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BR9910801A - Derivados da pirazolina, a preparação dos mesmose a aplicação dos mesmos como um medicamento - Google Patents

Derivados da pirazolina, a preparação dos mesmose a aplicação dos mesmos como um medicamento

Info

Publication number
BR9910801A
BR9910801A BR9910801-1A BR9910801A BR9910801A BR 9910801 A BR9910801 A BR 9910801A BR 9910801 A BR9910801 A BR 9910801A BR 9910801 A BR9910801 A BR 9910801A
Authority
BR
Brazil
Prior art keywords
preparation
same
derivatives
medicine
application
Prior art date
Application number
BR9910801-1A
Other languages
English (en)
Inventor
Maria Rosa Cuberes-Altisent
Juana Maria Berrocal-Romero
Mariamontserrat Contijoch-Llobet
Jordi Frigola-Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of BR9910801A publication Critical patent/BR9910801A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE PIRAZOLINA, APREPARAçãO DOS MESMOS E A APLICAçãO DOS MESMOSCOMO UM MEDICAMENTO". A presente invenção refere-se anovos derivados de pirazolina que tem a fórmula geral (1), bemcomo aos sais fisiologicamente aceitáveis dos mesmos, aprocessos na terapia humana e veterinária e a composiçõesfarmacêuticas que contenham os mesmos. Os novos compostosda invenção podem ser usados na indústria farmacêutica comointermediários e na preparação de medicamentos. De modoespecífico, eles podem ser usados para a preparação demedicamentos utilizados para o tratamento de inflamação e deoutros problemas associados à inflamação e outros processosmediados pela ciclooxigenase-2, por exemplo, artrite, tratamento dador e tratamento da febre.
BR9910801-1A 1998-05-29 1999-05-27 Derivados da pirazolina, a preparação dos mesmose a aplicação dos mesmos como um medicamento BR9910801A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009801129A ES2137138B1 (es) 1998-05-29 1998-05-29 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
PCT/ES1999/000156 WO1999062884A1 (es) 1998-05-29 1999-05-27 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos

Publications (1)

Publication Number Publication Date
BR9910801A true BR9910801A (pt) 2001-11-27

Family

ID=8303969

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910801-1A BR9910801A (pt) 1998-05-29 1999-05-27 Derivados da pirazolina, a preparação dos mesmose a aplicação dos mesmos como um medicamento

Country Status (32)

Country Link
US (2) USRE38963E1 (pt)
EP (1) EP1083171B1 (pt)
JP (1) JP4633928B2 (pt)
KR (1) KR100603666B1 (pt)
CN (1) CN1189459C (pt)
AR (1) AR018402A1 (pt)
AT (1) ATE265437T1 (pt)
AU (1) AU752001B2 (pt)
BG (1) BG64950B1 (pt)
BR (1) BR9910801A (pt)
CA (1) CA2333475C (pt)
CO (1) CO5031241A1 (pt)
CU (1) CU22995A3 (pt)
CZ (1) CZ298391B6 (pt)
DE (1) DE69916828T2 (pt)
DK (1) DK1083171T3 (pt)
ES (2) ES2137138B1 (pt)
GE (1) GEP20043237B (pt)
HU (1) HUP0102102A3 (pt)
IS (1) IS2040B (pt)
LT (1) LT4879B (pt)
LV (1) LV12632B (pt)
NO (1) NO316600B1 (pt)
NZ (1) NZ508990A (pt)
PL (1) PL344412A1 (pt)
PT (1) PT1083171E (pt)
RU (1) RU2233272C2 (pt)
SI (1) SI20580B (pt)
SK (1) SK285550B6 (pt)
TW (1) TW572898B (pt)
WO (1) WO1999062884A1 (pt)
ZA (1) ZA200007638B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL146851A0 (en) 1999-06-16 2002-07-25 Univ Temple 1- (4-sulfamylaryl)- 3- substituted -5-ayl-2-pyrazolines as inhibitors of cyclooxygenase-2
PT1175214E (pt) 1999-12-08 2005-04-29 Pharmacia Corp Composicoes de inibidor de ciclo-oxigenase-2 com um inicio rapido do seu efito terapeutico
ES2174757B1 (es) * 2001-04-06 2003-11-01 Esteve Labor Dr Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6878729B2 (en) * 2001-05-04 2005-04-12 The Procter & Gamble Company Medicinal uses of dihydropyrazoles
ES2183720B1 (es) 2001-06-18 2004-01-16 Esteve Labor Dr Procedimiento para la preparacion de derivados de 1,5-diaril-3-trifluorometil-delta2-pirazolinas racemicas y enantiomericamente puras.
DE602004002832T2 (de) 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
ES2238923B1 (es) * 2004-02-16 2006-11-01 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados pirazolinicos sustituidos.
US7998996B2 (en) * 2004-02-17 2011-08-16 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
ES2278503B1 (es) * 2005-06-27 2008-06-16 Laboratorios Del Dr. Esteve, S.A. Epoxidacion de cetonas alfa, beta - insaturadas.
WO2007009704A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
EP1743638A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
WO2007009706A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
EP1743636A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Combination of a substituted pyrazoline compound and a drug used in food-related disorders
EP1743642A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
EP1745781A1 (en) * 2005-07-15 2007-01-24 Laboratorios Del Dr. Esteve, S.A. Combination of pyrazoline type cannabinoid receptor antagonist and statin
WO2007009699A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
EP1743643A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. New formulations of substituted pyrazoline compounds
ES2330993B1 (es) * 2005-07-15 2010-07-06 Laboratorios Del Dr. Esteve, S.A. Combinacion de antagonista del receptor de cannabinoides de tipo pirazolina y estatina.
ES2326724B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Nuevas formulaciones de compuestos de pirazolina sustituidos.
EP1757587A1 (en) * 2005-07-15 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1849784A1 (en) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Indoline-substituted pyrazoline compounds, their preparation and use as medicaments
WO2007009710A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds: methods for their preparation
ES2336883B1 (es) * 2005-07-15 2011-03-22 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
WO2007009693A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A Combination of a substituted pyrazoline compound and a drug used in food-related disorders
EP1760078A1 (en) * 2005-07-15 2007-03-07 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds; methods for their preparation
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1749526A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
WO2007009692A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
ES2330716B1 (es) * 2005-07-15 2010-07-09 Laboratorios Del Dr.Esteve, S.A. Formulaciones farmaceuticas de compuestos de pirazolina sustituidos.
AR061623A1 (es) * 2006-06-26 2008-09-10 Novartis Ag Derivados de acido fenilacetico
JP2010516679A (ja) * 2007-01-19 2010-05-20 マリンクロット インコーポレイテッド 診断用および治療用シクロオキシゲナーゼ−２結合リガンド
EP3009137A1 (en) 2014-10-16 2016-04-20 Ecuphar N.V. Pyrazoline-derived compound and its use in a weekly dosage regime against inflammation and pain derived from degenerative joint disease in mammals
EP4029502A1 (en) 2021-01-15 2022-07-20 Ecuphar N.V. Pyrazoline-derived compound (enflicoxib) for use in the prevention and/or treatment of pain and inflammation associated to surgery in mammals
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases
US12208085B2 (en) 2022-05-31 2025-01-28 Ecuphar Nv Pyrazoline-derived compound for use in the prevention and/or treatment of pain and inflammation associated to surgery in mammals

