BR9811657A - Clonagem usando-se núcleos doadores oriundos de células diferenciadas não-carentes de soro - Google Patents
Clonagem usando-se núcleos doadores oriundos de células diferenciadas não-carentes de soroInfo
- Publication number
- BR9811657A BR9811657A BR9811657-6A BR9811657A BR9811657A BR 9811657 A BR9811657 A BR 9811657A BR 9811657 A BR9811657 A BR 9811657A BR 9811657 A BR9811657 A BR 9811657A
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- differentiated
- serum
- production
- cloning
- Prior art date
Links
- 238000010367 cloning Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 6
- 210000002257 embryonic structure Anatomy 0.000 abstract 2
- 210000003754 fetus Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000003855 cell nucleus Anatomy 0.000 abstract 1
- 210000004940 nucleus Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 230000000644 propagated effect Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/04—Cells produced using nuclear transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Patente de Invenção: <B>"CLONAGEM USANDO-SE NúCLEOS DOADORES ORIUNDOS DE CéLULAS DIFERENCIADAS NãO-CARENTES DE SORO''<D>. é provido um método aperfeiçoado de transferência nuclear envolvendo o transplante de núcleos de célula diferenciada doadora oriundos de células não-carentes de soro para dentro de oócitos enucleados da mesma espécie como a célula doadora. As unidades de transferência nuclear resultantes são úteis para a multiplicação de genótipos e genótipos transgênicos pela produção de fetos e de prole, e para a produção de células de CICM isogênicas, incluindo células de tronco ou embriónicas isogênicas humanas. Produção de prole, fetos e embriões de mamífero transgênicos ou geneticamente engenheirados é faciliatado pelo presente método uma vez que a fonte de célula diferenciada dos núcleos doadores pode ser geneticamente modificada e clonalmente propagada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88828397A | 1997-07-03 | 1997-07-03 | |
| PCT/US1998/012800 WO1999001163A1 (en) | 1997-07-03 | 1998-06-24 | Cloning using donor nuclei from non-serum starved, differentiated cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9811657A true BR9811657A (pt) | 2000-09-05 |
Family
ID=25392916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9811657-6A BR9811657A (pt) | 1997-07-03 | 1998-06-24 | Clonagem usando-se núcleos doadores oriundos de células diferenciadas não-carentes de soro |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1017422A4 (pt) |
| JP (1) | JP2001509361A (pt) |
| CN (2) | CN101003800A (pt) |
| AU (1) | AU8154398A (pt) |
| BR (1) | BR9811657A (pt) |
| CA (1) | CA2294916A1 (pt) |
| IL (1) | IL133786A0 (pt) |
| NZ (1) | NZ502129A (pt) |
| WO (1) | WO1999001163A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
| ATE278775T1 (de) * | 1998-01-16 | 2004-10-15 | Agrobiogen Gmbh | Effizienter kerntransfer mit fetalen fibroblasten |
| US6331659B1 (en) | 1998-01-21 | 2001-12-18 | University Of Hawaii | Cumulus cells as nuclear donors |
| JP2002511234A (ja) * | 1998-03-16 | 2002-04-16 | リレグ ピーティーワイ リミテッド | ブタの核移植 |
| AUPP294898A0 (en) * | 1998-04-15 | 1998-05-07 | Monash University | Method of nuclear transfer |
| US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
| EP1375654A3 (en) * | 1998-11-02 | 2008-01-16 | GTC Biotherapeutics, Inc. | Transgenic and cloned mammals |
| EP1818397A1 (en) * | 1998-11-02 | 2007-08-15 | Trustees Of Tufts College | Methods for cloning animals |
| WO2000025578A2 (en) * | 1999-04-26 | 2000-05-11 | Trustees Of Tufts College | Methods for cloning animals |
| JP2002537785A (ja) | 1999-03-04 | 2002-11-12 | ピーピーエル セラピューティクス （スコットランド） リミテッド | 体細胞の遺伝的改変とそれらの使用 |
| EP1109890A4 (en) * | 1999-06-30 | 2004-12-29 | Hwang Woo Suk | PROCESS FOR OBTAINING CLONED HUMAN EMBRYOS USING INTER-SPECIES TRANSPLANTATION TECHNIQUES OF CORES |
