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BR9814880A - HormÈnios de glicoproteìna bifuncionais de cadeia única - Google Patents

HormÈnios de glicoproteìna bifuncionais de cadeia única

Info

Publication number
BR9814880A
BR9814880A BR9814880-0A BR9814880A BR9814880A BR 9814880 A BR9814880 A BR 9814880A BR 9814880 A BR9814880 A BR 9814880A BR 9814880 A BR9814880 A BR 9814880A
Authority
BR
Brazil
Prior art keywords
single chain
subunit
ligand
glycoprotein
glycoprotein hormones
Prior art date
Application number
BR9814880-0A
Other languages
English (en)
Inventor
Irving Boime
David Ben-Menahem
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of BR9814880A publication Critical patent/BR9814880A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: <B>"HORMÈNIOS DE GLICOPROTEìNA BIFUNCIONAIS DE CADEIA úNICA"<D>. Descreve-se agonistas e/ou antagonistas de cadeia única dos hormónios de glicoproteína. Estas proteínas são das fórmulas: (1) ß¹-(ligante¹)~ m~-<244>- (ligante²)~ n~- ß² (1); ou ß¹-(ligante)~ m~-ß²-(ligante)n- <244> ou (2) ß¹-ligante¹)~ m~- ß² -(ligante²)~ n~-<244>; ou (3) <244>-(ligante¹)~ m~-ß¹-(ligante²)~ n~-ß², em que cada um de ß¹ e ß² tem a sequência de aminoácidos da subunidade <225> de um hormónio de glicoproteína de vertebrado ou uma variante do mesmo; "<244>" designa a subunidade <244> de um hormónio de glicoproteína de vertebrado ou uma variante do mesmo; "ligante" refere-se a uma porção covalentemente ligada que espaceja as subunidades ß¹ e ß² em distâncias da subunidade <244> e de uma das outras eficaz para reter referida atividade, e cada um de m e n é , independentemente, 0 ou 1.
BR9814880-0A 1997-11-17 1998-11-09 HormÈnios de glicoproteìna bifuncionais de cadeia única BR9814880A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/971,439 US6103501A (en) 1997-11-17 1997-11-17 Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
PCT/US1998/023744 WO1999025849A1 (en) 1997-11-17 1998-11-09 Single-chain bifunctional glycoprotein hormones

Publications (1)

Publication Number Publication Date
BR9814880A true BR9814880A (pt) 2000-10-03

Family

ID=25518394

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814880-0A BR9814880A (pt) 1997-11-17 1998-11-09 HormÈnios de glicoproteìna bifuncionais de cadeia única

Country Status (16)

Country Link
US (1) US6103501A (pt)
EP (1) EP1032688B1 (pt)
JP (1) JP4255618B2 (pt)
KR (1) KR20010032147A (pt)
CN (1) CN1173037C (pt)
AU (1) AU754296B2 (pt)
BR (1) BR9814880A (pt)
CA (1) CA2308571C (pt)
CZ (1) CZ299742B6 (pt)
DE (1) DE69839779D1 (pt)
HU (1) HUP0004394A3 (pt)
IL (2) IL135995A0 (pt)
NO (1) NO20002527L (pt)
PL (1) PL342853A1 (pt)
TR (1) TR200001406T2 (pt)
WO (1) WO1999025849A1 (pt)

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US6635256B1 (en) * 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US7994278B1 (en) 1999-08-06 2011-08-09 Nobel Biosciences Llc Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
EP1224301A2 (en) * 1999-10-08 2002-07-24 Biofocus Discovery Limited Methods and compositions for targeting a cell
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
JP2001333772A (ja) * 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
WO2001081406A2 (en) * 2000-04-25 2001-11-01 Washington University Single-chain fertility hormones with variable lh activity
US6987172B2 (en) * 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
WO2004078061A2 (en) 2003-03-04 2004-09-16 Aspenbio, Inc. Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
US20080039372A1 (en) * 2005-07-21 2008-02-14 The Trustees Of Columbia University In The City Of New York Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
CA2628725A1 (en) 2005-11-15 2007-05-31 Glycofi, Inc. Production of glycoproteins with reduced o-glycosylation
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
WO2007092252A2 (en) * 2006-02-03 2007-08-16 Modigene Inc Long-acting polypeptides and methods of producing same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
CA2721459A1 (en) * 2008-05-20 2009-11-26 Merck Sharp & Dohme Corp. Efficient production of heterologous proteins using mannosyl transferase inhibitors
EP2324121B1 (en) 2008-08-12 2012-11-07 GlycoFi, Inc. Improved vectors and yeast strains for protein production: ca2+ atpase overexpression
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
AU2012286048A1 (en) 2011-07-18 2014-02-20 Arts Biologics A/S Long acting luteinizing hormone (LH) compound
BR112014025951A2 (pt) 2012-04-19 2017-07-11 Opko Biologics Ltd variantes de oxintomodulina de longa ação e métodos de produção do mesmo
US9808534B2 (en) 2012-11-20 2017-11-07 Opko Biologics Ltd. Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
PH12017501089B1 (en) 2014-12-10 2022-06-22 Opko Biologics Ltd Methods of producing long acting ctp-modified growth hormone polypeptides
KR102172937B1 (ko) 2015-06-19 2020-11-03 옵코 바이오로직스 리미티드 장기-작용성 응고 인자 및 그의 제조 방법
SG10202100189WA (en) 2016-07-11 2021-02-25 Opko Biologics Ltd Long-acting coagulation factor vii and methods of producing same
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
CN106279436B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 活化的人凝血因子vii融合蛋白及其制备方法与用途
WO2018032638A1 (zh) * 2016-08-19 2018-02-22 安源医药科技（上海）有限公司 用于构建融合蛋白的连接肽
CN106256835A (zh) * 2016-08-19 2016-12-28 安源医药科技（上海）有限公司 高糖基化人生长激素融合蛋白及其制备方法与用途
CN106317226B (zh) * 2016-08-19 2017-09-05 安源医药科技（上海）有限公司 用于构建融合蛋白的连接肽
CN107827987B (zh) * 2017-01-04 2021-04-27 华侨大学 一种促黄体激素类似物及其制备方法
CN110950964B (zh) * 2018-09-26 2021-06-18 安源医药科技（上海）有限公司 突变型单链人凝血因子viii融合蛋白及其制备方法与用途
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US20220143131A1 (en) 2019-05-16 2022-05-12 Ceva Sante Animale Compositions and Methods for increasing Reproduction Performance in Non Human Mammals Using Recombinant Luteinizing Hormone
US12365715B2 (en) * 2019-08-30 2025-07-22 Syntex S.A. Recombinant chorionic gonadotropin, procedure for preparation, pharmaceutical compositions and uses of the same
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CA1213537A (en) * 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
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DK0725795T3 (da) * 1994-08-12 2004-05-17 Univ Washington Enkelt-kæde form af glycoprotein-hormon-kvartetten

Also Published As

Publication number Publication date
WO1999025849A1 (en) 1999-05-27
DE69839779D1 (de) 2008-09-04
KR20010032147A (ko) 2001-04-16
IL135995A (en) 2007-03-08
CA2308571A1 (en) 1999-05-27
IL135995A0 (en) 2001-05-20
NO20002527D0 (no) 2000-05-16
HUP0004394A3 (en) 2003-04-28
CN1173037C (zh) 2004-10-27
EP1032688B1 (en) 2008-07-23
JP2001523465A (ja) 2001-11-27
NO20002527L (no) 2000-07-10
TR200001406T2 (tr) 2000-12-21
CZ299742B6 (cs) 2008-11-05
AU754296B2 (en) 2002-11-14
EP1032688A1 (en) 2000-09-06
CN1290301A (zh) 2001-04-04
HUP0004394A2 (hu) 2001-09-28
CA2308571C (en) 2013-04-23
AU1313199A (en) 1999-06-07
PL342853A1 (en) 2001-07-16
JP4255618B2 (ja) 2009-04-15
US6103501A (en) 2000-08-15
CZ20001774A3 (cs) 2000-10-11

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: O DEPOSITANTE DEIXOU DE APRESENTAR MANIFESTACAO SOBRE O PARECER NEGATIVO DE FOLHAS 75 A 76 PUBLICADO NA RPI N.O 1981, DE 23/12/2008. ASSIM, DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. PORTANTO, INDEFIRO O PRESENTE PEDIDO.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.