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
GB2060660B (en) * 1979-10-18 1983-11-23 Bostik Ltd Adhesives containing pyrazoline activators
JPS5818363A (ja) * 1981-07-13 1983-02-02 アメリカン・サイアナミド・カンパニ− 複素環式置換アミノピラゾリン類およびその薬としての用途
ATE57690T1 (de) * 1987-01-05 1990-11-15 Du Pont Pyrazolin mit insektizidischer aktivitaet.
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
ES2182991T3 (es) * 1995-05-25 2003-03-16 Searle & Co Metodo para la preparar 3-haloalquil-1h-pirazoles.
GB9520584D0 (en) * 1995-10-09 1995-12-13 Fujisawa Pharmaceutical Co Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
JP4633928B2 (ja) 2011-02-16
JP2002516908A (ja) 2002-06-11
LT4879B (lt) 2002-01-25
AU3932999A (en) 1999-12-20
ES2221382T3 (es) 2004-12-16
USRE38963E1 (en) 2006-01-31
AU752001B2 (en) 2002-09-05
ZA200007638B (en) 2001-11-13
PL344412A1 (en) 2001-11-05
EP1083171A1 (en) 2001-03-14
TW572898B (en) 2004-01-21
WO1999062884A1 (es) 1999-12-09
HUP0102102A2 (hu) 2002-03-28
DE69916828D1 (de) 2004-06-03
GEP20043237B (en) 2004-05-25
ES2137138A1 (es) 1999-12-01
US6353117B1 (en) 2002-03-05
AR018402A1 (es) 2001-11-14
LT2000108A (en) 2001-09-25
LV12632A (lv) 2001-03-20
IS2040B (is) 2005-08-15
CN1307566A (zh) 2001-08-08
CA2333475C (en) 2009-12-08
DK1083171T3 (da) 2004-08-09
NO20006029L (no) 2001-01-26
ATE265437T1 (de) 2004-05-15
ES2137138B1 (es) 2000-09-16
SI20580B (sl) 2007-10-31
NZ508990A (en) 2002-12-20
DE69916828T2 (de) 2005-04-14
EP1083171B1 (en) 2004-04-28
NO316600B1 (no) 2004-03-01
KR100603666B1 (ko) 2006-07-24
IS5736A (is) 2000-11-28
LV12632B (en) 2001-07-20
RU2233272C2 (ru) 2004-07-27
CZ298391B6 (cs) 2007-09-19
PT1083171E (pt) 2004-09-30
HUP0102102A3 (en) 2002-06-28
BG105005A (en) 2001-08-31
CA2333475A1 (en) 1999-12-09
SK18072000A3 (sk) 2001-07-10
CZ20004418A3 (en) 2001-06-13
BG64950B1 (bg) 2006-10-31
CU22995A3 (es) 2004-10-12
NO20006029D0 (no) 2000-11-28
CN1189459C (zh) 2005-02-16
SK285550B6 (sk) 2007-03-01
CO5031241A1 (es) 2001-04-27
KR20010052437A (ko) 2001-06-25
SI20580A (sl) 2001-12-31

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B09B Patent application refused [chapter 9.2 patent gazette]

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