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BR9811594A - Compostos de dipeptìdeo sulfonilados que inibem adesão de leucócito mediada por vla-4 - Google Patents

Compostos de dipeptìdeo sulfonilados que inibem adesão de leucócito mediada por vla-4

Info

Publication number
BR9811594A
BR9811594A BR9811594-4A BR9811594A BR9811594A BR 9811594 A BR9811594 A BR 9811594A BR 9811594 A BR9811594 A BR 9811594A BR 9811594 A BR9811594 A BR 9811594A
Authority
BR
Brazil
Prior art keywords
compounds
leukocyte adhesion
vla
sulphonylated
mediated leukocyte
Prior art date
Application number
BR9811594-4A
Other languages
English (en)
Inventor
Eugene D Thorsett
Christopher M Semko
Michael A Pleiss
Anthony Kreft
Francine S Grant
Reinhardt Bernhard Baudy
Dimitrios Sarantakis
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of BR9811594A publication Critical patent/BR9811594A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção:<B>"COMPOSTOS DE DIPEPTìDEO SULFONILADOS QUE INIBEM ADESãO DE LEUCóCITOS MEDIADA POR VLA-4"<D>. Descritos são os compostos que ligam VLA-4. Certos desses compostos também inibem adesão de leucócito e, em particular, adesão de leucócito mediada por VLA-4. Tais compostos são úteis no tratamento de doenças inflamatórias em um paciente mamífero, por exemplo, ser humano, tais como asma, doença de Alzheimer, aterosclerose, demência da AIDS, diabetes, doença de intestino inflamatório, artrite reumatóide, transplante de tecido, metástase de tumor e isquemia miocardial. Os compostos podem também ser administrados para o tratamento de doenças de cérebro inflamatórias tal como esclerose múltipla.
BR9811594-4A 1997-07-31 1998-07-31 Compostos de dipeptìdeo sulfonilados que inibem adesão de leucócito mediada por vla-4 BR9811594A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90442397A 1997-07-31 1997-07-31
PCT/US1998/016070 WO1999006437A1 (en) 1997-07-31 1998-07-31 Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (1)

Publication Number Publication Date
BR9811594A true BR9811594A (pt) 2000-09-05

Family

ID=25419137

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811594-4A BR9811594A (pt) 1997-07-31 1998-07-31 Compostos de dipeptìdeo sulfonilados que inibem adesão de leucócito mediada por vla-4

Country Status (12)

Country Link
EP (1) EP0994896A1 (pt)
JP (1) JP2001512139A (pt)
KR (1) KR20010022405A (pt)
CN (1) CN1265672A (pt)
AU (1) AU8823498A (pt)
BR (1) BR9811594A (pt)
CA (1) CA2290748A1 (pt)
HU (1) HUP0003921A3 (pt)
IL (1) IL133637A0 (pt)
NO (1) NO20000452L (pt)
PL (1) PL338457A1 (pt)
WO (1) WO1999006437A1 (pt)

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PT1265606E (pt) * 1999-08-13 2007-01-31 Biogen Idec Inc Inibidores da adesão celular
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US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
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JP2003531141A (ja) 2000-04-17 2003-10-21 セルテック アール アンド ディ リミテッド エナミン誘導体
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
WO2002004426A1 (en) 2000-07-07 2002-01-17 Celltech R & D Limited Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
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Also Published As

Publication number Publication date
WO1999006437A1 (en) 1999-02-11
HUP0003921A3 (en) 2001-03-28
IL133637A0 (en) 2001-04-30
NO20000452D0 (no) 2000-01-28
JP2001512139A (ja) 2001-08-21
EP0994896A1 (en) 2000-04-26
CN1265672A (zh) 2000-09-06
PL338457A1 (en) 2000-11-06
KR20010022405A (ko) 2001-03-15
AU8823498A (en) 1999-02-22
NO20000452L (no) 2000-03-27
HUP0003921A2 (hu) 2001-02-28
CA2290748A1 (en) 1999-02-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007.