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BR9810795A - Processo para preparação de n-(5-amino-2-ciano-4-flúor-fenil)-sulfonamidas e intermediários - Google Patents

Processo para preparação de n-(5-amino-2-ciano-4-flúor-fenil)-sulfonamidas e intermediários

Info

Publication number
BR9810795A
BR9810795A BR9810795-0A BR9810795A BR9810795A BR 9810795 A BR9810795 A BR 9810795A BR 9810795 A BR9810795 A BR 9810795A BR 9810795 A BR9810795 A BR 9810795A
Authority
BR
Brazil
Prior art keywords
cyano
phenyl
amino
preparing
intermediates
Prior art date
Application number
BR9810795-0A
Other languages
English (en)
Inventor
Achim Hupperts
Mark Wilhelm
David Erdman
Reinhard Lantzsch
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR9810795A publication Critical patent/BR9810795A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE N-(5-AMINO-2-CIANO-4-FLúOR-FENIL)-SULFONAMIDAS E INTERMEDIáRIOS"<D>. A invenção refere-se a um processo para preparação de N-(5-amino-2-ciano-4-flúor-fenil)-sulfonamidas em que, em uma primeira etapa, a 2-amino-4,5-diflúor-benzonitrila é reagida com haletos de sulfonila na presença de um aceitador de ácido e na presença de um diluente a temperaturas entre 0°C e 150°C e, em uma segunda etapa, as N-(2-ciano-4,5-diflúor-fenil)-sulfonamidas e/ou N-(2-ciano-4,5-diflúor-fenil)-sulfonimidas obtidas na primeira etapa como substâncias puras ou como misturas com amónia reagiram na presença de um diluente em uma temperatura entre 100°C e 200°C. A invenção refere-se além disso, a novos intermediários do processo.
BR9810795-0A 1997-07-24 1998-07-13 Processo para preparação de n-(5-amino-2-ciano-4-flúor-fenil)-sulfonamidas e intermediários BR9810795A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19731783A DE19731783A1 (de) 1997-07-24 1997-07-24 Verfahren zur Herstellung von N-(5-Amino-2-cyano-4-fluor-phenyl)-sulfonamiden und neue Zwischenprodukte
PCT/EP1998/004324 WO1999005098A1 (de) 1997-07-24 1998-07-13 Verfahren zur herstellung von n-(5-amino-2-cyano-4-fluor-phenyl)-sulfonamiden und neue zwischenprodukte

Publications (1)

Publication Number Publication Date
BR9810795A true BR9810795A (pt) 2000-07-25

Family

ID=7836724

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810795-0A BR9810795A (pt) 1997-07-24 1998-07-13 Processo para preparação de n-(5-amino-2-ciano-4-flúor-fenil)-sulfonamidas e intermediários

Country Status (11)

Country Link
US (2) US6310206B1 (pt)
EP (1) EP1003718B1 (pt)
JP (1) JP2001510823A (pt)
CN (1) CN1265095A (pt)
AT (1) ATE265425T1 (pt)
AU (1) AU8860798A (pt)
BR (1) BR9810795A (pt)
DE (2) DE19731783A1 (pt)
DK (1) DK1003718T3 (pt)
IL (1) IL133719A0 (pt)
WO (1) WO1999005098A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962932A1 (de) * 1999-12-24 2001-06-28 Bayer Ag Verfahren zur Herstellung von N-substituierten 2,4-Diamino-5-fluor-benzonitrilen und neue Zwischenprodukte
JP5518573B2 (ja) * 2010-05-26 2014-06-11 三菱マテリアル株式会社 フッ素化スルホンイミド化合物の製造方法
CN114957049B (zh) * 2022-06-13 2023-10-03 河北冠龙农化有限公司 一种n-苯基-n-三氯甲硫基苯磺酰胺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4303376A1 (de) 1993-02-05 1994-08-11 Bayer Ag Substituierte Triazolinone
EP0648749B1 (de) 1993-08-18 1997-12-10 Bayer Ag N-Cyanoaryl-Stickstoffheterocyclen
US5681794A (en) 1993-08-18 1997-10-28 Bayer Aktiengesellschaft N-cyanoaryl-nitrogen heterocycles
JPH0770041A (ja) 1993-09-01 1995-03-14 Ihara Chem Ind Co Ltd ３，４−ジフルオロ−６−ニトロベンゾニトリル
DE4335438A1 (de) 1993-10-18 1995-04-20 Bayer Ag 4-Cyanophenyliminoheterocyclen
DE4414568A1 (de) 1994-04-27 1995-11-02 Bayer Ag Heterocyclylbenzonitrile
NZ319673A (en) * 1995-10-17 2000-06-23 Astra Pharma Prod Quinazoline compounds for inflammatory disorders such rheumatoid arthritis or osteoarthritis

Also Published As

Publication number Publication date
WO1999005098A1 (de) 1999-02-04
EP1003718A1 (de) 2000-05-31
AU8860798A (en) 1999-02-16
IL133719A0 (en) 2001-04-30
DK1003718T3 (da) 2004-08-16
US20030040626A1 (en) 2003-02-27
CN1265095A (zh) 2000-08-30
US6310206B1 (en) 2001-10-30
JP2001510823A (ja) 2001-08-07
ATE265425T1 (de) 2004-05-15
EP1003718B1 (de) 2004-04-28
US6545154B2 (en) 2003-04-08
DE19731783A1 (de) 1999-01-28
DE59811294D1 (de) 2004-06-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.