[go: up one dir, main page]

BR9808466A - Método para distribuição oral de proteìnas - Google Patents

Método para distribuição oral de proteìnas

Info

Publication number
BR9808466A
BR9808466A BR9808466-6A BR9808466A BR9808466A BR 9808466 A BR9808466 A BR 9808466A BR 9808466 A BR9808466 A BR 9808466A BR 9808466 A BR9808466 A BR 9808466A
Authority
BR
Brazil
Prior art keywords
protein distribution
composition
oral protein
oral
hydrogel matrix
Prior art date
Application number
BR9808466-6A
Other languages
English (en)
Inventor
Nicholas A Peppas
Anthony M Lowman
Tsuneji Nagai
Mariko Morishita
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of BR9808466A publication Critical patent/BR9808466A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"MéTODO PARA DISTRIBUIçãO ORAL DE PROTEìNAS" A presente invenção refere-se a uma composição e método para a administração oral de componentes bioativos a vertebrados. O método compreende a etapa de administrar oralmente ao vertebrado uma composição que compreende uma matriz de hidrogel intumescível e uma composição bioativa contida dentro de matriz de hidrogel.
BR9808466-6A 1997-04-02 1998-04-02 Método para distribuição oral de proteìnas BR9808466A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US6136797P 1997-10-08 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
BR9808466A true BR9808466A (pt) 2001-08-07

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808466-6A BR9808466A (pt) 1997-04-02 1998-04-02 Método para distribuição oral de proteìnas

Country Status (14)

Country Link
EP (1) EP0975328A1 (pt)
JP (1) JP2002512607A (pt)
KR (1) KR20010005952A (pt)
CN (1) CN1259045A (pt)
AU (1) AU727053B2 (pt)
BR (1) BR9808466A (pt)
CA (1) CA2285457A1 (pt)
IL (1) IL132176A0 (pt)
NO (1) NO994757L (pt)
NZ (1) NZ500075A (pt)
PL (1) PL335974A1 (pt)
TR (1) TR199903240T2 (pt)
WO (1) WO1998043615A1 (pt)
YU (1) YU49699A (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE10040592A1 (de) * 2000-08-15 2002-03-07 Aventis Res & Tech Gmbh & Co Formulierung zur verbesserten Aufnahme von Wirkstoffen und deren Verwendung
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
GB0206048D0 (en) * 2002-03-14 2002-04-24 Croda Int Plc Use
ES2425392T3 (es) 2002-03-20 2013-10-15 Mannkind Corporation Cartucho para un aparato de inhalación
ES2385934T3 (es) 2004-08-20 2012-08-03 Mannkind Corporation Catálisis de la síntesis de dicetopiperazina.
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
US8110212B2 (en) 2005-04-07 2012-02-07 Drexel University Bioactive thermogelling polymer systems and methods of their use
US11744803B2 (en) 2005-07-29 2023-09-05 Stichting Groningen Centre for Drug Rese PH-controlled pulsatile delivery system, methods for preparation and use thereof
AU2006275424B2 (en) * 2005-08-01 2013-01-10 Mannkind Corporation Method of preserving the function of insulin-producing cells
US7799344B2 (en) 2005-09-14 2010-09-21 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US8039431B2 (en) 2006-02-22 2011-10-18 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
EP2389960B1 (en) 2006-06-15 2018-02-28 MicroVention, Inc. Environmentally responsive hydrogel
BRPI0821070B1 (pt) 2007-12-21 2018-10-23 Microvention Inc dispositivo para implantação e método para a preparação de um filamento de hidrogel para implantação em um animal
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
DK2293833T3 (en) 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
DK2424775T3 (en) 2009-04-30 2016-05-23 Technip France A method and system for sharing a mooring line
US8551528B2 (en) 2009-06-12 2013-10-08 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
EP2480166B1 (en) 2009-09-24 2017-11-29 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
CA2777171C (en) 2009-10-26 2017-09-19 Microvention, Inc. Embolization device constructed from expansile polymer
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
MY180552A (en) 2011-04-01 2020-12-02 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (en) 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
MX394255B (es) 2013-07-18 2025-03-24 Mannkind Corp Composiciones farmaceuticas en polvo seco estables al calor y metodos
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
CN106456836B (zh) 2014-04-29 2019-12-06 微仙美国有限公司 包含活性剂的聚合物
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
WO2024130101A1 (en) * 2022-12-16 2024-06-20 Wake Forest University Health Sciences Hydrogel compositions and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
IT1050353B (it) * 1966-01-06 1981-03-10 Ceskoslovenska Akademie Ved Supporti per sostanze biologigamente attive
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (fr) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie Matiere seche hydratable en un gel aqueux contenant des particules de polymeres dispersees, procede pour sa preparation et son application en biologie

