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BR9910016A - Microesferas, processo de preparação das mesmas, e, composições farmacêuticas - Google Patents

Microesferas, processo de preparação das mesmas, e, composições farmacêuticas

Info

Publication number
BR9910016A
BR9910016A BR9910016-9A BR9910016A BR9910016A BR 9910016 A BR9910016 A BR 9910016A BR 9910016 A BR9910016 A BR 9910016A BR 9910016 A BR9910016 A BR 9910016A
Authority
BR
Brazil
Prior art keywords
microspheres
carbon atoms
alkyl group
preparation process
pharmaceutical compositions
Prior art date
Application number
BR9910016-9A
Other languages
English (en)
Inventor
Nicole Bru-Magniez
Catherine Le Visage
Elias Fattal
Patrick Couvreur
Pascal Breton
Original Assignee
Virsol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virsol filed Critical Virsol
Publication of BR9910016A publication Critical patent/BR9910016A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2335/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

"MICROESFERAS, PROCESSO DE PREPARAçãO DAS MESMAS, E, COMPOSIçõES FARMACêUTICAS". A presente invenção tem por objeto novas microesferas notadamente úteis no domínio farmacêutico como vetores particulares destinados ao transporte de substâncias biologicamente ativas, particularmente substâncias hidrófilas, em vista de uma administração oral. De acordo com a invenção, estas microesferas são constituídas por uma rede contínua de um material de suporte no qual é eventualmente dispersa uma substância, o referido material de suporte contendo pelo menos 70% em peso de um homopolímero constituído por unidades recorrentes respondendo à fórmula geral (I) em que R~ 1~ representa um grupo alquila tendo de 1 a 6 átomos de carbono ou um grupo (CH~ 2~)~ m~ -COOR~ 3~ em que m é um inteiro compreendido entre 1 e 5 e R~ 3~ representa um grupo alquila tendo de 1 a 6 átomos de carbono; - R~ 2~ representa um grupo alquila tendo de 1 a 6 átomos de carbono, e - n é um inteiro compreendido entre 1 e 5. Aplicação: domínio farmacêutico.
BR9910016-9A 1998-04-29 1999-04-28 Microesferas, processo de preparação das mesmas, e, composições farmacêuticas BR9910016A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9805424A FR2778100B1 (fr) 1998-04-29 1998-04-29 Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant
PCT/FR1999/001005 WO1999055309A1 (fr) 1998-04-29 1999-04-28 Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
BR9910016A true BR9910016A (pt) 2001-01-09

Family

ID=9525849

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910016-9A BR9910016A (pt) 1998-04-29 1999-04-28 Microesferas, processo de preparação das mesmas, e, composições farmacêuticas

Country Status (15)

Country Link
US (1) US6440461B1 (pt)
EP (1) EP1082104A1 (pt)
JP (1) JP2002513042A (pt)
KR (1) KR20010043060A (pt)
CN (1) CN1146408C (pt)
AR (1) AR019114A1 (pt)
AU (1) AU752644B2 (pt)
BR (1) BR9910016A (pt)
CA (1) CA2330481A1 (pt)
FR (1) FR2778100B1 (pt)
HU (1) HUP0101649A3 (pt)
PL (1) PL343687A1 (pt)
RU (1) RU2227018C2 (pt)
SK (1) SK16312000A3 (pt)
WO (1) WO1999055309A1 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4611561B2 (ja) * 2000-04-12 2011-01-12 Ｄｉｃ株式会社 新規なビニル系樹脂およびその製造方法
FR2812551B1 (fr) * 2000-08-07 2003-03-28 Virsol Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
AU2002211602A1 (en) * 2000-10-11 2002-04-22 Johns Hopkins University Polymer controlled delivery of a therapeutic agent
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US8598092B2 (en) * 2005-02-02 2013-12-03 Halliburton Energy Services, Inc. Methods of preparing degradable materials and methods of use in subterranean formations
JP5339673B2 (ja) * 2006-08-31 2013-11-13 キヤノン株式会社 微粒子の製造方法
US8106234B2 (en) * 2009-05-07 2012-01-31 OptMed, Inc Methylidene malonate process
US8975435B2 (en) 2009-05-07 2015-03-10 Optmed, Inc. Methylidene malonate process
CA2768149A1 (en) * 2009-07-14 2011-01-20 Lucia Irene Gonzalez Stereoisomer peptides and their polymer conjugates for hiv disease
WO2011059779A2 (en) * 2009-10-29 2011-05-19 Lucia Irene Gonzalez Ligand-targeted multi- stereoisomer peptide polymer conjugates and uses thereof
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
WO2012054616A2 (en) 2010-10-20 2012-04-26 Bioformix, Llc Synthesis of methylene malonates substantially free of impurities
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
EP2768897B1 (en) 2011-10-19 2019-01-23 Sirrus, Inc. Methods for making methylene beta-diketone monomers
US9234107B2 (en) 2012-03-30 2016-01-12 Sirrus, Inc. Ink coating formulations and polymerizable systems for producing the same
CA2869108A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
EP3153530B1 (en) 2012-03-30 2021-02-24 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
US10047192B2 (en) 2012-06-01 2018-08-14 Sirrus, Inc. Optical material and articles formed therefrom
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
JP6549038B2 (ja) 2012-11-30 2019-07-24 シラス・インコーポレイテッド エレクトロニクス適用のための複合組成物
WO2014110388A1 (en) 2013-01-11 2014-07-17 Bioformix Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
CN110709436B (zh) 2017-06-02 2022-06-28 阿科玛法国公司 可固化组合物及其用途
EP3758668B1 (en) * 2018-07-25 2022-02-23 Firmenich SA Process for preparing microcapsules
WO2020123579A1 (en) * 2018-12-11 2020-06-18 Sirrus, Inc. Polymerization of 1,1-dicarbonyl 1-alkenes
CN114127220B (zh) 2019-07-19 2024-01-19 阿科玛法国公司 可用于获得非致敏性的固化产品的可固化组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
DE19508049C2 (de) 1995-02-23 1997-02-06 Schering Ag Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln
FR2755136B1 (fr) * 1996-10-25 1999-01-22 Virsol Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
HUP0101649A3 (en) 2002-10-28
CN1303274A (zh) 2001-07-11
JP2002513042A (ja) 2002-05-08
CA2330481A1 (en) 1999-11-04
KR20010043060A (ko) 2001-05-25
AU752644B2 (en) 2002-09-26
EP1082104A1 (fr) 2001-03-14
AR019114A1 (es) 2001-12-26
CN1146408C (zh) 2004-04-21
WO1999055309A1 (fr) 1999-11-04
HUP0101649A2 (hu) 2002-03-28
SK16312000A3 (sk) 2001-04-09
US6440461B1 (en) 2002-08-27
PL343687A1 (en) 2001-08-27
FR2778100B1 (fr) 2001-05-04
FR2778100A1 (fr) 1999-11-05
RU2227018C2 (ru) 2004-04-20
AU3428899A (en) 1999-11-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.