[go: up one dir, main page]

BR9712372A - Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica. - Google Patents

Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica.

Info

Publication number
BR9712372A
BR9712372A BR9712372-2A BR9712372A BR9712372A BR 9712372 A BR9712372 A BR 9712372A BR 9712372 A BR9712372 A BR 9712372A BR 9712372 A BR9712372 A BR 9712372A
Authority
BR
Brazil
Prior art keywords
polymer
nanoparticles formed
compound
pharmaceutical composition
statistically
Prior art date
Application number
BR9712372-2A
Other languages
English (en)
Inventor
Nicole Bru-Magniez
Xavier Guillon
Pascal Breton
Patric Couvreur
Francois Lescure
Claude Roques-Carmes
Gerard Riess
Original Assignee
Virsol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virsol filed Critical Virsol
Publication of BR9712372A publication Critical patent/BR9712372A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/10—Esters
    • C08F22/12—Esters of phenols or saturated alcohols
    • C08F22/14—Esters having no free carboxylic acid groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymerisation Methods In General (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE NANOPARTìCULAS FORMADAS POR UM POLìMERO ESTATìSTICO, NANOPARTìCULAS FOMADAS POR UM POLìMERO ESTATìSTICO DE PELO MENOS UM COMPOSTO, E, COMPOSIçãO FARMACêUTICAS". A invenção refere-se a um processo de preparação de nanopartículas formadas por um polímero estatístico de pelo menos um composto de fórmula (I) na qual A representa um grupo (a) ou um grupo (b), R~ 1~ e R~ 2~, idênticos ou diferentes, representam um grupo C~ 1~ -C~ 6~ alquila linear ou ramificado; n = 1, 2, 3,4 ou 5, caracterizado pelo fato do monómero ser previamente solubilizado em um solvente orgânico aprótico miscível em água, formando com o meio de polimerização uma mistura não solvente para o polímero formado. A invenção refere-se igualmente as ditas manopartículas, contendo eventualmente uma ou mais moléculas biologicamente ativas, e composições farmacêuticas contendo as mesmas.
BR9712372-2A 1996-10-25 1997-10-24 Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica. BR9712372A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9613039A FR2755136B1 (fr) 1996-10-25 1996-10-25 Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant
PCT/FR1997/001907 WO1998018455A1 (fr) 1996-10-25 1997-10-24 Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives

Publications (1)

Publication Number Publication Date
BR9712372A true BR9712372A (pt) 2000-01-25

Family

ID=9497032

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712372-2A BR9712372A (pt) 1996-10-25 1997-10-24 Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica.

Country Status (23)