Also Published As

Publication number Publication date
NZ500075A (en) 2001-03-30
PL335974A1 (en) 2000-06-05
KR20010005952A (ko) 2001-01-15
NO994757D0 (no) 1999-09-30
NO994757L (no) 1999-11-29
CN1259045A (zh) 2000-07-05
IL132176A0 (en) 2001-03-19
WO1998043615A1 (en) 1998-10-08
EP0975328A1 (en) 2000-02-02
AU727053B2 (en) 2000-11-30
YU49699A (sh) 2002-12-10
CA2285457A1 (en) 1998-10-08
AU6880998A (en) 1998-10-22
TR199903240T2 (xx) 2000-05-22
JP2002512607A (ja) 2002-04-23

Similar Documents

Publication Publication Date Title
BR9808466A (pt) Método para distribuição oral de proteìnas
BR9807577A (pt) Método para prevenir e retardar o inìcio da doença de alzheimer e sua composição
BR9611137A (pt) Composições e métodos para distribuição bucal de agentes farmacêuticos
BR9608067A (pt) Composição terapêutica compreendendo um antígeno ou um gerador in vivo de um composto que compreende uma sequência de ácidos aminados
PT952829E (pt) Composicao farmaceutica de fenofibrato que apresenta uma biodisponibilidade elevada e seu modo de preparacao
BR9602542A (pt) Composto método para o tratamento de uma doença dependente da fosforilase de glicogénio composição farmacéutica e processo para a preparação de um composto
PT96438A (pt) Processo para preparacao de anti-oxidante lipideo-selectivos e de composicoes farmaceuticas que os contem
IT1255258B (it) Composizioni farmaceutiche per l'applicazione per via nasale.
BR9502555A (pt) Composiçao que consiste de um dendrímero e de uma substancia ativa ocluida no dendrímero processo para a preparaçao de uma tal composiçao e processo para liberaçao de uma substancia ativa
ITMI951021A0 (it) Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante
BR9910508A (pt) Preparações farmacêuticas estabilizadas de derivados de ácido gama-aminobutìrico e processo para a sua preparação
FI970522A7 (fi) Koostumukset ja menetelmät pidennetyn paikallisanestesian aikaansaamis eksi
BR9909138A (pt) Combinação para o tratamento de dependência de álcool e drogas contendo um antagonista de opióide e um modulador de complexo receptor de nmda
FI963679L (fi) Stabiloitu koostumus peptidien antamiseksi suun kautta
BR9808875A (pt) Combinação de analgésicos
BR9713215A (pt) Formulação de partìcula revestida
ES2168457T3 (es) Composiciones farmaceuticas que comprenden una superoxido dismutasa.
ES2181710T3 (es) Adenovirus recombinantes y su utilizacion en terapia genica para el tratamiento de las patologias oculares.
BR9809678A (pt) Derivados de triptolìdeo úteis no tratamento de doenças autoimunes
BR9809673A (pt) Derivados de triptolida úteis no tratamento de doenças autoimunes
BR9507451A (pt) Composição farmacêutica uso de uma quantidade de (i) um antígeno padronizado em conjunto com uma quantidade de (ii) um polipeptídeo e produto contendo uma quantidade de (i) um antígeno padronizado em conjunto com uma quantidade de (ii) um polipeptídeo
PT1012186E (pt) Utilizacao de produto(s) da proteina kgf e de produto(s) da proteina glp-2 para a preparacao de um medicamento
ES2096727T5 (es) Productos cosmeticos y farmaceuticos que contienen extensinas.
DE59611383D1 (de) Darreichungsform zur applikation von pharmazeutischen wirkstoffen und hilfsstoffen und verfahren zur herstellung derselben
HUP9900507A3 (en) Use of levobupivacaine for producing pharmaceutical composition as an anaesthetic in pregnancy

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007.