BR9808029A - Processo para a produção de compostos, novos compostos, preparado farmacêutico que contém os mesmos e utilização desses compostos - Google Patents
Processo para a produção de compostos, novos compostos, preparado farmacêutico que contém os mesmos e utilização desses compostosInfo
- Publication number
- BR9808029A BR9808029A BR9808029-6A BR9808029A BR9808029A BR 9808029 A BR9808029 A BR 9808029A BR 9808029 A BR9808029 A BR 9808029A BR 9808029 A BR9808029 A BR 9808029A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- production
- pharmaceutical preparation
- preparation containing
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 10
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
<MU><B> PROCESSO PARA A PRODUçãO DE COMPOSTOS, NOVOS COMPOSTOS, PREPARADO FARMACêUTICO QUE CONTéM OS MESMOS E UTILIZAçãO DESSES COMPOSTOS<D><MV>.Expõe-se um processo para a produção de compostos da fórmula (III) em que A representa CH=CH ou s W representa O X representa S, O ou NR^ 2^em que o resíduo R^ 2^ é hidrogênio ou alquila C~ 1~-C~ 6~, Y representa CH ou N, R representa naftil, tienil ou fenil que é opcionalmente mono-substituído ou di-substituído com alquila C~ 1~-C~ 3~, CF~ 3~, F, Cl ou bromo, R^ 1^ representa hidrogênio ou alquila C~ 1~-C~ 6~ e n representa 1-3 pela redução de um composto da fórmula geral IV, em que A,W,X,Y,R,R^ 1^ e n têm os mesmos significados estabelecidos anteriormente, com alumínio ativado em um solvente protéico. A invenção também se relaciona com novos compostos de fórmula III e com preparados farmacêuticos que contêm estes compostos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19711616A DE19711616A1 (de) | 1997-03-20 | 1997-03-20 | Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
| PCT/EP1998/001535 WO1998042704A1 (de) | 1997-03-20 | 1998-03-17 | Verbessertes verfahren zur herstellung von thiazolidindionen und neue thiazolidindione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9808029A true BR9808029A (pt) | 2000-03-08 |
Family
ID=7824011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9808029-6A BR9808029A (pt) | 1997-03-20 | 1998-03-17 | Processo para a produção de compostos, novos compostos, preparado farmacêutico que contém os mesmos e utilização desses compostos |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6258832B1 (pt) |
| EP (1) | EP0970077B1 (pt) |
| JP (2) | JP3484200B2 (pt) |
| KR (1) | KR100340353B1 (pt) |
| CN (1) | CN1105718C (pt) |
| AR (1) | AR012124A1 (pt) |
| AT (1) | ATE240324T1 (pt) |
| AU (1) | AU726048B2 (pt) |
| BR (1) | BR9808029A (pt) |
| CA (1) | CA2285208C (pt) |
| DE (2) | DE19711616A1 (pt) |
| DK (1) | DK0970077T3 (pt) |
| ES (1) | ES2198053T3 (pt) |
| HU (1) | HUP0001551A3 (pt) |
| IL (1) | IL131772A (pt) |
| NO (1) | NO313292B1 (pt) |
| NZ (1) | NZ337608A (pt) |
| PL (1) | PL192201B1 (pt) |
| PT (1) | PT970077E (pt) |
| RS (1) | RS49771B (pt) |
| RU (1) | RU2181724C2 (pt) |
| TR (1) | TR199902197T2 (pt) |
| TW (1) | TW487707B (pt) |
| WO (1) | WO1998042704A1 (pt) |
| ZA (1) | ZA982326B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE319702T1 (de) | 1999-08-02 | 2006-03-15 | Verfahren zur herstellung von benzothiophen- derivaten | |
| US6531609B2 (en) | 2000-04-14 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for the preparation of thiazolidinedione derivatives |
| FR2820741A1 (fr) * | 2001-02-14 | 2002-08-16 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| FR2820742B1 (fr) * | 2001-02-14 | 2005-03-11 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| CA2441941A1 (en) * | 2001-04-06 | 2002-10-17 | F. Hoffmann-La Roche Ag | Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth |
| MXPA03010435A (es) | 2001-05-15 | 2004-03-09 | Hoffmann La Roche | Derivados de oxazol acido carboxilico sustituidos para uso como activadores de proliferacion del peroximosa(ppar-alfa y gama) en el tratamiento de diabetes. |
