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BR9711160A - Composições farmacêuticas para neutralizar danosss a células ou tecido, prcoessos para o tratamento de indivìduo para neutralizar danos a células, tecido ou órgão e para a conservação ex vivo de 'rogão, tecido ou células, e, composto. - Google Patents

Composições farmacêuticas para neutralizar danosss a células ou tecido, prcoessos para o tratamento de indivìduo para neutralizar danos a células, tecido ou órgão e para a conservação ex vivo de 'rogão, tecido ou células, e, composto.

Info

Publication number
BR9711160A
BR9711160A BR9711160-0A BR9711160A BR9711160A BR 9711160 A BR9711160 A BR 9711160A BR 9711160 A BR9711160 A BR 9711160A BR 9711160 A BR9711160 A BR 9711160A
Authority
BR
Brazil
Prior art keywords
tissue
cells
damage
neutralize
organ
Prior art date
Application number
BR9711160-0A
Other languages
English (en)
Inventor
Abraham Novogrodsky
Alexander Levitzki
Aviv Gazit
Original Assignee
Morresearch Applic Ltd
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morresearch Applic Ltd, Yissum Res Dev Co filed Critical Morresearch Applic Ltd
Publication of BR9711160A publication Critical patent/BR9711160A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSIçõES FARMACêUTICAS PARA NEUTRALIZAR DANOS A CéLULAS OU TECIDO, PROCESSOS PARA O TRATAMENTO DE UM INDIVìDUO PARA NEUTRALIZAR DANOS A CéLULAS, TECIDO OU óRGãO E PARA A CONSERVAçãO EX VIVO DE óRGãO, TECIDO OU CéLULAS, E, COMPOSTO". Compostos úteis para neutralizar efeitos tóxicos indesejados em células, tecidos ou órgãos, apresentando a fórmula (I) em que: Ar é um grupo de fórmulas (i) ou (ii), n é O ou, quando Ar tem a fórmula (i), acima, então n também pode ser 1, R é CN, -C(S)NH~ 2~, -C(S)NH~ 2~, -C(O)NHR~ 3~ ou, quando R~ 1~ é 4-NO~ 2~ e R~ 2~ é ou 3-OH, então R também pode ser um grupo de fórmulas (iii), (iv), (v), (vi) em que R~ 3~ é H, fenila, fenila(alquila inferior) ou piridilmetila; R~ 1~ e R~ 2~ são, cada um, independentemente, H, OH, NO~ 2~ ou, quando R é CN, também CH~ 3~, F ou CF~ 3~, desde que ambos, R~ 1~ e R~ 2~, sejam simultaneamente H.
BR9711160-0A 1996-08-14 1997-08-14 Composições farmacêuticas para neutralizar danosss a células ou tecido, prcoessos para o tratamento de indivìduo para neutralizar danos a células, tecido ou órgão e para a conservação ex vivo de 'rogão, tecido ou células, e, composto. BR9711160A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11906996A IL119069A0 (en) 1996-08-14 1996-08-14 Pharmaceutical composition comprising tyrphostins
PCT/IL1997/000276 WO1998006391A1 (en) 1996-08-14 1997-08-14 Pharmaceutical compositions comprising tyrphostins

Publications (1)

Publication Number Publication Date
BR9711160A true BR9711160A (pt) 2000-01-11

Family

ID=11069189

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9711160-0A BR9711160A (pt) 1996-08-14 1997-08-14 Composições farmacêuticas para neutralizar danosss a células ou tecido, prcoessos para o tratamento de indivìduo para neutralizar danos a células, tecido ou órgão e para a conservação ex vivo de 'rogão, tecido ou células, e, composto.

