BR9911358A - Derivados de 1,3-oxazolina e 1,3-tiazolina, processos para a sua preparação e sua aplicação como composições praguicidas - Google Patents
Derivados de 1,3-oxazolina e 1,3-tiazolina, processos para a sua preparação e sua aplicação como composições praguicidasInfo
- Publication number
- BR9911358A BR9911358A BR9911358-9A BR9911358A BR9911358A BR 9911358 A BR9911358 A BR 9911358A BR 9911358 A BR9911358 A BR 9911358A BR 9911358 A BR9911358 A BR 9911358A
- Authority
- BR
- Brazil
- Prior art keywords
- oxazoline
- processes
- preparation
- application
- derivatives
- Prior art date
Links
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical class C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 title abstract 3
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000575 pesticide Substances 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000895 acaricidal effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000749 insecticidal effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE 1,3-OXAZOLINA E 1,3-TIAZOLINA, PROCESSOS PARA A SUA PREPARAçãO E SUA APLICAçãO COMO COMPOSIçõES PRAGUICIDAS"<D>. Derivados de 1,3-oxazolina e 1,3-tiazolina da fórmula (I), na qual os símbolos têm os seguintes significados: A é fenila, piridila, pirimidinila, pirazinila, pirazolila ou tienila, E é uma ligação simples, (C~ 1~-C~ 4~)-alquileno, -O-CH~ 2~- ou -CH~ 2~-O-, G é um radical do grupo: Z é oxigênio ou enxofre. Compostos da fórmula (I) possuem especialmente um efeito acaricida e inseticida muito bom com respeito ao espectro de ação e à intensidade do efeito.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19826671A DE19826671A1 (de) | 1998-06-16 | 1998-06-16 | 1,3-Oxazolin- und 1,3-Thiazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| PCT/EP1999/003776 WO1999065901A1 (de) | 1998-06-16 | 1999-06-01 | 1,3-oxazolin- und 1,3-thiazolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schädlingsbekämpfungsmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9911358A true BR9911358A (pt) | 2001-03-13 |
Family
ID=7870979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9911358-9A BR9911358A (pt) | 1998-06-16 | 1999-06-01 | Derivados de 1,3-oxazolina e 1,3-tiazolina, processos para a sua preparação e sua aplicação como composições praguicidas |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6265350B1 (pt) |
| EP (1) | EP1087967B1 (pt) |
| JP (1) | JP2002518389A (pt) |
| KR (1) | KR20010052959A (pt) |
| CN (1) | CN1305476A (pt) |
| AR (1) | AR018673A1 (pt) |
| AT (1) | ATE252578T1 (pt) |
| AU (1) | AU750324B2 (pt) |
| BR (1) | BR9911358A (pt) |
| CA (1) | CA2335352A1 (pt) |
| CO (1) | CO5050288A1 (pt) |
| DE (2) | DE19826671A1 (pt) |
| ES (1) | ES2209451T3 (pt) |
| HU (1) | HUP0102360A3 (pt) |
| ID (1) | ID26652A (pt) |
| IL (1) | IL140236A (pt) |
| PL (1) | PL345041A1 (pt) |
| TR (1) | TR200003690T2 (pt) |
| WO (1) | WO1999065901A1 (pt) |
| ZA (1) | ZA200007301B (pt) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19858192A1 (de) * | 1998-12-17 | 2000-06-21 | Aventis Cropscience Gmbh | 4-Trifluormethyl-3-oxazolylpyridine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
| JP4730485B2 (ja) * | 2000-06-01 | 2011-07-20 | 日産化学工業株式会社 | 安定化される農薬組成物 |
| TWI275589B (en) * | 2000-06-22 | 2007-03-11 | Dow Agrosciences Llc | 2-(3,5-disubstituted-4-pyridyl)-4-(thienyl, thiazolyl or arylphenyl)-1,3-oxazoline compounds |
| DE10039477A1 (de) * | 2000-08-08 | 2002-02-21 | Aventis Cropscience Gmbh | Heterocyclylalkylazol-Derivate und ihre Verwendung als Schädlingsbekämpfungsmittel |
| DE10104871A1 (de) * | 2001-02-03 | 2002-08-08 | Aventis Cropscience Gmbh | Verfahren zur Kontrolle von Schadorganismen in Nutzpflanzenkulturen |
