BR9710648A - S¡ntese de indolilmaleimidas - Google Patents
S¡ntese de indolilmaleimidasInfo
- Publication number
- BR9710648A BR9710648A BR9710648A BR9710648A BR9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A
- Authority
- BR
- Brazil
- Prior art keywords
- indolylmaleimides
- synthesis
- Prior art date
Links
- WIQRSJOCVVPMPS-UHFFFAOYSA-N 3-(1h-indol-2-yl)pyrrole-2,5-dione Chemical class O=C1NC(=O)C(C=2NC3=CC=CC=C3C=2)=C1 WIQRSJOCVVPMPS-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1373196P | 1996-03-20 | 1996-03-20 | |
| PCT/US1997/004416 WO1997034890A1 (en) | 1996-03-20 | 1997-03-20 | Synthesis of indolylmaleimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9710648A true BR9710648A (pt) | 1999-08-17 |
Family
ID=21761453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9710648A BR9710648A (pt) | 1996-03-20 | 1997-03-20 | S¡ntese de indolilmaleimidas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5919946A (pt) |
| EP (1) | EP0888339A4 (pt) |
| JP (1) | JP3258334B2 (pt) |
| KR (1) | KR20000064764A (pt) |
| CN (1) | CN1225634A (pt) |
| AU (1) | AU2217797A (pt) |
| BR (1) | BR9710648A (pt) |
| CA (1) | CA2249205A1 (pt) |
| IL (1) | IL126272A0 (pt) |
| WO (1) | WO1997034890A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| CN1671694A (zh) | 2002-06-05 | 2005-09-21 | 詹森药业有限公司 | 作为激酶抑制剂的二吲哚基－顺丁烯二酰亚胺衍生物 |
| WO2003103663A2 (en) * | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| WO2006061212A1 (en) | 2004-12-08 | 2006-06-15 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| RS51826B (sr) | 2005-02-09 | 2012-02-29 | Arqule Inc. | Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera |
| EP2392574B1 (en) | 2007-06-22 | 2013-12-18 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| AU2008268613A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| CA2690799C (en) | 2007-06-22 | 2015-06-16 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| CN105153126B (zh) * | 2015-09-10 | 2017-10-24 | 东华大学 | 一种双吲哚马来酰亚胺类化合物的制备方法 |
| EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| WO2019090205A1 (en) | 2017-11-06 | 2019-05-09 | Snap Bio, Inc. | Pim kinase inhibitor compositions, methods, and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537902A (en) * | 1979-06-11 | 1985-08-27 | Merck & Co., Inc. | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
| US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
| US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| BR9404830A (pt) * | 1993-12-07 | 1995-08-08 | Lilly Co Eli | Composto e processo para sua preparação |
| TW425397B (en) * | 1993-12-07 | 2001-03-11 | Lilly Co Eli | Novel bis-indolemaleimide macrocycle derivatives their preparation process, intermediates for their preparation and their use as Protein Kinase C inhibitors |
| US5545636A (en) * | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| ATE290378T1 (de) * | 1993-12-23 | 2005-03-15 | Lilly Co Eli | Proteinkinase c-inhibitoren |
| US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
-
1997
- 1997-03-20 CA CA002249205A patent/CA2249205A1/en not_active Abandoned
- 1997-03-20 CN CN97194663A patent/CN1225634A/zh active Pending
- 1997-03-20 JP JP53366997A patent/JP3258334B2/ja not_active Expired - Fee Related
- 1997-03-20 US US08/821,356 patent/US5919946A/en not_active Expired - Fee Related
- 1997-03-20 BR BR9710648A patent/BR9710648A/pt not_active Application Discontinuation
- 1997-03-20 IL IL12627297A patent/IL126272A0/xx unknown
- 1997-03-20 WO PCT/US1997/004416 patent/WO1997034890A1/en not_active Ceased
- 1997-03-20 KR KR1019980707527A patent/KR20000064764A/ko not_active Withdrawn
- 1997-03-20 AU AU22177/97A patent/AU2217797A/en not_active Abandoned
- 1997-03-20 EP EP97915167A patent/EP0888339A4/en not_active Withdrawn
-
1999
- 1999-02-11 US US09/248,263 patent/US6037475A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1225634A (zh) | 1999-08-11 |
| JPH11511487A (ja) | 1999-10-05 |
| CA2249205A1 (en) | 1997-09-25 |
| AU2217797A (en) | 1997-10-10 |
| EP0888339A1 (en) | 1999-01-07 |
| JP3258334B2 (ja) | 2002-02-18 |
| US5919946A (en) | 1999-07-06 |
| WO1997034890A1 (en) | 1997-09-25 |
| US6037475A (en) | 2000-03-14 |
| EP0888339A4 (en) | 2001-02-28 |
| KR20000064764A (ko) | 2000-11-06 |
| IL126272A0 (en) | 1999-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT945132E (pt) | Composicao de ibuprofeno | |
| BR9509200A (pt) | Composição de matéria | |
| BR9701294A (pt) | Composição geradora de gás | |
| BR9507179A (pt) | Derivados de 3-aril-4-hidróxi-delta3-dihidrotiofena | |
| BR9509716A (pt) | Composição de redução de pregas | |
| PT1032396E (pt) | Esterilizacao de glucocorticoesteroides | |
| EP0968223A4 (en) | BIOKON JUGATION OF MACROMOLECULES | |
| PT892640E (pt) | Composicoes farmaceuticas de micofenolato entericamente revestidas | |
| PT1014987E (pt) | Composicoes orais de levosimendano | |
| BR9710577A (pt) | Composi-Æo de xampu | |
| BR9509436A (pt) | Inibidores de síntese de apoliproteina-B | |
| BR9710648A (pt) | S¡ntese de indolilmaleimidas | |
| PT829205E (pt) | Producao de condimento | |
| BR9711363A (pt) | Sintese de bis-indolilmaleimidas | |
| PT923594E (pt) | Compostos de bromotiacumicina | |
| ID28032A (id) | TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2 | |
| ID16838A (id) | Komposisi dekafluoropentana | |
| IT1295934B1 (it) | Procedimento migliorato per la sintesi di alchilpoliglucosidi | |
| BR9607046A (pt) | Derivados de 3-pirrolidiliden-2-ona-cefalosporinas | |
| DE69625500D1 (de) | Achselzusammensetzungen | |
| ID22379A (id) | Hidrogenasi imina enamina | |
| ID17419A (id) | Komposisi dekafluoropentana | |
| BR9708718A (pt) | Sínteses de aminas substituídas | |
| PT1060159E (pt) | Sintese de beta-aminoacidos quirais | |
| ID21769A (id) | Komposisi-komposisi cangkokan hasil kopolimerisasi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |