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BR9811058A - Formulação auto-emulsificante para compostos lipofìlicos - Google Patents

Formulação auto-emulsificante para compostos lipofìlicos

Info

Publication number
BR9811058A
BR9811058A BR9811058-6A BR9811058A BR9811058A BR 9811058 A BR9811058 A BR 9811058A BR 9811058 A BR9811058 A BR 9811058A BR 9811058 A BR9811058 A BR 9811058A
Authority
BR
Brazil
Prior art keywords
self
diglyceride
monoglyceride
emulsifying formulation
compounds
Prior art date
Application number
BR9811058-6A
Other languages
English (en)
Inventor
Walter Morozowich
Ping Gao
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR9811058A publication Critical patent/BR9811058A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Silicon Polymers (AREA)

Abstract

<B>FORMULAçãO AUTO-EMULSIFICANTE PARA COMPOSTOS LIPOFìLICOS<D>. A presente invenção fornece uma composição farmacêutica nova com base no uso de uma fase de óleo específica que compeende um agente lipofílico farmaceuticamente ativo, uma mistura de diglicerídeo e monoglicerídeo em uma razão de aproximadamente 9:1 a aproximadamente 6:4 em peso (diglicerídeo : monoglicerídeo), em que o diglicerídeo e monoglicerídeo são ésteres de ácido graxo mono ou di-insaturados de glicerol tendo comprimento de cadeia de dezesseis a vinte e dois carbonos, um ou mais solventes farmaceuticamente aceitáveis e um ou mais agentes tensoativos farmaceuticamente aceitáveis. A composição está em forma de formulação auto-emulsificante que fornece elevada concentração e elevada biodisponibilidade oral para compostos lipofílicos.
BR9811058-6A 1997-07-29 1998-07-27 Formulação auto-emulsificante para compostos lipofìlicos BR9811058A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5401297P 1997-07-29 1997-07-29
US5407897P 1997-07-29 1997-07-29
PCT/US1998/014818 WO1999006024A1 (en) 1997-07-29 1998-07-27 Self-emulsifying formulation for lipophilic compounds

Publications (1)

Publication Number Publication Date
BR9811058A true BR9811058A (pt) 2000-09-05

Family

ID=26732506

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811058-6A BR9811058A (pt) 1997-07-29 1998-07-27 Formulação auto-emulsificante para compostos lipofìlicos

Country Status (22)

Country Link
EP (1) EP0999826B1 (pt)
JP (2) JP2002511099A (pt)
KR (1) KR100509776B1 (pt)
CN (1) CN1208047C (pt)
AT (1) ATE265847T1 (pt)
AU (1) AU728698B2 (pt)
BR (1) BR9811058A (pt)
CA (1) CA2294031E (pt)
CZ (1) CZ297206B6 (pt)
DE (1) DE69823663T2 (pt)
DK (1) DK0999826T3 (pt)
ES (1) ES2219895T3 (pt)
FI (1) FI20000170A7 (pt)
HU (1) HU226114B1 (pt)
NO (1) NO328591B1 (pt)
NZ (1) NZ502569A (pt)
PL (1) PL191780B1 (pt)
PT (1) PT999826E (pt)
RU (1) RU2211021C2 (pt)
SI (1) SI0999826T1 (pt)
SK (1) SK284511B6 (pt)
WO (1) WO1999006024A1 (pt)

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Also Published As

Publication number Publication date
KR20010022365A (ko) 2001-03-15
WO1999006024A1 (en) 1999-02-11
FI20000170L (fi) 2000-01-28
PL338509A1 (en) 2000-11-06
ATE265847T1 (de) 2004-05-15
AU8573998A (en) 1999-02-22
SK284511B6 (sk) 2005-05-05
CA2294031A1 (en) 1999-02-11
CA2294031C (en) 2005-01-18
CZ2000157A3 (cs) 2000-05-17
NO20000467D0 (no) 2000-01-28
DE69823663D1 (de) 2004-06-09
PL191780B1 (pl) 2006-07-31
KR100509776B1 (ko) 2005-08-24
SI0999826T1 (en) 2004-12-31
NO328591B1 (no) 2010-03-29
HU226114B1 (en) 2008-04-28
CN1208047C (zh) 2005-06-29
EP0999826A1 (en) 2000-05-17
DE69823663T2 (de) 2005-05-19
SK172000A3 (en) 2000-07-11
PT999826E (pt) 2004-09-30
HUP0002486A3 (en) 2001-03-28
JP5227301B2 (ja) 2013-07-03
NZ502569A (en) 2002-05-31
JP2010070562A (ja) 2010-04-02
NO20000467L (no) 2000-03-29
AU728698B2 (en) 2001-01-18
CN1261790A (zh) 2000-08-02
FI20000170A7 (fi) 2000-01-28
ES2219895T3 (es) 2004-12-01
JP2002511099A (ja) 2002-04-09
EP0999826B1 (en) 2004-05-06
HUP0002486A1 (hu) 2000-12-28
CA2294031E (en) 2012-04-03
CZ297206B6 (cs) 2006-10-11
DK0999826T3 (da) 2004-07-26
RU2211021C2 (ru) 2003-08-27
HK1028883A1 (zh) 2001-03-09

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Date Code Title Description
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, POR INCIDENCIA NOS ARTIGOS 8O E 13 DA LPI, LEI DE NUMERO 9.279 DE 14/05/1996, ATRAVES DE PUBLICACAO 9.2 NA RPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B15G Petition not considered as such [chapter 15.7 patent gazette]

Free format text: DESCONHECIDA A PETICAO DE TRANSFERENCIA NO 020090116792/SP DE 14/12/2009, POR AUSENCIA DE FUNDAMENTACAO LEGAL, VISTO QUE O PEDIDO FOI ARQUIVADO CONFORME PUBLICADO NA RPI 2039 DE 02/02/2010.

B25B Requested transfer of rights rejected

Owner name: PHARMACIA AND UPJOHN COMPANY (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08H Application fees: decision cancelled [chapter 8.8 patent gazette]