BR9911223A - Proteìnas de ligação à angiostatina, peptìdeos de ligação a um fragmento n-terminal do plasminogênio, ácidos nucleicos codificantes das referidas proteìnas e peptìdeos, vetores compreendendo o referidos ácidos nucleicos, células recombinantes contendo os referidos vetores, anticorpos que se ligam às referidas proteìnas ou peptìdeos, células recombinantes que expressam os referidos anticorpos , método de varredura de compostos capazes de interagir com as referidas proteìnas, compostos identificados pelo referido método, uso das referidas proteìnas, peptìdeos ou compostos na preparação de medicamentos para o tratamento de doença ou desordem relacionada à angiogênese e preparação farmacêutica contendo as referidas proteìnas, peptìdeos ou compostos. - Google Patents
Proteìnas de ligação à angiostatina, peptìdeos de ligação a um fragmento n-terminal do plasminogênio, ácidos nucleicos codificantes das referidas proteìnas e peptìdeos, vetores compreendendo o referidos ácidos nucleicos, células recombinantes contendo os referidos vetores, anticorpos que se ligam às referidas proteìnas ou peptìdeos, células recombinantes que expressam os referidos anticorpos , método de varredura de compostos capazes de interagir com as referidas proteìnas, compostos identificados pelo referido método, uso das referidas proteìnas, peptìdeos ou compostos na preparação de medicamentos para o tratamento de doença ou desordem relacionada à angiogênese e preparação farmacêutica contendo as referidas proteìnas, peptìdeos ou compostos.Info
- Publication number
- BR9911223A BR9911223A BR9911223-0A BR9911223A BR9911223A BR 9911223 A BR9911223 A BR 9911223A BR 9911223 A BR9911223 A BR 9911223A BR 9911223 A BR9911223 A BR 9911223A
- Authority
- BR
- Brazil
- Prior art keywords
- proteins
- peptides
- compounds
- antibodies
- vectors
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 230000033115 angiogenesis Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 5
- 108090000765 processed proteins & peptides Proteins 0.000 title 5
- 150000001875 compounds Chemical class 0.000 title 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 102000039446 nucleic acids Human genes 0.000 title 2
- 108020004707 nucleic acids Proteins 0.000 title 2
- 150000007523 nucleic acids Chemical class 0.000 title 2
- 239000013598 vector Substances 0.000 title 2
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 102000028537 angiostatin binding proteins Human genes 0.000 title 1
- 108091009317 angiostatin binding proteins Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 102000012936 Angiostatins Human genes 0.000 abstract 2
- 108010079709 Angiostatins Proteins 0.000 abstract 2
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 abstract 2
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
MOLéCULAS RELACIONADAS à ANGIOGêNESE A presente invenção proporciona a sequência de uma proteína capaz de agir como um receptor de Angiostatina, bem como a sequência nucleotídica do gene que codifica a mesma. A invenção também se relaciona ao uso das mesmas em métodos de varredura, em que novas substâncias são criadas exibindo as mesmas e vantajosas propriedades anti-angiogênicas da Angiostatina.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8926698P | 1998-06-15 | 1998-06-15 | |
| SE9802130A SE9802130D0 (sv) | 1998-06-15 | 1998-06-15 | Angiogenesis related molecules |
| SE9804372A SE9804372D0 (sv) | 1998-12-17 | 1998-12-17 | Angiogenesis related molecules |
| US11438698P | 1998-12-29 | 1998-12-29 | |
| PCT/EP1999/004109 WO1999066038A1 (en) | 1998-06-15 | 1999-06-11 | Angiostatin-binding protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9911223A true BR9911223A (pt) | 2001-03-06 |