Country Status (11)

Country Link
US (2) US6426366B1 (pt)
EP (1) EP0923371B1 (pt)
JP (1) JP2001504085A (pt)
CN (1) CN1232392A (pt)
AT (1) ATE266398T1 (pt)
AU (1) AU728672B2 (pt)
BR (1) BR9711160A (pt)
CA (1) CA2263325A1 (pt)
DE (1) DE69729104D1 (pt)
IL (1) IL119069A0 (pt)
WO (1) WO1998006391A1 (pt)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
JP2003525862A (ja) * 1999-01-27 2003-09-02 ザ ユニヴァーシティー オブ サウス フロリダ ヒト癌の治療のためのｓｔａｔ３シグナル伝達の阻害
WO2001026645A1 (en) * 1999-10-12 2001-04-19 Temple University-Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof
IL159270A0 (en) * 2001-06-14 2004-06-01 Yissum Res Dev Co Non-myeloablative tolerogenic treatment with tyrphostins
US6433018B1 (en) * 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
US7638122B2 (en) * 2003-03-07 2009-12-29 University Of South Florida Stat3 antagonists and their use as vaccines against cancer
BRPI0416981A (pt) 2003-12-11 2007-02-21 Univ Texas compostos para tratamento de doenças proliferativas de célula
ES2368741T3 (es) 2004-02-25 2011-11-21 Dana-Farber Cancer Institute, Inc. Inhibidores del receptor 1 del factor de crecimiento de tipo insulina para inhibir el crecimiento de células tumorales.
AU2007234455B2 (en) * 2006-03-31 2012-10-04 The Board Of Regents Of The University Of Texas System Orally bioavailable caffeic acid related anticancer drugs
WO2008005954A2 (en) * 2006-06-30 2008-01-10 The Board Of Regents Of The University Of Texas System Tryphostin-analogs for the treatment of cell proliferative diseases
MX2010012064A (es) * 2008-05-05 2010-12-06 Schering Corp Uso secuencial de agentes quimioterapeuticos citotoxicos para el tratamiento de cancer.
EP2307367B1 (en) 2008-07-08 2014-09-24 Board of Regents, The University of Texas System Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
WO2011080261A1 (en) 2009-12-28 2011-07-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for improved cardiomyogenic differentiation of pluripotent cells
TWI846678B (zh) 2017-11-10 2024-07-01 美國德州系統大學評議委員會 咖啡酸衍生物及其用途

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
CH484603A (de) 1966-03-21 1970-01-31 Ciba Geigy Schädlingsbekämpfungsmittel, enthaltend bestimmte Malodinitrile
US3551573A (en) 1967-11-08 1970-12-29 Monsanto Co Insecticidal composition and method containing anilinomethylene malonitriles
US3726662A (en) * 1970-01-14 1973-04-10 Monsanto Co Herbicidal anilinomethylene-malononitriles
IT7819093A0 (it) * 1977-01-10 1978-01-06 Ciba Geigy Prodotti antielmintici e loro impiego.
AU632992B2 (en) 1987-12-24 1993-01-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
RU2024514C1 (ru) 1991-10-01 1994-12-15 Иркутский институт органической химии СО РАН Комплекс 1-этилимидазола с аскорбатом цинка, повышающий устойчивость организма к действию диоксида азота и обладающий цитопротекторным и антигипоксическим действием
US5284868A (en) 1991-10-09 1994-02-08 Eli Lilly And Company Pharmaceutical compounds
US5972598A (en) * 1992-09-17 1999-10-26 Board Of Trustess Of The University Of Illinois Methods for preventing multidrug resistance in cancer cells
AU691820B2 (en) * 1993-07-15 1998-05-28 Cancer Research Campaign Technology Limited Prodrugs of protein tyrosine kinase inhibitors
IL107736A (en) 1993-11-24 2001-01-11 Yissum Res Dev Co Pharmaceutical composition for the prevention of septic shock and for the treatment of chronic inflammatory diseases
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
WO1995024190A2 (en) 1994-03-07 1995-09-14 Sugen, Inc. Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
AU709191B2 (en) * 1995-09-11 1999-08-26 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis

Also Published As

Publication number Publication date
EP0923371B1 (en) 2004-05-12
AU728672B2 (en) 2001-01-18
AU3782297A (en) 1998-03-06
WO1998006391A1 (en) 1998-02-19
EP0923371A1 (en) 1999-06-23
DE69729104D1 (de) 2004-06-17
ATE266398T1 (de) 2004-05-15
CN1232392A (zh) 1999-10-20
CA2263325A1 (en) 1998-02-19
US20030013748A1 (en) 2003-01-16
IL119069A0 (en) 1996-11-14
US6426366B1 (en) 2002-07-30
JP2001504085A (ja) 2001-03-27

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: NOTOX LTD. (IL)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.