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BR9808911A - Armazanamento e manutenção aperfeiçoados de produtos de sangue - Google Patents

Armazanamento e manutenção aperfeiçoados de produtos de sangue

Info

Publication number
BR9808911A
BR9808911A BR9808911-0A BR9808911A BR9808911A BR 9808911 A BR9808911 A BR 9808911A BR 9808911 A BR9808911 A BR 9808911A BR 9808911 A BR9808911 A BR 9808911A
Authority
BR
Brazil
Prior art keywords
maintenance
blood products
improved storage
addition
red blood
Prior art date
Application number
BR9808911-0A
Other languages
English (en)
Other versions
BR9808911B1 (pt
Inventor
Secondo Dottori
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of BR9808911A publication Critical patent/BR9808911A/pt
Publication of BR9808911B1 publication Critical patent/BR9808911B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A61L2103/05—
    • A61L2103/09—

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Packages (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

Patente de Invenção:<B>"ARMAZENAMENTO E MANUTENçãO APERFEIçOADOS DE PRODUTOS DE SANGUE"<D>. A manutenção da membrana celular de concentrados de hemácias e plaquetas é melhorada pela adição de 1 mM - 10 mM de L-carnitina e derivados. Essa melhora permite um prolongamento do período de viabilidade de concentrados de hemácias e plaquetas em bolsas além dos períodos atuais. Além disso, os materiais assim tratados exibem uma meia-vida em circulação prolongada após a transfusão a um paciente. As melhoras na manutenção da membrana conseguidas por esse método permitem a irradiação de recipientes fechados de produtos de sangue, para esterilizá-los substancialmente e destruir leucócitos da mesma maneira
BRPI9808911-0A 1997-04-16 1998-04-15 métodos para melhorar a manutenção da membrana e supressão da lise de um concentrado de plaquetas (pc), para esterilizar substancialmente um pc, para o tratamento de um pc e para melhorar a manutenção de membrana e suprimir a lise de um pc. BR9808911B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/840,765 US6482585B2 (en) 1997-04-16 1997-04-16 Storage and maintenance of blood products including red blood cells and platelets
PCT/IT1998/000086 WO1998046073A1 (en) 1997-04-16 1998-04-15 Improved storage and maintenance of blood products

Publications (2)

Publication Number Publication Date
BR9808911A true BR9808911A (pt) 2000-08-01
BR9808911B1 BR9808911B1 (pt) 2010-09-21

Family

ID=25283169

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9808911-0A BR9808911B1 (pt) 1997-04-16 1998-04-15 métodos para melhorar a manutenção da membrana e supressão da lise de um concentrado de plaquetas (pc), para esterilizar substancialmente um pc, para o tratamento de um pc e para melhorar a manutenção de membrana e suprimir a lise de um pc.

Country Status (20)

Country Link
US (2) US6482585B2 (pt)
EP (1) EP0975214B1 (pt)
JP (1) JP4467649B2 (pt)
KR (1) KR100508408B1 (pt)
CN (2) CN1698430A (pt)
AT (1) ATE257326T1 (pt)
AU (1) AU739842B2 (pt)
BR (1) BR9808911B1 (pt)
CA (1) CA2286721A1 (pt)
CZ (1) CZ298671B6 (pt)
DE (1) DE69821002T2 (pt)
DK (1) DK0975214T3 (pt)
ES (1) ES2212288T3 (pt)
HU (1) HUP0001936A3 (pt)
IL (1) IL132271A (pt)
NZ (1) NZ500534A (pt)
PL (1) PL192684B1 (pt)
PT (1) PT975214E (pt)
SK (1) SK284688B6 (pt)
WO (1) WO1998046073A1 (pt)

