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BR9712392A - Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidina - Google Patents

Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidina

Info

Publication number
BR9712392A
BR9712392A BR9712392-7A BR9712392A BR9712392A BR 9712392 A BR9712392 A BR 9712392A BR 9712392 A BR9712392 A BR 9712392A BR 9712392 A BR9712392 A BR 9712392A
Authority
BR
Brazil
Prior art keywords
pyrimidine
dimethyl
methyl
formula
fluorophenylamino
Prior art date
Application number
BR9712392-7A
Other languages
English (en)
Inventor
You Wha Hong
Young Nam Lee
Hong Bae Kim
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019960049380A external-priority patent/KR0185292B1/ko
Priority claimed from KR1019960049381A external-priority patent/KR100193080B1/ko
Priority claimed from KR1019960049382A external-priority patent/KR100209587B1/ko
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of BR9712392A publication Critical patent/BR9712392A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSOS PARA PREPARAR 5,6-DIMETIL-2-(4-FLUOROFENIL-AMINO) - 4 - (1 - METIL - 1, 2, 3, 4 - TETRAIDROISQUINOLIN - 2 -IL) PIRIMIDINA, 4 - HALOGENO - 2 - (4 - FLUOROFENILAMINO) - 5, 6 -DIMETIL-PIRIMIDINA E 1-IMETIL-1,2,3,4-TETRAIDROISOQUINOLINA, E, DERIVADO DE PIRIMIDINA". A presente invenção refere-se primeiro a um processo para preparação de 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil-1,2,3,4-tetraidroisoquinoli n-2-il) pirimidina, representada pela fórmula (I): e seus sais de adição de ácido, segundo a um processo para preparação de um intermediário para preparar o composto (I) e, terceiro, a um novo composto intermediário. Mais especificamente, a presente invenção refere-se, primeiro a um processo para a preparação de 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil-1,2,3,4-tetraidroisquinolim- 5-il)pirimidina, representada pela fórmula (I), e seus sais de adição ácidos, pela reação de um derivado de pirimidina, representado pela fórmula (II-A), em que Hal representa um halogênio, com 1-metil-1,2,3,4-tetraisoquinolina representada pela fórmula (III), segundo, a um processo para preparação do derivado de pirimidina de fórmula II-A) e do composto de fórmula (III)e terceiro, a um novo composto intermediário, incluindo o derivado de fórmula(II-A).
BR9712392-7A 1996-10-29 1997-10-27 Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidina BR9712392A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1019960049380A KR0185292B1 (ko) 1996-10-29 1996-10-29 (s)-피리미딘 유도체의 제조방법
KR1019960049381A KR100193080B1 (ko) 1996-10-29 1996-10-29 (r)-피리미딘 유도체의 제조방법
KR1019960049382A KR100209587B1 (ko) 1996-10-29 1996-10-29 피리미딘 유도체의 제조방법
PCT/KR1997/000204 WO1998018784A1 (en) 1996-10-29 1997-10-27 Process for preparation of pyrimidine derivatives

Publications (1)

Publication Number Publication Date
BR9712392A true BR9712392A (pt) 2000-01-25

Family

ID=27349413

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712392-7A BR9712392A (pt) 1996-10-29 1997-10-27 Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidina

Country Status (5)

Country Link
AR (1) AR009133A1 (pt)
BR (1) BR9712392A (pt)
HU (1) HU226752B1 (pt)
TR (1) TR199900943T2 (pt)
WO (1) WO1998018784A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100272471B1 (ko) * 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
GB0110338D0 (en) * 2001-04-27 2001-06-20 Sb Pharmco Inc Novel processes
CA2493618A1 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US7776873B2 (en) 2005-12-01 2010-08-17 Yuhan Corporation Method for treating damage to gastric mucosa
PL2007362T3 (pl) 2006-04-04 2019-02-28 Kg Acquisition Llc Doustne postacie leku obejmujące czynnik przeciwpłytkowy i inhibitor kwasu
CN102993173B (zh) * 2012-12-28 2014-09-03 山东大学 洛氟普啶的制备方法
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
CN105601611A (zh) * 2014-11-19 2016-05-25 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶多晶型物及其制备方法
CN107759562B (zh) * 2016-08-21 2020-10-23 常州四药制药有限公司 一种盐酸洛氟普啶的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1182584A (en) * 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
FI95376C (fi) * 1989-03-22 1996-01-25 Ciba Geigy Ag Mikrobisidiset 2-anilino-pyrimidiinijohdannaiset
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
ES2201112T3 (es) * 1994-08-13 2004-03-16 Yuhan Corporation Nuevos derivados de pirimidina y procedimientos para su preparacion.

Also Published As

Publication number Publication date
WO1998018784A1 (en) 1998-05-07
HUP9903520A3 (en) 2002-01-28
TR199900943T2 (xx) 1999-12-21
HUP9903520A1 (hu) 2000-05-28
HU226752B1 (en) 2009-09-28
AR009133A1 (es) 2000-03-08

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2257 DE 08-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.