[go: up one dir, main page]

BR9713241A - Compostos farmacêuticos que compreendem poliaminas substituìdas por grupos com afinidade por elétrons - Google Patents

Compostos farmacêuticos que compreendem poliaminas substituìdas por grupos com afinidade por elétrons

Info

Publication number
BR9713241A
BR9713241A BR9713241-1A BR9713241A BR9713241A BR 9713241 A BR9713241 A BR 9713241A BR 9713241 A BR9713241 A BR 9713241A BR 9713241 A BR9713241 A BR 9713241A
Authority
BR
Brazil
Prior art keywords
electron affinity
groups
pharmaceutical compounds
polyamines
replaced
Prior art date
Application number
BR9713241-1A
Other languages
English (en)
Inventor
Li-Xi Yang
Kurt G Hofer
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Publication of BR9713241A publication Critical patent/BR9713241A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS FARMACêUTICOS QUE COMPREENDEM POLIAMINAS SUBSTITUìDAS POR GRUPOS COM AFINIDADE POR ELéTRONS"<D>. Esta invenção proporciona um composto ou um sal do mesmo o qual compreende uma poliamina que contém pelo menos dois grupos com afinidade por elétrons. Em uma modalidade preferida, o composto de poliamina possui estrutura (1), onde A é um espaçador, R^ 1^, R^ 2^, R^ 3^ R^ 4^ são independentemente hidrogênio, hidrocarboneto, hidrocarnoneto heterossubstituído, heteroarila, heteroarila heterossubstuída ou um grupo com afinidade por elétrons que contém substituinte; e o composto contém pelo menos uma funcionalidade amina terciária com três substituintes, cada um dos quais contém independentemente pelo menos um grupo com afinidade por elétrons ou um grupo hidrofílico.
BR9713241-1A 1996-09-30 1997-09-29 Compostos farmacêuticos que compreendem poliaminas substituìdas por grupos com afinidade por elétrons BR9713241A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/722,396 US6060604A (en) 1995-03-31 1996-09-30 Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
PCT/US1997/017408 WO1998014190A1 (en) 1996-09-30 1997-09-29 Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups

Publications (1)

Publication Number Publication Date
BR9713241A true BR9713241A (pt) 2000-04-04

Family

ID=24901655

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713241-1A BR9713241A (pt) 1996-09-30 1997-09-29 Compostos farmacêuticos que compreendem poliaminas substituìdas por grupos com afinidade por elétrons

Country Status (10)

Country Link
US (3) US6060604A (pt)
EP (1) EP0956016A4 (pt)
JP (1) JP2001501932A (pt)
KR (1) KR20000048682A (pt)
CN (1) CN1232395A (pt)
AU (1) AU725206B2 (pt)
BR (1) BR9713241A (pt)
CA (1) CA2265558A1 (pt)
NO (1) NO991534L (pt)
WO (1) WO1998014190A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
IL146126A0 (en) 1999-04-30 2002-07-25 Slil Biomedical Corp Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
ES2269138T3 (es) 1999-04-30 2007-04-01 Cellgate, Inc. Poliaminas y su uso en terapia.
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
AU2002235126A1 (en) 2000-11-08 2002-05-21 Slil Biomedical Corporation Novel polyamine analog-amino acid conjugates useful as anticancer agents
AU2002340224B2 (en) 2001-10-16 2008-11-27 Progen Pharmaceuticals, Inc Oligoamine compounds and derivatives thereof for cancer therapy
US6723755B2 (en) 2002-06-12 2004-04-20 Piotr Chomczynski Method of treating rosacea
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7812057B2 (en) * 2004-08-25 2010-10-12 Molecular Research Center, Inc. Cosmetic compositions
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
AU2014209218B2 (en) * 2013-01-25 2018-06-07 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA784711A (en) * 1968-05-07 Carlo Erba S.P.A. Imidazole-derivatives and process for their preparation
CA519633A (en) * 1955-12-20 E. Carpenter Joseph Cationic surface active agents
US2653977A (en) * 1953-09-29 Chxnx
US2477653A (en) * 1943-08-10 1949-08-02 W H Reisner Mfg Company Primary electrical training test board apparatus
US2447653A (en) * 1945-01-08 1948-08-24 Commericial Solvents Corp Nitro amines and process for preparing same
US3013020A (en) * 1958-01-24 1961-12-12 Miles Lab N,n'-bis-phenyl-alkylene-diamines
US4871759A (en) * 1973-06-18 1989-10-03 Mercer James B Method of treatment of mesenteric adenitis
US4282232A (en) * 1979-04-26 1981-08-04 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US4371540A (en) * 1979-09-14 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells
DE2948884A1 (de) * 1979-12-05 1981-06-11 Basf Ag, 6700 Ludwigshafen 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
US5196413A (en) * 1984-12-10 1993-03-23 Johnson Matthey, Inc. Platinum complexes and the like
US5032617A (en) * 1985-05-03 1991-07-16 Sri International Substituted benzamide radiosensitizers
US5215738A (en) * 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
US5041653A (en) * 1985-05-03 1991-08-20 Sri International Substituted benzamide radiosensitizers
US4665191A (en) * 1985-05-06 1987-05-12 Texaco Inc. Mannich condensates
US4727068A (en) * 1985-10-23 1988-02-23 Johnson Matthey, Inc. Radiosensitization by cobalt and Fe(III) complexes
GB8607159D0 (en) * 1986-03-22 1986-04-30 Smith & Nephew Ass Pharmaceutical composition
US5183940A (en) * 1986-07-14 1993-02-02 Imperial Chemical Industries Plc Poly-(n-[2-hydroxybenzyl])-1,2-diaminoethanes
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
CA1339133C (en) * 1987-03-13 1997-07-29 Rikuo Nasu Imidazole compounds and biocidal composition comprising the same for controlling harmful organisms
US5026694A (en) * 1987-04-13 1991-06-25 The British Columbia Cancer Foundation Platinum complexes with one radiosensitizing ligand
US4921963A (en) * 1987-04-13 1990-05-01 British Columbia Cancer Foundation Platinum complexes with one radiosensitizing ligand
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
US5236944A (en) * 1988-03-28 1993-08-17 Janssen Pharmaceutica N.V. Compounds, compositions and anti-neoplastic methods
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
US5073639A (en) * 1988-11-25 1991-12-17 Warner-Lambert Company Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
IL92597A0 (en) * 1988-12-14 1990-08-31 Yasunori Nishijima President K Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
JP2627441B2 (ja) * 1989-01-19 1997-07-09 大鵬薬品工業株式会社 １―アセトキシム―２―ニトロイミダゾール誘導体
US5100885A (en) * 1989-08-01 1992-03-31 Johnson Matthey, Inc. Copper radiosensitizers
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
KR927003539A (ko) * 1990-01-26 1992-12-18 스즈끼 쯔네시 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
CA2089657C (en) * 1990-08-16 2002-05-14 Neil F. Martin Topical treatment of blepharitis
US5294715A (en) * 1991-02-01 1994-03-15 University Of Pittsburgh Acridine-intercalator based hypoxia selective cytotoxins
NZ244613A (en) * 1991-10-29 1996-05-28 Bracco International B V Subst A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand
CA2324959C (en) * 1991-11-12 2002-11-12 Pfizer Limited Phthalimido compounds as intermediates for producing substance p receptor antagonists
US5389661A (en) * 1991-12-05 1995-02-14 Warner-Lambert Company Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
TW218017B (pt) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
MX9304399A (es) * 1992-07-31 1994-02-28 Warner Lambert Co Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
ATE267009T1 (de) * 1993-02-23 2004-06-15 Brigham & Womens Hospital Calciumrezeptoraktive moleküle
JPH06345728A (ja) * 1993-06-11 1994-12-20 Nissan Chem Ind Ltd Ｎ−置換アゾール誘導体の製造方法
US5456908A (en) * 1994-03-01 1995-10-10 The University Of Kentucky Research Foundation Polyamine-polyamine and polyamine-protein transport inhibitor conjugates and their use as pharmaceuticals and in research relating to polyamine transport
US5498190A (en) * 1994-06-27 1996-03-12 Handsontoys, Inc. Flexible foam construction toy and method of manufacturing same
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups

Also Published As

Publication number Publication date
KR20000048682A (ko) 2000-07-25
US6060604A (en) 2000-05-09
CA2265558A1 (en) 1998-04-09
NO991534D0 (no) 1999-03-29
US6057453A (en) 2000-05-02
AU725206B2 (en) 2000-10-05
EP0956016A1 (en) 1999-11-17
CN1232395A (zh) 1999-10-20
EP0956016A4 (en) 2001-11-14
JP2001501932A (ja) 2001-02-13
AU4655497A (en) 1998-04-24
NO991534L (no) 1999-03-29
WO1998014190A1 (en) 1998-04-09
US6255495B1 (en) 2001-07-03

Similar Documents

Publication Publication Date Title
BR9713241A (pt) Compostos farmacêuticos que compreendem poliaminas substituìdas por grupos com afinidade por elétrons
CY1111278T1 (el) Συστημα ασφαλειας
BR0212733A (pt) Composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
BR9810231A (pt) Processo para produção de dispersões sólidas de paroxetina
TR200002224T2 (tr) Matris-bozucu metalloproteinasları inhibe eden sülfonilamino türevleri.
NO933482D0 (no) N-sulfonyl-2-oksoindol-derivater som har affinitet for vasopressin- og/eller ocytocin-reseptorer
BR9905806A (pt) Catalisador de polimerização e processo de polimerização
BR0111222A (pt) Derivados fosfonados de glicopeptìdeo
PT800519E (pt) Compostos moduladores de receptores de esteroides e metodos
ATE305453T1 (de) Selektive inhibitoren viraler oder bakterieller neuraminidase
MX168396B (es) Membrana microporosa modificada de carga procedimiento para modificacion de carga de dicha membrana y procedimiento para la filtracion de fluidos
ATE234092T1 (de) 2-alkylpyrrolidine
BR9712831A (pt) Inibidores tricìclicos de farnesil proteìna transferase
EA200100411A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
TR199801641T2 (xx) Tropan t�revleri bunlar�n haz�rlanmas� ve kullan�m�
FR2763244B1 (fr) Composition vaccinale multivalente a porteur mixte
BR0116904A (pt) Composição e método para inibição da formação de hidratos de gases
BR9610527A (pt) Novos derivados de substâncias de ciclodepsipeptìdeo pf1022
BR0016952A (pt) Compostos derivados de fenil-piperazina substituìdos, composição farmacêutica, uso e método
BR9909739A (pt) Benzotiadiazóis e derivados
HUP0103203A2 (hu) Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények
DE69404910D1 (de) Anti-Festlaufschutz für Verbindungen, insbesondere für den Erdölsektor
BR0208169A (pt) Composto quìmicos
BR0111897A (pt) Composto, método para tratar um indivìduo afligido por alguns distúrbios dos sistemas nervosos periférico e central, composição farmacêutica, e, uso de um composto
BR9705456A (pt) Compostos heterocìclicos, processo de aminometila para sua preparação e composições farmacêuticas que os contêm.

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1833 DE 21/02/2006.