Family
ID=27484811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9911223-0A BR9911223A (pt) | 1998-06-15 | 1999-06-11 | Proteìnas de ligação à angiostatina, peptìdeos de ligação a um fragmento n-terminal do plasminogênio, ácidos nucleicos codificantes das referidas proteìnas e peptìdeos, vetores compreendendo o referidos ácidos nucleicos, células recombinantes contendo os referidos vetores, anticorpos que se ligam às referidas proteìnas ou peptìdeos, células recombinantes que expressam os referidos anticorpos , método de varredura de compostos capazes de interagir com as referidas proteìnas, compostos identificados pelo referido método, uso das referidas proteìnas, peptìdeos ou compostos na preparação de medicamentos para o tratamento de doença ou desordem relacionada à angiogênese e preparação farmacêutica contendo as referidas proteìnas, peptìdeos ou compostos. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1088069B1 (pt) |
| JP (1) | JP2002518008A (pt) |
| KR (1) | KR20010052887A (pt) |
| CN (2) | CN1170931C (pt) |
| AR (1) | AR019862A1 (pt) |
| AT (1) | ATE295417T1 (pt) |
| AU (2) | AU769933B2 (pt) |
| BR (1) | BR9911223A (pt) |
| CA (1) | CA2330228A1 (pt) |
| CY (1) | CY1105675T1 (pt) |
| CZ (1) | CZ20004671A3 (pt) |
| DE (1) | DE69925271T2 (pt) |
| EA (1) | EA200100037A1 (pt) |
| ES (1) | ES2242400T3 (pt) |
| HU (1) | HUP0102758A2 (pt) |
| ID (1) | ID28136A (pt) |
| IL (2) | IL139873A0 (pt) |
| NO (1) | NO20006192L (pt) |
| PL (1) | PL344979A1 (pt) |
| PT (1) | PT1088069E (pt) |
| TR (1) | TR200003695T2 (pt) |
| TW (1) | TWI243852B (pt) |
| WO (1) | WO1999066038A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040022788A1 (en) | 1998-05-19 | 2004-02-05 | Moser Tammy L. | Compositions and methods for promoting or inhibiting angiogenesis |
| US6444431B1 (en) | 1998-05-19 | 2002-09-03 | Duke University | Angiostatin receptor |
| GB2397577A (en) * | 2001-11-01 | 2004-07-28 | Amersham Plc | Human angiomotin-like protein 1 |
| ATE553120T1 (de) | 2001-11-16 | 2012-04-15 | Eisai R&D Man Co Ltd | Proteine der jeap familie, bestandteile der dichten verbindungsstellen der exokrinen drüsen |
| US7276588B2 (en) | 2002-08-16 | 2007-10-02 | Duke University | Antibody of human mitochondrial voltage dependent anion channel |
| KR20060120181A (ko) * | 2003-10-28 | 2006-11-24 | 안티캔서, 인코포레이티드 | 네스틴 발현 줄기 세포를 이용하여 신생 혈관을 영상화하기위한 혈관 형성 모델 |
| GB0330079D0 (en) * | 2003-12-20 | 2004-02-04 | Bioinvent Int Ab | Vaccine |
| WO2007110209A1 (en) * | 2006-03-29 | 2007-10-04 | Bioinvent International Ab | Biological materials and uses thereof |
| CN104878094B (zh) * | 2015-04-30 | 2019-01-15 | 北京大北农科技集团股份有限公司 | 用于检测除草剂耐受性玉米植物dbn9888的核酸序列及其检测方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8501682A (nl) * | 1985-06-11 | 1987-01-02 | Tno | Nieuw, uit bloed geisoleerd eiwit, werkwijze ter bereiding van dit eiwit, antilichamen tegen het nieuwe eiwit en farmaceutische preparaten, die het eiwit of de antilichamen bevatten. |
-
1999
- 1999-06-10 TW TW088109676A patent/TWI243852B/zh not_active IP Right Cessation
- 1999-06-11 ES ES99927981T patent/ES2242400T3/es not_active Expired - Lifetime
- 1999-06-11 AT AT99927981T patent/ATE295417T1/de not_active IP Right Cessation
- 1999-06-11 PL PL99344979A patent/PL344979A1/xx not_active Application Discontinuation
- 1999-06-11 EA EA200100037A patent/EA200100037A1/ru unknown
- 1999-06-11 WO PCT/EP1999/004109 patent/WO1999066038A1/en not_active Ceased
- 1999-06-11 IL IL13987399A patent/IL139873A0/xx active IP Right Grant
- 1999-06-11 JP JP2000554847A patent/JP2002518008A/ja active Pending
