BR9712587A - Nucleic acid, nucleic acid molecule, probe, recombinant expression vector, cell, processes for producing an h. pylori and to detect the presence of a helicobacter pylori nucleic acid in a sample, h. pylori isolated, cell, cellular and secreted envelope polypeptides from h. pylori or fragments thereof, fusion protein, vaccine formulation for the prophylaxis or treatment of an h. pylori, and processes to treat or reduce a risk of h. pylori in a subject and to produce a vaccine formulation. - Google Patents
Nucleic acid, nucleic acid molecule, probe, recombinant expression vector, cell, processes for producing an h. pylori and to detect the presence of a helicobacter pylori nucleic acid in a sample, h. pylori isolated, cell, cellular and secreted envelope polypeptides from h. pylori or fragments thereof, fusion protein, vaccine formulation for the prophylaxis or treatment of an h. pylori, and processes to treat or reduce a risk of h. pylori in a subject and to produce a vaccine formulation.Info
- Publication number
- BR9712587A BR9712587A BR9712587-3A BR9712587A BR9712587A BR 9712587 A BR9712587 A BR 9712587A BR 9712587 A BR9712587 A BR 9712587A BR 9712587 A BR9712587 A BR 9712587A
- Authority
- BR
- Brazil
- Prior art keywords
- pylori
- nucleic acid
- processes
- cell
- vaccine formulation
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 6
- 108020004707 nucleic acids Proteins 0.000 title abstract 6
- 150000007523 nucleic acids Chemical class 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 5
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 229960005486 vaccine Drugs 0.000 title abstract 5
- 238000009472 formulation Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000523 sample Substances 0.000 title abstract 3
- 230000001413 cellular effect Effects 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000003259 recombinant expression Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 241000590002 Helicobacter pylori Species 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 229940037467 helicobacter pylori Drugs 0.000 title 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"áCIDO NUCLéICO, MOLéCULA DE áCIDO NUCLéICO, SONDA, VETOR DE EXPRESSãO RECOMBINANTE, CéLULA, PROCESSOS PARA PRODUZIR UM POLIPEPTìDEO DE H. PYLORI E PARA DETECTAR A PRESENçA DE UM áCIDO NUCLéICO DE HELICOBACTER PYLORI EM UMA AMOSTRA, POLIPEPTìDEO DE H. PYLORI ISOLADO, POLIPEPTìDEOS DE ENVELOPE DE CéLULA, CELULAR E SECRETADO DE H. PYLORI OU SEUS FRAGMENTOS, PROTEìNA DE FUSãO, FORMULAçãO DE VACINA PARA A PROFILAXIA OU TRATAMENTO DE UMA INFECçãO POR H. PYLORI, E, PROCESSOS PARA TRATAR OU REDUZIR UM RISCO DE INFECçãO POR H. PYLORI EM UM SUJEITO E PARA PRODUZIR UMA FORMULAçãO DE VACINA". Descreve-se preparações recombinantes ou substancialmente puras de polipeptídeos de H. pylori. Os ácidos nucléicos que codificam os polipeptídeos também são descritos. Os polipeptídeos de H. pylori são úteis para diagnósticos e composições de vacina."NUCLEIC ACID, NUCLEIC ACID MOLECULE, PROBE, RECOMBINANT EXPRESSION VECTOR, CELL, PROCESSES TO PRODUCE A POLYPEPTIDE OF H. PYLORI AND TO DETECT THE PRESENCE OF A NUCLÉIC ACID OF HYORACLE, PILOT OF HELICOLE H. PYLORI CELL, CELLULAR AND SECRET SECRETARY ENVELOPE POLYPEPTIDS OR ITS FRAGMENTS, FUSION PROTEIN, VACCINE FORMULATION FOR PROPHYLAXIS OR TREATMENT OF AN INFECTION BY H. PYLORI, AND PROCESSES TO TREAT REDUCING HYDRO OR REDUCING HYDRO REDUCING PROTECTION. . PYLORI IN A SUBJECT AND TO PRODUCE A VACCINE FORMULATION ". Recombinant or substantially pure preparations of H. pylori polypeptides are described. Nucleic acids encoding polypeptides are also described. H. pylori polypeptides are useful for diagnostics and vaccine compositions.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73915096A | 1996-10-28 | 1996-10-28 | |
| US75973996A | 1996-12-06 | 1996-12-06 | |
| US89192897A | 1997-07-14 | 1997-07-14 | |
| PCT/US1997/019575 WO1998018323A1 (en) | 1996-10-28 | 1997-10-28 | Nucleic acid and amino acid sequences relating to helicobacter pylori and vaccine compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9712587A true BR9712587A (en) | 1999-10-26 |
Family
ID=27419246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9712587-3A BR9712587A (en) | 1996-10-28 | 1997-10-28 | Nucleic acid, nucleic acid molecule, probe, recombinant expression vector, cell, processes for producing an h. pylori and to detect the presence of a helicobacter pylori nucleic acid in a sample, h. pylori isolated, cell, cellular and secreted envelope polypeptides from h. pylori or fragments thereof, fusion protein, vaccine formulation for the prophylaxis or treatment of an h. pylori, and processes to treat or reduce a risk of h. pylori in a subject and to produce a vaccine formulation. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0973394A4 (en) |
| JP (1) | JP2001504329A (en) |
| KR (1) | KR20000052831A (en) |
| CN (1) | CN1235513A (en) |
| AR (1) | AR009600A1 (en) |
| AU (1) | AU734052B2 (en) |
| BR (1) | BR9712587A (en) |
| CA (1) | CA2265523A1 (en) |
| EE (1) | EE9900176A (en) |
| ID (1) | ID22065A (en) |
| IL (1) | IL129397A0 (en) |
| IS (1) | IS5005A (en) |
| NO (1) | NO991995L (en) |
| NZ (1) | NZ334568A (en) |
| PL (1) | PL333169A1 (en) |
| SA (1) | SA98180918A (en) |
| SK (1) | SK34699A3 (en) |
| TR (1) | TR199900940T2 (en) |
| WO (1) | WO1998018323A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406703B1 (en) | 1993-07-27 | 2002-06-18 | Csl Limited | Treatment of H. pylori associated gastroduodenal disease |
| US5871749A (en) * | 1993-07-27 | 1999-02-16 | Csl Limited | Therapeutic treatment of H. pylori associated gastroduodenal disease |
| DE19730425A1 (en) | 1997-07-16 | 1999-01-21 | Henkel Teroson Gmbh | Heat-curing laundry-resistant shell sealant |
| AU4793499A (en) * | 1998-07-27 | 2000-02-21 | Aventis Pasteur Limited | (chlamydia) antigens and corresponding dna fragments and uses thereof |
| SE9901548D0 (en) * | 1999-04-29 | 1999-04-29 | Astra Ab | Helicobacter pylori antigens |
| GB9914945D0 (en) * | 1999-06-25 | 1999-08-25 | Smithkline Beecham Biolog | Novel compounds |
| AUPQ347199A0 (en) * | 1999-10-15 | 1999-11-11 | Csl Limited | Novel polypeptide fragments |
| CN101532000A (en) | 2000-03-08 | 2009-09-16 | 诺维信公司 | Variants with altered properties |
| GB0010371D0 (en) * | 2000-04-29 | 2000-06-14 | Astrazeneca Ab | Helicobacter pylori antigens |
| GB0010370D0 (en) * | 2000-04-29 | 2000-06-14 | Astrazeneca Ab | Helicobacter pylori antigens |
| EP2695938B1 (en) | 2011-03-17 | 2016-11-30 | National UniversityCorporation Mie University | Antibody production method |
| JP6959937B2 (en) * | 2015-12-14 | 2021-11-05 | テクニシェ ユニバーシタット ミュンヘン | Helicobacter pylori vaccine |
| CN115724922B (en) * | 2022-07-19 | 2023-08-22 | 四川大学华西医院 | A kind of Helicobacter pylori vaccine recombinant protein antigen TonB and its preparation method and application |
| CN115581201A (en) * | 2022-08-26 | 2023-01-10 | 云南省农业科学院花卉研究所 | Diploid rose F induced by stem segment as explant 1 -61 plant regeneration method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9300139L (en) * | 1993-01-19 | 1994-07-20 | Medicarb Ab | Preparation of a new drug |
-
1997
- 1997-10-28 NZ NZ334568A patent/NZ334568A/en unknown
- 1997-10-28 WO PCT/US1997/019575 patent/WO1998018323A1/en not_active Ceased
- 1997-10-28 AU AU50933/98A patent/AU734052B2/en not_active Ceased
- 1997-10-28 PL PL97333169A patent/PL333169A1/en unknown
- 1997-10-28 JP JP52071098A patent/JP2001504329A/en active Pending
- 1997-10-28 TR TR1999/00940T patent/TR199900940T2/en unknown
- 1997-10-28 AR ARP970105002A patent/AR009600A1/en not_active Application Discontinuation
- 1997-10-28 KR KR1019990703660A patent/KR20000052831A/en not_active Withdrawn
- 1997-10-28 CN CN97199233A patent/CN1235513A/en active Pending
- 1997-10-28 ID IDW990160A patent/ID22065A/en unknown
- 1997-10-28 SK SK346-99A patent/SK34699A3/en unknown
- 1997-10-28 BR BR9712587-3A patent/BR9712587A/en not_active IP Right Cessation
- 1997-10-28 EP EP97913847A patent/EP0973394A4/en not_active Withdrawn
- 1997-10-28 CA CA002265523A patent/CA2265523A1/en not_active Abandoned
- 1997-10-28 IL IL12939797A patent/IL129397A0/en unknown
- 1997-10-28 EE EEP199900176A patent/EE9900176A/en unknown
-
1998
- 1998-02-28 SA SA98180918A patent/SA98180918A/en unknown
-
1999
- 1999-03-18 IS IS5005A patent/IS5005A/en unknown
- 1999-04-27 NO NO991995A patent/NO991995L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5093398A (en) | 1998-05-22 |
| EP0973394A1 (en) | 2000-01-26 |
| IL129397A0 (en) | 2000-02-17 |
| SK34699A3 (en) | 2000-04-10 |
| EP0973394A4 (en) | 2005-03-30 |
| NZ334568A (en) | 2000-04-28 |
| KR20000052831A (en) | 2000-08-25 |
| CA2265523A1 (en) | 1998-05-07 |
| WO1998018323A1 (en) | 1998-05-07 |
| NO991995D0 (en) | 1999-04-27 |
| AR009600A1 (en) | 2000-04-26 |
| TR199900940T2 (en) | 1999-09-21 |
| NO991995L (en) | 1999-06-28 |
| JP2001504329A (en) | 2001-04-03 |
| PL333169A1 (en) | 1999-11-22 |
| SA98180918A (en) | 2005-12-03 |
| AU734052B2 (en) | 2001-05-31 |
| EE9900176A (en) | 1999-12-15 |
| ID22065A (en) | 1999-08-26 |
| IS5005A (en) | 1999-03-18 |
| CN1235513A (en) | 1999-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A,7A,8A, 9A E 10A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1908 DE 31/07/2007. |