BR9506667A - Composto intermediário de cloro-pirimidina processo para a preparação do composto intermediário de cloro-pirimidina processo para a preparação de 2,5-diamino-4,6-dicloro-pirimidina processo para a preparação de 2,6-diamino-purinas e processo para a preparação de (1s,4s)-4-2-amino-6-(ciclo-propil-amino)-9h-purin-9-il¾-2-ciclo-penteno-1-metanol - Google Patents

Composto intermediário de cloro-pirimidina processo para a preparação do composto intermediário de cloro-pirimidina processo para a preparação de 2,5-diamino-4,6-dicloro-pirimidina processo para a preparação de 2,6-diamino-purinas e processo para a preparação de (1s,4s)-4-2-amino-6-(ciclo-propil-amino)-9h-purin-9-il¾-2-ciclo-penteno-1-metanol

Info

Publication number: BR9506667A
Authority: BR; Brazil
Prior art keywords: preparation; pyrimidine; diamino; cyclo; amino
Prior art date: 1994-02-04

Application number

BR9506667A

Other languages

English (en)

Inventor

Susan Mary Daluge

Martin Michael Tolar

Michelle Joanne Ferry Fugett

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-04

Filing date

1995-02-03

Publication date

1997-09-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10749873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9506667(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-03 Application filed by Wellcome Found filed Critical Wellcome Found

1997-09-16 Publication of BR9506667A publication Critical patent/BR9506667A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Public Health (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Catalysts (AREA)
Indole Compounds (AREA)
Saccharide Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal Substances (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BR9506667A 1994-02-04 1995-02-03 Composto intermediário de cloro-pirimidina processo para a preparação do composto intermediário de cloro-pirimidina processo para a preparação de 2,5-diamino-4,6-dicloro-pirimidina processo para a preparação de 2,6-diamino-purinas e processo para a preparação de (1s,4s)-4-2-amino-6-(ciclo-propil-amino)-9h-purin-9-il¾-2-ciclo-penteno-1-metanol BR9506667A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9402161A GB9402161D0 (en)	1994-02-04	1994-02-04	Chloropyrimidine intermediates
PCT/GB1995/000225 WO1995021161A1 (en)	1994-02-04	1995-02-03	Chloropyrimide intermediates

Publications (1)

Publication Number	Publication Date
BR9506667A true BR9506667A (pt)	1997-09-16

Family

ID=10749873

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9506667A BR9506667A (pt)	1994-02-04	1995-02-03	Composto intermediário de cloro-pirimidina processo para a preparação do composto intermediário de cloro-pirimidina processo para a preparação de 2,5-diamino-4,6-dicloro-pirimidina processo para a preparação de 2,6-diamino-purinas e processo para a preparação de (1s,4s)-4-2-amino-6-(ciclo-propil-amino)-9h-purin-9-il¾-2-ciclo-penteno-1-metanol

Country Status (27)

Country	Link
US (8)	US6448403B1 (pt)
EP (1)	EP0741710B1 (pt)
JP (1)	JP3670012B2 (pt)
KR (1)	KR100355983B1 (pt)
CN (2)	CN1105109C (pt)
AT (1)	ATE192742T1 (pt)
AU (1)	AU690203B2 (pt)
BR (1)	BR9506667A (pt)
DE (1)	DE69516847T2 (pt)
DK (1)	DK0741710T3 (pt)
ES (1)	ES2148486T3 (pt)
FI (1)	FI112477B (pt)
GB (1)	GB9402161D0 (pt)
GR (1)	GR3033850T3 (pt)
HU (1)	HU223096B1 (pt)
IL (1)	IL112539A (pt)
MX (1)	MX9603091A (pt)
MY (1)	MY113775A (pt)
NO (1)	NO310819B1 (pt)
NZ (1)	NZ278948A (pt)
PL (1)	PL183885B1 (pt)
PT (1)	PT741710E (pt)
RU (1)	RU2140913C1 (pt)
SG (1)	SG47918A1 (pt)
TW (1)	TW390877B (pt)
WO (1)	WO1995021161A1 (pt)
ZA (1)	ZA95884B (pt)

Families Citing this family (42)

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GB9402161D0 (en) *	1994-02-04	1994-03-30	Wellcome Found	Chloropyrimidine intermediates
CA2145928C (en) *	1994-04-27	2007-10-09	Gerhard Stucky	N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
ZA9510482B (en) *	1994-12-12	1996-09-17	Smithkline Beecham Plc	Pharmaceuticals
SK285229B6 (sk)	1997-05-13	2006-09-07	Lonza Ag	Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
GB9721780D0 (en) *	1997-10-14	1997-12-10	Glaxo Group Ltd	Process for the synthesis of chloropurine intermediates
AU2702899A (en) *	1997-10-24	1999-05-17	Glaxo Group Limited	Process for preparing a chiral nucleoside analogue
EP1032573A1 (en) *	1997-11-12	2000-09-06	Glaxo Group Limited	Process for preparing a chiral nucleoside analogue
SK284594B6 (sk) *	1997-11-27	2005-07-01	Lonza Ag	Spôsob výroby derivátov aminoalkoholov a ich soli
DK1013647T3 (da) *	1998-12-21	2003-03-10	Lonza Ag	Fremgangsmåde til fremstilling af N-(amino-4,6-dihalogenpyrimidin)-formamider
CA2440809A1 (en) *	2001-03-01	2002-09-12	Conforma Therapeutics Corp.	Methods for treating genetically-defined proliferative disorders with hsp90 inhibitors
EP1440072A4 (en) *	2001-10-30	2005-02-02	Conforma Therapeutic Corp	PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
US20070129334A1 (en) *	2001-10-30	2007-06-07	Conforma Therapeutics Corporation	Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
US6780635B2 (en)	2001-12-27	2004-08-24	Council Of Scientific And Industrial Research	Process for the preparation of optically active azabicyclo heptanone derivatives
KR100573859B1 (ko) *	2002-07-15	2006-04-25	경동제약 주식회사	9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의제조방법
US7560231B2 (en) *	2002-12-20	2009-07-14	Roche Molecular Systems, Inc.	Mannitol and glucitol derivatives
WO2004099208A1 (en) *	2003-04-30	2004-11-18	Teva Pharmaceutical Industries Ltd.	Process for the preparation of famciclovir
JPWO2004103979A1 (ja) *	2003-05-26	2006-07-20	住友化学株式会社	Ｎ−（２−アミノ−４，６−ジクロロピリミジン−５−イル）ホルムアミドの製造方法
KR100573860B1 (ko) *	2003-06-13	2006-04-25	경동제약 주식회사	2-아미노-9-(2-치환에틸)푸린을 이용한 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의 제조방법
US6930093B2 (en) *	2003-07-10	2005-08-16	Valeant Research & Development	Use of ribofuranose derivatives against inflammatory bowel diseases
KR100573861B1 (ko) *	2003-07-18	2006-04-25	경동제약 주식회사	2-아미노-9-(2-할로게노에틸)푸린 및 그 중간체로서의 2-아미노-6,8-디클로로-9-(2-히드록시에틸)푸린의 제조방법
US20050143400A1 (en) *	2003-09-04	2005-06-30	Genny Shamai	Process for preparing famciclovir
GB0320738D0 (en)	2003-09-04	2003-10-08	Glaxo Group Ltd	Novel process
BRPI0414533A (pt) *	2003-09-18	2006-11-07	Conforma Therapeutics Corp	composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90
DE102004002055A1 (de) *	2004-01-15	2005-08-11	Degussa Ag	Verfahren zur Herstellung von 2-Amino-4,6-dichlor-5-formamidopyrimidin
EA012799B1 (ru) *	2004-08-16	2009-12-30	Кварк Фармасьютикалс, Инк.	Терапевтические применения ингибиторов rtp801
WO2006105372A2 (en)	2005-03-30	2006-10-05	Conforma Therapeutics Corporation	Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
GB2426247A (en)	2005-05-20	2006-11-22	Arrow Int Ltd	Methods of preparing purine derivatives such as famciclovir
WO2007035963A2 (en) *	2005-09-23	2007-03-29	Conforma Therapeutics Corporation	Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors
EP1857458A1 (en) *	2006-05-05	2007-11-21	SOLMAG S.p.A.	Process for the preparation of abacavir
CN100465174C (zh) *	2006-06-13	2009-03-04	中国科学院上海有机化学研究所	制备光学纯阿巴卡韦的方法
WO2008072074A1 (en) *	2006-12-11	2008-06-19	Aurobindo Pharma Limited	An improved process for the preparation of purine derivative
EP1939196A1 (en)	2006-12-21	2008-07-02	Esteve Quimica, S.A.	Process for the preparation of abacavir
EP2170840A1 (en) *	2007-06-21	2010-04-07	Aurobindo Pharma Ltd	An improved process for preparing purine derivative
EP2085397A1 (en)	2008-01-21	2009-08-05	Esteve Quimica, S.A.	Crystalline form of abacavir
SMT201800290T1 (it)	2010-01-27	2018-07-17	Viiv Healthcare Co	Terapia antivirale
CZ305457B6 (cs)	2011-02-28	2015-09-30	Ústav organické chemie a biochemie, Akademie věd ČR v. v. i.	Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
EP2962693B1 (en)	2013-02-27	2019-01-09	Kyoto University	Pharmaceutical composition comprising abacavir for the treatment of cancer
CN104672239A (zh) *	2013-11-26	2015-06-03	上海迪赛诺化学制药有限公司	一种采用一锅法制备阿巴卡韦式v中间体的工艺
CN109456329B (zh) *	2018-11-19	2021-03-09	迪嘉药业集团有限公司	一种泛昔洛韦的制备方法
CN113292507B (zh) *	2021-06-25	2022-07-19	潍坊奥通药业有限公司	一种2-氨基-6-氯鸟嘌呤及其中间体的制备方法
CN116239596A (zh) *	2022-11-28	2023-06-09	安徽贝克制药股份有限公司	一种阿巴卡韦杂质a的制备方法及用途
CN118852029B (zh) *	2024-09-23	2025-02-07	苏州开元民生科技股份有限公司	一种制备2-氨基-4,6-二氯-5-甲酰胺基嘧啶的方法

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EP0141927B1 (en)	1983-08-18	1991-10-30	Beecham Group Plc	Antiviral guanine derivatives
DE3582399D1 (de)	1984-09-20	1991-05-08	Beecham Group Plc	Purin-derivate und ihre pharmazeutische verwendung.
MY101126A (en) *	1985-12-13	1991-07-31	Beecham Group Plc	Novel compounds
US4965270A (en)	1987-05-30	1990-10-23	Beecham Group P.L.C.	Purine derivatives
GB8724765D0 (en)	1987-10-22	1987-11-25	Beecham Group Plc	Process
US5631370A (en)	1988-01-20	1997-05-20	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
GB2243609B (en) *	1988-01-20	1992-03-11	Univ Minnesota	Dideoxydidehydrocarbocyclic pyrimidines
US4916224A (en)	1988-01-20	1990-04-10	Regents Of The University Of Minnesota	Dideoxycarbocyclic nucleosides
GB8815265D0 (en)	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
GB8916698D0 (en)	1989-07-21	1989-09-06	Beecham Group Plc	Novel process
GB8918827D0 (en)	1989-08-17	1989-09-27	Beecham Group Plc	Novel compounds
MY104575A (en)	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
CZ287049B6 (cs)	1992-01-22	2000-08-16	Lonza A. G.	N-5-chráněné 2,5-diamino-4,6-dichlorpyrimidiny a způsob jejich přípravy
JPH05320143A (ja) *	1992-03-18	1993-12-03	Mochida Pharmaceut Co Ltd	新規ピリミジン誘導体
GB9402161D0 (en) *	1994-02-04	1994-03-30	Wellcome Found	Chloropyrimidine intermediates
CA2145928C (en)	1994-04-27	2007-10-09	Gerhard Stucky	N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation

1994
- 1994-02-04 GB GB9402161A patent/GB9402161D0/en active Pending
1995
- 1995-02-03 IL IL11253995A patent/IL112539A/xx not_active IP Right Cessation
- 1995-02-03 EP EP95907107A patent/EP0741710B1/en not_active Expired - Lifetime
- 1995-02-03 NZ NZ278948A patent/NZ278948A/en not_active IP Right Cessation
- 1995-02-03 BR BR9506667A patent/BR9506667A/pt not_active IP Right Cessation
- 1995-02-03 AT AT95907107T patent/ATE192742T1/de active
- 1995-02-03 KR KR1019960704228A patent/KR100355983B1/ko not_active Expired - Lifetime
- 1995-02-03 ZA ZA95884A patent/ZA95884B/xx unknown
- 1995-02-03 HU HU9602114A patent/HU223096B1/hu active IP Right Grant
- 1995-02-03 WO PCT/GB1995/000225 patent/WO1995021161A1/en not_active Ceased
- 1995-02-03 PT PT95907107T patent/PT741710E/pt unknown
- 1995-02-03 DE DE69516847T patent/DE69516847T2/de not_active Expired - Lifetime
- 1995-02-03 PL PL95315713A patent/PL183885B1/pl unknown
- 1995-02-03 MY MYPI95000246A patent/MY113775A/en unknown
- 1995-02-03 DK DK95907107T patent/DK0741710T3/da active
- 1995-02-03 CN CN95191478A patent/CN1105109C/zh not_active Expired - Lifetime
- 1995-02-03 CN CNB021023441A patent/CN1161343C/zh not_active Expired - Lifetime
- 1995-02-03 RU RU96118435A patent/RU2140913C1/ru active
- 1995-02-03 US US08/682,743 patent/US6448403B1/en not_active Expired - Lifetime
- 1995-02-03 ES ES95907107T patent/ES2148486T3/es not_active Expired - Lifetime
- 1995-02-03 AU AU15438/95A patent/AU690203B2/en not_active Expired
- 1995-02-03 JP JP52046795A patent/JP3670012B2/ja not_active Expired - Lifetime
- 1995-02-03 SG SG1996005343A patent/SG47918A1/en unknown
- 1995-03-14 TW TW084102412A patent/TW390877B/zh not_active IP Right Cessation
1996
- 1996-07-30 MX MX9603091A patent/MX9603091A/es unknown
- 1996-08-02 NO NO19963239A patent/NO310819B1/no not_active IP Right Cessation
- 1996-08-02 FI FI963070A patent/FI112477B/fi not_active IP Right Cessation
1997
- 1997-10-24 US US08/957,603 patent/US6087501A/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,606 patent/US6555687B1/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,605 patent/US5917042A/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,043 patent/US5917041A/en not_active Expired - Lifetime
1999
- 1999-10-15 US US09/419,416 patent/US6552193B1/en not_active Expired - Lifetime
2000
- 2000-06-30 GR GR20000401551T patent/GR3033850T3/el unknown
2002
- 2002-06-27 US US10/184,482 patent/US6870053B2/en not_active Expired - Fee Related
2003
- 2003-03-18 US US10/389,815 patent/US20030187263A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1139924A (zh)	1997-01-08
SG47918A1 (en)	1998-04-17
IL112539A0 (en)	1995-05-26
NO963239L (no)	1996-10-02
HU223096B1 (hu)	2004-03-29
ES2148486T3 (es)	2000-10-16
FI112477B (fi)	2003-12-15
PL315713A1 (en)	1996-11-25
US5917041A (en)	1999-06-29
DE69516847D1 (de)	2000-06-15
US6870053B2 (en)	2005-03-22
FI963070L (fi)	1996-08-02
PL183885B1 (pl)	2002-07-31
TW390877B (en)	2000-05-21
US6087501A (en)	2000-07-11
MX9603091A (es)	1998-01-31
JPH09508412A (ja)	1997-08-26
US6552193B1 (en)	2003-04-22
CN1161343C (zh)	2004-08-11
RU2140913C1 (ru)	1999-11-10
FI963070A0 (fi)	1996-08-02
US5917042A (en)	1999-06-29
US20020173649A1 (en)	2002-11-21
US6555687B1 (en)	2003-04-29
EP0741710B1 (en)	2000-05-10
AU1543895A (en)	1995-08-21
GB9402161D0 (en)	1994-03-30
NZ278948A (en)	1998-01-26
HK1004087A1 (en)	1998-11-13
EP0741710A1 (en)	1996-11-13
HU9602114D0 (en)	1996-09-30
AU690203B2 (en)	1998-04-23
GR3033850T3 (en)	2000-10-31
KR100355983B1 (ko)	2002-12-28
NO310819B1 (no)	2001-09-03
HUT75300A (en)	1997-05-28
NO963239D0 (no)	1996-08-02
CN1105109C (zh)	2003-04-09
MY113775A (en)	2002-05-31
US6448403B1 (en)	2002-09-10
IL112539A (en)	2000-08-31
DE69516847T2 (de)	2000-10-26
WO1995021161A1 (en)	1995-08-10
ZA95884B (en)	1996-08-05
JP3670012B2 (ja)	2005-07-13
PT741710E (pt)	2000-09-29
ATE192742T1 (de)	2000-05-15
DK0741710T3 (da)	2000-08-14
US20030187263A1 (en)	2003-10-02
CN1388123A (zh)	2003-01-01

Publication	Publication Date	Title
BR9506667A (pt)	1997-09-16	Composto intermediário de cloro-pirimidina processo para a preparação do composto intermediário de cloro-pirimidina processo para a preparação de 2,5-diamino-4,6-dicloro-pirimidina processo para a preparação de 2,6-diamino-purinas e processo para a preparação de (1s,4s)-4-2-amino-6-(ciclo-propil-amino)-9h-purin-9-il¾-2-ciclo-penteno-1-metanol
DK0628044T3 (da)	2003-11-17	Terapeutiske nucleosider
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