| DE60316290T2 (de) * | 2002-07-03 | 2008-06-12 | F. Hoffmann-La Roche Ag | Oxazolderivate und deren verwendung als insulinsensibilisatoren |
| ES2350340T3 (es) * | 2002-08-30 | 2011-01-21 | F. Hoffmann-La Roche Ag | Nuevos compuestos de 2-aril-tiazol como agonistas de pparalfa y ppargamma. |
| PL375878A1 (en) * | 2002-09-12 | 2005-12-12 | F.Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| BR0316556A (pt) * | 2002-11-25 | 2005-10-04 | Hoffmann La Roche | Compostos, processo para a preparação de um composto, composição farmacêutica que compreende esse composto, sua utilização e método para o tratamento e/ou profilaxia de enfermidades que são moduladas por agonistas ppar(alfa) e/ou ppary |
| MXPA05013732A (es) * | 2003-06-26 | 2006-03-08 | Hoffmann La Roche | Proceso para preparacion de sensibilizador de insulina y compuesto intermediario del mismo. |
| US11852360B2 (en) | 2019-12-10 | 2023-12-26 | Lg Electronics Inc. | Air management apparatus or device |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| WO1986007056A1 (en) | 1985-05-21 | 1986-12-04 | Pfizer Inc. | Hypoglycemic thiazolidinediones |
| GB8713861D0 (en) | 1987-06-13 | 1987-07-15 | Beecham Group Plc | Compounds |
| DE3856378T2 (de) | 1987-09-04 | 2000-05-11 | Beecham Group P.L.C., Brentford | Substituierte Thiazolidindionderivate |
| HU217432B (hu) | 1988-03-08 | 2000-01-28 | Pfizer Inc. | Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények |
| US5061717A (en) | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| US5330998A (en) | 1988-03-08 | 1994-07-19 | Pfizer Inc. | Thiazolidinedione derivatives as hypoglycemic agents |
| MX15171A (es) | 1988-03-08 | 1993-05-01 | Pfizer | Derivados de tiazolidinodiona hipoglicemicos |
| ATE205206T1 (de) * | 1990-04-27 | 2001-09-15 | Sankyo Co | Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren |
| CA2087437A1 (en) | 1990-08-23 | 1992-02-24 | Steven W. Goldstein | Hypoglycemic hydroxyurea derivatives |
| EP0618915A1 (en) * | 1991-12-20 | 1994-10-12 | The Upjohn Company | A reduction method for substituted 5-methylene-thiazolidinediones |
| FR2688220A1 (fr) | 1992-03-06 | 1993-09-10 | Adir | Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE4317320A1 (de) * | 1993-05-25 | 1994-12-01 | Boehringer Mannheim Gmbh | Neue Thiazolidindione und diese enthaltende Arzneimittel |
| DK0684242T3 (da) | 1993-12-27 | 1999-11-01 | Japan Tobacco Inc | Isoxazolidindionderivat og anvendelse deraf |
-
1997
- 1997-03-20 DE DE19711616A patent/DE19711616A1/de not_active Withdrawn
-
1998
- 1998-03-17 TW TW087103935A patent/TW487707B/zh not_active IP Right Cessation
- 1998-03-17 KR KR1019997008445A patent/KR100340353B1/ko not_active Expired - Fee Related
- 1998-03-17 EP EP98916974A patent/EP0970077B1/de not_active Expired - Lifetime
- 1998-03-17 TR TR1999/02197T patent/TR199902197T2/xx unknown
- 1998-03-17 US US09/381,247 patent/US6258832B1/en not_active Expired - Fee Related
- 1998-03-17 DK DK98916974T patent/DK0970077T3/da active
- 1998-03-17 AU AU70361/98A patent/AU726048B2/en not_active Ceased
- 1998-03-17 NZ NZ337608A patent/NZ337608A/en unknown
- 1998-03-17 RU RU99122023/04A patent/RU2181724C2/ru not_active IP Right Cessation
- 1998-03-17 PL PL335903A patent/PL192201B1/pl not_active IP Right Cessation
- 1998-03-17 PT PT98916974T patent/PT970077E/pt unknown
- 1998-03-17 RS YUP-466/99A patent/RS49771B/sr unknown
- 1998-03-17 IL IL13177298A patent/IL131772A/en not_active IP Right Cessation
- 1998-03-17 AT AT98916974T patent/ATE240324T1/de not_active IP Right Cessation
- 1998-03-17 HU HU0001551A patent/HUP0001551A3/hu unknown
- 1998-03-17 CN CN98803388A patent/CN1105718C/zh not_active Expired - Fee Related
- 1998-03-17 DE DE59808365T patent/DE59808365D1/de not_active Expired - Fee Related