| EP1117763A4 (en) * | 1999-06-30 | 2004-12-01 | Hwang Woo Suk | PROCESS FOR PRODUCING CLONED TIGERS USING INTER-SPECIES CORE TRANSPLANTATION TECHNIQUE |
| RU2205536C2 (ru) * | 1999-06-30 | 2003-06-10 | Воо-Сук ХВАНГ | Способ получения клонированной коровы |
| CA2388497A1 (en) * | 1999-10-15 | 2001-04-26 | Advanced Cell Technology, Inc. | Method of producing differentiated progenitor cells by culturing morula or inner cell mass cells |
| DE10084883D2 (de) * | 2000-06-08 | 2004-04-29 | Trostner Jens | Verfahren zur genetischen Rekonstruktion von menschlichen Organen |
| NZ524523A (en) | 2000-08-03 | 2006-02-24 | Therapeutic Human Polyclonals | Production of humanized antibodies in transgenic animals |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| NZ526243A (en) * | 2000-11-30 | 2006-02-24 | Stemron Inc | Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same |
| MXPA03005624A (es) * | 2000-12-22 | 2004-12-03 | Vaurox Llc | Metodos para clonar mamiferos usando cromatina reprogramada del donador o celulas donadoras. |
| ATE466089T1 (de) | 2000-12-22 | 2010-05-15 | Agronomique Inst Nat Rech | Positionsunabhängige und gewebespezifische expression eines transgens in der milch eines transgen-tieres |
| JP4381139B2 (ja) | 2001-08-13 | 2009-12-09 | エンブレクス，インコーポレイテッド | 鳥類の卵の処理方法 |
| US20030204860A1 (en) * | 2002-04-01 | 2003-10-30 | David Melican | Method for selecting cell lines to be used for nuclear transfer in mammalian species |
| US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| RU2308281C1 (ru) * | 2006-04-05 | 2007-10-20 | ГУ Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской академии медицинских наук (ГУ НИИ фармакологии ТНЦ СО РАМН) | Способ клонирования in vitro регионарных стволовых клеток поджелудочной железы |
| JP5087625B2 (ja) | 2006-09-01 | 2012-12-05 | セラピューティック・ヒューマン・ポリクローナルズ・インコーポレーテッド | 非ヒトトランスジェニック動物におけるヒトまたはヒト化免疫グロブリンの発現強化 |
| EP2267153A1 (en) | 2009-05-26 | 2010-12-29 | Université Claude Bernard Lyon 1 | Identification of netrin-1 receptor unc5c gene mutation in solid cancers |
| US10865383B2 (en) | 2011-07-12 | 2020-12-15 | Lineage Cell Therapeutics, Inc. | Methods and formulations for orthopedic cell therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1149898A2 (en) * | 1993-12-23 | 2001-10-31 | Infigen, Inc. | Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals |
| GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| ATE278775T1 (de) * | 1998-01-16 | 2004-10-15 | Agrobiogen Gmbh | Effizienter kerntransfer mit fetalen fibroblasten |
-
1998
- 1998-06-24 NZ NZ502129A patent/NZ502129A/en unknown
- 1998-06-24 CN CNA2007100081920A patent/CN101003800A/zh active Pending
- 1998-06-24 AU AU81543/98A patent/AU8154398A/en not_active Abandoned
- 1998-06-24 CN CN98807691A patent/CN1265599A/zh active Pending
- 1998-06-24 WO PCT/US1998/012800 patent/WO1999001163A1/en not_active Ceased
- 1998-06-24 EP EP19980931400 patent/EP1017422A4/en not_active Withdrawn
- 1998-06-24 JP JP2000500926A patent/JP2001509361A/ja active Pending
- 1998-06-24 BR BR9811657-6A patent/BR9811657A/pt not_active Application Discontinuation
- 1998-06-24 CA CA002294916A patent/CA2294916A1/en not_active Abandoned
- 1998-06-24 IL IL13378698A patent/IL133786A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001509361A (ja) | 2001-07-24 |
| CN101003800A (zh) | 2007-07-25 |
| AU8154398A (en) | 1999-01-25 |
| CN1265599A (zh) | 2000-09-06 |
| EP1017422A1 (en) | 2000-07-12 |
| CA2294916A1 (en) | 1999-01-14 |
| EP1017422A4 (en) | 2002-10-29 |
| IL133786A0 (en) | 2001-04-30 |
| NZ502129A (en) | 2005-02-25 |
| WO1999001163A1 (en) | 1999-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. PORTANTO, INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO - DE ACORDO COM O ART. 8O DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |