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BR9811580A - Composições parentéricas de alatrofloxacina - Google Patents

Composições parentéricas de alatrofloxacina

Info

Publication number
BR9811580A
BR9811580A BR9811580-4A BR9811580A BR9811580A BR 9811580 A BR9811580 A BR 9811580A BR 9811580 A BR9811580 A BR 9811580A BR 9811580 A BR9811580 A BR 9811580A
Authority
BR
Brazil
Prior art keywords
alatrofloxacin
parenteral compositions
compositions
mesylate
parenteral
Prior art date
Application number
BR9811580-4A
Other languages
English (en)
Inventor
Robert Mark Guinn
John Francis Lambert
Subramanian Sam Guhan
Stanley Walter Walinsky
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9811580A publication Critical patent/BR9811580A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçõES PARENTéRICAS DE ALATROFLOXACINA"<D>. A presente invenção refere-se com mesilato de alatrofloxacina substancialmente isento de impurezas menos polares, as composições parentéricas de mesilato de alatrofloxacina e a processos para a purificação de mesilato de alatrofloxacina.
BR9811580-4A 1997-08-01 1998-07-23 Composições parentéricas de alatrofloxacina BR9811580A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5424697P 1997-08-01 1997-08-01
PCT/IB1998/001122 WO1999006430A1 (en) 1997-08-01 1998-07-23 Alatrofloxacin parenteral compositions

Publications (1)

Publication Number Publication Date
BR9811580A true BR9811580A (pt) 2000-08-22

Family

ID=21989735

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811580-4A BR9811580A (pt) 1997-08-01 1998-07-23 Composições parentéricas de alatrofloxacina

Country Status (40)

Country Link
US (1) US6194429B1 (pt)
EP (1) EP1000086B1 (pt)
JP (1) JP3463928B2 (pt)
KR (1) KR20010022495A (pt)
CN (1) CN1265671A (pt)
AP (1) AP1031A (pt)
AR (1) AR015417A1 (pt)
AT (1) ATE259827T1 (pt)
AU (1) AU734863B2 (pt)
BG (1) BG104105A (pt)
BR (1) BR9811580A (pt)
CA (1) CA2296466C (pt)
CO (1) CO4970688A1 (pt)
DE (1) DE69821767T2 (pt)
DK (1) DK1000086T3 (pt)
DZ (1) DZ2576A1 (pt)
EA (1) EA002120B1 (pt)
ES (1) ES2214716T3 (pt)
GT (1) GT199800112A (pt)
HN (1) HN1998000106A (pt)
HR (1) HRP980417B1 (pt)
HU (1) HUP0004793A3 (pt)
ID (1) ID24374A (pt)
IL (1) IL134156A0 (pt)
IS (1) IS5339A (pt)
MA (1) MA24626A1 (pt)
NO (1) NO20000485L (pt)
NZ (1) NZ502249A (pt)
OA (1) OA11281A (pt)
PA (1) PA8456701A1 (pt)
PE (1) PE103799A1 (pt)
PL (1) PL338477A1 (pt)
PT (1) PT1000086E (pt)
SK (1) SK1012000A3 (pt)
TN (1) TNSN98146A1 (pt)
TW (1) TW538043B (pt)
UY (1) UY25113A1 (pt)
WO (1) WO1999006430A1 (pt)
YU (1) YU2500A (pt)
ZA (1) ZA986874B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ517706A (en) * 1999-10-08 2004-01-30 Affinium Pharm Inc Fab I inhibitors
EP1121933A1 (en) * 2000-02-02 2001-08-08 Pfizer Products Inc. Premixed alatrofloxacin injectable compositions
DE60230934D1 (de) 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
ES2518316T3 (es) * 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
ATE409485T1 (de) 2003-03-17 2008-10-15 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
SI1828167T1 (sl) * 2004-06-04 2014-12-31 Debiopharm International Sa Forum "Apres-Demain" Akrilamidni derivati kot anitibiotična sredstva
EP1973902A2 (en) * 2005-12-05 2008-10-01 Affinium Pharmaceuticals, Inc. 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
RS58898B1 (sr) 2012-06-19 2019-08-30 Debiopharm Int Sa Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida
US20170049844A1 (en) * 2014-04-25 2017-02-23 Naurex Inc. Stable compositions of neuroactive peptides
PT3419628T (pt) 2016-02-26 2021-01-05 Debiopharm Int Sa Medicamento para o tratamento de infeções do pé diabético
KR20200121816A (ko) 2018-02-02 2020-10-26 리플 테라퓨틱스 코포레이션 스테로이드 이량체를 포함하는 유리 제제 및 이의 용도
WO2020154815A1 (en) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
CA3129508A1 (en) 2019-02-14 2020-08-20 Debiopharm International S.A. Solid formulations of afabicin with histidine
CN113939306B (zh) 2019-06-14 2024-07-19 德彪药业国际股份公司 用于治疗涉及生物膜的细菌感染的药物及其用途
US20220347305A1 (en) 2019-08-07 2022-11-03 Ripple Therapeutics Corporation Controlled release drug dimers
CA3176134A1 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3713672A1 (de) 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
US5256791A (en) 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
PL179996B1 (en) 1994-01-18 2000-11-30 Pfizer Method of and intermediate products for obtaining salts of naphtyridinocarboxylic acids
TW420610B (en) 1994-04-07 2001-02-01 Pfizer A pharmaceutical composition for treating a H. pylori infection or gastric or duodenal ulcers
US5475116A (en) 1994-04-29 1995-12-12 Pfizer Inc. Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones
DE69503066T2 (de) 1995-06-06 1998-10-15 Pfizer Inc., New York, N.Y. KRISTALLFORM VON WASSERFREIEN 7-((1a,5a,6a)-6-AMINO-3-AZABICYCLO (3.1.0.) HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDIN-CARBONSÄURE METHANESULFONSÄURE SALZ
US5939550A (en) * 1995-06-15 1999-08-17 Pfizer Inc. Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide
EP0850060A1 (en) 1995-08-29 1998-07-01 Pfizer Inc. Zwitterionic forms of trovafloxacin
KR100274736B1 (ko) * 1995-08-29 2000-12-15 디. 제이. 우드, 스피겔 알렌 제이 6-엔-(엘-에이엘에이-엘-에이엘에이)-트로바플록사신 전구약물의 폴리모프
GB9524466D0 (en) 1995-11-30 1996-01-31 Pfizer Ltd Process
JPH1087617A (ja) 1996-07-09 1998-04-07 Pfizer Inc キノリン系抗生物質の合成に有用な中間体の製法

Also Published As

Publication number Publication date
OA11281A (en) 2002-11-19
YU2500A (sh) 2002-09-19
PT1000086E (pt) 2004-05-31
PL338477A1 (en) 2000-11-06
PA8456701A1 (es) 2000-05-24
NO20000485D0 (no) 2000-01-31
CA2296466A1 (en) 1999-02-11
PE103799A1 (es) 1999-10-25
GT199800112A (es) 2000-01-15
KR20010022495A (ko) 2001-03-15
CO4970688A1 (es) 2000-11-07
UY25113A1 (es) 2000-12-29
HRP980417B1 (en) 2002-10-31
NZ502249A (en) 2001-11-30
CA2296466C (en) 2003-04-15
AP9801310A0 (en) 1998-09-30
ATE259827T1 (de) 2004-03-15
SK1012000A3 (en) 2000-09-12
US6194429B1 (en) 2001-02-27
ZA986874B (en) 2000-01-31
EP1000086A1 (en) 2000-05-17
EA200000086A1 (ru) 2000-08-28
EA002120B1 (ru) 2001-12-24
HRP980417A2 (en) 1999-08-31
AU734863B2 (en) 2001-06-21
TW538043B (en) 2003-06-21
IS5339A (is) 2000-01-14
ES2214716T3 (es) 2004-09-16
HUP0004793A3 (en) 2001-10-29
HUP0004793A2 (hu) 2001-04-28
NO20000485L (no) 2000-03-27
MA24626A1 (fr) 1999-04-01
HN1998000106A (es) 1999-01-08
AU8236898A (en) 1999-02-22
AP1031A (en) 2001-12-21
WO1999006430A1 (en) 1999-02-11
TNSN98146A1 (fr) 2005-03-15
CN1265671A (zh) 2000-09-06
DK1000086T3 (da) 2004-05-17
DE69821767T2 (de) 2005-01-13
IL134156A0 (en) 2001-04-30
JP3463928B2 (ja) 2003-11-05
DZ2576A1 (fr) 2003-02-22
JP2001512133A (ja) 2001-08-21
AR015417A1 (es) 2001-05-02
EP1000086B1 (en) 2004-02-18
DE69821767D1 (de) 2004-03-25
BG104105A (bg) 2000-08-31
ID24374A (id) 2000-07-13

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. PORTANTO, INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO - DE ACORDO COM O ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.