Country Link
US (2) US6211273B1 (pt)
EP (1) EP0934059B1 (pt)
JP (1) JP2001504530A (pt)
KR (1) KR20000052813A (pt)
CN (1) CN1237903A (pt)
AR (1) AR009127A1 (pt)
AT (1) ATE245171T1 (pt)
AU (1) AU736097B2 (pt)
BR (1) BR9712372A (pt)
CA (1) CA2269783C (pt)
CZ (1) CZ144099A3 (pt)
DE (1) DE69723571T2 (pt)
FR (1) FR2755136B1 (pt)
HU (1) HUP9904359A3 (pt)
IL (1) IL129355A0 (pt)
NO (1) NO991942L (pt)
NZ (1) NZ335094A (pt)
PL (1) PL332957A1 (pt)
RU (1) RU2214421C2 (pt)
SK (1) SK55599A3 (pt)
TW (1) TW503109B (pt)
WO (1) WO1998018455A1 (pt)
ZA (1) ZA979550B (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2774096B1 (fr) * 1998-01-29 2000-04-07 Virsol Nouveaux copolymeres tensioactifs a base de methylidene malonate
FR2778100B1 (fr) * 1998-04-29 2001-05-04 Virsol Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant
FR2789314B1 (fr) * 1999-02-09 2001-04-27 Virsol Materiau de suture de plaies a base de methylidene malonate
WO2001077238A1 (fr) * 2000-04-12 2001-10-18 Dainippon Ink And Chemicals, Inc. Composition de revetement antisalissure et nouvelle resine
JP4611561B2 (ja) * 2000-04-12 2011-01-12 Ｄｉｃ株式会社 新規なビニル系樹脂およびその製造方法
FR2812551B1 (fr) * 2000-08-07 2003-03-28 Virsol Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
AU2002211602A1 (en) * 2000-10-11 2002-04-22 Johns Hopkins University Polymer controlled delivery of a therapeutic agent
KR100457824B1 (ko) * 2001-08-10 2004-11-18 한국화학연구원 용액 열분해법에 의한 나노 크기 2가 금속 산화물 분말의제조
JP3961312B2 (ja) 2002-02-26 2007-08-22 株式会社デンソー 内燃機関の制御装置
US8697120B2 (en) * 2006-05-01 2014-04-15 Johns Hopkins University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
EP2123262A1 (en) * 2008-05-20 2009-11-25 Consorzio per il Centro di Biomedica Moleculare Scrl Polyelectrolyte-encapsulated gold nanoparticles capable of crossing blood-brain barrier
RU2390016C2 (ru) * 2008-06-16 2010-05-20 Государственное образовательное учреждение высшего профессионального образования Иркутский государственный университет путей сообщения (ИрГУПС (ИрИИТ)) Способ определения рифампицина
US8106234B2 (en) * 2009-05-07 2012-01-31 OptMed, Inc Methylidene malonate process
US8975435B2 (en) 2009-05-07 2015-03-10 Optmed, Inc. Methylidene malonate process
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
WO2012054616A2 (en) 2010-10-20 2012-04-26 Bioformix, Llc Synthesis of methylene malonates substantially free of impurities
US9279022B1 (en) * 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
EP2768897B1 (en) 2011-10-19 2019-01-23 Sirrus, Inc. Methods for making methylene beta-diketone monomers
US9234107B2 (en) 2012-03-30 2016-01-12 Sirrus, Inc. Ink coating formulations and polymerizable systems for producing the same
EP3153530B1 (en) 2012-03-30 2021-02-24 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
CA2869108A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
US10047192B2 (en) 2012-06-01 2018-08-14 Sirrus, Inc. Optical material and articles formed therefrom
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
JP6549038B2 (ja) 2012-11-30 2019-07-24 シラス・インコーポレイテッド エレクトロニクス適用のための複合組成物
WO2014110388A1 (en) 2013-01-11 2014-07-17 Bioformix Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
WO2016205605A1 (en) * 2015-06-19 2016-12-22 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
CN110709436B (zh) 2017-06-02 2022-06-28 阿科玛法国公司 可固化组合物及其用途
WO2020123579A1 (en) * 2018-12-11 2020-06-18 Sirrus, Inc. Polymerization of 1,1-dicarbonyl 1-alkenes
CN114127220B (zh) 2019-07-19 2024-01-19 阿科玛法国公司 可用于获得非致敏性的固化产品的可固化组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2965725D1 (en) * 1978-07-19 1983-07-28 Patrick Couvreur Biodegradable nanoparticles, pharmaceutical compositions containing them and process for their preparation
FR2611705B1 (fr) * 1987-03-05 1989-07-13 Union Pharma Scient Appl Procede de preparation de monesters ou diesters de l'acide endoethano-9, 10 dihydro-9, 10 anthracene bicarboxylique-11, 11, nouveaux monesters ou diesters ainsi prepares et utilisation de ceux-ci pour la preparation de methylenemalonates symetriques ou asymetriques
FR2722411B1 (fr) * 1994-07-18 1996-10-04 Union Pharma Scient Appl Immunonanoparticules revetues d'anticorps monoclonaux anti-beta2 microglobuline et leur utilisation pour la prophylaxie et/ou le traitement de pathologies dues a une infection par le virus hiv

Also Published As

Publication number Publication date
EP0934059B1 (fr) 2003-07-16
WO1998018455A1 (fr) 1998-05-07
FR2755136A1 (fr) 1998-04-30
NZ335094A (en) 2001-05-25
KR20000052813A (ko) 2000-08-25
FR2755136B1 (fr) 1999-01-22
AR009127A1 (es) 2000-03-08
US6211273B1 (en) 2001-04-03
US20010006989A1 (en) 2001-07-05
CA2269783C (en) 2005-01-11
HUP9904359A3 (en) 2000-11-28
JP2001504530A (ja) 2001-04-03
PL332957A1 (en) 1999-10-25
DE69723571D1 (de) 2003-08-21
ATE245171T1 (de) 2003-08-15
HUP9904359A2 (hu) 2000-05-28
NO991942L (no) 1999-06-23
CN1237903A (zh) 1999-12-08
CZ144099A3 (cs) 1999-09-15
US6420468B2 (en) 2002-07-16
ZA979550B (en) 1998-05-12
EP0934059A1 (fr) 1999-08-11
TW503109B (en) 2002-09-21
AU4950997A (en) 1998-05-22
NO991942D0 (no) 1999-04-23
AU736097B2 (en) 2001-07-26
CA2269783A1 (en) 1998-05-07
SK55599A3 (en) 2000-03-13
RU2214421C2 (ru) 2003-10-20
IL129355A0 (en) 2000-02-17
DE69723571T2 (de) 2004-06-03

Similar Documents

Publication Publication Date Title
BR9712372A (pt) Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica.
ATE45283T1 (de) Zusammensetzungen fuer die herstellung von mikropartikeln durch extrusion fuer verzoegerte abgabe von biologisch aktiven substanzen und so erhaltene mikropartikel.
BR8504463A (pt) Resina quimicamente endurecivel,processo para sua preparacao,misturas de compostos e misturas endurecidas de compostos
BR9908537A (pt) Copolìmeros biocompatìveis e utilização dos mesmos
BR9305427A (pt) Processo de preparação de composições betume-polímero, aplicação das composições obtidas para a realização de revestimentos e solução mãe de polimero para a obtenção das ditas composições
BR9910611A (pt) Composição de catalisador para polimerizar monÈmeros
BR9815464A (pt) Polìmero, processo de preparação de polìmeros, utilização de um polìmero, composição, associação de pelo menos um polìmero com pelo menos um composto e composição cosmética
BR9815570A (pt) Composto, processo de preparação dos compostos, utilização de pelo menos um composto, composição cosmética ou farmacêutica e utilização de pelos menos um polìmero
BR9916711A (pt) Composto, composição de tensoativo, processo para preparar compostos, agente de modificação de viscosidade, e, auxiliar de flotação de minério
BR9505057A (pt) Composição curável para revestimento método para revestir um substrato revestimento e revestimento compósito
BR0014446A (pt) Composições catalisadoras organometais
BR9811802A (pt) Composições contendo fìler, estabilizadas à sedimentação, curáveis por radiação
BR9910016A (pt) Microesferas, processo de preparação das mesmas, e, composições farmacêuticas
ATE394437T1 (de) Verwendung von dispersionen silylterminierter polymerer als dichtmassen
BR0103844A (pt) Sistema de aditivo polimérico múltiplo, processo para produzir o mesmo, composição polimérica, e, processo para produzir a mesma
BR9916145A (pt) Composição de revestimento consistindo de pelo menos três componentes, a sua preparação e uso
PT1158962E (pt) Processo para a preparacao de formas de dosagem solidas que contem ciclodextrina
TW354793B (en) Polycarbonate resin with high flowability and process for producing the same
BR0208323A (pt) Partìcula dispersìvel em água, método de deposição de um agente de benefìcio sobre um substrato, e, composição
BR9505045A (pt) Composição de revestimento curável método para revestir um substrato revestimento compósito
KR910004888A (ko) 직물연화 조성물
BR0115590A (pt) Materiais de revestimento de pó curável, processo para sua preparação e sistema misturador para materiais de revestimento em pó
KR960034338A (ko) 1액형도료조성물 및 그의 도장방법
BR0103843A (pt) Sistema de aditivo polimérico, processo para produzir o mesmo, composição polimérica, e, processo para produzir a mesma
KR927003488A (ko) 술폰화제 및 술폰화법

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1834 DE 01/03/2006.