| AU2002345791B2 (en) * | 2001-06-22 | 2007-05-17 | Dow Agrosciences Llc | 2-(2,6-disubstituted phenyl)-4-aryl-5-alkyl-1,3-oxazoline compounds useful as insecticides and acaricides |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| US7998986B2 (en) | 2001-12-21 | 2011-08-16 | Exelixis Patent Company Llc | Modulators of LXR |
| JP4164031B2 (ja) * | 2002-02-14 | 2008-10-08 | ファルマシア コーポレーション | P38mapキナーゼのモジュレータとしての置換されたピリジノン |
| US6573286B1 (en) | 2002-06-21 | 2003-06-03 | Dow Agrosciences Llc | 2-(2,6-disubstituted phenyl)-4-aryl-5-alkyl-1,3-oxazoline compounds |
| US20040156742A1 (en) * | 2003-02-11 | 2004-08-12 | Milan Jolanda Bianca | Synergistically-effective cyclohexylethan-1-yl ester mixtures as malodour counteractants as measured physiologically and psychometrically and methods for using same |
| US20050106192A1 (en) * | 2003-11-13 | 2005-05-19 | Parekh Prabodh P. | Synergistically-effective composition of zinc ricinoleate and one or more substituted monocyclic organic compounds and use thereof for preventing and/or suppressing malodors |
| KR20070095952A (ko) | 2004-12-16 | 2007-10-01 | 버텍스 파마슈티칼스 인코포레이티드 | 염증성 질환, 증식성 질환 및 면역학적으로 매개된 질환치료용 Tec 계열 단백질 키나제의 억제제로서 유용한피리드-2-온 |
| CA2600079A1 (en) * | 2005-03-21 | 2006-09-28 | Basf Aktiengesellschaft | Insecticidal mixtures |
| CA2608116A1 (en) | 2005-05-10 | 2006-11-16 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| US8012554B2 (en) * | 2007-09-12 | 2011-09-06 | Pactiv Corporation | Bags having odor management capabilities |
| EP2200985B1 (en) | 2007-09-14 | 2011-07-13 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
| NZ584148A (en) | 2007-09-14 | 2011-05-27 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
| CA2696948C (en) | 2007-09-14 | 2013-04-30 | Jose Maria Cid-Nunez | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
| CN102143955B (zh) | 2008-09-02 | 2013-08-14 | Omj制药公司 | 作为代谢型谷氨酸受体调节剂的3-氮杂二环[3.1.0]己烷衍生物 |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| CN106518856B (zh) | 2008-12-19 | 2020-04-28 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的化合物 |
| CN102439015B (zh) | 2009-05-12 | 2015-05-13 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2440001T3 (es) | 2009-05-12 | 2014-01-27 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos |
| JP2013526540A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| SG185524A1 (en) * | 2010-05-12 | 2012-12-28 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2552879T3 (es) | 2010-11-08 | 2015-12-02 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| EP3733185B1 (en) | 2011-09-30 | 2022-12-07 | Vertex Pharmaceuticals Incorporated | Treating non-small cell lung cancer with atr inhibitors |
| CA2850566C (en) | 2011-09-30 | 2022-05-03 | Vertex Pharmaceuticals Incorporated | Process for making 4-[chloro-n-hydroxycarbonimidoyl]phenyl derivative |
| EP2833973B1 (en) | 2012-04-05 | 2017-09-13 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
| US20130317069A1 (en) * | 2012-05-08 | 2013-11-28 | Dow Agrosciences Llc | 2,4-(substituted aromatic)-1,3-oxazoline compounds as a seed treatment to control pests |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US8999632B2 (en) | 2012-10-04 | 2015-04-07 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| EA033889B1 (ru) | 2014-01-21 | 2019-12-05 | Янссен Фармацевтика Нв | Комбинация на основе лиганда sv2a и положительного аллостерического модулятора метаботропного глутаматергического рецептора 2 подтипа |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
| CA2943363A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| MX395066B (es) | 2015-09-30 | 2025-03-24 | Vertex Pharma | Método para tratar cáncer usando una combinación de agentes que dañan el adn e inhibidores de proteína relacionada con ataxia telangiectasia y rad3 (atr). |
| ES2747768T3 (es) | 2017-03-20 | 2020-03-11 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| US20220378756A1 (en) | 2019-09-19 | 2022-12-01 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| AU2022215844A1 (en) | 2021-02-02 | 2023-09-14 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977171A (en) | 1988-06-09 | 1990-12-11 | Yashima Chemical Industrial Co., Ltd. | Oxa- or thia-zoline derivative |
| AU634608B2 (en) | 1989-12-09 | 1993-02-25 | Kyoyu Agri Co., Ltd. | 2-substituted phenyl-2-oxazoline or thiazoline derivatives, process for producing the same and insectides and acaricides containing the same |
| DE69313281T2 (de) | 1992-05-26 | 1998-03-12 | Du Pont | Arthropodizide oxazoline und thiazoline |
| TW259693B (pt) * | 1993-08-04 | 1995-10-11 | Du Pont | |
| DE4401098A1 (de) | 1994-01-17 | 1995-07-20 | Bayer Ag | Diphenyloxazolin-Derivate |
| WO1996022283A1 (en) * | 1995-01-20 | 1996-07-25 | E.I. Du Pont De Nemours And Company | Insecticidal and acaricidal oxazolines and thiazolines |
| DE19528778A1 (de) | 1995-08-04 | 1997-02-06 | Bayer Ag | 4-Alkyl-1,3-oxa(thia)zolin-Derivate |
| DE19548419A1 (de) | 1995-12-22 | 1997-06-26 | Bayer Ag | Substituierte Thiazoline |
-
1998
- 1998-06-16 DE DE19826671A patent/DE19826671A1/de not_active Withdrawn
-
1999
- 1999-06-01 WO PCT/EP1999/003776 patent/WO1999065901A1/de not_active Ceased
- 1999-06-01 JP JP2000554726A patent/JP2002518389A/ja active Pending
- 1999-06-01 CN CN99807444A patent/CN1305476A/zh active Pending
- 1999-06-01 CA CA002335352A patent/CA2335352A1/en not_active Abandoned
- 1999-06-01 EP EP99927818A patent/EP1087967B1/de not_active Expired - Lifetime
- 1999-06-01 AT AT99927818T patent/ATE252578T1/de not_active IP Right Cessation
- 1999-06-01 DE DE59907464T patent/DE59907464D1/de not_active Expired - Fee Related
- 1999-06-01 HU HU0102360A patent/HUP0102360A3/hu unknown
- 1999-06-01 IL IL14023699A patent/IL140236A/xx not_active IP Right Cessation
- 1999-06-01 ES ES99927818T patent/ES2209451T3/es not_active Expired - Lifetime
- 1999-06-01 ID IDW20002618A patent/ID26652A/id unknown
- 1999-06-01 BR BR9911358-9A patent/BR9911358A/pt not_active Application Discontinuation
- 1999-06-01 KR KR1020007014344A patent/KR20010052959A/ko not_active Withdrawn
- 1999-06-01 PL PL99345041A patent/PL345041A1/xx not_active Application Discontinuation
- 1999-06-01 TR TR2000/03690T patent/TR200003690T2/xx unknown
- 1999-06-01 AU AU45038/99A patent/AU750324B2/en not_active Ceased
- 1999-06-11 AR ARP990102820A patent/AR018673A1/es active IP Right Grant
- 1999-06-14 US US09/332,225 patent/US6265350B1/en not_active Expired - Fee Related
- 1999-06-16 CO CO99037535A patent/CO5050288A1/es unknown
-
2000
- 2000-12-08 ZA ZA200007301A patent/ZA200007301B/en unknown
-
2001
- 2001-06-21 US US09/886,551 patent/US6670307B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2335352A1 (en) | 1999-12-23 |
| ID26652A (id) | 2001-01-25 |
| DE19826671A1 (de) | 1999-12-23 |
| AU750324B2 (en) | 2002-07-18 |
| KR20010052959A (ko) | 2001-06-25 |
| TR200003690T2 (tr) | 2001-06-21 |
| AR018673A1 (es) | 2001-11-28 |
| US20020068828A1 (en) | 2002-06-06 |
| CO5050288A1 (es) | 2001-06-27 |
| PL345041A1 (en) | 2001-11-19 |
| IL140236A0 (en) | 2002-02-10 |
| ES2209451T3 (es) | 2004-06-16 |
| ATE252578T1 (de) | 2003-11-15 |
| EP1087967B1 (de) | 2003-10-22 |
| JP2002518389A (ja) | 2002-06-25 |
| HUP0102360A3 (en) | 2002-03-28 |
| EP1087967A1 (de) | 2001-04-04 |
| WO1999065901A1 (de) | 1999-12-23 |
| AU4503899A (en) | 2000-01-05 |
| ZA200007301B (en) | 2002-02-08 |
| IL140236A (en) | 2005-08-31 |
| DE59907464D1 (de) | 2003-11-27 |
| US6670307B2 (en) | 2003-12-30 |
| US6265350B1 (en) | 2001-07-24 |
| CN1305476A (zh) | 2001-07-25 |
| HUP0102360A2 (hu) | 2001-10-28 |
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