- 1998-03-17 JP JP54484098A patent/JP3484200B2/ja not_active Expired - Fee Related
- 1998-03-17 BR BR9808029-6A patent/BR9808029A/pt not_active Application Discontinuation
- 1998-03-17 ES ES98916974T patent/ES2198053T3/es not_active Expired - Lifetime
- 1998-03-17 WO PCT/EP1998/001535 patent/WO1998042704A1/de not_active Ceased
- 1998-03-17 CA CA002285208A patent/CA2285208C/en not_active Expired - Fee Related
- 1998-03-19 ZA ZA9802326A patent/ZA982326B/xx unknown
- 1998-03-20 AR ARP980101266A patent/AR012124A1/es active IP Right Grant
-
1999
- 1999-09-17 NO NO19994505A patent/NO313292B1/no unknown
-
2001
- 2001-02-14 US US09/783,494 patent/US6441185B2/en not_active Expired - Fee Related
-
2003
- 2003-08-21 JP JP2003297751A patent/JP2004067697A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9808029A (pt) | Processo para a produção de compostos, novos compostos, preparado farmacêutico que contém os mesmos e utilização desses compostos | |
| BR9913592A (pt) | Compostos, processo de preparação dos compostos, e, composições farmacêuticas | |
| BR9914451A (pt) | Composto de oxazol, processo para sua preparação, composição farmacêutica compreendendo dito composto, uso da composição e métodos de tratamento | |
| BR0012434A (pt) | Composto, processo para a preparação do mesmo, uso de um composto, composição farmacêutica. | |
| BR9911783A (pt) | Compostos cìclicos substituìdos, processo para sua preparação e composições farmacêuticas que os contêm | |
| PT80913B (pt) | Processo para a preparacao de novos compostos ciano-substituidos | |
| BR0306150A (pt) | Composto, uso de um composto, e, composição farmacêutica | |
| BR0108871A (pt) | Composto, processo de preparação de compostos, e, composição farmacêutica | |
| BR9910326A (pt) | Processo para preeparar isoxazóis, composto, processo para preparar compostos, uso de compostos, e, processo para preparar tioéteres | |
| BR9910371A (pt) | Composto, composição farmacêutica, agente para controlar os receptores relacionados com a retinóide, processos de prevenção e terapia da diabetes mellitus, de prevenção e terapia da hiperlipemia, para acentuar uma sensibilidade à insulina, para melhorar uma resistência à insulina, de prevenção e terapia da tolerância à glicose prejudicada, de prevenção e terapia de uma doença inflamatória, de prevenção de uma esclerose arterial, e, uso do composto | |
| EA200400815A1 (ru) | Контролируемый синтез зипразидона и его композиции | |
| AR048213A1 (es) | 1-(4-mono-y di-halometilsulfonilfenil)-2-acilamino-fluorpropanoles analogos al florfenicol | |
| LV10949A (lv) | Aizvietoti 4-fenil-4piperidinkarboksamidi to iegusanas panemiens farmaceitiska kompozicija | |
| DK317382A (da) | Fremgangsmaade til fremstilling af pyrrolidinderivater | |
| UY28528A1 (es) | Nuevos compuestos | |
| BRPI0406500A (pt) | processo farmacêutico e compostos preparados pelo mesmo | |
| ES557663A0 (es) | Un procedimiento para la sintesis de derivados de imidazol. | |
| CA2118102A1 (fr) | Nouveaux derives de 1,2,3,4-tetrahydronaphtalene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FI841738A0 (fi) | Imidazol-etanolestrar. | |
| BR9813217A (pt) | Tetraciclos, processo para a produção dos mesmos e preparações farmacêuticas contendo estes compostos | |
| PT89643A (pt) | Processo para a preparacao de derivados de 2-{(4-piperidinil)-metil}-1,2,3,4-tetrahidro-isoquinoleina e de composicoes farmaceuticas que os contem | |
| BR9912870A (pt) | Processo para sìntese de derivados de (1h) - benzo (c)quinolizina-3-onas | |
| BR8803402A (pt) | Poliisocianatos aromaticos,processo para a sua preparacao e utilizacao | |
| PT921119E (pt) | Novos derivados de pirrol, processo para a sua preparacao e as composicoes farmaceuticas que os contem | |
| CA2180621A1 (fr) | Nouveaux derives d'acide aminophenylphosphonique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |