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BR9909898A - Processo para purificação de um derivado de cefalosporina - Google Patents

Processo para purificação de um derivado de cefalosporina

Info

Publication number
BR9909898A
BR9909898A BR9909898-9A BR9909898A BR9909898A BR 9909898 A BR9909898 A BR 9909898A BR 9909898 A BR9909898 A BR 9909898A BR 9909898 A BR9909898 A BR 9909898A
Authority
BR
Brazil
Prior art keywords
purification
cephalosporin derivative
cefixime
ceph
vwhich
Prior art date
Application number
BR9909898-9A
Other languages
English (en)
Inventor
Martin Decristoforo
Johannes Ludescher
Hubert Sturm
Werner Veit
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of BR9909898A publication Critical patent/BR9909898A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PURIFICAçãO DE UM DERIVADO DE CEFALOSPORINA"<D>. Processo para purificação de cefixima através de um novo sal de terc-octilamina de um intermediário que pode ser cristalino e que pode ser produzido em uma reação de pote de ácido 7-amino-3-vinil-cef-3-em-4-carboxílico.
BR9909898-9A 1998-04-02 1999-03-31 Processo para purificação de um derivado de cefalosporina BR9909898A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0057598A AT406773B (de) 1998-04-02 1998-04-02 Neues salz von 7-(2-(aminothiazol-4yl)-2-
PCT/EP1999/002222 WO1999051607A2 (en) 1998-04-02 1999-03-31 Process for purification of a cephalosporin derivative

Publications (1)

Publication Number Publication Date
BR9909898A true BR9909898A (pt) 2000-12-26

Family

ID=3494225

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909898-9A BR9909898A (pt) 1998-04-02 1999-03-31 Processo para purificação de um derivado de cefalosporina

Country Status (15)

Country Link
US (1) US6825345B2 (pt)
EP (1) EP1068211B1 (pt)
JP (1) JP2002510694A (pt)
KR (1) KR20010034671A (pt)
CN (1) CN1134447C (pt)
AT (2) AT406773B (pt)
AU (1) AU3603599A (pt)
BR (1) BR9909898A (pt)
CA (1) CA2326441C (pt)
DE (1) DE69937143T2 (pt)
ES (1) ES2293720T3 (pt)
ID (1) ID26210A (pt)
TR (1) TR200002838T2 (pt)
WO (1) WO1999051607A2 (pt)
ZA (1) ZA200004899B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT404727B (de) * 1997-01-16 1999-02-25 Biochemie Gmbh Kristallines salz von cefixim und verfahren zu dessen herstellung
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
US7244842B2 (en) * 2002-11-15 2007-07-17 Orchid Chemicals & Pharmaceuticals Ltd. Amorphous hydrate of a cephalosporin antibiotic
AU2003294161A1 (en) * 2003-03-20 2004-10-11 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of cefoxitin
ATE423123T1 (de) * 2004-12-21 2009-03-15 Lupin Ltd Verfahren zur hestellung von cefixim
EP1863822B1 (en) * 2005-03-29 2009-10-14 Hetero Drugs Limited An improved process for the preparation of cefixime
CN1312158C (zh) * 2005-05-20 2007-04-25 天津市医药集团技术发展有限公司 一种头孢克肟的制备方法
CN101812075B (zh) * 2010-05-07 2012-06-13 郝志艳 一种头孢克肟化合物及其新制法
CN103265562A (zh) * 2013-05-29 2013-08-28 四川方向药业有限责任公司 头孢克肟的制备方法
CN103965217A (zh) * 2014-05-21 2014-08-06 广州白云山制药股份有限公司广州白云山化学制药厂 3-三嗪环-7-（噻唑羧甲氧亚氨基）头孢烷酸的制备方法
CN103965216A (zh) * 2014-05-21 2014-08-06 广州白云山制药股份有限公司广州白云山化学制药厂 7-（噻唑羧甲氧亚氨基)- 3-三嗪环头孢化合物的制造方法
WO2016142902A1 (en) * 2015-03-11 2016-09-15 Lupin Limited Cefixime with reduced surface area and high stability

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS58986A (ja) * 1981-05-07 1983-01-06 Fujisawa Pharmaceut Co Ltd セフェム化合物
JPS57192392A (en) * 1981-05-19 1982-11-26 Sankyo Co Ltd Production of 3-alkoxymethylcephalosporin
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
DE3377061D1 (en) * 1982-06-03 1988-07-21 Hoffmann La Roche Process for the preparation of 1-sulfo-2-oxoazetidine derivatives
EP0096296B1 (de) 1982-06-03 1987-07-29 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 1-Sulfo-2-oxoazetidinderivate
JPS59163387A (ja) * 1983-03-07 1984-09-14 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリンの製造方法
JPH0692416B2 (ja) * 1985-03-13 1994-11-16 三共株式会社 セフアロスポラン酸誘導体
DE3779768D1 (de) * 1986-02-07 1992-07-23 Hoffmann La Roche Verfahren zur herstellung von carbonsaeureamiden.
US5359057A (en) 1986-02-07 1994-10-25 Hoffmann-La Roche Inc. Acylation of amines
JPH01242589A (ja) * 1988-03-22 1989-09-27 Fujisawa Pharmaceut Co Ltd セフエム化合物
KR950700311A (ko) * 1992-02-05 1995-01-16 게오르게스 그렐리니, 한스 루돌프하우스 3-세펨-4-카복실산 유도체의 정제방법(Process for the purification of a 3-cephem-4-carboxylic acid derivatives)
DK0658558T3 (da) * 1993-11-17 2001-04-17 Biochemie Gmbh Adskillelse af cephalosporinisomere
AT403049B (de) * 1995-08-14 1997-10-27 Biochemie Gmbh Abreicherung von 7-adca in 3-vinyl-aca
AT404251B (de) * 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim
EP0831093A1 (en) * 1996-09-23 1998-03-25 F. Hoffmann-La Roche Ag 1-Carba-(dethia)-Cephalosporin Derivatives
TW538045B (en) * 1997-01-16 2003-06-21 Biochemie Gmbh Process for purifying cefixime

Also Published As

Publication number Publication date
TR200002838T2 (tr) 2001-02-21
AU3603599A (en) 1999-10-25
EP1068211B1 (en) 2007-09-19
ID26210A (id) 2000-12-07
CN1134447C (zh) 2004-01-14
US20030208065A1 (en) 2003-11-06
CN1295576A (zh) 2001-05-16
WO1999051607A3 (en) 2000-01-27
WO1999051607A2 (en) 1999-10-14
AT406773B (de) 2000-08-25
ES2293720T3 (es) 2008-03-16
HK1034078A1 (en) 2001-10-12
ZA200004899B (en) 2001-12-24
ATE373666T1 (de) 2007-10-15
CA2326441A1 (en) 1999-10-14
JP2002510694A (ja) 2002-04-09
US6825345B2 (en) 2004-11-30
DE69937143T2 (de) 2008-06-12
KR20010034671A (ko) 2001-04-25
EP1068211A2 (en) 2001-01-17
ATA57598A (de) 2000-01-15
DE69937143D1 (de) 2007-10-31
CA2326441C (en) 2008-03-18

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL: CO7D 501/22; CO7D 277/82; CO7D 501/00; CO7D 501/06; CO7D 277/74; A61K 31/546.

Ipc: C07D 501/22 (2008.04), C07D 277/74 (2008.04)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O, 13 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.