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BR9710587A - Inibidores de canal de potássio - Google Patents

Inibidores de canal de potássio

Info

Publication number
BR9710587A
BR9710587A BR9710587-2A BR9710587A BR9710587A BR 9710587 A BR9710587 A BR 9710587A BR 9710587 A BR9710587 A BR 9710587A BR 9710587 A BR9710587 A BR 9710587A
Authority
BR
Brazil
Prior art keywords
optionally substituted
alkyl
potassium channel
channel inhibitors
aryl
Prior art date
Application number
BR9710587-2A
Other languages
English (en)
Inventor
Neil A Castle
Sean P Hollinshead
Philip F Hughes
Jose S Mendonza
Joseph W Wilson
George Amato
Serge Beaudoin
Michael Gross
Grant Mcnaughton-Smith
Original Assignee
Icagen Inc
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icagen Inc, Lilly Co Eli filed Critical Icagen Inc
Publication of BR9710587A publication Critical patent/BR9710587A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Heads (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Optical Communication System (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Amplifiers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"INIBIDORES DE CANAL DE POTáSSIO" Compostos de fórmula genérica (I) 0nde R^ 1^ é H, alquila ou é selecionado do grupo consistindo em um arila opcionalmente substituído, um hetero arila opcionalmente substituído, um hetero ciclila opcionalmente substitupido e um carbo ciclo alquila opcionalmente substituído; R^ 2^ é selecionado do grupo consistindo em alquila, um arila opcionalmente substituído, um hetero arila opcionalmente substituído, um hetero ciclila opcionalmente substituído e um carbo ciclo alquila opcionalmente substituído; R^ 3^ é hidrogênio ou metila; R^ 4^ é hidrogênio ou metila; X^ 1^ é C=O, C=S, ou SO~ 2~; X^ 2^ é C=O ou SO~ 2~; Y^ 1^ é O, (CH~ 2~)~ p~, CH~ 2~O, HC=CH ou NH; onde p é 0, 1 ou 2; Y^ 2^ é O, (CH~ 2~)~ q~, HC=CH ou NH; onde q é 0 ou 1; Z é H, OR^ 5^ ou NR^ 6^R^ 7^; onde R^ 5^ é H, (CH~ 2~)~ m~-R^ 8^; ou C (O) - (CH~ 2~)~ m~ -R^ 8^; m=1 a 5; R^ 8^ é N (R^ 9^)~ 2~, N (R^ 9^)~ 3~ L ou CO~ 2~R^ 9^; onde cada R^ 9^ é independentemente selecionado de H ou alquila; e L é um contra íon; R^ 6^ é H ou alquila; R^ 7^ é H, alquila ou CO~ 2~R^ 10^ onde R^ 10^ é alquila; ou seus sais ou pró-drogas farmaceuticamente aceitáveis são úteis como inibidores de canal de potássio e úteis para o tratamento de arritmias cardíacas e desordens proliferativas de células.
BR9710587-2A 1996-07-26 1997-07-23 Inibidores de canal de potássio BR9710587A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2254796P 1996-07-26 1996-07-26
US08/893,160 US6083986A (en) 1996-07-26 1997-07-15 Potassium channel inhibitors
PCT/US1997/012559 WO1998004521A1 (en) 1996-07-26 1997-07-23 Potassium channel inhibitors

Publications (1)

Publication Number Publication Date
BR9710587A true BR9710587A (pt) 2000-10-31

Family

ID=26696048

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9710587-2A BR9710587A (pt) 1996-07-26 1997-07-23 Inibidores de canal de potássio

Country Status (12)

Country Link
US (1) US6083986A (pt)
EP (1) EP0923543B1 (pt)
JP (1) JP2002513385A (pt)
KR (1) KR20000029605A (pt)
AT (1) ATE250571T1 (pt)
AU (1) AU734711B2 (pt)
BR (1) BR9710587A (pt)
CA (1) CA2261814A1 (pt)
DE (1) DE69725153T2 (pt)
HU (1) HUP0003250A3 (pt)
IL (1) IL128205A (pt)
WO (1) WO1998004521A1 (pt)

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Also Published As

Publication number Publication date
AU3803597A (en) 1998-02-20
HK1020334A1 (en) 2000-04-14
HUP0003250A1 (hu) 2002-01-28
IL128205A (en) 2003-09-17
ATE250571T1 (de) 2003-10-15
JP2002513385A (ja) 2002-05-08
IL128205A0 (en) 1999-11-30
WO1998004521A1 (en) 1998-02-05
KR20000029605A (ko) 2000-05-25
AU734711B2 (en) 2001-06-21
EP0923543A1 (en) 1999-06-23
EP0923543B1 (en) 2003-09-24
CA2261814A1 (en) 1998-02-05
HUP0003250A3 (en) 2002-02-28
US6083986A (en) 2000-07-04
DE69725153D1 (de) 2003-10-30
DE69725153T2 (de) 2004-06-09

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