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US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
HUP0203441A3 (en) * 1999-10-11 2004-01-28 Sigma Tau Ind Farmaceuti Use of l-carnitine and its alkanoyl derivatives as osmotic agents and solutions for medical use
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
RU2245145C1 (ru) * 2003-10-01 2005-01-27 Российский государственный медицинский университет Средство нормализации агрегационных свойств тромбоцитов и эритроцитов и морфоденситометрических характеристик эритроцитов
ATE494777T1 (de) * 2003-10-09 2011-01-15 Core Dynamics Ltd Verfahren zum tiefgefrieren, auftauen und transplantieren von lebensfähigem knorpel
EP1711053A2 (en) * 2004-02-02 2006-10-18 I.M.T. Interface Multigrad Technology Ltd. Biological material and methods and solutions for preservation thereof
WO2005073652A2 (en) * 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Apparatus, system and method for lyophilization
US7892726B2 (en) * 2004-06-07 2011-02-22 Core Dynamics Limited Method for sterilizing lyophilized eukaryotic anuclear cells with gamma irradiation
EP1778007A1 (en) * 2004-08-12 2007-05-02 I.M.T. Interface Multigrad Technology Ltd. Method and apparatus for freezing or thawing of a biological material
US20080160496A1 (en) * 2005-02-22 2008-07-03 Victor Rzepakovsky Preserved Viable Cartilage, Method for Its Preservation, and System and Devices Used Therefor
FR2884717B1 (fr) * 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions Erythrocytes renfermant de l'arginine deiminase
EP1909565A2 (en) * 2005-08-03 2008-04-16 Interface Multigrad Technology (IMT) Ltd. Somatic cells for use in cell therapy
US7462485B2 (en) * 2005-10-07 2008-12-09 Glaser Lawrence F Modified erythrocytes and uses thereof
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US20090202978A1 (en) * 2008-02-13 2009-08-13 Ginadi Shaham Method and apparatus for freezing of a biological material
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
JP2013507447A (ja) 2009-10-12 2013-03-04 ニュー ヘルス サイエンシーズ、インク． 酸素減損装置及び赤血球から酸素を除去する方法
CN102711865B (zh) 2009-10-12 2015-08-19 新健康科学股份有限公司 具有氧和二氧化碳消耗能力的血液贮藏袋系统和消耗装置
EP2490751B1 (en) 2009-10-23 2016-11-09 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
ES2959120T3 (es) 2010-08-25 2024-02-20 Hemanext Inc Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento
PT2635114T (pt) 2010-11-05 2020-06-16 New Health Sciences Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
CA2826969C (en) 2010-11-29 2019-02-19 New York Blood Center, Inc. Method of blood pooling and storage
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
AU2012240016B2 (en) 2011-04-07 2016-11-10 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
JP2014518283A (ja) * 2011-07-05 2014-07-28 ニュー・ヘルス・サイエンシーズ・インコーポレイテッド 赤血球の長期保存システムおよび使用方法
ES2984863T3 (es) 2011-08-10 2024-10-31 Hemanext Inc Dispositivo integrado de filtrado de leucocitos, oxígeno y/o agotamiento de CO2, y separación de plasma
US9877476B2 (en) 2013-02-28 2018-01-30 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
KR20250033333A (ko) 2015-03-10 2025-03-07 헤마넥스트 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
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ES3042959T3 (en) 2015-05-18 2025-11-24 Hemanext Inc Methods for the storage of whole blood, and compositions thereof
US11147876B2 (en) 2016-05-27 2021-10-19 Hemanext Inc. Anaerobic blood storage and pathogen inactivation method
DE102017218847A1 (de) 2017-10-23 2019-04-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Verbesserung der Stabilität von Blut und Blutprodukten
CN114786481A (zh) * 2019-11-29 2022-07-22 新泽西鲁特格斯州立大学 用于储存血液制品的组合物、试剂盒和方法及其使用方法
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Also Published As

Publication number Publication date
NZ500534A (en) 2001-05-25
IL132271A0 (en) 2001-03-19
HUP0001936A3 (en) 2001-03-28
HUP0001936A2 (hu) 2000-10-28
ATE257326T1 (de) 2004-01-15
US6960428B2 (en) 2005-11-01
BR9808911B1 (pt) 2010-09-21
CZ368199A3 (cs) 2000-04-12
CZ298671B6 (cs) 2007-12-19
SK142799A3 (en) 2000-05-16
CN1698430A (zh) 2005-11-23
JP4467649B2 (ja) 2010-05-26
WO1998046073A1 (en) 1998-10-22
KR100508408B1 (ko) 2005-08-17
AU739842B2 (en) 2001-10-18
DK0975214T3 (da) 2004-05-10
PT975214E (pt) 2004-05-31
CN1252687A (zh) 2000-05-10
HK1025477A1 (en) 2000-11-17
DE69821002D1 (de) 2004-02-12
ES2212288T3 (es) 2004-07-16
US20010049089A1 (en) 2001-12-06
US20030022228A1 (en) 2003-01-30
IL132271A (en) 2005-12-18
SK284688B6 (sk) 2005-09-08
JP2001523225A (ja) 2001-11-20
DE69821002T2 (de) 2004-07-08
EP0975214B1 (en) 2004-01-07
CA2286721A1 (en) 1998-10-22
EP0975214A1 (en) 2000-02-02
US6482585B2 (en) 2002-11-19
PL336294A1 (en) 2000-06-19
AU7078198A (en) 1998-11-11
PL192684B1 (pl) 2006-11-30
KR20010006464A (ko) 2001-01-26

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/09/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2259 DE 22-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.