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BR9911779A - Benzotiofenos, benzofuranos e indóis úteis no tratamento de resistência à insulina e hiperglicemia - Google Patents

Benzotiofenos, benzofuranos e indóis úteis no tratamento de resistência à insulina e hiperglicemia

Info

Publication number
BR9911779A
BR9911779A BR9911779-7A BR9911779A BR9911779A BR 9911779 A BR9911779 A BR 9911779A BR 9911779 A BR9911779 A BR 9911779A BR 9911779 A BR9911779 A BR 9911779A
Authority
BR
Brazil
Prior art keywords
hyperglycemia
insulin resistance
benzofurans
treatment
benzothiophenes
Prior art date
Application number
BR9911779-7A
Other languages
English (en)
Inventor
Jay Edward Wrobel
Arlene Joan Dietrich
Madelene Miyoko Antane
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9911779A publication Critical patent/BR9911779A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Patente de Invenção: <B>"BENZOTIOFENOS, BENZOFURANOS E INDóIS úTEIS NO TRATAMENTO DE RESISTêNCIA à INSULINA E HIPERGLICEMIA"<D>. A presente invenção proporciona compostos da fórmula (I) em que Ar é (a), (b) ou (c) A, B, C, D, E, X, Y, Z1 e Z2 são conforme definido na descrição ou um sal farmaceuticamente aceitável dos mesmos, os quais são úteis no tratamento de distúrbios metabólicos relacionados à resistência à insulina ou hiperglicemia.
BR9911779-7A 1998-05-12 1999-05-10 Benzotiofenos, benzofuranos e indóis úteis no tratamento de resistência à insulina e hiperglicemia BR9911779A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7671298A 1998-05-12 1998-05-12
PCT/US1999/010209 WO1999061435A1 (en) 1998-05-12 1999-05-10 Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia

Publications (1)

Publication Number Publication Date
BR9911779A true BR9911779A (pt) 2001-02-06

Family

ID=22133746

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911779-7A BR9911779A (pt) 1998-05-12 1999-05-10 Benzotiofenos, benzofuranos e indóis úteis no tratamento de resistência à insulina e hiperglicemia

Country Status (22)

Country Link
EP (1) EP1077969A1 (pt)
JP (1) JP2002516321A (pt)
KR (1) KR20010043539A (pt)
CN (1) CN1308626A (pt)
AR (1) AR015294A1 (pt)
AU (1) AU756337B2 (pt)
BG (1) BG104918A (pt)
BR (1) BR9911779A (pt)
CA (1) CA2330620A1 (pt)
EA (1) EA200001175A1 (pt)
EE (1) EE200000653A (pt)
HR (1) HRP20000767A2 (pt)
HU (1) HUP0101792A3 (pt)
ID (1) ID26244A (pt)
IL (1) IL139132A0 (pt)
NO (1) NO20005677L (pt)
PL (1) PL344081A1 (pt)
SK (1) SK16992000A3 (pt)
TR (1) TR200003333T2 (pt)
TW (1) TW510900B (pt)
WO (1) WO1999061435A1 (pt)
ZA (1) ZA200005961B (pt)

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US20030013709A1 (en) * 2001-06-07 2003-01-16 Wyeth Combination of a PTPase inhibitor and an alpha-glucosidase inhibitor
US20020198203A1 (en) * 2001-06-07 2002-12-26 Wyeth Combination of a PTPase inhibitor and a thiazolidinedione agent
US20020198201A1 (en) * 2001-06-07 2002-12-26 Wyeth Combination of a PTPase inhibitor and an aldose reductase inhibitor
US6734197B2 (en) 2001-06-07 2004-05-11 Wyeth Combination therapy for type II diabetes or Syndrome X
WO2002098414A1 (en) * 2001-06-07 2002-12-12 Wyeth Methods using ptpase inhibitors and insulin
US20020198202A1 (en) * 2001-06-07 2002-12-26 Wyeth Combination of a PTPase inhibitor and an antilipemic agent
WO2003000253A1 (en) 2001-06-20 2003-01-03 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
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CA2509222A1 (en) 2002-12-10 2004-06-24 Wyeth Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
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US7718377B2 (en) 2003-05-29 2010-05-18 Kyoto Pharmaceutical Industries, Ltd. Insulin resistance curative and method of screening the same
US7504401B2 (en) 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
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Also Published As

Publication number Publication date
IL139132A0 (en) 2001-11-25
TR200003333T2 (tr) 2001-02-21
JP2002516321A (ja) 2002-06-04
AU756337B2 (en) 2003-01-09
BG104918A (bg) 2001-08-31
HUP0101792A2 (hu) 2002-01-28
TW510900B (en) 2002-11-21
NO20005677D0 (no) 2000-11-10
EE200000653A (et) 2002-04-15
HRP20000767A2 (en) 2001-10-31
PL344081A1 (en) 2001-09-24
ZA200005961B (en) 2001-10-24
EP1077969A1 (en) 2001-02-28
CA2330620A1 (en) 1999-12-02
SK16992000A3 (sk) 2001-04-09
EA200001175A1 (ru) 2001-06-25
NO20005677L (no) 2000-12-05
AU3893999A (en) 1999-12-13
KR20010043539A (ko) 2001-05-25
WO1999061435A1 (en) 1999-12-02
HUP0101792A3 (en) 2003-01-28
AR015294A1 (es) 2001-04-18
ID26244A (id) 2000-12-07
CN1308626A (zh) 2001-08-15

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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