BR9810234A - Utilização de derivados da tetraidropiridna para a preparação de medicamentos para o tratamento das doenças que provocam uma desmielinização - Google Patents
Utilização de derivados da tetraidropiridna para a preparação de medicamentos para o tratamento das doenças que provocam uma desmielinizaçãoInfo
- Publication number
- BR9810234A BR9810234A BR9810234-6A BR9810234A BR9810234A BR 9810234 A BR9810234 A BR 9810234A BR 9810234 A BR9810234 A BR 9810234A BR 9810234 A BR9810234 A BR 9810234A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- alkyl
- alkoxy
- phenyl
- mono
- Prior art date
Links
- 208000016192 Demyelinating disease Diseases 0.000 title abstract 2
- 206010012305 Demyelination Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical class C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- -1 phenoxy, phenylamino Chemical group 0.000 abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000005111 carboxyalkoxy group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 208000030499 combat disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000005504 styryl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>''UTILIZAçãO DE DERIVADOS DA TETRAIDROPIRIDINA PARA A PREPARAçãO DE MEDICAMENTOS PARA O TRATAMENTO DAS DOENçAS QUE PROVOCAM UMA DESMIELINIZAçãO''<D>. A invenção refere-se à utilização de um composto de fórmula (I) na qual: R~ 1~ representa um halogênio ou um grupo CF~ 3~, (C~ 1~-C~ 4~)alquila ou (C~ 1~-C~ 4~)alcóxi; Y representa um átomo de nitrogênio ou um grupo CH; Z' e Z'' representam cada um deles o hidrogênio ou um grupo (C~ 1~-C~ 3~) alquila, ou então um representa o hidrogênio e o outro um grupo hidróxi, ou ainda os dois, juntos, representam um grupo oxo; Z representa: um radical fenila; um radical fenila monossubstituído por um substituinte X, X sendo: (a) um grupo (C~ 1~-C~ 6~)alquila, (C~ 1~-C~ 6~)alcóxi, (C~ 3~-C~ 7~)carboxialquila, (C~ 1~-C~ 4~)alcoxicarbonil(C~ 1~-C~ 6~)alquila, (C~ 3~-C~ 7~)carboxialcóxi ou (C~ 1~-C~ 4~)alcoxicarbonil(C~ 1~-C~ 6~)alcóxi; (b) um grupo escolhido entre um (C~ 3~-C~ 7~)cicloalquila, (C~ 3~-C~ 7~)cicloalquilóxi, (C~ 3~-C~ 7~)cicloalquilmetila, (C~ 3~-C~ 7~)cicloalquilamino e cicloexenila, o dito grupo podendo ser substituído por um halogênio, hidróxi, (C~ 1~-C~ 4~)alcóxi, carbóxi, (C~ 1~-C~ 4~)alcoxicarbonila, amino, mono- ou di-(C~ 1~-C~ 4~)alquilamino; ou (c) um grupo escolhido entre uma fenila, fenóxi, fenilamino, N-(C~ 1~-C~ 3~)alquilfenilamino, fenilmetila, feniletila, fenilcarbonila, feníltio, fenilsulfonila, fenilsulfinila e estirila, o dito grupo podendo ser mono- ou polissubstituído no grupo fenila por um halogênio, CF~ 3~, (C~ 1~-C~ 4~)alquila, (C~ 1~-C~ 4~)alcóxi, ciano, amino, mono- ou di-(C~ 1~-C~ 4~)alquilamino, (C~ 1~-C~ 4~)acilamino, carbóxi, (C~ 1~-C~ 4~)alcoxicarbonila, aminocarbonila, mono ou di-(C~ 1~-C~ 4~)alquilaminocarbonila, amino(C~ 1~-C~ 4~)alquila, hidróxi(C~ 1~-C~ 4~)alquila ou halogênio(C~ 1~-C~ 4~)alquila; um radical fenila dissubstituído por um substituinte R~ 2~, R~ 2~ sendo um halogênio ou um grupo hidróxi, metila, etila, (C~ 3~-C~ 6~)alquila, (C~ 1~-C~ 4~)alcóxi ou trifluormetila e por um substituinte X, X sendo tal como definido acima; um radical 1-naftila ou 2-naftila; um radical 1-naftila ou 2-naftila, substituído nas posições 5, 6, 7 e/ou 8 por um ou dois grupos hidroxila, um ou dois grupos (C~ 1~-C~ 4~)alcóxi, ou um grupo 6,7-metilenodióxi; ou então Z'' é o hidrogênio e Z e Z' representam, cada um deles independentemente, um grupo fenila não-substituído ou mono-, di- ou trissubstituído; ou de um de seus sais e solvatos farmaceuticamente aceitáveis, para a preparação de composições farmacêuticas destinadas a combater as doenças que provocam uma desmielinização.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9705275A FR2762514B1 (fr) | 1997-04-29 | 1997-04-29 | Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation |
| PCT/FR1998/000774 WO1998048802A1 (fr) | 1997-04-29 | 1998-04-17 | Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810234A true BR9810234A (pt) | 2000-09-19 |
Family
ID=9506415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810234-6A BR9810234A (pt) | 1997-04-29 | 1998-04-17 | Utilização de derivados da tetraidropiridna para a preparação de medicamentos para o tratamento das doenças que provocam uma desmielinização |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6344464B1 (pt) |
| EP (1) | EP0979079B1 (pt) |
| JP (1) | JP3956059B2 (pt) |
| AR (1) | AR012504A1 (pt) |
| AT (1) | ATE269077T1 (pt) |
| AU (1) | AU7436498A (pt) |
| BR (1) | BR9810234A (pt) |
| CA (1) | CA2288241C (pt) |
| DE (1) | DE69824576T2 (pt) |
| DK (1) | DK0979079T3 (pt) |
| ES (1) | ES2222593T3 (pt) |
| FR (1) | FR2762514B1 (pt) |
| NO (1) | NO325163B1 (pt) |
| PT (1) | PT979079E (pt) |
| SI (1) | SI0979079T1 (pt) |
| UY (1) | UY24973A1 (pt) |
| WO (1) | WO1998048802A1 (pt) |
| ZA (1) | ZA983602B (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763847B1 (fr) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| FR2823748B1 (fr) * | 2001-04-20 | 2004-02-20 | Sanofi Synthelabo | Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| DE60220779T2 (de) * | 2001-04-20 | 2008-03-06 | Sanofi-Aventis | Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten |
| EP3492100B1 (en) | 2001-06-26 | 2021-12-08 | Amgen Inc. | Antibodies to opgl |
| WO2003002187A2 (en) * | 2001-06-26 | 2003-01-09 | Photomed Technologies, Inc. | Multiple wavelength illuminator |
| FR2831166B1 (fr) * | 2001-10-18 | 2004-02-27 | Sanofi Synthelabo | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
| PL377091A1 (pl) | 2002-09-06 | 2006-01-23 | Amgen, Inc. | Ludzkie monoklonalne przeciwciało przeciw-IL-1R1, o właściwościach terapeutycznych |
| MXPA05007019A (es) * | 2002-12-30 | 2005-08-18 | Amgen Inc | Terapia de combinacion con factores co-estimuladores. |
| US7838522B2 (en) | 2004-11-17 | 2010-11-23 | Ares Trading S.A. | Benzothiazole formulations and use thereof |
| PT1828160E (pt) | 2004-12-21 | 2012-01-05 | Merck Serono Sa | Derivados cíclicos de sulfonilamino e sua utilização |
| CN101208320B (zh) | 2005-01-31 | 2012-01-11 | 默克雪兰诺有限公司 | N-羟基酰胺衍生物及其用途 |
| DK1904048T3 (da) * | 2005-07-15 | 2011-12-19 | Merck Serono Sa | GLEPP-1-inhibitorer i behandlingen af autoimmune og/eller inflammatoriske forstyrrelser |
| BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| EP1933860A2 (en) | 2005-09-01 | 2008-06-25 | Ares Trading S.A. | Treatment of optic neuritis |
| US20090324569A1 (en) * | 2007-11-21 | 2009-12-31 | Decode Genetics Ehf | Biaryl pde4 inhibitors for treating inflammatory, cardiovascular and cns disorders |
| KR101707597B1 (ko) * | 2010-12-07 | 2017-02-17 | 한국전자통신연구원 | 홀 센서리스 ｂｌｄｃ 모터용 전원 공급 모듈 |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| LT4452267T (lt) | 2021-12-23 | 2025-06-10 | Cilcare Dev | 4-fenil-tetrahidropiridino dariniai, skirti klausos ligų gydymui |
| US20250283174A1 (en) | 2022-05-16 | 2025-09-11 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2531707A1 (fr) | 1982-08-16 | 1984-02-17 | Midy Spa | Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques |
| FR2662355B1 (fr) | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
| FR2736053B1 (fr) * | 1995-06-28 | 1997-09-19 | Sanofi Sa | Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
| FR2740343B1 (fr) | 1995-10-26 | 1999-01-22 | Sanofi Sa | Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique |
-
1997
- 1997-04-29 FR FR9705275A patent/FR2762514B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-17 CA CA002288241A patent/CA2288241C/en not_active Expired - Fee Related
- 1998-04-17 AU AU74364/98A patent/AU7436498A/en not_active Abandoned
- 1998-04-17 AT AT98921552T patent/ATE269077T1/de not_active IP Right Cessation
- 1998-04-17 DK DK98921552T patent/DK0979079T3/da active
- 1998-04-17 DE DE69824576T patent/DE69824576T2/de not_active Expired - Fee Related
- 1998-04-17 ES ES98921552T patent/ES2222593T3/es not_active Expired - Lifetime
- 1998-04-17 BR BR9810234-6A patent/BR9810234A/pt not_active Application Discontinuation
- 1998-04-17 JP JP54664898A patent/JP3956059B2/ja not_active Expired - Fee Related
- 1998-04-17 US US09/403,507 patent/US6344464B1/en not_active Expired - Fee Related
- 1998-04-17 EP EP98921552A patent/EP0979079B1/fr not_active Expired - Lifetime
- 1998-04-17 SI SI9830677T patent/SI0979079T1/xx unknown
- 1998-04-17 WO PCT/FR1998/000774 patent/WO1998048802A1/fr not_active Ceased
- 1998-04-17 PT PT98921552T patent/PT979079E/pt unknown
- 1998-04-23 UY UY24973A patent/UY24973A1/es not_active Application Discontinuation
- 1998-04-27 AR ARP980101935A patent/AR012504A1/es unknown
- 1998-04-29 ZA ZA983602A patent/ZA983602B/xx unknown
-
1999
- 1999-10-27 NO NO19995245A patent/NO325163B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO995245D0 (no) | 1999-10-27 |
| DK0979079T3 (da) | 2004-10-25 |
| ZA983602B (en) | 1998-11-02 |
| AR012504A1 (es) | 2000-10-18 |
| ATE269077T1 (de) | 2004-07-15 |
| DE69824576T2 (de) | 2005-06-30 |
| EP0979079A1 (fr) | 2000-02-16 |
| US6344464B1 (en) | 2002-02-05 |
| CA2288241A1 (en) | 1998-11-05 |
| DE69824576D1 (de) | 2004-07-22 |
| UY24973A1 (es) | 1998-07-16 |
| JP2002501498A (ja) | 2002-01-15 |
| FR2762514B1 (fr) | 1999-10-22 |
| NO325163B1 (no) | 2008-02-11 |
| AU7436498A (en) | 1998-11-24 |
| FR2762514A1 (fr) | 1998-10-30 |
| PT979079E (pt) | 2004-10-29 |
| WO1998048802A1 (fr) | 1998-11-05 |
| NO995245L (no) | 1999-12-27 |
| CA2288241C (en) | 2006-10-03 |
| ES2222593T3 (es) | 2005-02-01 |
| SI0979079T1 (en) | 2004-10-31 |
| JP3956059B2 (ja) | 2007-08-08 |
| EP0979079B1 (fr) | 2004-06-16 |
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