- 1999-06-11 ID IDW20010096A patent/ID28136A/id unknown
- 1999-06-11 BR BR9911223-0A patent/BR9911223A/pt not_active Application Discontinuation
- 1999-06-11 CZ CZ20004671A patent/CZ20004671A3/cs unknown
- 1999-06-11 KR KR1020007014231A patent/KR20010052887A/ko not_active Withdrawn
- 1999-06-11 AU AU45134/99A patent/AU769933B2/en not_active Ceased
- 1999-06-11 CN CNB99807425XA patent/CN1170931C/zh not_active Expired - Fee Related
- 1999-06-11 TR TR2000/03695T patent/TR200003695T2/xx unknown
- 1999-06-11 CN CNA2004100560052A patent/CN1626552A/zh active Pending
- 1999-06-11 PT PT99927981T patent/PT1088069E/pt unknown
- 1999-06-11 HU HU0102758A patent/HUP0102758A2/hu unknown
- 1999-06-11 AR ARP990102798A patent/AR019862A1/es active IP Right Grant
- 1999-06-11 DE DE69925271T patent/DE69925271T2/de not_active Expired - Fee Related
- 1999-06-11 CA CA002330228A patent/CA2330228A1/en not_active Abandoned
- 1999-06-11 EP EP99927981A patent/EP1088069B1/en not_active Expired - Lifetime
-
2000
- 2000-11-23 IL IL139873A patent/IL139873A/en not_active IP Right Cessation
- 2000-12-06 NO NO20006192A patent/NO20006192L/no not_active Application Discontinuation
-
2004
- 2004-05-11 AU AU2004201999A patent/AU2004201999B2/en not_active Ceased
-
2005
- 2005-08-02 CY CY20051100920T patent/CY1105675T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1088069B1 (en) | 2005-05-11 |
| CA2330228A1 (en) | 1999-12-23 |
| ATE295417T1 (de) | 2005-05-15 |
| PT1088069E (pt) | 2005-09-30 |
| EP1088069A1 (en) | 2001-04-04 |
| ES2242400T3 (es) | 2005-11-01 |
| WO1999066038A1 (en) | 1999-12-23 |
| CN1626552A (zh) | 2005-06-15 |
| NO20006192L (no) | 2001-02-14 |
| CZ20004671A3 (cs) | 2001-10-17 |
| PL344979A1 (en) | 2001-11-19 |
| DE69925271T2 (de) | 2006-02-23 |
| IL139873A (en) | 2008-08-07 |
| CN1305527A (zh) | 2001-07-25 |
| AU769933B2 (en) | 2004-02-12 |
| JP2002518008A (ja) | 2002-06-25 |
| CN1170931C (zh) | 2004-10-13 |
| AR019862A1 (es) | 2002-03-20 |
| HUP0102758A2 (hu) | 2001-11-28 |
| CY1105675T1 (el) | 2010-12-22 |
| IL139873A0 (en) | 2002-02-10 |
| AU4513499A (en) | 2000-01-05 |
| TWI243852B (en) | 2005-11-21 |
| KR20010052887A (ko) | 2001-06-25 |
| AU2004201999A1 (en) | 2004-06-10 |
| ID28136A (id) | 2001-05-03 |
| DE69925271D1 (de) | 2005-06-16 |
| TR200003695T2 (tr) | 2001-06-21 |
| EA200100037A1 (ru) | 2001-06-25 |
| NO20006192D0 (no) | 2000-12-06 |
| AU2004201999B2 (en) | 2007-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25C | Requirement related to requested transfer of rights |
Owner name: PHARMACIA AND UPJOHN AB (SE) Free format text: A FIM DE ATENDER A PETICAO DE TRANSFERENCIA NO 020040014230/RJ DE 03/12/2004, CABE AO REQUERENTE APRESENTAR AS GUIAS DE RECOLHIMENTO REFERENTE A OUTRAS DUAS TRANSFERENCIAS, UMA VEZ QUE FORAM APRESENTADAS 03 DOCUMENTOS DE CESSAO, COMO TAMBEM DEVERA CONSTAR NO DOCUMENTO DE CESSAO A DEVIDA LEGALIZACAO CONSULAR. |
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| B25A | Requested transfer of rights approved |
Owner name: LARS HOLMGREN (SE) , BORIS TROYANOVSKY (SE) Free format text: TRANSFERIDO DE: PHARMACIA AND UPJOHN AB |
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| B25A | Requested transfer of rights approved |
Owner name: LARS HOLMGREN (SE) Free format text: TRANSFERIDO DE: BORIS TROYANOVSKY |
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| B25A | Requested transfer of rights approved |
Owner name: BIOINVENT INTERNATIONAL AB (SE) Free format text: TRANSFERIDO DE: LARS HOLMGREN |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A E 5A ANUIDADES. |
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| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |