BR9909775A - Amida, uso de amidas e preparação farmacêutica - Google Patents
Amida, uso de amidas e preparação farmacêuticaInfo
- Publication number
- BR9909775A BR9909775A BR9909775-3A BR9909775A BR9909775A BR 9909775 A BR9909775 A BR 9909775A BR 9909775 A BR9909775 A BR 9909775A BR 9909775 A BR9909775 A BR 9909775A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- hydrogen
- branched
- unbranched
- amides
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 4
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 2
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 102000005600 Cathepsins Human genes 0.000 abstract 1
- 108010084457 Cathepsins Proteins 0.000 abstract 1
- 108010044467 Isoenzymes Proteins 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000005495 pyridazyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
Abstract
"AMIDA, USO DE AMIDAS E PREPARAçãO FARMACêUTICA". A invenção refere-se a amidas da fórmula geral (I) e às suas formas tautoméricas e isoméricas, as suas possíveis formas enancioméricas e diastereoméricas e possíveis sais fisiologicamente compatíveis, onde as variáveis têm os seguintes significados: R1 é alquila C~ 1~-C~ 6~, fenila, naftila, quinolila, piridila, pirimidila, piridazila, quinazolila e quinoxalila, onde os anéis podem ainda ser substituídos com até 2 radicais R4; R2 é -(CH2)m-R8, onde R8 é fenila, ciclohexila ou indolila e m é 1 a 6; X é uma ligação,-CH2 -, -CH~ 2~CH~ 2~-,-CH=CH -, -C<154>C-, -CONH-, -,-SO~ 2~NH -, e R1-X juntos podem também ser a fórmula (a), R3 é hidrogênio e CO-NR 6 R 7; R4 é hidrogênio, alquila C~ 1~-C~ 4~ ramificada ou não ramificada e O-alquila C~ 1~-C~ 4~; R5 é hidrogênio, alquila C~ 1~-C~ 4~e O-alquila C~ 1~-C~ 4~ ramificada ou não ramificada; R6 é hidrogênio, C~ 1~-C~ 6~ alquila ramificada ou não ramificada; R7 é hidrogênio, alquila C~ 1~-C~ 6~ ramificada ou não ramificada; e n é 0, 1 ou 2. As amidas da fórmula (I) são inibidoras de enzimas, especialmente proteases de cisteína como as calpeínas (proteases de cisteína dependentes de cálcio) e suas isoenzimas e catepsinas, tais como B e L.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19818614A DE19818614A1 (de) | 1998-04-20 | 1998-04-20 | Neue substituierte Amide, deren Herstellung und Anwendung |
| PCT/EP1999/002618 WO1999054294A1 (de) | 1998-04-20 | 1999-04-19 | Neue substituierte amide, deren herstellung und anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9909775A true BR9909775A (pt) | 2000-12-19 |
Family
ID=7865830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9909775-3A BR9909775A (pt) | 1998-04-20 | 1999-04-19 | Amida, uso de amidas e preparação farmacêutica |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6448254B1 (pt) |
| EP (1) | EP1073631A1 (pt) |
| JP (1) | JP2002512221A (pt) |
| KR (1) | KR20010042836A (pt) |
| CN (1) | CN1297432A (pt) |
| AU (1) | AU753402B2 (pt) |
| BG (1) | BG104855A (pt) |
| BR (1) | BR9909775A (pt) |
| CA (1) | CA2328435A1 (pt) |
| DE (1) | DE19818614A1 (pt) |
| HR (1) | HRP20000776A2 (pt) |
| HU (1) | HUP0101624A3 (pt) |
| ID (1) | ID26402A (pt) |
| IL (1) | IL138412A0 (pt) |
| NO (1) | NO20005266L (pt) |
| PL (1) | PL343465A1 (pt) |
| SK (1) | SK13942000A3 (pt) |
| TR (1) | TR200003028T2 (pt) |
| WO (1) | WO1999054294A1 (pt) |
| ZA (1) | ZA200006711B (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6683581B2 (en) * | 2000-12-29 | 2004-01-27 | Bellsouth Intellectual Property Corporation | Antenna alignment devices |
| DE10114762A1 (de) * | 2001-03-26 | 2002-10-02 | Knoll Gmbh | Verwendung von Cysteinprotease-Inhibitoren |
| EP1411933A1 (en) * | 2001-08-03 | 2004-04-28 | SmithKline Beecham Corporation | Alpha-ketoamide derivatives as cathepsin k inhibitors |
| JP2005515254A (ja) * | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | カテプシンｋ阻害剤として有用なシクロアルキルケトアミド誘導体 |
| EP1562897B1 (en) | 2002-11-12 | 2009-09-16 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer s disease |
| GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| KR101194176B1 (ko) * | 2003-12-22 | 2012-10-24 | 아지노모토 가부시키가이샤 | 신규한 페닐알라닌 유도체 |
| CN104788328B (zh) | 2004-06-24 | 2017-09-12 | 沃泰克斯药物股份有限公司 | Atp‑结合弹夹转运蛋白的调控剂 |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| EP1979367A2 (en) * | 2005-12-24 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Quinolin-4-one derivatives as modulators of abc transporters |
| WO2007079139A2 (en) | 2005-12-28 | 2007-07-12 | Vertex Pharmaceuticals, Inc. | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| CN101616908B (zh) | 2006-12-29 | 2014-09-10 | Abbvie德国有限责任两合公司 | 羧酰胺化合物及它们作为钙蛋白酶抑制剂的用途 |
| TWI453019B (zh) * | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
