BR9905634A - Piperidinas 4-substituìdas, composições farmacêuticas e processo para tratamento de desordens do sistema nervoso central em seres humanos - Google Patents
Piperidinas 4-substituìdas, composições farmacêuticas e processo para tratamento de desordens do sistema nervoso central em seres humanosInfo
- Publication number
- BR9905634A BR9905634A BR9905634-8A BR9905634A BR9905634A BR 9905634 A BR9905634 A BR 9905634A BR 9905634 A BR9905634 A BR 9905634A BR 9905634 A BR9905634 A BR 9905634A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- treatment
- pharmaceutical compositions
- substituted piperidines
- nervous system
- Prior art date
Links
- -1 4-substituted piperidines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
- 206010041250 Social phobia Diseases 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000012154 norepinephrine uptake Effects 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 230000013275 serotonin uptake Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"PIPERIDINAS 4-SUBSTITUìDAS, COMPOSIçõES FARMACêUTICAS E PROCESSO PARA TRATAMENTO DE DESORDENS DO SISTEMA NERVOSO CENTRAL EM SERES HUMANOS"<D>. Novas piperidinas 4-substituídas de fórmula genérica (I) são descritas conde R~ 1~ e R~ 2~ são radicais arila, substituídos ou não, que são obtidos como misturas racêmicas e como enanciómeros puros. Estes compostos e seus farmaceuticamente aceitáveis inibem retomada de serotonina e/ou noradrenalina, e são úteis como antidepressivos. Outras potenciais aplicações terapêuticas destes compostos são tratamento de bulimia nervosa, desordens compulsivas obsessivas, alcoolismo, ansiedade, pânico, dor, síndrome pré-menstrual, e fobia social assim como profilaxia de enxaqueca.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009802420A ES2157148B1 (es) | 1998-11-18 | 1998-11-18 | Nuevas piperidinas 4-sustituidas. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9905634A true BR9905634A (pt) | 2000-09-26 |
| BR9905634B1 BR9905634B1 (pt) | 2012-09-04 |
Family
ID=8305832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9905634-8A BR9905634B1 (pt) | 1998-11-18 | 1999-11-17 | piperidinas 4-substituìdas. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1002794B1 (pt) |
| JP (1) | JP4667552B2 (pt) |
| KR (1) | KR100646675B1 (pt) |
| AR (1) | AR028805A1 (pt) |
| AT (1) | ATE422199T1 (pt) |
| AU (1) | AU757177B2 (pt) |
| BR (1) | BR9905634B1 (pt) |
| CA (1) | CA2288533C (pt) |
| CY (1) | CY1108955T1 (pt) |
| CZ (1) | CZ296053B6 (pt) |
| DE (1) | DE69940378D1 (pt) |
| DK (1) | DK1002794T3 (pt) |
| ES (2) | ES2157148B1 (pt) |
| HR (1) | HRP990354B1 (pt) |
| HU (1) | HU227558B1 (pt) |
| IL (1) | IL132862A0 (pt) |
| NO (1) | NO314401B1 (pt) |
| PL (1) | PL196329B1 (pt) |
| PT (1) | PT1002794E (pt) |
| RU (1) | RU2232753C2 (pt) |
| TR (1) | TR199902839A3 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2485355A1 (en) * | 2002-05-30 | 2003-12-11 | Head Explorer A/S | The use of milnacipran for the treatment of tension-type headache |
| UA77536C2 (en) * | 2002-07-03 | 2006-12-15 | Lundbeck & Co As H | Secondary aminoaniline piperidines as mch1 antagonists and their use |
| AR041879A1 (es) * | 2002-11-01 | 2005-06-01 | Neurosearch As | Derivados de piperidina y su utilizacion como inhibidores de la reabsocion de los neurotransmisores monoamina |
| WO2005092885A1 (en) * | 2004-02-27 | 2005-10-06 | Eli Lilly And Company | 4-amino-piperidine derivatives as monoamine uptake inhibitors |
| WO2006009831A1 (en) | 2004-06-18 | 2006-01-26 | Wyeth | Processes for preparing 6-alkyl-5-arylsulfonyl- dihydrophenanthridines |
| EP1854785A1 (en) * | 2006-05-12 | 2007-11-14 | Faes Farma, S.A. | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions |
| EP2066630A1 (en) * | 2006-08-23 | 2009-06-10 | Pfizer Products Incorporated | Piperidine derivatives |
| EP2358675B9 (en) * | 2008-11-14 | 2019-09-11 | Theravance, Inc. | 4-[2-(2-Fluorophenoxymethyl)phenyl]piperidine compounds |
| EP2419405A1 (en) * | 2009-04-15 | 2012-02-22 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| EP2390248A1 (en) | 2010-05-24 | 2011-11-30 | Faes Farma, S.A. | Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies |
| CN103025714A (zh) | 2010-05-24 | 2013-04-03 | 飞思药物有限公司 | 用于治疗及预防淀粉样蛋白病理状态的氟芬辛衍生物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203149A (en) * | 1968-06-10 | 1970-08-26 | Ici Ltd | Piperidine derivatives |
| JPH0615529B2 (ja) * | 1985-04-01 | 1994-03-02 | エーザイ株式会社 | 新規ピペリジン誘導体 |
| JPH0840999A (ja) * | 1994-08-04 | 1996-02-13 | Yamanouchi Pharmaceut Co Ltd | フルオロインダン誘導体 |
| AUPN037195A0 (en) * | 1995-01-03 | 1995-01-27 | Australian Nuclear Science & Technology Organisation | Piperidine-based sigma receptor ligands |
| CO5150201A1 (es) * | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
-
1998
- 1998-11-18 ES ES009802420A patent/ES2157148B1/es not_active Expired - Fee Related
-
1999
- 1999-11-04 CA CA002288533A patent/CA2288533C/en not_active Expired - Fee Related
- 1999-11-08 HU HU9904086A patent/HU227558B1/hu not_active IP Right Cessation
- 1999-11-09 AR ARP990105657A patent/AR028805A1/es active IP Right Grant
- 1999-11-10 DK DK99500208T patent/DK1002794T3/da active
- 1999-11-10 PT PT99500208T patent/PT1002794E/pt unknown
- 1999-11-10 EP EP99500208A patent/EP1002794B1/en not_active Expired - Lifetime
- 1999-11-10 AT AT99500208T patent/ATE422199T1/de active
- 1999-11-10 IL IL13286299A patent/IL132862A0/xx not_active IP Right Cessation
- 1999-11-10 ES ES99500208T patent/ES2323742T3/es not_active Expired - Lifetime
- 1999-11-10 DE DE69940378T patent/DE69940378D1/de not_active Expired - Lifetime
- 1999-11-10 CZ CZ19993995A patent/CZ296053B6/cs not_active IP Right Cessation
- 1999-11-11 AU AU59366/99A patent/AU757177B2/en not_active Ceased
- 1999-11-16 HR HR990354A patent/HRP990354B1/xx not_active IP Right Cessation
- 1999-11-17 TR TR1999/02839A patent/TR199902839A3/tr unknown
- 1999-11-17 NO NO19995643A patent/NO314401B1/no not_active IP Right Cessation
- 1999-11-17 BR BRPI9905634-8A patent/BR9905634B1/pt not_active IP Right Cessation
- 1999-11-17 PL PL336607A patent/PL196329B1/pl not_active IP Right Cessation
- 1999-11-17 KR KR1019990051053A patent/KR100646675B1/ko not_active Expired - Fee Related
- 1999-11-17 RU RU99124412/04A patent/RU2232753C2/ru not_active IP Right Cessation
- 1999-11-18 JP JP32888599A patent/JP4667552B2/ja not_active Expired - Fee Related
-
2009
- 2009-04-02 CY CY20091100388T patent/CY1108955T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: C07D 211/22, A61K 31/4465, A61P 25/24 Ipc: C07D 211/22 (2008.04), A61K 31/4465 (2008.04), A61 |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AOS ARTIGOS 8, 13, 24 E 25 DA LPI |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/09/2012, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE AS 15A E 16A ANUIDADES. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2342 DE 24-11-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |