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BR9712298A - Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion protein - Google Patents

Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion protein

Info

Publication number
BR9712298A
BR9712298A BR9712298-0A BR9712298A BR9712298A BR 9712298 A BR9712298 A BR 9712298A BR 9712298 A BR9712298 A BR 9712298A BR 9712298 A BR9712298 A BR 9712298A
Authority
BR
Brazil
Prior art keywords
tuberculosis
polypeptide
expression vector
biological sample
recombinant expression
Prior art date
Application number
BR9712298-0A
Other languages
Portuguese (pt)
Inventor
Steven G Reed
Yasir A W Skeiky
Davin C Dillon
Antonio Campos-Neto
Raymond Houghton
Thomas S Vedvivk
Daniel R Twardizk
Michael J Lodes
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/818,111 external-priority patent/US6338852B1/en
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of BR9712298A publication Critical patent/BR9712298A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"POLIPEPTìDEO, MOLéCULA DE DNA, VETOR DE EXPRESSãO RECOMBINANTE, CéLULA HOSPEDEIRA, PROCESSO PARA DETECTAR INFECçãO POR M. TUBERCULOSIS EM UMA AMOSTRA BIOLóGICA, KIT DIAGNóSTICO, ANTICORPOS MONOCLONAL, E, POLICLONAL, E, PROTEìNA DE FUSãO". Compostos e processos para diagnosticar tuberculose são descritos. Os compostos providos incluem polipeptídeos que contém pelo menos uma porção antigênica de uma ou mais proteínas de M. tuberculosis , e sequências de DNA codificando estes polipeptídeo s. Os kits diagnósticos contendo estes polipeptídeos ou sequências de DNA e um reagente de detecção apropriado podem ser usados para detecção de infecção por M. tuberculosis em pacientes e amostras biológicas. Os anticorpos dirigidos contra estes polipeptídeos são também providos."POLYPEPTIDE, DNA MOLECULE, RECOMBINANT EXPRESSION VECTOR, HOSTING CELL, PROCESS TO DETECT INFECTION BY M. TUBERCULOSIS IN A BIOLOGICAL SAMPLE, DIAGNOSTIC KIT, MONOCLONAL ANTIBODIES, AND, POLYCLEAN, AND, POLYCLEAN. Compounds and processes for diagnosing tuberculosis are described. The compounds provided include polypeptides that contain at least an antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding these polypeptides. Diagnostic kits containing these polypeptides or DNA sequences and an appropriate detection reagent can be used to detect M. tuberculosis infection in patients and biological samples. Antibodies directed against these polypeptides are also provided.

BR9712298-0A 1996-10-11 1997-10-07 Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion protein BR9712298A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72962296A 1996-10-11 1996-10-11
US08/818,111 US6338852B1 (en) 1995-09-01 1997-03-13 Compounds and methods for diagnosis of tuberculosis
PCT/US1997/018214 WO1998016645A2 (en) 1996-10-11 1997-10-07 Compounds and methods for diagnosis of tuberculosis

Publications (1)

Publication Number Publication Date
BR9712298A true BR9712298A (en) 2000-10-24

Family

ID=27111919

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712298-0A BR9712298A (en) 1996-10-11 1997-10-07 Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion protein

Country Status (11)

Country Link
EP (1) EP0934415A2 (en)
JP (1) JP2001500383A (en)
AU (1) AU4750597A (en)
BR (1) BR9712298A (en)
CA (1) CA2268036A1 (en)
CZ (1) CZ126699A3 (en)
IL (2) IL129389A0 (en)
NO (1) NO991693L (en)
PL (1) PL333304A1 (en)
TR (1) TR199901569T2 (en)
WO (1) WO1998016645A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6991797B2 (en) 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US6982085B2 (en) 1997-04-02 2006-01-03 Statens Serum Institut TB diagnostic based on antigens from M. tuberculosis
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
US7087713B2 (en) 2000-02-25 2006-08-08 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
CA2296419A1 (en) * 1997-07-16 1999-01-28 Institut Pasteur A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
US20030027774A1 (en) * 1999-03-18 2003-02-06 Ronald C. Hendrickson Tuberculosis antigens and methods of use therefor
AU773268B2 (en) * 1999-05-04 2004-05-20 Rutgers, The State University Of New Jersey Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
US7009042B1 (en) 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
DE60033583T2 (en) * 1999-10-07 2007-09-13 Corixa Corp. CSC, Wilmington A MYCOBACTERIUM TUBERCULOSIS ENCODING SEQUENCE FOR THE EXPRESSION OF HETEROLOGICAL PROTEINS
US6316205B1 (en) 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
EP2133100B1 (en) 2000-06-20 2011-10-05 Corixa Corporation MTB32A Antigen of mycobacterium tuberculosis with inactivated active site and fusion proteins thereof
AU2001271963A1 (en) * 2000-07-10 2002-01-21 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
US7393539B2 (en) 2001-06-22 2008-07-01 Health Protection Agency Mycobacterial antigens expressed under low oxygen tension
AU2002314358C1 (en) 2001-07-04 2009-03-26 The Secretary Of State For Health Mycobacterial antigens expressed during latency
WO2003010309A1 (en) * 2001-07-25 2003-02-06 Tosoh Corporation Oligonucleotides for detecting tubercle bacillus and method therefor
GB0125535D0 (en) * 2001-10-24 2001-12-12 Microbiological Res Authority Mycobacterial genes down-regulated during latency
AU2003213118A1 (en) 2002-02-15 2003-09-09 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
US8475735B2 (en) 2004-11-01 2013-07-02 Uma Mahesh Babu Disposable immunodiagnostic test system
WO2006053871A2 (en) 2004-11-16 2006-05-26 Crucell Holland B.V. Multivalent vaccines comprising recombinant viral vectors
ES2524572T3 (en) 2005-04-29 2014-12-10 Glaxosmithkline Biologicals S.A. Novel procedure for prevention or treatment of infection with M. tuberculosis
AU2006272567B2 (en) * 2005-07-26 2011-10-06 Rutgers, The State University Of New Jersey Antibody profiles characteristic of tuberculosis state
CN100999550B (en) 2006-01-10 2010-10-06 中国人民解放军第三○九医院 Tubercle branch bacillus fusion protein and application thereof
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
WO2008140478A2 (en) 2006-11-01 2008-11-20 Immport Therapeutics, Inc. Compositions and methods for immunodominant antigens
HUE031184T2 (en) 2010-01-27 2017-06-28 Glaxosmithkline Biologicals Sa Modified tuberculosis antigens
CN115746092B (en) * 2022-08-12 2024-08-13 齐鲁工业大学 Spirulina platensis phycocyanin active peptide with antioxidant and anti-aging activities and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244539A1 (en) * 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) * 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
EP0419355B1 (en) * 1989-09-19 2000-02-09 N.V. Innogenetics S.A. Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis
FR2677365B1 (en) * 1991-06-07 1995-08-04 Pasteur Institut MYCOBACTERIUM PROTEINS AND APPLICATIONS.
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria
DK79893D0 (en) * 1993-07-02 1993-07-02 Statens Seruminstitut NEW VACCINE
DK79793D0 (en) * 1993-07-02 1993-07-02 Statens Seruminstitut DIAGNOSTIC TEST
US5714593A (en) * 1995-02-01 1998-02-03 Institut Pasteur DNA from mycobacterium tuberculosis which codes for a 45/47 kilodalton protein
IL123506A (en) * 1995-09-01 2004-12-15 Corixa Corp Polypeptide compounds and compositions for immunotherapy and diagnosis of tuberculosis
CA2230927A1 (en) * 1995-09-01 1997-03-13 Corixa Corporation Compounds and methods for diagnosis of tuberculosis

Also Published As

Publication number Publication date
WO1998016645A3 (en) 1998-08-06
NO991693L (en) 1999-06-09
CA2268036A1 (en) 1998-04-23
IL121936A0 (en) 1998-03-10
NO991693D0 (en) 1999-04-09
TR199901569T2 (en) 2000-12-21
WO1998016645A2 (en) 1998-04-23
AU4750597A (en) 1998-05-11
IL129389A0 (en) 2000-02-17
JP2001500383A (en) 2001-01-16
CZ126699A3 (en) 1999-09-15
PL333304A1 (en) 1999-11-22
EP0934415A2 (en) 1999-08-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]