BR (1) | BRPI9912178B1 (pt) |
| CA (1) | CA2330178C (pt) |
| IL (1) | IL139464A0 (pt) |
| TW (1) | TWI232108B (pt) |
| WO (1) | WO1999066954A1 (pt) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229679B (en) * | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| JP3620696B2 (ja) * | 1998-09-07 | 2005-02-16 | 泰久 福井 | ホスファチジルイノシトール−３，４，５−三リン酸を認識するモノクローナル抗体 |
| WO2001052875A1 (en) * | 2000-01-18 | 2001-07-26 | Ludwig Institute For Cancer Research | Vegf-d/vegf-c/vegf peptidomimetic inhibitor |
| EP1441763A2 (en) * | 2001-11-07 | 2004-08-04 | Inex Pharmaceuticals Corp. | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
| US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US20040013649A1 (en) * | 2002-05-10 | 2004-01-22 | Inex Pharmaceuticals Corporation | Cancer vaccines and methods of using the same |
| US7569225B2 (en) | 2002-08-12 | 2009-08-04 | The Council Of The Queensland Institute Of Medical Research | Immunogenic lipopeptides comprising T-helper and B-cell epitopes |
| KR100531760B1 (ko) * | 2003-04-28 | 2005-11-29 | 대한민국(관리부서 : 농림부 국립수의과학검역원) | 구제역 바이러스의 감염여부를 진단하는 방법 및 이를구현하기 위한 진단키트 |
| CN1290579C (zh) * | 2003-10-15 | 2006-12-20 | 北京迪威华宇生物技术有限公司 | 重组口蹄疫病毒vp1融合蛋白疫苗 |
| CN1318592C (zh) * | 2003-11-11 | 2007-05-30 | 中国农业科学院兰州兽医研究所 | O型口蹄疫病毒dna疫苗及其制备方法 |
| EP1874343A4 (en) | 2005-04-19 | 2009-07-22 | Lilly Co Eli | MONOVALENT AND MULTIPURPOSE SYNTHETIC POLYSACCHARIDIC ANATIGENS FOR IMMUNOLOGICAL INTERVENTION IN PATHOLOGY |
| ES2319483B1 (es) * | 2006-08-02 | 2010-02-10 | Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria | Construccion peptidica dendrimerica para la prevencion de la fiebre aftosa en animales. |
| CN101659695B (zh) * | 2008-08-27 | 2012-08-29 | 中牧实业股份有限公司 | O型口蹄疫合成肽疫苗 |
| CN101659696B (zh) * | 2008-08-27 | 2013-03-13 | 中牧实业股份有限公司 | 亚洲一型口蹄疫合成肽疫苗 |
| FR2945290A1 (fr) * | 2009-05-07 | 2010-11-12 | Maan Zrein | Anticorps biomarqueur et dispositif de diagnostic pour la detection de certaines maladies auto-immunes |
| CN101579522B (zh) * | 2009-05-12 | 2012-09-12 | 陶钰 | 一种新型畜用肽苗及其制备方法 |
| CN101643500B (zh) * | 2009-05-19 | 2012-06-06 | 中牧实业股份有限公司 | 一种亚洲一型口蹄疫合成肽疫苗 |
| CN101565457B (zh) * | 2009-06-04 | 2014-04-02 | 中牧实业股份有限公司 | 一种合成肽疫苗及其制备方法 |
| CN105175516B (zh) * | 2009-06-04 | 2018-11-27 | 中牧实业股份有限公司 | 一种动物用肽疫苗及其制备 |
| US9109014B2 (en) * | 2009-11-02 | 2015-08-18 | The Trustees Of The University Of Pennsylvania | Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom |
| CN102274496B (zh) * | 2010-06-12 | 2015-05-06 | 吴晓琰 | 一种O/Asia I型口蹄疫病毒两价基因工程多肽疫苗及制备方法和用途 |
| US8765141B2 (en) * | 2010-07-01 | 2014-07-01 | The United States Of America, As Represented By The Secretary Of Agriculture | Development of a marker foot and mouth disease virus vaccine candidate that is attenuated in the natural host |
| AU2010357208A1 (en) | 2010-07-08 | 2013-02-21 | United Biomedical, Inc. | Designer peptide-based PCV2 vaccine |
| CN102175852A (zh) * | 2011-01-06 | 2011-09-07 | 云南省畜牧兽医科学院 | 一种口蹄疫固相竞争elisa检测方法 |
| JP2016501850A (ja) * | 2012-11-16 | 2016-01-21 | ユナイテッド・バイオメディカル・インコーポレーテッドＵｎｉｔｅｄ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ | 口蹄疫（ｆｍｄ）に対する合成ペプチドベースの緊急ワクチン |
| WO2014145951A2 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Foot and mouth disease virus (fmdv) consensus proteins, coding sequences therefor and vaccines made therefrom |
| CN104961808B (zh) * | 2013-03-25 | 2018-09-04 | 中国牧工商(集团)总公司 | 用于制备牛口蹄疫o型肽疫苗的多肽及其制备方法和用途 |
| CN105906693B (zh) * | 2014-03-07 | 2020-01-14 | 中牧实业股份有限公司 | 合成肽疫苗及其制备方法与应用 |
| CN105418738B (zh) * | 2015-07-03 | 2019-04-19 | 申联生物医药（上海）有限公司 | 口蹄疫病毒a型抗原多肽、融合抗原多肽及疫苗 |
| CN104961809B (zh) * | 2015-07-10 | 2018-06-26 | 中牧实业股份有限公司 | 牛口蹄疫o型结构蛋白vp1抗体酶联免疫检测试剂盒 |
| TWI760322B (zh) * | 2016-01-29 | 2022-04-11 | 美商百靈佳殷格翰動物保健美國有限公司 | 重組腺病毒載體裝載之fmdv疫苗及其用途 |
| CN106226519A (zh) * | 2016-07-18 | 2016-12-14 | 洛阳现代生物技术研究院有限公司 | 一种o型口蹄疫病毒抗体化学发光检测试剂盒 |
| WO2018066948A2 (ko) * | 2016-10-05 | 2018-04-12 | 서울대학교산학협력단 | 다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 제조방법 |
| CN107365367A (zh) * | 2017-08-16 | 2017-11-21 | 山东省农业科学院奶牛研究中心 | A型口蹄疫病毒vp1蛋白抗原表位基因多肽及其应用 |
| CN109232720B (zh) * | 2018-09-13 | 2021-11-23 | 中国农业科学院兰州兽医研究所 | 一种口蹄疫O型病毒sIgA抗体ELISA检测试剂盒及其应用 |
| CA3124375A1 (en) * | 2018-12-19 | 2020-06-25 | United Biomedical, Inc. | Artificial promiscuous t helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| KR102451412B1 (ko) | 2019-06-18 | 2022-10-11 | 대한민국 | 세포성, 체액성 면역 반응의 동시 유도 및 광범위한 방어능을 갖는 신규 면역 증강용 단백질 및 이를 포함하는 구제역 백신 조성물 |
| WO2020263062A1 (ko) * | 2019-06-28 | 2020-12-30 | (주)플럼라인생명과학 | 구제역 바이러스 백신 조성물 |
| CN111803626A (zh) * | 2020-07-08 | 2020-10-23 | 申联生物医药（上海）股份有限公司 | 猪口蹄疫o型和a型二价合成肽疫苗及其制备方法与应用 |
| CN111978380A (zh) * | 2020-09-02 | 2020-11-24 | 天康生物股份有限公司 | 野生型气肿疽梭菌细胞毒素a及其制备方法、应用和疫苗 |
| CN113061587B (zh) * | 2021-04-30 | 2023-03-31 | 中国农业科学院兰州兽医研究所 | 一种抗原谱拓展o型口蹄疫病毒株及其构建方法和应用 |
| CN117304277B (zh) * | 2023-09-26 | 2024-03-08 | 中国农业科学院兰州兽医研究所 | 一种o型口蹄疫病毒vp4蛋白t细胞表位多肽及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1983003547A1 (en) * | 1982-04-14 | 1983-10-27 | Bittle, James, L. | Synthetic picornavirus antigen |
| US4769237A (en) * | 1983-03-25 | 1988-09-06 | Bittle James L | Synthetic picornavirus antigen |
| US4732971A (en) * | 1985-06-03 | 1988-03-22 | Eli Lilly And Company | Synthetic vaccines for foot and mouth disease |
| US5476765A (en) * | 1987-01-09 | 1995-12-19 | United Biomedical, Inc. | Synthetic peptide compositions with immunoreactivities to antibodies to HTLV and as vaccines |
| GB8920357D0 (en) * | 1989-09-08 | 1989-10-25 | Wellcome Found | Peptides |
| US5106726A (en) * | 1990-02-16 | 1992-04-21 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| JP3795914B2 (ja) * | 1993-04-27 | 2006-07-12 | ユナイテッド・バイオメディカル・インコーポレイテッド | ワクチン用免疫原性ｌｈｒｈペプチド構築体および合成普遍免疫刺激器 |
| WO1995011998A1 (en) * | 1993-10-26 | 1995-05-04 | United Biomedical, Inc. | Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics |
-
1998
- 1998-06-20 US US09/100,600 patent/US6107021A/en not_active Expired - Lifetime
-
1999
- 1999-04-16 TW TW088106134A patent/TWI232108B/zh active
- 1999-06-09 AR ARP990102738A patent/AR019152A1/es active IP Right Grant
- 1999-06-21 WO PCT/US1999/013921 patent/WO1999066954A1/en not_active Ceased
- 1999-06-21 KR KR1020007014480A patent/KR100602553B1/ko not_active Expired - Lifetime
- 1999-06-21 EP EP99931845.4A patent/EP1089759B1/en not_active Expired - Lifetime
- 1999-06-21 JP JP2000555640A patent/JP2002518461A/ja active Pending
- 1999-06-21 CN CNB998074020A patent/CN100435846C/zh not_active Expired - Lifetime
- 1999-06-21 CN CN2007101969366A patent/CN101353373B/zh not_active Expired - Lifetime
- 1999-06-21 CN CN2008101441383A patent/CN101386641B/zh not_active Ceased
- 1999-06-21 AU AU48266/99A patent/AU754939B2/en not_active Expired
- 1999-06-21 BR BRPI9912178A patent/BRPI9912178B1/pt not_active IP Right Cessation
- 1999-06-21 IL IL13946499A patent/IL139464A0/xx not_active IP Right Cessation
- 1999-06-21 CA CA2330178A patent/CA2330178C/en not_active Expired - Lifetime
- 1999-06-21 CN CN2008101610837A patent/CN101469017B/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN101386641A (zh) | 2009-03-18 |
| KR20010053042A (ko) | 2001-06-25 |
| CA2330178A1 (en) | 1999-12-29 |
| WO1999066954A1 (en) | 1999-12-29 |
| CN101469017A (zh) | 2009-07-01 |
| EP1089759B1 (en) | 2017-02-01 |
| AU4826699A (en) | 2000-01-10 |
| AR019152A1 (es) | 2001-12-26 |
| CN101386641B (zh) | 2012-12-05 |
| JP2002518461A (ja) | 2002-06-25 |
| CN101469017B (zh) | 2012-11-07 |
| EP1089759A4 (en) | 2005-02-02 |
| AU754939B2 (en) | 2002-11-28 |
| CN101353373A (zh) | 2009-01-28 |
| EP1089759A1 (en) | 2001-04-11 |
| IL139464A0 (en) | 2001-11-25 |
| CN1354674A (zh) | 2002-06-19 |
| KR100602553B1 (ko) | 2006-07-20 |
| US6107021A (en) | 2000-08-22 |
| CN100435846C (zh) | 2008-11-26 |
| CN101353373B (zh) | 2013-06-19 |
| CA2330178C (en) | 2013-10-15 |
| TWI232108B (en) | 2005-05-11 |
| BRPI9912178B1 (pt) | 2017-03-28 |
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