[go: up one dir, main page]

BR9813213A - Composições orais de levosimendan - Google Patents

Composições orais de levosimendan

Info

Publication number
BR9813213A
BR9813213A BR9813213-0A BR9813213A BR9813213A BR 9813213 A BR9813213 A BR 9813213A BR 9813213 A BR9813213 A BR 9813213A BR 9813213 A BR9813213 A BR 9813213A
Authority
BR
Brazil
Prior art keywords
levosimendan
oral compositions
polymorphic form
oral
describes
Prior art date
Application number
BR9813213-0A
Other languages
English (en)
Inventor
Maarit Harjula
Ilkka Larma
Saila Antila
Lasse Lehtonen
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of BR9813213A publication Critical patent/BR9813213A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSIçõES ORAIS DE LEVOSIMENDAN" é descrita uma composição para administração oral compreendendo a forma polimórfica cristalina (I) do levosimendan substancialmente pura como um componente ativo juntamente com um veículo farmaceuticamente aceitável. A forma polimórfica (I) do levosimendan é rapidamente absorvida a partir do trato gastrointestinal e é útil no tratamento da doença cardíaca congestiva.
BR9813213-0A 1997-09-26 1998-09-24 Composições orais de levosimendan BR9813213A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI973804A FI973804A7 (fi) 1997-09-26 1997-09-26 Levosimendaanin oraalisia koostumuksia
PCT/FI1998/000753 WO1999016443A1 (en) 1997-09-26 1998-09-24 Oral compositions of levosimendan

Publications (1)

Publication Number Publication Date
BR9813213A true BR9813213A (pt) 2000-08-29

Family

ID=8549609

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813213-0A BR9813213A (pt) 1997-09-26 1998-09-24 Composições orais de levosimendan

Country Status (35)

Country Link
US (1) US6355269B1 (pt)
EP (1) EP1014987B1 (pt)
JP (1) JP4493840B2 (pt)
KR (1) KR100762022B1 (pt)
CN (1) CN1149994C (pt)
AR (1) AR013519A1 (pt)
AT (1) ATE260659T1 (pt)
AU (1) AU732489B2 (pt)
BG (1) BG64746B1 (pt)
BR (1) BR9813213A (pt)
CA (1) CA2304702C (pt)
CZ (1) CZ294984B6 (pt)
DE (1) DE69822172T2 (pt)
DK (1) DK1014987T3 (pt)
EA (1) EA001647B1 (pt)
EE (1) EE03854B1 (pt)
ES (1) ES2217580T3 (pt)
FI (1) FI973804A7 (pt)
GE (1) GEP20032943B (pt)
HR (1) HRP20000171B1 (pt)
HU (1) HUP0003757A3 (pt)
ID (1) ID24486A (pt)
IL (1) IL134802A (pt)
MX (1) MXPA00002956A (pt)
MY (1) MY118156A (pt)
NO (1) NO320047B1 (pt)
NZ (1) NZ503207A (pt)
PL (1) PL190862B1 (pt)
PT (1) PT1014987E (pt)
RS (1) RS49708B (pt)
SI (1) SI1014987T1 (pt)
SK (1) SK283187B6 (pt)
TR (1) TR200000635T2 (pt)
WO (1) WO1999016443A1 (pt)
YU (1) YU17700A (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI980901A7 (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI980902A7 (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI20000577A0 (fi) * 2000-03-13 2000-03-13 Orion Yhtymae Oy Pyridatsinyylifenyylihydratsoneja
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
IL156310A0 (en) 2000-12-22 2004-01-04 Baxter Int Method for preparing submicron particle suspensions
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
FI20011465A0 (fi) * 2001-07-04 2001-07-04 Orion Corp Pyridatsinonijohdannaisen uusi käyttö
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
WO2003026611A2 (en) 2001-09-26 2003-04-03 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
KR20120090940A (ko) 2009-07-14 2012-08-17 시플라 리미티드 레보시멘단의 제조방법 및 상기 제조방법에 사용되는 중간체
CN104418810A (zh) * 2013-09-04 2015-03-18 北京博时安泰科技发展有限公司 一种左西孟旦的合成新路线
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
US11969424B2 (en) 2019-12-16 2024-04-30 Tenax Therapeutics, Inc. Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF)
CN111548310B (zh) * 2020-05-12 2021-07-02 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型及其制备方法
CN111718299B (zh) * 2020-07-23 2023-03-10 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型b及其制备方法
US11760730B2 (en) * 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan

Also Published As

Publication number Publication date
AR013519A1 (es) 2000-12-27
EP1014987B1 (en) 2004-03-03
JP4493840B2 (ja) 2010-06-30
EA200000360A1 (ru) 2000-10-30
KR20010030679A (ko) 2001-04-16
AU732489B2 (en) 2001-04-26
BG104250A (en) 2000-12-29
CZ294984B6 (cs) 2005-04-13
MY118156A (en) 2004-09-30
NO20001585D0 (no) 2000-03-27
CN1149994C (zh) 2004-05-19
HRP20000171B1 (en) 2009-06-30
MXPA00002956A (es) 2003-05-19
HK1032001A1 (en) 2001-07-06
SI1014987T1 (en) 2004-08-31
PL190862B1 (pl) 2006-02-28
HRP20000171A2 (en) 2000-12-31
SK283187B6 (sk) 2003-03-04
CN1271282A (zh) 2000-10-25
WO1999016443A1 (en) 1999-04-08
YU17700A (sh) 2002-10-18
AU9350698A (en) 1999-04-23
US6355269B1 (en) 2002-03-12
NO320047B1 (no) 2005-10-17
HUP0003757A3 (en) 2001-07-30
JP2001517702A (ja) 2001-10-09
EE200000187A (et) 2001-04-16
ATE260659T1 (de) 2004-03-15
IL134802A0 (en) 2001-04-30
FI973804A7 (fi) 1999-03-27
KR100762022B1 (ko) 2007-09-28
DE69822172T2 (de) 2005-02-24
BG64746B1 (bg) 2006-02-28
EA001647B1 (ru) 2001-06-25
HUP0003757A2 (hu) 2001-05-28
CA2304702C (en) 2007-09-04
GEP20032943B (en) 2003-04-25
ES2217580T3 (es) 2004-11-01
PT1014987E (pt) 2004-06-30
NZ503207A (en) 2001-04-27
CA2304702A1 (en) 1999-04-08
SK3842000A3 (en) 2000-09-12
EP1014987A1 (en) 2000-07-05
CZ2000919A3 (cs) 2000-09-13
TR200000635T2 (tr) 2000-09-21
PL339461A1 (en) 2000-12-18
NO20001585L (no) 2000-03-27
ID24486A (id) 2000-07-20
DK1014987T3 (da) 2004-05-24
RS49708B (sr) 2007-12-31
FI973804A0 (fi) 1997-09-26
IL134802A (en) 2004-01-04
DE69822172D1 (de) 2004-04-08
EE03854B1 (et) 2002-10-15

Similar Documents

Publication Publication Date Title
BR9813213A (pt) Composições orais de levosimendan
TR200001840T2 (tr) Arile bağlı azopolisiklik bileşikler
TWI265029B (en) Formulations for pharmaceutical agents ionizable as free acids or free bases
WO1999007351A3 (en) Indole derivatives and their use as mcp-1 antagonists
ATE218580T1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
EA200400881A1 (ru) Азаарилпиперазины
ATE290015T1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
NZ514574A (en) Novel method of treatment
CA2274074A1 (en) Novel compounds with analgesic effect
RU99128072A (ru) Новая форма s-омепразола
EA200301165A1 (ru) Лекарственное средство на основе оксикодона
CA2239174A1 (en) Novel compounds with analgesic effect
ATE218582T1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
PT1147110E (pt) Derivados de pirazino (aza)-indol
AU3850600A (en) Dalda analogs and their use
JP2005508338A5 (pt)
CA2377174A1 (en) Oral administration forms for administering a fixed tramadol and diclofenac combination
CA2302568A1 (en) Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
CA2290446A1 (en) Method and compositions for administering taxanes orally to human patients
TR200001869T2 (tr) Terapetik Maddeler
HUP0203303A3 (en) Compositions for administering taxanes orally to human patients
KR910000665A (ko) 이미다조퀴녹살린 화합물, 이의 제조방법 및 이의 용도
TR200200401T2 (tr) PEG-IFN-a ile birlikte mikofenolat mofetil
DE69713067D1 (de) Aminotetralinderivate, deren zusammensetzungen sowie deren verwendung
CA2473749A1 (en) Pure populations of astrocyte restricted precursor cells and methods for isolation and use thereof

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE NAO ATENDE AO REQUISITO DE NOVIDADE ( ART. 8O E 11 DA LPI ); NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ART. 8O E 13 DA LPI )

B12B Appeal against refusal [chapter 12.2 patent gazette]