| DE102008027133A1 (de) * | 2008-05-30 | 2009-12-03 | Ls Medcap Gmbh | Vollsynthetisches Albumin-Analogon |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| SG10201504084QA (en) | 2009-03-20 | 2015-06-29 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| WO2012076639A1 (en) | 2010-12-09 | 2012-06-14 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors v |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CN109966264A (zh) | 2012-02-27 | 2019-07-05 | 沃泰克斯药物股份有限公司 | 药物组合物及其施用 |
| RU2014144285A (ru) | 2012-04-03 | 2016-05-27 | Эббви Дойчланд Гмбх Унд Ко. Кг | Карбоксамидные соединения и их применение в качестве ингибиторов кальпаина v |
| US9701639B2 (en) | 2014-10-07 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| US10590084B2 (en) | 2016-03-09 | 2020-03-17 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| WO2018009417A1 (en) | 2016-07-05 | 2018-01-11 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| CA3038331A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4000204A1 (de) | 1990-01-05 | 1991-07-11 | Steag Ag | Vorrichtung zum dosierten austragen von schuettfaehigem feststoff |
| US5289954A (en) | 1990-01-05 | 1994-03-01 | Steag Aktiengesellschaft | Device for metered removal of flowable solid material |
| CA2098702A1 (en) | 1990-12-28 | 1992-06-29 | James C. Powers | Peptide ketoamides, ketoacids, and ketoesters |
| CA2098609A1 (en) | 1990-12-28 | 1992-06-29 | Raymond T. Bartus | Use of calpain inhibitors in the inhibition and treatment of neurodegeneration |
| CA2071621C (en) | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
| EP0650368A1 (en) | 1992-06-24 | 1995-05-03 | Cortex Pharmaceuticals, Inc. | Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity |
| JP2848232B2 (ja) | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | アルデヒド誘導体 |
| WO1994019320A1 (en) | 1993-02-22 | 1994-09-01 | Merck Sharp & Dohme Limited | Aromatic compounds, compositions containing them and their use in therapy |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
| WO1996039194A1 (en) * | 1995-06-06 | 1996-12-12 | Athena Neurosciences, Inc. | Novel cathepsin and methods and compositions for inhibition thereof |
| WO1997010231A1 (en) | 1995-09-14 | 1997-03-20 | Cephalon, Inc. | Ketomethylene group-containing cysteine and serine protease inhibitors |
| CA2238175A1 (en) | 1995-11-28 | 1997-06-19 | Cephalon, Inc. | D-amino acid derived inhibitors of cysteine and serine proteases |
-
1998
- 1998-04-20 DE DE19818614A patent/DE19818614A1/de not_active Withdrawn
-
1999
- 1999-04-19 ID IDW20002112A patent/ID26402A/id unknown
- 1999-04-19 CA CA002328435A patent/CA2328435A1/en not_active Abandoned
- 1999-04-19 IL IL13841299A patent/IL138412A0/xx unknown
- 1999-04-19 BR BR9909775-3A patent/BR9909775A/pt not_active IP Right Cessation
- 1999-04-19 US US09/647,677 patent/US6448254B1/en not_active Expired - Fee Related
- 1999-04-19 AU AU36071/99A patent/AU753402B2/en not_active Ceased
- 1999-04-19 JP JP2000544635A patent/JP2002512221A/ja active Pending
- 1999-04-19 CN CN99805245A patent/CN1297432A/zh active Pending
- 1999-04-19 TR TR2000/03028T patent/TR200003028T2/xx unknown
- 1999-04-19 EP EP99917996A patent/EP1073631A1/de not_active Withdrawn
- 1999-04-19 HU HU0101624A patent/HUP0101624A3/hu unknown
- 1999-04-19 HR HR20000776A patent/HRP20000776A2/hr not_active Application Discontinuation
- 1999-04-19 KR KR1020007011600A patent/KR20010042836A/ko not_active Withdrawn
- 1999-04-19 SK SK1394-2000A patent/SK13942000A3/sk unknown
- 1999-04-19 WO PCT/EP1999/002618 patent/WO1999054294A1/de not_active Ceased
- 1999-04-19 PL PL99343465A patent/PL343465A1/xx not_active Application Discontinuation
-
2000
- 2000-10-13 BG BG104855A patent/BG104855A/xx unknown
- 2000-10-19 NO NO20005266A patent/NO20005266L/no not_active Application Discontinuation
- 2000-11-17 ZA ZA200006711A patent/ZA200006711B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL343465A1 (en) | 2001-08-13 |
| HUP0101624A2 (hu) | 2001-11-28 |
| HUP0101624A3 (en) | 2003-02-28 |
| CA2328435A1 (en) | 1999-10-28 |
| US6448254B1 (en) | 2002-09-10 |
| AU3607199A (en) | 1999-11-08 |
| SK13942000A3 (sk) | 2001-05-10 |
| EP1073631A1 (de) | 2001-02-07 |
| BG104855A (en) | 2001-05-31 |
| KR20010042836A (ko) | 2001-05-25 |
| DE19818614A1 (de) | 1999-10-21 |
| ID26402A (id) | 2000-12-21 |
| NO20005266D0 (no) | 2000-10-19 |
| IL138412A0 (en) | 2001-10-31 |
| TR200003028T2 (tr) | 2001-01-22 |
| ZA200006711B (en) | 2002-01-09 |
| JP2002512221A (ja) | 2002-04-23 |
| AU753402B2 (en) | 2002-10-17 |
| WO1999054294A1 (de) | 1999-10-28 |
| NO20005266L (no) | 2000-10-19 |
| HRP20000776A2 (en) | 2001-06-30 |
| CN1297432A (zh) | 2001-05-30 |
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